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36 Newest Publications of de Gruyter

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Genotyping of the hemochromatosis HFE p.H63D and p.C282Y mutations by high-resolution melting with the Rotor-Gene 6000® instrument

17-Jun-2011 | Paulo Caleb Junior Lima Santos; Renata Alonso Gadi Soares; Jose Eduardo Krieger; Elvira Maria Guerra-Shinohara; ..., Clinical Chemistry , 2011

Abstract Background: The genotyping of HFE p.C282Y and p.H63D mutations is one of the most requested molecular analyses in the laboratorial routine. In this scenario, the main aim was to develop a genotyping assay that has advantages compared to other methods. Methods: Genotypes for the HFE ...


Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-κB activation

23-May-2011 | Cornelia Rieke; Anja Papendieck; Olga Sokolova; Michael Naumann, Biological Chemistry, 2011

Abstract Helicobacter pylori, the etiological agent of several human gastric diseases, induces the transcription factor nuclear factor-κB (NF-κB) in colonized epithelial cells leading to the release of proinflammatory mediators. Activation of NF-κB involves the IκB kinase (IKK)-complex composed ...


Organelle stress-induced activating transcription factor-3 downregulates low-density lipoprotein receptor expression in Sk-Hep1 human liver cells

23-May-2011 | Joo Hyun Lim; Hyo Jung Lee; Youngmi Kim Pak; Won-Ho Kim; Jihyun Song, Biological Chemistry, 2011

Abstract The low-density lipoprotein receptor (LDLR) plays a central role in cholesterol homeostasis. Here, we provide evidence that an increase in endoplasmic reticulum (ER) stress response or a disturbance of mitochondrial function inhibits LDLR expression in human liver Sk-Hep1 cells. Both ...


Synthesis of recombinant high density lipoprotein with apolipoprotein A-I and apolipoprotein A-V

23-May-2011 | Xinbo Zhang; Baosheng Chen, Biological Chemistry, 2011

Abstract It has been shown that apolipoprotein A-V (apoA-V) over-expression significantly lowers plasma triglyceride levels and decreases atherosclerotic lesion development. To assess the feasibility of recombinant high density lipoprotein (rHDL) reconstituted with apoA-V and apolipoprotein A-I ...


The role of cathepsin E in terminal differentiation of keratinocytes

23-May-2011 | Tomoyo Kawakubo; Atsushi Yasukochi; Kuniaki Okamoto; Yoshiko Okamoto; Seiji Nakamura; Kenji Yamamoto, Biological Chemistry, 2011

Abstract Cathepsin E (CatE) is predominantly expressed in the rapidly regenerating gastric mucosal cells and epidermal keratinocytes, in addition to the immune system cells. However, the role of CatE in these cells remains unclear. Here we report a crucial role of CatE in keratinocyte terminal ...


High catalytic efficiency and resistance to denaturing in bacterial Rho GTPase-activating proteins

23-May-2011 | Yael Litvak; Rena Levin-Klein; Moti Avner; Zvi Selinger, Biological Chemistry, 2011

Abstract Several major bacterial pathogens use the type III secretion system (TTSS) to deliver virulence factors into host cells. Bacterial Rho GTPase activating proteins (RhoGAPs) comprise a remarkable family of type III secreted toxins that modulate cytoskeletal dynamics and manipulate cellular ...


Implementation of computerized add-on testing for hospitalized patients in a large academic medical center

12-Apr-2011 | Ji Yeon Kim; Irina K. Kamis; Balaji Singh; Shalini Batra; Roberta H. Dixon; Anand S. Dighe, Clinical Chemistry , 2011

Abstract Background: Physician requests for additional testing on an existing laboratory specimen (add-ons) are resource intensive and generally require a phone call to the laboratory. Verbal orders such as these have been noted to be associated with errors in accuracy. The aim of this study was ...


High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction

12-Apr-2011 | Akar Yilmaz; Seldag Bekpinar; Yesim Unlucerci; Figen Gurdol; Berrin Umman, Clinical Chemistry , 2011

Abstract Background: Increased concentrations of asymmetric dimethylarginine (ADMA) have been detected in patients with cardiovascular risk factors. In addition, high baseline plasma concentrations of ADMA have been shown to be an independent predictor of adverse outcomes in various disorders. ...


Pseudohypocalcemia caused by perchlorate (Irenat®)

12-Apr-2011 | Jürgen Durner; Ursula Winkler-Budenhofer; Simon Gahr; Walter Samtleben; Ulf Schönermarck, Clinical Chemistry , 2011

Abstract Background: Blood gas analysis (BGA), including measurement of ionized calcium, is performed routinely in patients with end stage renal disease on renal replacement therapy, especially when using citrate for regional anticoagulation. After installation of a new blood gas analyzer ...


False positive troponin result caused by a true macrotroponin

12-Apr-2011 | Etienne C.H.J. Michielsen; Pieter G.T. Bisschops; Marcel J.W. Janssen, Clinical Chemistry , 2011

Abstract Background: A 35-year-old female presented with complaints of tiredness, shortness of breath and recent onset of chest pain. The cardiac troponin I (cTnI) concentration was elevated at 6.4μg/L (Abbott Architect reference ...


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