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26 Newest Publications of de Gruyter

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Review: Factor V Leiden and FII 20210 testing in thromboembolic disorders

26-01-2011 | Tadej Pajič, Clinical Chemistry , 2011

Abstract Factor V Leiden and prothrombin (F2) c.20210G>A mutation detection are very important in order to define the increased relative risk for venous thromboembolism in selected patients. Use of DNA-based methods to detect both mutations has become widely available in clinical diagnostic ...

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Review: Hyperhomocysteinemia and thrombophilia

26-01-2011 | Mojca Božič-Mijovski, Clinical Chemistry , 2011

Abstract It is now widely accepted that hyperhomocysteinemia (HHC) is a risk factor for thrombophilia. HHC is the result of either impaired enzyme function or a deficiency of vitamin B (folate, B6, B12), or both, and can be treated with vitamin supplements. Measuring plasma total homocysteine ...

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Review: Pediatric thrombosis

26-01-2011 | Alenka Trampus-Bakija, Clinical Chemistry , 2011

Abstract Thrombotic risk factors and thrombosis in children has been receiving increased attention. True idiopathic thrombosis is extremely rare in children. Most patients have a significant underlying medical condition and the presence of a central catheter is the most important risk factor. ...

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Review: Methodological issues of genetic association studies

26-01-2011 | Ana-Maria Simundic, Clinical Chemistry , 2011

Abstract Genetic association studies explore the association between genetic polymorphisms and a certain trait, disease or predisposition to disease. It has long been acknowledged that many genetic association studies fail to replicate their initial positive findings. This raises concern about ...

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Review: Platelet physiology and antiplatelet agents

26-01-2011 | Tim Thijs; Benedicte P. Nuyttens; Hans Deckmyn; Katleen Broos, Clinical Chemistry , 2011

Abstract Apart from the central beneficial role platelets play in hemostasis, they are also involved in atherothrombotic diseases. Here, we review the current knowledge of platelet intracellular signal transduction pathways involved in platelet adhesion, activation, amplification of the ...

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An outline for a vocabulary of nominal properties and examinations – basic and general concepts and associated terms

10-11-2010 | Gunnar Nordin; René Dybkaer; Urban Forsum; Xavier Fuentes-Arderiu; Gunther Schadow; Françoise Pontet ..., Clinical Chemistry , 2010

Abstract Scientists of disciplines in clinical laboratory sciences have long recognized the need for a common language for efficient and safe request of investigations, reporting of results, and communication of experience and scientific achievements. Widening the scope, most scientific ...

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Nucleic acid reference materials (NARMs): definitions and issues

10-11-2010 | Deborah A. Payne; Cyril D.S. Mamotte; David Gancberg; Mario Pazzagli; Ron H.N. van Schaik; Heinz Schimmel; Fra ..., Clinical Chemistry , 2010

Abstract Molecular diagnostics is one of the most rapidly growing areas of laboratory medicine. This rapid growth of clinical molecular tests has outpaced the availability and development of reference methods and reference materials. Such methods and materials are important for the development, ...

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First certified reference material for cystatin C in human serum ERM-DA471/IFCC

10-11-2010 | Anders Grubb; Søren Blirup-Jensen; Veronica Lindström; Camilla Schmidt; Harald Althaus; Ingrid Zeger ..., Clinical Chemistry , 2010

Abstract The IFCC Working Group for the Standardisation of Cystatin C (WG-SCC), in collaboration with the Institute for Reference Materials and Measurements (IRMM), announces the availability of the new certified reference material ERM-DA471/IFCC. The material was characterised using a pure ...

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Review: Standardizing plasma protein measurements worldwide: a challenging enterprise

10-11-2010 | Giampaolo Merlini; Søren Blirup-Jensen; A. Myron Johnson; Joanna Sheldon; Ingrid Zegers; on behalf of the ..., Clinical Chemistry , 2010

Abstract The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma ...

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Translations of the “Evidence-Based Medicine” concept in different languages: is it time for international standardisation?

21-09-2010 | Joseph Watine, Clinical Chemistry , 2010

Abstract Although the concept of Evidence-Based Medicine (EBM) is quite popular among English speaking physicians, it still needs to be adopted by an overwhelming majority of health care professionals in countries where English is not familiar. Thus, this concept can be translated in many ...

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