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30 Newest Publications of de Gruyter

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IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase

24-Jun-2011 | Gerhard Schumann; Rainer Klauke; Francesca Canalias; Steffen Bossert-Reuther; Paul F.H. Franck; F.-Javier Gell ..., Clinical Chemistry , 2011

Abstract This paper is the ninth in a series dealing with reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C and the certification of reference preparations. Other parts deal with: Part 1. The concept of reference procedures for the measurement of ...


Comparative evaluation of capillary zone electrophoresis and HPLC in the determination of carbohydrate-deficient transferrin

13-Jun-2011 | Massimo Daves; Roberto Cemin; Mirella Floreani; Irene Pusceddu; Giovanni Cosio; Giuseppe Lippi, Clinical Chemistry , 2011

Abstract Background: Transferrin (Tf) glycoform lacking one or two complete or incomplete glycan chains (i.e., asialo-monosialo- and disialo-Tf) typically appear in blood after chronic alcohol consumption, though recently it was reported that monosialo-Tf is associated with trisialo-Tf but not ...


Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects

13-Jun-2011 | Abayomi O. Akanji; Abdulwahab N. Al-Isa; Lukman Thalib, Clinical Chemistry , 2011

Abstract Background: Acute coronary syndromes present clinically as a consequence of plaque rupture and thrombosis possibly related to altered homeostasis of thrombogenic factors. It is speculated that this vulnerability in adults should be predictable from blood levels of thrombogenic biomarkers ...


N Latex FLC – new monoclonal high-performance assays for the determination of free light chain kappa and lambda

11-Jun-2011 | (Henk te Velthuis et al), Clinical Chemistry , 2011

Clinical Chemistry and Laboratory Medicine, Volume 49, Issue 8, Page 1323-1332, August 2011.


Evaluation of a commercially available rapid urinary porphobilinogen test

31-May-2011 | Michael Vogeser; Thomas Stauch, Clinical Chemistry , 2011

Abstract Background: Demonstration of substantially increased urinary excretion of porphobilinogen is the cornerstone of diagnosing acute porphyria crisis. Because porphobilinogen testing is not implemented on clinical chemistry analysers, respective analyses are available in rather few clinical ...


High-throughput LC-MS/MS method for monitoring sirolimus and everolimus in the routine clinical laboratory

17-May-2011 | Mariela Ivanova; Carlo Artusi; Giulia Polo; Martina Zaninotto; Mario Plebani, Clinical Chemistry , 2011

Abstract Background: Immunosuppressant therapeutic drug monitoring (TDM) is an important requirement in post-transplant patient care. In recent years, high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has become a valid alternative to antibody-based ...


Blood cells characteristics as determinants of acute myocardial infarction

02-May-2011 | Roberto Cemin; Luca Donazzan; Giuseppe Lippi; Francesca Clari; Massimo Daves, Clinical Chemistry , 2011

Abstract Background: The aim of this study is to analyse the relation between red blood cells, platelets morphology and acute myocardial infarction (AMI), and to assess whether they could supplement the role of traditional cardiac biomarkers in the early identification of patients with AMI. ...


Confirmation of congenital adrenal hyperplasia by adrenal steroid profiling of filter paper dried blood samples using ultra-performance liquid chromatography-tandem mass spectrometry

12-Apr-2011 | Claudia Rossi; Lisa Calton; Heather A. Brown; Scott Gillingwater; A. Michael Wallace; Francesca Petrucci; Dome ..., Clinical Chemistry , 2011

Abstract Background: The specificity of screening for congenital adrenal hyperplasia by direct measurement of 17-hydroxyprogesterone in filter paper dried blood spot samples by immunoassay is low and has a high false-positive rate. In order to reduce the false-positive rate of this test, we ...


Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)

12-Apr-2011 | Andreas Kappel; Sina Stephan; Gerlinde Christ; Anja Haude-Barten; Madeleine Dahm; Herbert Schwarz; Bodo Fisch ..., Clinical Chemistry , 2011

Abstract Background: The Luminescent Oxygen Channeling Immunoassay (LOCI®) technology is a well-established homogeneous assay format that allows for fast, accurate, and highly sensitive quantitation of analytes. We set out to develop and prove a novel concept to establish a LOCI format that ...


Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis

12-Apr-2011 | Yoko Tabe; Yukiko Kawase; Kazunori Miyake; Naotake Satoh; Nanae Aritaka; Yasushi Isobe; Kazuo Oshimi; Norio ..., Clinical Chemistry , 2011

Abstract Background: The determination of polymerase chain reaction (PCR) amplification product sizes of the Bcl-2/IgH fusion gene from follicular lymphoma (FL) provides evidence of clonal identity. Methods: The present study describes detection of Bcl-2/IgH fusion gene clonality utilizing a ...


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