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57 Newest Publications of de Gruyter

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mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

06-Oct-2011 | Matthias Kotzsch; Julia Dorn; Kristina Doetzer; Barbara Schmalfeldt; Janna Krol; Gustavo Baretton; Marion Kie ..., Biological Chemistry, 2011

Abstract High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified ...


Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris

13-Sep-2011 | Hai Ling Li; Wen Hui Peng; Shi Tao Cui; Hou Lei; Yi Dong Wei; Wei Ming Li; Ya Wei Xu, Clinical Chemistry , 2011

Abstract Background: Vaspin was a recently identified adipokine, playing a protective role in many metabolic diseases. The present study aimed to investigate the association between vaspin plasma level and stable angina pectoris (SAP) and unstable angina pectoris (UAP). Methods: A total of 88 ...


Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors

30-Aug-2011 | Miriam Kuester; Gero L. Becker; Kornelia Hardes; Iris Lindberg; Torsten Steinmetzer; Manuel E. Than, Biological Chemistry, 2011

Abstract In eucaryotes, many secreted proteins and peptides are proteolytically excised from larger precursor proteins by a specific class of serine proteases, the proprotein/prohormone convertases (PCs). This cleavage is essential for substrate activation, making the PCs very interesting ...


Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP

28-Aug-2011 | Maria Arampatzidou; Kristina Mayer; Maria E. Iolyeva; Seblewongel Gebre Asrat; Mirunalini Ravichandran; Thomas ..., Biological Chemistry, 2011

Abstract Cathepsin B has been shown to not only reside within endo-lysosomes of intestinal epithelial cells, but it was also secreted into the extracellular space of intestinal mucosa in physiological and pathological conditions. In an effort to further investigate the function of this protease ...


Review: Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer

18-Jul-2011 | Athina Markou; Yu Liang; Evi Lianidou, Clinical Chemistry , 2011

Abstract Non-small cell lung carcinomas (NSCLC) account for about 80% of lung cancers and their remarkable heterogeneity manifests in histology, pathogenesis, prognosis, and response to treatments. Recent advances in molecular characterization help stratifying NSCLC patients for their potential ...


Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease

17-Jun-2011 | Chih-Chia Chang; Po-Hui Wang; Pen-Hua Su; Ding-Bang Lin; Tsung-Ho Ying; Shun-Fa Yang; Yi-Hsien Hsieh, Clinical Chemistry , 2011

Abstract Background: Pentraxin 3 (PTX3) plays an important role in innate immune responses and in inflammation disease. The aim of this study was to investigate the diagnostic and prognostic potential of PTX3 in pelvic inflammatory disease (PID) and correlate it with the severity and outcome of ...


Differential expression of CDC25 phosphatases splice variants in human breast cancer cells

16-Jun-2011 | Hélène Albert; Susana Santos; Eric Battaglia; Miguel Brito; Carolino Monteiro; Denyse Bagrel, Clinical Chemistry , 2011

Abstract Background: CDC25 phosphatases control cell cycle progression by activating cyclin dependent kinases. The three CDC25 isoforms encoding genes are submitted to alternative splicing events which generate at least two variants for CDC25A and five for both CDC25B and CDC25C. An ...


New serum biomarkers for detection of tuberculosis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

14-Jun-2011 | Ji-Yan Liu; Lei Jin; Meng-Yuan Zhao; Xin Zhang; Chi-Bo Liu; Yu-Xiang Zhang; Fu-Jian Li; Jian-Min Zhou; Hua-J ..., Clinical Chemistry , 2011

Abstract Background: New technologies for the early detection of tuberculosis (TB) are urgently needed. Pathological changes within an organ might be reflected in proteomic patterns in serum. The aim of the present study was to screen for the potential protein biomarkers in serum for the ...


Serum APRIL, a potential tumor marker in pancreatic cancer

25-May-2011 | Feng Wang; Lin Chen; Weifeng Ding; Guihua Wang; Yueping Wu; Jingchun Wang; Leilei Luo; Hui Cong; Yueguo Wan ..., Clinical Chemistry , 2011

Abstract Background: A proliferation-inducing ligand (APRIL) is a newly-found member in the tumor necrosis factor (TNF) superfamily. Our previous studies have already confirmed that APRIL is overexpressed in pancreatic cancer tumors, however, it is not expressed or has a weak expression in normal ...


Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries

23-May-2011 | Veerle Matheeussen; Lesley Baerts; Guido De Meyer; Gilles De Keulenaer; Pieter Van der Veken; Koen Augustyns; ..., Biological Chemistry, 2011

Abstract Dipeptidyl peptidase IV (DPPIV)/CD26 is by far the most extensively studied member of the prolyl oligopeptidase family of serine proteases. The discovery of the related enzymes DPP8 and DPP9 necessitates a (re-)evaluation of the DPPIV-like enzymatic activity in cells and organs. In this ...


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