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25 Newest Publications of de Gruyter

matching the following criteria

Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis

16-Sep-2011 | Ciprian N. Silaghi; Dana Fodor; Victor Cristea; Alexandra M. Crăciun, Clinical Chemistry , 2011

Abstract Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in ...


Dynamics of septin ring and collar formation in Saccharomyces cerevisiae

09-Aug-2011 | (Hsin Chen et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 8-9, Page 689-697, August 2011.


Septin9 is involved in septin filament formation and cellular stability

09-Aug-2011 | (Annette Füchtbauer et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 8-9, Page 769-777, August 2011.


Structural and biochemical properties of Sept7, a unique septin required for filament formation

09-Aug-2011 | (Eldar Zent et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 8-9, Page 791-797, August 2011.


Association of a functional polymorphism in the MMP7 gene promoter with susceptibility to vulnerable carotid plaque in a Han Chinese Population

04-Jul-2011 | Xiao-Fei Hu; Xiao-Ping Jin; Pei-Yang Hu; Min Zhu; Feng Wang; Xian-Fang Lin; Wei-Ling Li; Hong Ni; Li-Hua Yang, Clinical Chemistry , 2011

Abstract Background: Matrix metalloproteinase-7 (MMP-7) may play an important role in the development of vulnerable carotid plaque. An A-to-G transition (–181A/G) in the promoter region of MMP7 is functional in vitro by altering the transcriptional activity of the gene. The aim of this study was ...


The function of oxalic acid in the human metabolism

01-Jun-2011 | Daniel Stewart Robertson, Clinical Chemistry , 2011

Abstract Biochemical reactions in cells which involve oxalic acid are described. It is shown that this compound is required for the formation of uracil and orotic acid. The former is a component of RNA which is common to all cells in the human metabolism. On the basis of the biochemical reactions ...


TGFβ1 suppresses vascular smooth muscle cell motility by expression of N-cadherin

23-May-2011 | Johannes M. Nuessle; Klaudia Giehl; Rosa Herzog; Sylvia Stracke; Andre Menke, Biological Chemistry, 2011

Abstract Neointimal formation in atheromatous blood vessels is associated with both growth factor-induced differentiation of smooth muscle cells and endothelial-to-mesenchymal transition. Transforming growth factor beta (TGFβ)-signaling is well known to play a critical role in the regulation of ...


Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression

23-May-2011 | Michelle F. Maritz; Pauline J. van der Watt; Nina Holderness; Michael J. Birrer; Virna D. Leaner, Biological Chemistry, 2011

Abstract AP-1, a transcription factor comprised primarily of Jun and Fos family proteins, regulates genes involved in proliferation, differentiation and oncogenesis. Previous studies demonstrated that elevated expression of Jun and Fos family member proteins is associated with numerous human ...


Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence

23-May-2011 | Tomasz Kantyka; Karolina Plaza; Joanna Koziel; Danuta Florczyk; Hennig R. Stennicke; Ida B. Thogersen; Jan J. ..., Biological Chemistry, 2011

Abstract Bacterial proteases are considered virulence factors and it is presumed that by abrogating their activity, host endogenous protease inhibitors play a role in host defense against invading pathogens. Here we present data showing that Staphylococcus aureus cysteine proteases (staphopains) ...


Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation

12-Apr-2011 | Michał Zaąbczyk; Rafał Głowacki; Andrzej Machnik; Paweł Heród; Grzegorz Kazek; Hi ..., Clinical Chemistry , 2011

Abstract Background: A homocysteine (Hcy) metabolite, thioester Hcy-thiolactone, whose reaction with protein lysine residues affords N-homocysteinylated proteins, has been implicated in cardiovascular disease. Proteolytic turnover of N-homocysteinylated proteins generates the isopeptide ...


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