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44 Newest Publications of de Gruyter

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Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer

13-Dec-2011 | Jamshid Farahati; Dirk Roggenbuck; Elena Gilman; Martin Schütte; Elena Jagminaite; Rasoul Seyed Zakavi; T ..., Clinical Chemistry , 2011

Abstract Background: The presence of thyroid peroxidase antibodies (TPOab) are reported to be associated with improved outcome among breast cancer patients. We evaluated the correlation between TPOab and diagnostic parameters among newly diagnosed breast cancer patients. Methods: Three hundred ...


Promising approaches in using magnetic nanoparticles in oncology

06-Oct-2011 | Georgy Mikhaylov; Olga Vasiljeva, Biological Chemistry, 2011

Abstract The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of ...


Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts

06-Oct-2011 | Stefan Tholen; Martin L. Biniossek; Anna-Lena Geßler; Sebastian Müller; Juliane Weißer; Jayachan ..., Biological Chemistry, 2011

Abstract The endolysosomal cysteine endoprotease cathepsin L is secreted from cells in a variety of pathological conditions such as cancer and arthritis. We compared the secretome composition and extracellular proteolytic cleavage events in cell supernatants of cathepsin L-deficient and wild-type ...


The significance of the Cα substituent in the selective inhibition of matrix metalloproteinases 1 and 9

06-Oct-2011 | Riyad Domingo; Kelly Chibale; Edward D. Sturrock, Biological Chemistry, 2011

Abstract Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence there is a burgeoning need to develop inhibitors that bind selectively to structurally similar MMPs. The ...


Review: Increased plasma concentrations of tumour markers in the absence of neoplasia

06-Sep-2011 | Jaume Trapé; Xavier Filella; Montse Alsina-Donadeu; Lluïsa Juan-Pereira; Àngels Bosch-Ferrer; Ra ..., Clinical Chemistry , 2011

Abstract Tumour markers are a very heterogeneous group of molecules that are generally found in very small concentrations in the plasma and serum of healthy individuals. In the process of neoplastic differentiation the cell can synthesize, release, or induce synthesis of other cells, thus ...


Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors

30-Aug-2011 | Miriam Kuester; Gero L. Becker; Kornelia Hardes; Iris Lindberg; Torsten Steinmetzer; Manuel E. Than, Biological Chemistry, 2011

Abstract In eucaryotes, many secreted proteins and peptides are proteolytically excised from larger precursor proteins by a specific class of serine proteases, the proprotein/prohormone convertases (PCs). This cleavage is essential for substrate activation, making the PCs very interesting ...


Phenotype of Gc-globulin influences the macrophage activating factor (MAF) levels in serum

23-Aug-2011 | Evi Debruyne; Marijn Speeckaert; Yannick Vande Weygaerde; Joris Delanghe, Clinical Chemistry , 2011

Abstract Background: Gc-globulin is a polymorphic protein with three phenotypes: Gc 1-1, Gc 2-1 and Gc 2-2. Deglycosylation of Gc-globulin results in a Gc-macrophage activating factor (Gc-MAF). This study investigated the potential of MAF as a tumour marker and the influence of Gc-phenotypes on ...


Differential expression of CDC25 phosphatases splice variants in human breast cancer cells

16-Jun-2011 | Hélène Albert; Susana Santos; Eric Battaglia; Miguel Brito; Carolino Monteiro; Denyse Bagrel, Clinical Chemistry , 2011

Abstract Background: CDC25 phosphatases control cell cycle progression by activating cyclin dependent kinases. The three CDC25 isoforms encoding genes are submitted to alternative splicing events which generate at least two variants for CDC25A and five for both CDC25B and CDC25C. An ...


The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and prostate-specific antigen (PSA) in prostate cancer

15-Jun-2011 | Adam Daragó; Andrzej Sapota; Józef Matych; Marzenna Nasiadek; Małgorzata Skrzypińska-Gawrys ..., Clinical Chemistry , 2011

Abstract Background: The objective of the present study is to explore the association between zinc concentrations and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and total prostate-specific antigen (tPSA) levels in the serum of patients with prostate cancer (PCa) and ...


Post-transcriptional regulation of human cathepsin L expression

23-May-2011 | Shivani Mittal; Riyaz A. Mir; Shyam S. Chauhan, Biological Chemistry, 2011

Abstract The expression of cathepsin L, a lysosomal protease, is known to be elevated in cancer and other pathologies. Multiple splice variants of human cathepsin L with variable 5′UTRs exist, which encode for the same protein. Previously we have observed that variant hCATL A (bearing the longest ...


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