26-01-2011 | Tadej Pajič, Clinical Chemistry , 2011

Abstract Factor V Leiden and prothrombin (F2) c.20210G>A mutation detection are very important in order to define the increased relative risk for venous thromboembolism in selected patients. Use of DNA-based methods to detect both mutations has become widely available in clinical diagnostic ...

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26-01-2011 | Mojca Božič-Mijovski, Clinical Chemistry , 2011

Abstract It is now widely accepted that hyperhomocysteinemia (HHC) is a risk factor for thrombophilia. HHC is the result of either impaired enzyme function or a deficiency of vitamin B (folate, B6, B12), or both, and can be treated with vitamin supplements. Measuring plasma total homocysteine ...

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26-01-2011 | Alenka Trampus-Bakija, Clinical Chemistry , 2011

Abstract Thrombotic risk factors and thrombosis in children has been receiving increased attention. True idiopathic thrombosis is extremely rare in children. Most patients have a significant underlying medical condition and the presence of a central catheter is the most important risk factor. ...

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26-01-2011 | Ana-Maria Simundic, Clinical Chemistry , 2011

Abstract Genetic association studies explore the association between genetic polymorphisms and a certain trait, disease or predisposition to disease. It has long been acknowledged that many genetic association studies fail to replicate their initial positive findings. This raises concern ...

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26-01-2011 | Tim Thijs; Benedicte P. Nuyttens; Hans Deckmyn; Katleen Broos, Clinical Chemistry , 2011

Abstract Apart from the central beneficial role platelets play in hemostasis, they are also involved in atherothrombotic diseases. Here, we review the current knowledge of platelet intracellular signal transduction pathways involved in platelet adhesion, activation, amplification of the ...

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10-11-2010 | Gunnar Nordin; René Dybkaer; Urban Forsum; Xavier Fuentes-Arderiu; Gunther Schadow; Françoise Pontet ..., Clinical Chemistry , 2010

Abstract Scientists of disciplines in clinical laboratory sciences have long recognized the need for a common language for efficient and safe request of investigations, reporting of results, and communication of experience and scientific achievements. Widening the scope, most scientific ...

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10-11-2010 | Deborah A. Payne; Cyril D.S. Mamotte; David Gancberg; Mario Pazzagli; Ron H.N. van Schaik; Heinz Schimmel; Fra ..., Clinical Chemistry , 2010

Abstract Molecular diagnostics is one of the most rapidly growing areas of laboratory medicine. This rapid growth of clinical molecular tests has outpaced the availability and development of reference methods and reference materials. Such methods and materials are important for the ...

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10-11-2010 | Anders Grubb; Søren Blirup-Jensen; Veronica Lindström; Camilla Schmidt; Harald Althaus; Ingrid Zeger ..., Clinical Chemistry , 2010

Abstract The IFCC Working Group for the Standardisation of Cystatin C (WG-SCC), in collaboration with the Institute for Reference Materials and Measurements (IRMM), announces the availability of the new certified reference material ERM-DA471/IFCC. The material was characterised using a pure ...

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10-11-2010 | Giampaolo Merlini; Søren Blirup-Jensen; A. Myron Johnson; Joanna Sheldon; Ingrid Zegers; on behalf of the ..., Clinical Chemistry , 2010

Abstract The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma ...

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21-09-2010 | Joseph Watine, Clinical Chemistry , 2010

Abstract Although the concept of Evidence-Based Medicine (EBM) is quite popular among English speaking physicians, it still needs to be adopted by an overwhelming majority of health care professionals in countries where English is not familiar. Thus, this concept can be translated in many ...

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