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52 Newest Publications of de Gruyter

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Serum concentration of neopterin on admission does not improve the diagnostic performance of highly-sensitive troponin I

13-12-2011 | Martina Montagnana; Giuseppe Lippi; Elisa Danese; Gian Luca Salvagno; Gianfranco Cervellin; Gian Cesare Guidi, Clinical Chemistry , 2011

Clinical Chemistry and Laboratory Medicine, Volume 0, Issue 0, Page -, Ahead of Print.

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Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer

13-12-2011 | Paula J. McDonald; Judith A. Strachan; Jayne Digby; Robert J.C. Steele; Callum G. Fraser, Clinical Chemistry , 2011

Abstract Background: Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age. Methods: A single estimate of faecal haemoglobin concentration was ...

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Soluble transcobalamin receptor, sCD320, is present in human serum and relates to serum cobalamin – establishment and validation of an ELISA

13-12-2011 | Johan Frederik Berg Arendt; Edward V. Quadros; Ebba Nexo, Clinical Chemistry , 2011

Abstract Background: The cell-surface receptor, TCblR/CD320, binds and internalizes transcobalamin-bound cobalamin. So far, no assay has been developed in order to quantify the soluble form of the receptor. Methods: This study developed an ELISA employing a monoclonal antibody that recognized the ...

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Review: Increased plasma concentrations of tumour markers in the absence of neoplasia

06-09-2011 | Jaume Trapé; Xavier Filella; Montse Alsina-Donadeu; Lluïsa Juan-Pereira; Àngels Bosch-Ferrer; Ra ..., Clinical Chemistry , 2011

Abstract Tumour markers are a very heterogeneous group of molecules that are generally found in very small concentrations in the plasma and serum of healthy individuals. In the process of neoplastic differentiation the cell can synthesize, release, or induce synthesis of other cells, thus ...

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Influence of hemolysis on troponin testing: studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature

06-09-2011 | Giuseppe Lippi; Paola Avanzini; Mariella Dipalo; Rosalia Aloe; Gianfranco Cervellin, Clinical Chemistry , 2011

Abstract Background: Hemolyzed specimens are the leading pre-analytical problem in the laboratory practice, and exert a negative impact on test results. We assessed the reliability of Beckman Coulter UniCel Dxl 800 Accu-TnI testing on hemolyzed specimens. Methods: Twelve non-hemolyzed ...

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Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort

25-08-2011 | Edzard Schwedhelm; Vanessa Xanthakis; Renke Maas; Lisa M. Sullivan; Dorothee Atzler; Nicole Lüneburg; Nic ..., Clinical Chemistry , 2011

Abstract Background: Symmetric dimethylarginine (SDMA) is a by-product of protein methylation. Once released from proteins, SDMA is eliminated by the kidneys; consequently, plasma concentration has been suggested as a sensitive marker of renal function. Furthermore, recent work implicates SDMA in ...

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Bayesian analysis of an international ELISA comparability study

05-07-2011 | Katy Klauenberg; Bernd Ebert; Jan Voigt; Monika Walzel; James E. Noble; Alex E. Knight; Clemens Elster, Clinical Chemistry , 2011

Abstract Background: Immunoassays are biochemical tests applied to measure even very small amounts of substance using the highly specific binding between an antibody and its antigen. They have a wide range of applications. The measurement however, might be associated with substantial uncertainty; ...

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A simple micro-photometric method for urinary iodine determination

24-06-2011 | Gabriele Grimm; Heidelinde Lindorfer; Heidi Kieweg; Rodrig Marculescu; Martha Hoffmann; Alois Gessl; Manfred ..., Clinical Chemistry , 2011

Abstract Background: Urinary iodide concentration (UIC) is useful to evaluate nutritional iodine status. In clinical settings UIC helps to exclude blocking of the thyroid gland by excessive endogenous iodine, if diagnostic or therapeutic administration of radio-iodine is indicated. Therefore, ...

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IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase

24-06-2011 | Gerhard Schumann; Rainer Klauke; Francesca Canalias; Steffen Bossert-Reuther; Paul F.H. Franck; F.-Javier Gell ..., Clinical Chemistry , 2011

Abstract This paper is the ninth in a series dealing with reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C and the certification of reference preparations. Other parts deal with: Part 1. The concept of reference procedures for the measurement of ...

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Diagnostic utility of a soluble cytokeratin 18 assay for gastrointestinal graft-vs.-host disease detection

17-06-2011 | Miguel Waterhouse; Ewa Samek; Marta Torres; Hartmut Bertz; Jürgen Finke, Clinical Chemistry , 2011

Abstract Background: Gastrointestinal/liver graft-vs.-host disease is a frequent complication after allogeneic hematopoietic cell transplantation. Endoscopic biopsies are needed to confirm clinical diagnosis, but this is not always feasible due to concurrent complications after transplantation. ...

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