13-12-2011 | Igor Mindukshev; Stepan Gambaryan; Linda Kehrer; Claudia Schuetz; Anna Kobsar; Natalia Rukoyatkina; Viacheslav ..., Clinical Chemistry , 2011

Abstract Background: Determinations of platelet receptor functions are indispensable diagnostic indicators of cardiovascular and hemostatic diseases including hereditary and acquired receptor defects and receptor responses to drugs. However, presently available techniques for assessing ...

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16-06-2011 | Ngoc Minh Pham; Wang Zhenjie; Makiko Morita; Keizo Ohnaka; Masahiro Adachi; Hisaya Kawate; Ryoichi Takayanagi ..., Clinical Chemistry , 2011

Abstract Background: The association between coffee intake and circulating levels of C-reactive protein (CRP) may be modified by oxidative stress. The authors examined the relation of coffee consumption to serum CRP considering potential interactions of serum γ-glutamyltransferase (GGT) and ...

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27-05-2011 | Marianna Orlova; Tania Di Pietrantonio; Erwin Schurr, Clinical Chemistry , 2011

Abstract Since the completion of the human genome sequence, the study of common genetic polymorphisms in complex human diseases has become a main activity of human genetics. Employing genome-wide association studies, hundreds of modest genetic risk factors have been identified. In infectious ...

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25-05-2011 | Feng Wang; Lin Chen; Weifeng Ding; Guihua Wang; Yueping Wu; Jingchun Wang; Leilei Luo; Hui Cong; Yueguo Wan ..., Clinical Chemistry , 2011

Abstract Background: A proliferation-inducing ligand (APRIL) is a newly-found member in the tumor necrosis factor (TNF) superfamily. Our previous studies have already confirmed that APRIL is overexpressed in pancreatic cancer tumors, however, it is not expressed or has a weak expression in ...

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23-05-2011 | Jan Stöhr; Kerstin Elfrink; Nicole Weinmann; Holger Wille; Dieter Willbold; Eva Birkmann; Detlev Riesner, Biological Chemistry, 2011

Abstract The conversion of the cellular isoform of the prion protein (PrPC) into the pathologic isoform (PrPSc) is the key event in prion diseases. To study the conversion process, an in vitro system based on varying the concentration of low amounts of sodium dodecyl sulfate (SDS) has been ...

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23-05-2011 | Tatyana V. Nikitina; Lyudmila I. Tischenko; Wolfgang A. Schulz, Biological Chemistry, 2011

Abstract The products of transcription by the multisubunit enzyme RNA polymerase III (Pol III), such as 5S rRNA, tRNAs, U6 snRNA, are important for cell growth, proliferation and differentiation. The known range of the Pol III transcriptome has expanded over recent years, and novel functions ...

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23-05-2011 | Cornelia Rieke; Anja Papendieck; Olga Sokolova; Michael Naumann, Biological Chemistry, 2011

Abstract Helicobacter pylori, the etiological agent of several human gastric diseases, induces the transcription factor nuclear factor-κB (NF-κB) in colonized epithelial cells leading to the release of proinflammatory mediators. Activation of NF-κB involves the IκB kinase (IKK)-complex ...

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17-05-2011 | Cristina D. de Castilhos; Jamila Mezzalira; Mariana P.S. Goldim; Frederico G. Werlang; Janice C. Coelho, Clinical Chemistry , 2011

Abstract Background: Dried blood spots (DBS) on filter paper is a valuable sampling technique in clinical chemistry, but the stability of enzymes used in the diagnosis of lysosomal storage diseases (LSDs) needs to be evaluated. Methods: In a first experiment, blood from 20 subjects was ...

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27-04-2011 | Clinical Chemistry , 2011

Molecular Tumor Diagnostic Advances in Clinical and Diagnostic Immunology The Brain: Biological and Cerebral Diseases New Avenues in Laboratory Diagnostics

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12-04-2011 | Slavica Dodig; Darko Richter; Renata Zrinski-Topić, Clinical Chemistry , 2011

Abstract The major characteristic of asthma is persistent airway inflammation that fails to resolve spontaneously. Dysregulation of pro- and anti-inflammatory mechanisms is responsible for the development of chronic inflammation. The inflammatory reaction is mediated by numerous cells and ...

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