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28 Newest Publications of de Gruyter

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Wound degradomics – current status and future perspectives

05-08-2011 | Olivia Hermes; Pascal Schlage; Ulrich auf dem Keller, Biological Chemistry, 2011

Abstract Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic activity at ...

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IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase

24-06-2011 | Gerhard Schumann; Rainer Klauke; Francesca Canalias; Steffen Bossert-Reuther; Paul F.H. Franck; F.-Javier Gell ..., Clinical Chemistry , 2011

Abstract This paper is the ninth in a series dealing with reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C and the certification of reference preparations. Other parts deal with: Part 1. The concept of reference procedures for the measurement of ...

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Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects

23-05-2011 | Ute Bank; Anke Heimburg; Astrid Wohlfarth; Gudrun Koch; Karsten Nordhoff; Heiko Julius; Martin Helmuth; Doree ..., Biological Chemistry, 2011

Abstract The discovery of the DP4-related enzymes DP8 and DP9 raised controversial discussion regarding the physiological and pathophysiological function of distinct members of the DP4 family. Particularly with regard to their potential relevance in regulating immune functions, it is of interest ...

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Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries

23-05-2011 | Veerle Matheeussen; Lesley Baerts; Guido De Meyer; Gilles De Keulenaer; Pieter Van der Veken; Koen Augustyns; ..., Biological Chemistry, 2011

Abstract Dipeptidyl peptidase IV (DPPIV)/CD26 is by far the most extensively studied member of the prolyl oligopeptidase family of serine proteases. The discovery of the related enzymes DPP8 and DPP9 necessitates a (re-)evaluation of the DPPIV-like enzymatic activity in cells and organs. In this ...

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Myeloperoxidase-catalyzed oxidative inactivation of human kininogens: the impairment of kinin-precursor and prekallikrein-binding functions

23-05-2011 | Andrzej Kozik; Anna Golda; Pawel Mak; Piotr Suder; Jerzy Silberring; Anna Barbasz; Maria Rapala-Kozik, Biological Chemistry, 2011

Abstract Bradykinin-related vasoactive peptides (kinins) are important mediators of local and systemic inflammatory reactions. However, at local inflammatory foci, the production of kinins from proteinaceous precursors (kininogens) can be affected by reactive oxygen species released by phagocyte ...

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RNA-dependent RNA polymerases in RNA silencing

23-05-2011 | Yoshiko Maida; Kenkichi Masutomi, Biological Chemistry, 2011

Abstract RNA-dependent RNA polymerases (RdRPs) synthesize double-stranded RNAs that are processed into small RNAs and mediate gene silencing. Viral RdRPs and cellular RdRPs show little structural homology to each other. Cellular RdRPs play key roles in RNA silencing by producing complementary ...

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Effect of sample collection, temperature and time of storage on β-galactosidase and total hexosaminidase activities in dried blood collected on filter paper

17-05-2011 | Cristina D. de Castilhos; Jamila Mezzalira; Mariana P.S. Goldim; Frederico G. Werlang; Janice C. Coelho, Clinical Chemistry , 2011

Abstract Background: Dried blood spots (DBS) on filter paper is a valuable sampling technique in clinical chemistry, but the stability of enzymes used in the diagnosis of lysosomal storage diseases (LSDs) needs to be evaluated. Methods: In a first experiment, blood from 20 subjects was collected ...

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Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes

12-04-2011 | Beatriz Tavira; Eliecer Coto Garciá; Carmen Díaz-Corte; Francisco Ortega; Manuel Arias; Armando Torr ..., Clinical Chemistry , 2011

Abstract Background: Tacrolimus (Tac) is an immunosuppressive drug used to prevent post-transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose and prevent toxicity or rejection. Tac is metabolized by cytochrome-P450 (CYP) enzymes, and variation at the CYP and ...

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Determination of oxidative and occupational stress in palliative care workers

10-03-2011 | Ángela Casado; Alberto Castellanos; Ma Encarnación López-Fernández; Rocío Ruiz; Eulalia ..., Clinical Chemistry , 2011

Abstract Background: In previous work, we demonstrated that some occupational workers in stressful conditions can have increases in several markers of oxidative stress when compared to other workers. We investigated two antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) ...

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Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus

22-11-2010 | David Ruiz Carrillo; Christoph Parthier; Nadine Jänckel; Julia Grandke; Marco Stelter; Stephan Schilling; ..., Biological Chemistry, 2010

Abstract Although enzymes responsible for the cyclization of amino-terminal glutamine residues are present in both plant and mammal species, none have yet been characterized in bacteria. Based on low sequence homologies to plant glutaminyl cyclases (QCs), we cloned the coding sequences of ...

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