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30 Newest Publications of de Gruyter

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Differential expression of CDC25 phosphatases splice variants in human breast cancer cells

16-06-2011 | Hélène Albert; Susana Santos; Eric Battaglia; Miguel Brito; Carolino Monteiro; Denyse Bagrel, Clinical Chemistry , 2011

Abstract Background: CDC25 phosphatases control cell cycle progression by activating cyclin dependent kinases. The three CDC25 isoforms encoding genes are submitted to alternative splicing events which generate at least two variants for CDC25A and five for both CDC25B and CDC25C. An ...

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Review: Genetics of infectious diseases: hidden etiologies and common pathways

27-05-2011 | Marianna Orlova; Tania Di Pietrantonio; Erwin Schurr, Clinical Chemistry , 2011

Abstract Since the completion of the human genome sequence, the study of common genetic polymorphisms in complex human diseases has become a main activity of human genetics. Employing genome-wide association studies, hundreds of modest genetic risk factors have been identified. In infectious ...

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Review: Clustered regularly interspaced short palindromic repeats (CRISPRs): the hallmark of an ingenious antiviral defense mechanism in prokaryotes

23-05-2011 | Sinan Al-Attar; Edze R. Westra; John van der Oost; Stan J.J. Brouns, Biological Chemistry, 2011

Abstract Many prokaryotes contain the recently discovered defense system against mobile genetic elements. This defense system contains a unique type of repetitive DNA stretches, termed Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs). CRISPRs consist of identical repeated DNA ...

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Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal

23-05-2011 | Adam Gesing; Andrzej Bartke; Feiya Wang; Malgorzata Karbownik-Lewinska; Michal M. Masternak, Biological Chemistry, 2011

Abstract Growth hormone (GH) receptor knockout (GHRKO) mice are highly insulin sensitive and long-lived. Surgical visceral fat removal (VFR) improves insulin signaling in normal mice and rats and extends longevity in rats. We have previously demonstrated decreased expression of certain ...

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Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression

23-05-2011 | Michelle F. Maritz; Pauline J. van der Watt; Nina Holderness; Michael J. Birrer; Virna D. Leaner, Biological Chemistry, 2011

Abstract AP-1, a transcription factor comprised primarily of Jun and Fos family proteins, regulates genes involved in proliferation, differentiation and oncogenesis. Previous studies demonstrated that elevated expression of Jun and Fos family member proteins is associated with numerous human ...

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Recent insights into regulation of transcription by RNA polymerase III and the cellular functions of its transcripts

23-05-2011 | Tatyana V. Nikitina; Lyudmila I. Tischenko; Wolfgang A. Schulz, Biological Chemistry, 2011

Abstract The products of transcription by the multisubunit enzyme RNA polymerase III (Pol III), such as 5S rRNA, tRNAs, U6 snRNA, are important for cell growth, proliferation and differentiation. The known range of the Pol III transcriptome has expanded over recent years, and novel functions of ...

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Cloning and functional analysis of the dpm2 and dpm3 genes from Trichoderma reesei expressed in a Saccharomyces cerevisiae dpm1Δ mutant strain

23-05-2011 | Patrycja Zembek; Urszula Perlińska-Lenart; Katarzyna Rawa; Wioletta Górka-Nieć; Grażyna Pal ..., Biological Chemistry, 2011

Abstract In Trichoderma reesei, dolichyl phosphate mannose (dpm) synthase, a key enzyme in the O-glycosylation process, requires three proteins for full activity. In this study, the dpm2 and dpm3 genes coding for the DPMII and DPMIII subunits of T. reesei DPM synthase were cloned and functionally ...

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Molecular diagnostics for pharmacogenomic testing of fluoropyrimidine based-therapy: costs, methods and applications

20-04-2011 | Raffaele Di Francia; Massimiliano Berretta; Oriana Catapano; Lorella M.T. Canzoniero; Luigi Formisano, Clinical Chemistry , 2011

Abstract Genetic testing of drug response represents an important goal for targeted therapy. In particular, 5-fluorouracil (5-FU) is the backbone of several chemotherapic protocols for treatment of solid tumors. Unfortunately, in some patients, 5-FU is toxic and causes gastrointestinal and ...

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Review: Age-related macular degeneration: genetic and clinical findings

12-04-2011 | Haris Kokotas; Maria Grigoriadou; Michael B. Petersen, Clinical Chemistry , 2011

Abstract Age-related macular degeneration (AMD) is a sight threatening eye disease that affects millions of humans over the age of 65 years. It is considered to be the major cause of irreversible blindness in the elderly population in the developed world. The disease is prevalent in Europe and ...

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Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes

12-04-2011 | Beatriz Tavira; Eliecer Coto Garciá; Carmen Díaz-Corte; Francisco Ortega; Manuel Arias; Armando Torr ..., Clinical Chemistry , 2011

Abstract Background: Tacrolimus (Tac) is an immunosuppressive drug used to prevent post-transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose and prevent toxicity or rejection. Tac is metabolized by cytochrome-P450 (CYP) enzymes, and variation at the CYP and ...

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