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24 Newest Publications of de Gruyter

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Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis

16-09-2011 | Ciprian N. Silaghi; Dana Fodor; Victor Cristea; Alexandra M. Crăciun, Clinical Chemistry , 2011

Abstract Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in ...

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Conformational changes of the chaperone SecB upon binding to a model substrate – bovine pancreatic trypsin inhibitor (BPTI)

06-09-2011 | reference-global@degruyter.com (Michaela M. Haimann et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 10, Page 849-858, October 2011.

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Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors

30-08-2011 | Miriam Kuester; Gero L. Becker; Kornelia Hardes; Iris Lindberg; Torsten Steinmetzer; Manuel E. Than, Biological Chemistry, 2011

Abstract In eucaryotes, many secreted proteins and peptides are proteolytically excised from larger precursor proteins by a specific class of serine proteases, the proprotein/prohormone convertases (PCs). This cleavage is essential for substrate activation, making the PCs very interesting ...

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Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy

18-08-2011 | Anna V. Oláh; László Asztalos; Gergely Ivády; Éva Varga; Ágota M. Kovács; J& ..., Clinical Chemistry , 2011

Abstract Background: Mycophenolic acid (MPA), a selective inhibitor of lymphocyte proliferation, has lately been used to improve renal function and prolong graft survival in renal transplanted patients. Still, there is no consensus considering the recommended dosing and the therapeutic range of ...

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Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects

13-06-2011 | Abayomi O. Akanji; Abdulwahab N. Al-Isa; Lukman Thalib, Clinical Chemistry , 2011

Abstract Background: Acute coronary syndromes present clinically as a consequence of plaque rupture and thrombosis possibly related to altered homeostasis of thrombogenic factors. It is speculated that this vulnerability in adults should be predictable from blood levels of thrombogenic biomarkers ...

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Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

23-05-2011 | Adriana Miti Nakahata; Barbara Mayer; Christian Ries; Cláudia Alessandra Andrade de Paula; Marisa Karow; P ..., Biological Chemistry, 2011

Abstract Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (Kiapp=4.3nm) and prevents phorbol ester (PMA)-stimulated activation of ...

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Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects

23-05-2011 | Ute Bank; Anke Heimburg; Astrid Wohlfarth; Gudrun Koch; Karsten Nordhoff; Heiko Julius; Martin Helmuth; Doree ..., Biological Chemistry, 2011

Abstract The discovery of the DP4-related enzymes DP8 and DP9 raised controversial discussion regarding the physiological and pathophysiological function of distinct members of the DP4 family. Particularly with regard to their potential relevance in regulating immune functions, it is of interest ...

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DPP-4 inhibition increases GIP and decreases GLP-1 incretin effects during intravenous glucose tolerance test in Wistar rats

23-05-2011 | Ernst-Joachim Freyse; Sabine Berg; Klaus-Dieter Kohnert; Peter Heinke; Eckhard Salzsieder, Biological Chemistry, 2011

Abstract GIP metabolite [GIP (3–42)] and GLP-1 metabolite [GLP-1 (9–36) amide] have been reported to differ with regard to biological actions. Systemic DPP-4 inhibition can therefore reveal different actions of GIP and GLP-1. In catheter wearing Wistar rats, insulinotropic effects of equipotent ...

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Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers

23-05-2011 | Eric Grouzmann; Paul Bigliardi; Monique Appenzeller; André Pannatier; Thierry Buclin, Biological Chemistry, 2011

Abstract Substance P (SP), an undecapeptide belonging to the tachykinin family, is released during the activation of sensory nerves, and causes vasodilation, edema and pain through activation of tissular Neurokinin 1 receptors. SP proinflammatory effects are terminated by angiotensin converting ...

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PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice

23-05-2011 | Dirk Reinhold; Ute Bank; Dominik Entz; Alexander Goihl; Diana Stoye; Sabine Wrenger; Stefan Brocke; Anja Thi ..., Biological Chemistry, 2011

Abstract Cellular dipeptidyl peptidase IV (DP IV, CD26) and amino-peptidase N (APN, CD13) play regulatory roles in T cell activation and represent potential targets for treatment of inflammatory disorders. We have developed a novel therapeutic strategy, ‘peptidase-targeted Immunoregulation’ ...

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