06-10-2011 | Christian P. Sommerhoff; Hans Fritz, Biological Chemistry, 2011

No abstract available

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06-10-2011 | Riyad Domingo; Kelly Chibale; Edward D. Sturrock, Biological Chemistry, 2011

Abstract Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence there is a burgeoning need to develop inhibitors that bind selectively to structurally similar MMPs. The ...

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30-08-2011 | Miriam Kuester; Gero L. Becker; Kornelia Hardes; Iris Lindberg; Torsten Steinmetzer; Manuel E. Than, Biological Chemistry, 2011

Abstract In eucaryotes, many secreted proteins and peptides are proteolytically excised from larger precursor proteins by a specific class of serine proteases, the proprotein/prohormone convertases (PCs). This cleavage is essential for substrate activation, making the PCs very interesting ...

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05-08-2011 | Olivia Hermes; Pascal Schlage; Ulrich auf dem Keller, Biological Chemistry, 2011

Abstract Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic ...

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23-05-2011 | Iuri E. Gouvea; Jorge A.N. Santos; Fernanda M. Burlandy; Ivarne L.S. Tersariol; Edson E. da Silva; Maria A. Ju ..., Biological Chemistry, 2011

Abstract The 3C proteinase, essential for human poliovirus (PV) replication, has unique characteristics as its three-dimensional structure resembles chymotrypsin, but its catalytic nucleophile is a cysteine SH group rather than the OH group of serine. Here, we describe the use of tellurium ...

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23-05-2011 | Claudia Quezada; Sebastián Alarcón; Juan G. Cárcamo; Alejandro Yáñez; Paola Casanello; ..., Biological Chemistry, 2011

Abstract Oxidative stress has been linked to the podocytopathy, mes-angial expansion and progression of diabetic nephropathy. The major cell defence mechanism against oxidative stress is reduced glutathione (GSH). Some ABC transporters have been shown to extrude GSH, oxidised glutathione or ...

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23-05-2011 | Jiaxin Hu; Keith T. Gagnon; Jing Liu; Jonathan K. Watts; Jeja Syeda-Nawaz; C. Frank Bennett; Eric E. Swayze; ..., Biological Chemistry, 2011

Abstract Spinocerebellar ataxia-3 (also known as Machado-Joseph disease) is an incurable neurodegenerative disorder caused by expression of a mutant variant of ataxin-3 (ATX3) protein. Inhibiting expression of ATX3 would provide a therapeutic strategy, but indiscriminant inhibition of both ...

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23-05-2011 | Cornelia Rieke; Anja Papendieck; Olga Sokolova; Michael Naumann, Biological Chemistry, 2011

Abstract Helicobacter pylori, the etiological agent of several human gastric diseases, induces the transcription factor nuclear factor-κB (NF-κB) in colonized epithelial cells leading to the release of proinflammatory mediators. Activation of NF-κB involves the IκB kinase (IKK)-complex ...

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23-05-2011 | Ute Bank; Anke Heimburg; Astrid Wohlfarth; Gudrun Koch; Karsten Nordhoff; Heiko Julius; Martin Helmuth; Doree ..., Biological Chemistry, 2011

Abstract The discovery of the DP4-related enzymes DP8 and DP9 raised controversial discussion regarding the physiological and pathophysiological function of distinct members of the DP4 family. Particularly with regard to their potential relevance in regulating immune functions, it is of ...

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23-05-2011 | Siegfried Ansorge; Karsten Nordhoff; Ute Bank; Anke Heimburg; Heiko Julius; Doreen Breyer; Anja Thielitz; Dir ..., Biological Chemistry, 2011

Abstract The cellular dipeptidyl peptidase IV (DPIV, E.C.3.4.14.5, CD26) is a type II membrane peptidase with various physio-logical functions. Our main knowledge on DPIV comes from studies of soluble DPIV which plays a role in regulation of glucose homeostasis by inactivation of the ...

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