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34 Newest Publications of de Gruyter

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Status of serum-calcium and -albumin measurement in Argentina assessed in 300 representative laboratories with 20 fresh frozen single donation sera

30-Aug-2011 | Hedwig C.M. Stepman; Dietmar Stöckl; Rosana Acheme; Sandra Sesini; Daniel Mazziotta; Linda M. Thienpont, Clinical Chemistry , 2011

Abstract Background: The Fundación Bioquímica Argentina (FBA) performs external quality assessment (EQA) of >3200 laboratories. However, FBA realizes that sample non-commutability and predominant use of heterogeneous systems may bias the estimated performance and standardization status. To ...


Multicentre comparison of free thyroid hormones immunoassays: the Immunocheck study

17-Jun-2011 | Stefania Giovannini; Gian Carlo Zucchelli; Giorgio Iervasi; Annalisa Iervasi; Maria Rosa Chiesa; Antonella Mer ..., Clinical Chemistry , 2011

Abstract Background: In order to evaluate whether there is still present a very large variability in measured values and analytical performance among different free thyroid (FT) hormone immunoassays, we considered the results derived from an External Quality Assessment (EQA) scheme, named ...


Evaluation of a commercially available rapid urinary porphobilinogen test

31-May-2011 | Michael Vogeser; Thomas Stauch, Clinical Chemistry , 2011

Abstract Background: Demonstration of substantially increased urinary excretion of porphobilinogen is the cornerstone of diagnosing acute porphyria crisis. Because porphobilinogen testing is not implemented on clinical chemistry analysers, respective analyses are available in rather few clinical ...


Adaptation of the Diazyme Direct Enzymatic HbA1c Assay for a microplate reader at room temperature

17-May-2011 | Ilkka Penttilä; Karri Penttilä; Toivo Halonen; Kari Pulkki; Jukka Törrönen; Rainer Rauramaa, Clinical Chemistry , 2011

Abstract Background: Measurement of hemoglobin A1c (HbA1c) is a key diagnostic criterion and a key parameter for the follow-up of the treatment of diabetes mellitus. Typically, immunochemical assays of HbA1c are performed in clinical chemistry analyzers. In this study, we applied the HbA1c assay ...


Comparison of the results from two different External Quality Assessment Schemes supports the utility of robust quality specifications

17-May-2011 | Anna Carobene; Carlo Franzini; Ferruccio Ceriotti, Clinical Chemistry , 2011

Abstract Background: The definition of quality goals to evaluate the performance of laboratories participating in External Quality Assessment Schemes (EQAS) is currently not homogeneous. The aim of the work was to verify the applicability of quality goals based on biological variation comparing ...


ISW Abstracts

27-Apr-2011 | Clinical Chemistry , 2011

Clinical and Economic Advances in Prostate Cancer Diagnosis The Value of Improved Workflow Solutions Autonomous Biosensors – Technologies that Help to Bring Biomarkers to the Patient The Clinical Utility of Multiplex Biochips for the Detection of Multiple STI's and Respiratory Pathogens ...


Molecular diagnostics for pharmacogenomic testing of fluoropyrimidine based-therapy: costs, methods and applications

20-Apr-2011 | Raffaele Di Francia; Massimiliano Berretta; Oriana Catapano; Lorella M.T. Canzoniero; Luigi Formisano, Clinical Chemistry , 2011

Abstract Genetic testing of drug response represents an important goal for targeted therapy. In particular, 5-fluorouracil (5-FU) is the backbone of several chemotherapic protocols for treatment of solid tumors. Unfortunately, in some patients, 5-FU is toxic and causes gastrointestinal and ...


Review: Current role of liquid chromatography coupled to mass spectrometry in clinical toxicology screening methods

20-Apr-2011 | Véronique Viette; Marc Fathi; Serge Rudaz; Denis Hochstrasser; Jean-Luc Veuthey, Clinical Chemistry , 2011

Abstract Toxicological screening is the analysis of a biological specimen to detect and identify compounds in patients admitted to the hospital with acute intoxication of unknown origin. The screening of a wide range of toxicologically relevant compounds in biological samples is a serious ...


Review: Miniaturization and globalization of clinical laboratory activities

12-Apr-2011 | Murilo R. Melo; Samantha Clark; Daniel Barrio, Clinical Chemistry , 2011

Abstract Clinical laboratories provide an invaluable service to millions of people around the world in the form of quality diagnostic care. Within the clinical laboratory industry the impetus for change has come from technological development (miniaturization, nanotechnology, and their collective ...


Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis

12-Apr-2011 | Yoko Tabe; Yukiko Kawase; Kazunori Miyake; Naotake Satoh; Nanae Aritaka; Yasushi Isobe; Kazuo Oshimi; Norio ..., Clinical Chemistry , 2011

Abstract Background: The determination of polymerase chain reaction (PCR) amplification product sizes of the Bcl-2/IgH fusion gene from follicular lymphoma (FL) provides evidence of clonal identity. Methods: The present study describes detection of Bcl-2/IgH fusion gene clonality utilizing a ...


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