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96 Newest Publications of de Gruyter

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Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients

13-12-2011 | Katya Hekimian; Ernst-Ludwig Stein; Ulrich Pachmann; Katharina Pachmann, Clinical Chemistry , 2011

Abstract Background: The epithelial cell adhesion molecule (EpCAM) embedded in the plasma membrane of circulating epithelial tumor cells (CETC) is used for detection and enrichment of circulating tumor cells in peripheral blood and as a target for anti-epithelial antibodies elicited during immune ...

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Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris

13-09-2011 | Hai Ling Li; Wen Hui Peng; Shi Tao Cui; Hou Lei; Yi Dong Wei; Wei Ming Li; Ya Wei Xu, Clinical Chemistry , 2011

Abstract Background: Vaspin was a recently identified adipokine, playing a protective role in many metabolic diseases. The present study aimed to investigate the association between vaspin plasma level and stable angina pectoris (SAP) and unstable angina pectoris (UAP). Methods: A total of 88 ...

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Review: Increased plasma concentrations of tumour markers in the absence of neoplasia

06-09-2011 | Jaume Trapé; Xavier Filella; Montse Alsina-Donadeu; Lluïsa Juan-Pereira; Àngels Bosch-Ferrer; Ra ..., Clinical Chemistry , 2011

Abstract Tumour markers are a very heterogeneous group of molecules that are generally found in very small concentrations in the plasma and serum of healthy individuals. In the process of neoplastic differentiation the cell can synthesize, release, or induce synthesis of other cells, thus ...

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Influence of hemolysis on troponin testing: studies on Beckman Coulter UniCel Dxl 800 Accu-TnI and overview of the literature

06-09-2011 | Giuseppe Lippi; Paola Avanzini; Mariella Dipalo; Rosalia Aloe; Gianfranco Cervellin, Clinical Chemistry , 2011

Abstract Background: Hemolyzed specimens are the leading pre-analytical problem in the laboratory practice, and exert a negative impact on test results. We assessed the reliability of Beckman Coulter UniCel Dxl 800 Accu-TnI testing on hemolyzed specimens. Methods: Twelve non-hemolyzed ...

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Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women

30-08-2011 | Eva Greibe; Birgitte Horst Andreasen; Dorte L. Lildballe; Anne L. Morkbak; Anne-Mette Hvas; Ebba Nexo, Clinical Chemistry , 2011

Abstract Background: Currently, it is unknown whether the decline in plasma cobalamin observed during pregnancy is caused by malabsorption of the vitamin. This study examined cobalamin absorption and markers of cobalamin status during normal pregnancy. Methods: Twenty-seven pregnant Danish women ...

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Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort

25-08-2011 | Edzard Schwedhelm; Vanessa Xanthakis; Renke Maas; Lisa M. Sullivan; Dorothee Atzler; Nicole Lüneburg; Nic ..., Clinical Chemistry , 2011

Abstract Background: Symmetric dimethylarginine (SDMA) is a by-product of protein methylation. Once released from proteins, SDMA is eliminated by the kidneys; consequently, plasma concentration has been suggested as a sensitive marker of renal function. Furthermore, recent work implicates SDMA in ...

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Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapy

18-08-2011 | Anna V. Oláh; László Asztalos; Gergely Ivády; Éva Varga; Ágota M. Kovács; J& ..., Clinical Chemistry , 2011

Abstract Background: Mycophenolic acid (MPA), a selective inhibitor of lymphocyte proliferation, has lately been used to improve renal function and prolong graft survival in renal transplanted patients. Still, there is no consensus considering the recommended dosing and the therapeutic range of ...

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Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease

17-06-2011 | Chih-Chia Chang; Po-Hui Wang; Pen-Hua Su; Ding-Bang Lin; Tsung-Ho Ying; Shun-Fa Yang; Yi-Hsien Hsieh, Clinical Chemistry , 2011

Abstract Background: Pentraxin 3 (PTX3) plays an important role in innate immune responses and in inflammation disease. The aim of this study was to investigate the diagnostic and prognostic potential of PTX3 in pelvic inflammatory disease (PID) and correlate it with the severity and outcome of ...

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The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and prostate-specific antigen (PSA) in prostate cancer

15-06-2011 | Adam Daragó; Andrzej Sapota; Józef Matych; Marzenna Nasiadek; Małgorzata Skrzypińska-Gawrys ..., Clinical Chemistry , 2011

Abstract Background: The objective of the present study is to explore the association between zinc concentrations and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and total prostate-specific antigen (tPSA) levels in the serum of patients with prostate cancer (PCa) and ...

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Soluble ST2 is not independently associated with androgen and estrogen status in healthy males and females

10-06-2011 | Benjamin Dieplinger; Margot Egger; Werner Poelz; Christian Gabriel; Meinhard Haltmayer; Thomas Mueller, Clinical Chemistry , 2011

Abstract Background: Soluble ST2 (sST2) plasma concentrations are significantly higher in healthy men than in healthy women. The reason for the sex-specific difference of sST2 plasma concentrations is not established. The aim of this study was to evaluate the association of sST2 with sex-hormones ...

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