06-10-2011 | Larisa Ring; Iris Peröbner; Marisa Karow; Marianne Jochum; Peter Neth; Alexander Faussner, Biological Chemistry, 2011

Abstract WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four different signaling cascades. ...

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06-10-2011 | Regina Fluhrer; Frits Kamp; Gudula Grammer; Brigitte Nuscher; Harald Steiner; Klaus Beyer; Christian Haass, Biological Chemistry, 2011

Abstract Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid β-peptide. Four proteins ...

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06-10-2011 | Stefan Tholen; Martin L. Biniossek; Anna-Lena Geßler; Sebastian Müller; Juliane Weißer; Jayachan ..., Biological Chemistry, 2011

Abstract The endolysosomal cysteine endoprotease cathepsin L is secreted from cells in a variety of pathological conditions such as cancer and arthritis. We compared the secretome composition and extracellular proteolytic cleavage events in cell supernatants of cathepsin L-deficient and ...

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30-08-2011 | Eva Greibe; Birgitte Horst Andreasen; Dorte L. Lildballe; Anne L. Morkbak; Anne-Mette Hvas; Ebba Nexo, Clinical Chemistry , 2011

Abstract Background: Currently, it is unknown whether the decline in plasma cobalamin observed during pregnancy is caused by malabsorption of the vitamin. This study examined cobalamin absorption and markers of cobalamin status during normal pregnancy. Methods: Twenty-seven pregnant Danish ...

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30-08-2011 | Miriam Kuester; Gero L. Becker; Kornelia Hardes; Iris Lindberg; Torsten Steinmetzer; Manuel E. Than, Biological Chemistry, 2011

Abstract In eucaryotes, many secreted proteins and peptides are proteolytically excised from larger precursor proteins by a specific class of serine proteases, the proprotein/prohormone convertases (PCs). This cleavage is essential for substrate activation, making the PCs very interesting ...

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25-08-2011 | Edzard Schwedhelm; Vanessa Xanthakis; Renke Maas; Lisa M. Sullivan; Dorothee Atzler; Nicole Lüneburg; Nic ..., Clinical Chemistry , 2011

Abstract Background: Symmetric dimethylarginine (SDMA) is a by-product of protein methylation. Once released from proteins, SDMA is eliminated by the kidneys; consequently, plasma concentration has been suggested as a sensitive marker of renal function. Furthermore, recent work implicates ...

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09-08-2011 | Aminata Toure; Baptiste Rode; Gary R. Hunnicutt; Denise Escalier; Gérard Gacon, Biological Chemistry, 2011

Abstract The annulus is an electron-dense ring structure connecting the midpiece and the principal piece of the mammalian sperm flagellum. Proteins from the septin family have been shown to localize to the annulus. A septin complex is assembled early in spermiogenesis with the cochaperone ...

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05-08-2011 | Olivia Hermes; Pascal Schlage; Ulrich auf dem Keller, Biological Chemistry, 2011

Abstract Proteases are pivotal modulators of extracellular matrix components and bioactive proteins at all phases of cutaneous wound healing and thereby essentially contribute to the successful reestablishment of skin integrity upon injury. As a consequence, disturbance of proteolytic ...

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14-06-2011 | Ji-Yan Liu; Lei Jin; Meng-Yuan Zhao; Xin Zhang; Chi-Bo Liu; Yu-Xiang Zhang; Fu-Jian Li; Jian-Min Zhou; Hua-J ..., Clinical Chemistry , 2011

Abstract Background: New technologies for the early detection of tuberculosis (TB) are urgently needed. Pathological changes within an organ might be reflected in proteomic patterns in serum. The aim of the present study was to screen for the potential protein biomarkers in serum for the ...

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23-05-2011 | Yael Litvak; Rena Levin-Klein; Moti Avner; Zvi Selinger, Biological Chemistry, 2011

Abstract Several major bacterial pathogens use the type III secretion system (TTSS) to deliver virulence factors into host cells. Bacterial Rho GTPase activating proteins (RhoGAPs) comprise a remarkable family of type III secreted toxins that modulate cytoskeletal dynamics and manipulate ...

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