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24 Newest Publications of de Gruyter

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Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors

30-Aug-2011 | Miriam Kuester; Gero L. Becker; Kornelia Hardes; Iris Lindberg; Torsten Steinmetzer; Manuel E. Than, Biological Chemistry, 2011

Abstract In eucaryotes, many secreted proteins and peptides are proteolytically excised from larger precursor proteins by a specific class of serine proteases, the proprotein/prohormone convertases (PCs). This cleavage is essential for substrate activation, making the PCs very interesting ...


Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion

18-Jun-2011 | (Anke Ohler et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 7, Page 653-664, July 2011.


Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries

23-May-2011 | Veerle Matheeussen; Lesley Baerts; Guido De Meyer; Gilles De Keulenaer; Pieter Van der Veken; Koen Augustyns; ..., Biological Chemistry, 2011

Abstract Dipeptidyl peptidase IV (DPPIV)/CD26 is by far the most extensively studied member of the prolyl oligopeptidase family of serine proteases. The discovery of the related enzymes DPP8 and DPP9 necessitates a (re-)evaluation of the DPPIV-like enzymatic activity in cells and organs. In this ...


Expression and role of the cell surface protease seprase/fibroblast activation protein-α (FAP-α) in astroglial tumors

23-May-2011 | Rolf Mentlein; Kirsten Hattermann; Charles Hemion; Achim A. Jungbluth; Janka Held-Feindt, Biological Chemistry, 2011

Abstract Seprase or fibroblast activation protein-α (FAP-α) is a cell-surface serine protease that was previously described nearly exclusively on reactive and tumor stromal fibroblasts and thought to be involved in tissue remodeling. We investigated the expression and significance of FAP-α in ...


Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site

23-May-2011 | Kerstin Kühn-Wache; Joachim W. Bär; Torsten Hoffmann; Raik Wolf; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth, Biological Chemistry, 2011

Abstract Dipeptidyl peptidase 4/CD26 (DP4) is a multifunctional serine protease liberating dipeptide from the N-terminus of (oligo)peptides which can modulate the activity of these peptides. The enzyme is involved in physiological processes such as blood glucose homeostasis and immune response. ...


Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-κB activation

23-May-2011 | Cornelia Rieke; Anja Papendieck; Olga Sokolova; Michael Naumann, Biological Chemistry, 2011

Abstract Helicobacter pylori, the etiological agent of several human gastric diseases, induces the transcription factor nuclear factor-κB (NF-κB) in colonized epithelial cells leading to the release of proinflammatory mediators. Activation of NF-κB involves the IκB kinase (IKK)-complex composed ...


Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence

23-May-2011 | Tomasz Kantyka; Karolina Plaza; Joanna Koziel; Danuta Florczyk; Hennig R. Stennicke; Ida B. Thogersen; Jan J. ..., Biological Chemistry, 2011

Abstract Bacterial proteases are considered virulence factors and it is presumed that by abrogating their activity, host endogenous protease inhibitors play a role in host defense against invading pathogens. Here we present data showing that Staphylococcus aureus cysteine proteases (staphopains) ...


Poliovirus 3C proteinase inhibition by organotelluranes

23-May-2011 | Iuri E. Gouvea; Jorge A.N. Santos; Fernanda M. Burlandy; Ivarne L.S. Tersariol; Edson E. da Silva; Maria A. Ju ..., Biological Chemistry, 2011

Abstract The 3C proteinase, essential for human poliovirus (PV) replication, has unique characteristics as its three-dimensional structure resembles chymotrypsin, but its catalytic nucleophile is a cysteine SH group rather than the OH group of serine. Here, we describe the use of tellurium ...


Secretion of hepatoma-derived growth factor is regulated by N-terminal processing

18-Nov-2010 | Ketan Thakar; Tim Kröcher; Soniya Savant; Doron Gollnast; Sørge Kelm; Frank Dietz, Biological Chemistry, 2010

Abstract Hepatoma-derived growth factor (HDGF) was first purified as a growth factor secreted by hepatoma cells. It promotes angiogenesis and has been related to tumorigenesis. To date, little is known about the molecular mechanisms of HDGF functions and especially its routes or regulation of ...


Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining

23-Aug-2010 | Vivien R. Sutton; Joseph A. Trapani, Biological Chemistry, 2010

Abstract Proteases of the serine and cysteine protease families are involved in many processes crucial to the lytic functions of cytotoxic T lymphocytes and natural killer cells. In this study we describe those functions and attempt to place them in the pathophysiological context of defence to ...


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