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37 Newest Publications of de Gruyter

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Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients

13-12-2011 | Katya Hekimian; Ernst-Ludwig Stein; Ulrich Pachmann; Katharina Pachmann, Clinical Chemistry , 2011

Abstract Background: The epithelial cell adhesion molecule (EpCAM) embedded in the plasma membrane of circulating epithelial tumor cells (CETC) is used for detection and enrichment of circulating tumor cells in peripheral blood and as a target for anti-epithelial antibodies elicited during immune ...

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Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers

13-12-2011 | Elad Sharon; Jingli Zhang; Kevin Hollevoet; Seth M. Steinberg; Ira Pastan; Masanori Onda; Jochen Gaedcke; B. ..., Clinical Chemistry , 2011

Abstract Background: Tumor mesothelin overexpression is present in different malignancies, including the majority of patients with pancreatic or biliary cancers. The objective of this study was to evaluate the use of shed serum mesothelin and megakaryocyte potentiating factor (MPF) concentrations ...

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Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer

13-12-2011 | Jamshid Farahati; Dirk Roggenbuck; Elena Gilman; Martin Schütte; Elena Jagminaite; Rasoul Seyed Zakavi; T ..., Clinical Chemistry , 2011

Abstract Background: The presence of thyroid peroxidase antibodies (TPOab) are reported to be associated with improved outcome among breast cancer patients. We evaluated the correlation between TPOab and diagnostic parameters among newly diagnosed breast cancer patients. Methods: Three hundred ...

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mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

06-10-2011 | Matthias Kotzsch; Julia Dorn; Kristina Doetzer; Barbara Schmalfeldt; Janna Krol; Gustavo Baretton; Marion Kie ..., Biological Chemistry, 2011

Abstract High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified ...

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Review: Circulating tumor cells as emerging tumor biomarkers in breast cancer

29-07-2011 | Evi S. Lianidou; Athina Markou, Clinical Chemistry , 2011

Abstract Circulating tumor cells (CTCs) provide unique information for the management of breast cancer patients, since their detection and monitoring is useful for prognosis, prediction of response to therapy, or monitoring clinical course in patients with localized or metastatic disease. ...

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Review: Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer

18-07-2011 | Athina Markou; Yu Liang; Evi Lianidou, Clinical Chemistry , 2011

Abstract Non-small cell lung carcinomas (NSCLC) account for about 80% of lung cancers and their remarkable heterogeneity manifests in histology, pathogenesis, prognosis, and response to treatments. Recent advances in molecular characterization help stratifying NSCLC patients for their potential ...

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Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma

22-06-2011 | Shusai Yamada; Chiharu Tabata; Rie Tabata; Kazuya Fukuoka; Takashi Nakano, Clinical Chemistry , 2011

Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. MPM has a limited response to conventional chemotherapy and radiotherapy, so early diagnosis of MPM is very important. This study investigated the ...

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Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples

10-06-2011 | Martin Bomert; Gabi Köllisch; Marjut Roponen; Roger Lauener; Harald Renz; Petra I. Pfefferle; Nadia Al-F ..., Clinical Chemistry , 2011

Abstract Background: Multiplexed cytokine measurement offers many advantages over the conventional enzyme-linked immunosorbent assay (ELISA) format when applied in large-scale epidemiological studies or clinical trials. In the present study we set out to define the reliability and consistency of ...

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Serum APRIL, a potential tumor marker in pancreatic cancer

25-05-2011 | Feng Wang; Lin Chen; Weifeng Ding; Guihua Wang; Yueping Wu; Jingchun Wang; Leilei Luo; Hui Cong; Yueguo Wan ..., Clinical Chemistry , 2011

Abstract Background: A proliferation-inducing ligand (APRIL) is a newly-found member in the tumor necrosis factor (TNF) superfamily. Our previous studies have already confirmed that APRIL is overexpressed in pancreatic cancer tumors, however, it is not expressed or has a weak expression in normal ...

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Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

23-05-2011 | Adriana Miti Nakahata; Barbara Mayer; Christian Ries; Cláudia Alessandra Andrade de Paula; Marisa Karow; P ..., Biological Chemistry, 2011

Abstract Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (Kiapp=4.3nm) and prevents phorbol ester (PMA)-stimulated activation of ...

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