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819 Newest Publications of de Gruyter

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Monitoring quality indicators in laboratory medicine does not automatically result in quality improvement

13-12-2011 | Laura Sciacovelli; Oswald Sonntag; Andrea Padoan; Carlo Federico Zambon; Paolo Carraro; Mario Plebani, Clinical Chemistry , 2011

Abstract Background: Data on quality indicators (QIs) should be collected over time in order to identify and continuously monitor clinical laboratory performance and to improve patient safety by identifying and implementing effective interventions. The aim of the present study was to ascertain ...

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Review: The hCG assay or pregnancy test

13-12-2011 | Laurence A. Cole, Clinical Chemistry , 2011

Abstract This review examines human chorionic gonadotropin (hCG) or pregnancy tests from multiple perspectives. It first investigates the molecule hCG and shows that the term represents five independent molecules differing in carbohydrate and meric structure that share a common amino acid ...

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Mapping point-of-care performance using locally-smoothed median and maximum absolute difference curves

19-10-2011 | Gerald J. Kost; Nam K. Tran; Harpreet Singh, Clinical Chemistry , 2011

Abstract Background: The goal is to introduce visual performance mapping efficient for establishing acceptance criteria and facilitating decisions regarding the utility of hospital point-of-care devices. This approach uniquely reveals the quality of performance locally, as opposed to globally. ...

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Recent progress and clinical importance on pharmacogenetics in cancer therapy

19-10-2011 | Thomas I. Peng Soh; Wei Peng Yong; Federico Innocenti, Clinical Chemistry , 2011

Abstract Recent advances have provided unprecedented opportunities to identify prognostic and predictive markers of efficacy of cancer therapy. Genetic markers can be used to exclude patients who will not benefit from therapy, exclude patients at high risk of severe toxicity and adjust dosing. ...

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Highlight: The Winter School on Proteinases and Their Inhibitors

06-10-2011 | Christian P. Sommerhoff; Hans Fritz, Biological Chemistry, 2011

No abstract available

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mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer

06-10-2011 | Matthias Kotzsch; Julia Dorn; Kristina Doetzer; Barbara Schmalfeldt; Janna Krol; Gustavo Baretton; Marion Kie ..., Biological Chemistry, 2011

Abstract High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified ...

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Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

06-10-2011 | Oliver Schilling; Ulrich auf dem Keller; Christopher M. Overall, Biological Chemistry, 2011

Abstract Proteomic identification of protease cleavage site specificity (PICS) is a recent proteomic approach for the easy mapping of protease subsite preferences that determines both the prime- and non-prime side specificity concurrently. Here we greatly facilitate user access by providing an ...

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Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways

06-10-2011 | Larisa Ring; Iris Peröbner; Marisa Karow; Marianne Jochum; Peter Neth; Alexander Faussner, Biological Chemistry, 2011

Abstract WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four different signaling cascades. The ...

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The significance of the Cα substituent in the selective inhibition of matrix metalloproteinases 1 and 9

06-10-2011 | Riyad Domingo; Kelly Chibale; Edward D. Sturrock, Biological Chemistry, 2011

Abstract Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence there is a burgeoning need to develop inhibitors that bind selectively to structurally similar MMPs. The ...

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The Nicastrin ectodomain adopts a highly thermostable structure

06-10-2011 | Regina Fluhrer; Frits Kamp; Gudula Grammer; Brigitte Nuscher; Harald Steiner; Klaus Beyer; Christian Haass, Biological Chemistry, 2011

Abstract Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid β-peptide. Four proteins ...

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