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819 Newest Publications of de Gruyter

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Ultrasound markers for the detection of women at risk of developing pre-eclampsia

13-12-2011 | Guillaume Macé; Evelyne Cynober; Bruno Carbonne, Clinical Chemistry , 2011

Abstract Pre-eclampsia (PE) is a consequence of an abnormal placental invasion. Uterine artery Doppler (Ut-AD) is directly related to trophoblastic invasion of the spiral arteries, which occurs before 18 weeks’ gestation. A correct interpretation of Ut-AD indices and waveform patterns requires a ...

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Serum concentration of neopterin on admission does not improve the diagnostic performance of highly-sensitive troponin I

13-12-2011 | Martina Montagnana; Giuseppe Lippi; Elisa Danese; Gian Luca Salvagno; Gianfranco Cervellin; Gian Cesare Guidi, Clinical Chemistry , 2011

Clinical Chemistry and Laboratory Medicine, Volume 0, Issue 0, Page -, Ahead of Print.

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Recent progress and clinical importance on pharmacogenetics in cancer therapy

19-10-2011 | Thomas I. Peng Soh; Wei Peng Yong; Federico Innocenti, Clinical Chemistry , 2011

Abstract Recent advances have provided unprecedented opportunities to identify prognostic and predictive markers of efficacy of cancer therapy. Genetic markers can be used to exclude patients who will not benefit from therapy, exclude patients at high risk of severe toxicity and adjust dosing. ...

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Mapping point-of-care performance using locally-smoothed median and maximum absolute difference curves

19-10-2011 | Gerald J. Kost; Nam K. Tran; Harpreet Singh, Clinical Chemistry , 2011

Abstract Background: The goal is to introduce visual performance mapping efficient for establishing acceptance criteria and facilitating decisions regarding the utility of hospital point-of-care devices. This approach uniquely reveals the quality of performance locally, as opposed to globally. ...

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Promising approaches in using magnetic nanoparticles in oncology

06-10-2011 | Georgy Mikhaylov; Olga Vasiljeva, Biological Chemistry, 2011

Abstract The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of ...

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Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts

06-10-2011 | Stefan Tholen; Martin L. Biniossek; Anna-Lena Geßler; Sebastian Müller; Juliane Weißer; Jayachan ..., Biological Chemistry, 2011

Abstract The endolysosomal cysteine endoprotease cathepsin L is secreted from cells in a variety of pathological conditions such as cancer and arthritis. We compared the secretome composition and extracellular proteolytic cleavage events in cell supernatants of cathepsin L-deficient and wild-type ...

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The Nicastrin ectodomain adopts a highly thermostable structure

06-10-2011 | Regina Fluhrer; Frits Kamp; Gudula Grammer; Brigitte Nuscher; Harald Steiner; Klaus Beyer; Christian Haass, Biological Chemistry, 2011

Abstract Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid β-peptide. Four proteins ...

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The significance of the Cα substituent in the selective inhibition of matrix metalloproteinases 1 and 9

06-10-2011 | Riyad Domingo; Kelly Chibale; Edward D. Sturrock, Biological Chemistry, 2011

Abstract Matrix metalloproteinases (MMPs) cleave and degrade most components of the extracellular matrix, and unregulated MMP activity has been correlated to cancer and metastasis. Hence there is a burgeoning need to develop inhibitors that bind selectively to structurally similar MMPs. The ...

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Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways

06-10-2011 | Larisa Ring; Iris Peröbner; Marisa Karow; Marianne Jochum; Peter Neth; Alexander Faussner, Biological Chemistry, 2011

Abstract WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four different signaling cascades. The ...

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Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

06-10-2011 | Oliver Schilling; Ulrich auf dem Keller; Christopher M. Overall, Biological Chemistry, 2011

Abstract Proteomic identification of protease cleavage site specificity (PICS) is a recent proteomic approach for the easy mapping of protease subsite preferences that determines both the prime- and non-prime side specificity concurrently. Here we greatly facilitate user access by providing an ...

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