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819 Newest Publications of de Gruyter

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Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts

06-10-2011 | Stefan Tholen; Martin L. Biniossek; Anna-Lena Geßler; Sebastian Müller; Juliane Weißer; Jayachan ..., Biological Chemistry, 2011

Abstract The endolysosomal cysteine endoprotease cathepsin L is secreted from cells in a variety of pathological conditions such as cancer and arthritis. We compared the secretome composition and extracellular proteolytic cleavage events in cell supernatants of cathepsin L-deficient and wild-type ...

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Promising approaches in using magnetic nanoparticles in oncology

06-10-2011 | Georgy Mikhaylov; Olga Vasiljeva, Biological Chemistry, 2011

Abstract The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of ...

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Improving diagnosis of adult-type hypolactasia in patients with abdominal complaints

21-09-2011 | Brigitte C.M. Haberkorn; Anton A.M. Ermens; Ankie Koeken; Christa M. Cobbaert; Coen van Guldener, Clinical Chemistry , 2011

Abstract Background: Adult-type hypolactasia is caused by genetic lactase non-persistence. It is the most common cause of lactose intolerance, which results in gastrointestinal symptoms after ingestion of dairy products. Currently, lactose intolerance is investigated by the hydrogen breath test ...

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Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis

16-09-2011 | Ciprian N. Silaghi; Dana Fodor; Victor Cristea; Alexandra M. Crăciun, Clinical Chemistry , 2011

Abstract Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in ...

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Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris

13-09-2011 | Hai Ling Li; Wen Hui Peng; Shi Tao Cui; Hou Lei; Yi Dong Wei; Wei Ming Li; Ya Wei Xu, Clinical Chemistry , 2011

Abstract Background: Vaspin was a recently identified adipokine, playing a protective role in many metabolic diseases. The present study aimed to investigate the association between vaspin plasma level and stable angina pectoris (SAP) and unstable angina pectoris (UAP). Methods: A total of 88 ...

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The evaluation of colloidal gold immunochromatographic assay (GICA) for rapid diagnosis of influenza A disease

13-09-2011 | Xuehui Li; Hangwei Chen; Juan Wei; Nan Lv; Lanhua You, Clinical Chemistry , 2011

Abstract Background: A low cost colloidal gold immunochromatographic assay (GICA) for rapid detection of influenza A virus was developed. The assay was evaluated in this study. Methods: Six hundred and twenty-six patients were enrolled. All patients contributed two pharyngeal swabs, one used for ...

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Inflammatory markers in preeclamptic patients

13-09-2011 | Murat Can; Eray Sancar; Muge Harma; Berrak Guven; Gorkem Mungan; Serefden Acikgoz, Clinical Chemistry , 2011

Abstract Background: Preeclampsia is characterized by hypertension and proteinuria that begins in the second half of pregnancy. Endothelial dysfunction and trophoblastic hypoperfusion seen in preeclampsia suggested to be part of an increased maternal inflammatory response to pregnancy. In this ...

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Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections

06-09-2011 | reference-global@degruyter.com (Stephan Ludwig), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 10, Page 837-847, October 2011.

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Insulin modulates glucose-dependent insulinotropic polypeptide (GIP) secretion from enteroendocrine K cells in rats

06-09-2011 | reference-global@degruyter.com (Nigel Irwin et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 10, Page 909-918, October 2011.

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Influenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice

06-09-2011 | reference-global@degruyter.com (Yue Chen et al), Biological Chemistry, 2011

Biological Chemistry, Volume 392, Issue 10, Page 869-876, October 2011.

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