My watch list
my.chemeurope.com  
Login  

1,840 Newest Publications of Portland Press

rss
matching the following criteria

The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria

15-11-2014 | Marchi S; Pinton P, Biochemical Journal, 2014

In this issue of the Biochemical Journal, Wu et al. describe the characterization of new low-affinity Ca2+ indicators for monitoring Ca2+ levels in both the ER (endoplasmic reticulum) and mitochondria. In contrast with other ER Ca2+ sensors, these indicators emit in the red part of the spectrum, ...

more

The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

more

Metformin and respiratory chain complex I: the last piece of the puzzle?

01-11-2014 | Fontaine E, Biochemical Journal, 2014

Metformin is the most widely prescribed drug used to treat patients affected by Type2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to complex I ...

more

NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...

more

Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression

23-10-2014 | Almahariq M; Mei F; Wang H; Cao A; Yao S; Soong L; Sun J; Cong Y; Chen J; Cheng X, Biochemical Journal, 2014

The cyclic adenosine monophosphate (cAMP) signaling pathway plays an essential role in immune functions. In this study we examined the role of the cAMP/EPAC1 (exchange protein directly activated by cAMP) axis in regulatory T-cell (Treg)-mediated immune suppression using genetic and pharmacologic ...

more

Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin

22-10-2014 | Verma S; Leikina E; Melikov K; Chernomordik L, Biochemical Journal, 2014

Macrophage fusion that leads to osteoclast formation is one of the most important examples of cell-to-cell fusion in development, tissue homeostasis and immune response. Protein machinery that fuses macrophages remains to be identified. Here we explored fusion stage of osteoclast formation for ...

more

A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-10-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...

more

Structural Determinants of Host Specificity of Complement Factor H Recruitment by {Less than}i{Greater than}Streptococcus pneumoniae{Less than}/i{Greater than}

21-10-2014 | Achila D; Liu A; Banerjee R; Li Y; Martinez-Hackert E; Zhang J; Yan H, Biochemical Journal, 2014

Many human pathogens have strict host specificity, which affects not only their epidemiology but also development of animal models and vaccines. Complement factor H (FH) is recruited to pneumococcal cell surface in a human-specific manner via the N-terminal domain of the pneumococcal protein ...

more

Disruption of integrin{Minus Sign}fibronectin complexes by allosteric but not ligand-mimetic inhibitors

21-10-2014 | Mould A; Craig S; Byron S; Humphries M; Jowitt T, Biochemical Journal, 2014

Failure of Arg-Gly-Asp (RGD)-based inhibitors to reverse integrin−ligand binding has been reported, but the prevalence of this phenomenon among integrin heterodimers is currently unknown. Here we have studied the interaction of four different RGD-binding integrins (α5β1, αVβ1, αVβ3 and αVβ6) with ...

more

Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities

21-10-2014 | Nahomi R; DiMauro M; Wang B; Nagaraj R, Biochemical Journal, 2014

Previous studies have identified peptides in the ‘crystallin-domain’ of the small heat shock protein α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in Hsp20 (71GHFSVLLDVKHFSPEEIAVK91) and Hsp27 (93DRWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin ...

more

Page 1 From 184
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE