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1,795 Newest Publications of Portland Press

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Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site

15-07-2014 | Klug YA; Ashkenazi A; Viard M; Porat Z; Blumenthal R; Shai Y, Biochemical Journal, 2014

Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as viral fusion. A single function has been suggested for the lipid, binding to the membrane and thus ...

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Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG subcomplex

15-07-2014 | English G; Byron O; Cianfanelli FR; Prescott AR; Coulthurst SJ, Biochemical Journal, 2014

Gram-negative bacteria use the TypeVI secretion system (T6SS) to inject toxic proteins into rival bacteria or eukaryotic cells. However, the mechanism of the T6SS is incompletely understood. In the present study, we investigated a conserved component of the T6SS, TssK, using the antibacterial ...

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Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52

01-07-2014 | Mustafi SM; LeMaster DM; Hernandez G, Biochemical Journal, 2014

As co-chaperones of Hsp90 (heat-shock protein 90), FKBP51 (FK506-binding protein of 51kDa) and FKBP52 (FK506-binding protein of 52kDa) act as antagonists in regulating the hormone affinity and nuclear transport of steroid receptor complexes. Exchange of Leu119 in FKBP51 for Pro119 in FKBP52 has ...

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Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase

27-06-2014 | Sola-Carvajal A; Gil-Ortiz F; Garc{i}a-Carmona F; Rubio V; S{a}nchez-Ferrer A, Biochemical Journal, 2014

N-acetyl-D-mannosamine dehydrogenase (NAMDH) from the soil bacteroidete Flavobacterium sp 141-8 catalyses a rare NAD+-dependent oxidation of N-acetyl-D-mannosamine (ManNAc) into N-acetylmannosamino-lactone, which spontaneously hydrolyses into N-acetylmannosaminic acid. NAMDH belongs to the SDR ...

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Novel high throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action

27-06-2014 | Sheen C; Alpturk O; Sluis-Cremer N, Biochemical Journal, 2014

HIV-1 resistance to zidovudine (AZT) is associated with selection of M41L, D67N, K70R, L210W, T215F/Y and K219Q/E in reverse transcriptase (RT). These mutations decrease HIV-1 susceptibility to AZT by augmenting RT’s ability to excise the chain-terminating AZT-monophosphate (AZT-MP) moiety from ...

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Incorporating covalent and allosteric effects into rate equations: the case of muscle glycogen synthase

27-06-2014 | Palm D; Rohwer J; Hofmeyr J, Biochemical Journal, 2014

Several enzymes have been described that undergo both allosteric and covalent regulation, but to date there exists no succinct kinetic description that is able to account for both of these mechanisms of regulation. Muscle glycogen synthase, an enzyme implicated in the pathogenesis of several ...

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The consensus-based approach for gene/enzyme replacement therapies and crystallization strategies: the case of human alanine:glyoxylate aminotransferase.

24-06-2014 | Mesa-Torres N; Yunta C; Fabelo-Rosa I; Gonzalez-Rubio J; Sanchez-Ruiz J; Salido E; Albert A; Pey A, Biochemical Journal, 2014

Protein stability is a fundamental issue in biomedical and biotechnological applications of proteins. Among them, gene- and enzyme-replacement strategies are promising approaches to treat inherited diseases that may benefit from protein engineering techniques, even though these beneficial effects ...

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Insights into Substrate Binding and Catalysis in Bacterial Type I Dehydroquinase

24-06-2014 | Maneiro M; Pe{o}n A; Lence E; Otero J; Van Raaij M; Thompson P; Hawkins A; Gonz{a}lez-Bello C, Biochemical Journal, 2014

Structural, biochemical and computational studies to study the substrate binding and the role of the conserved residues of the type I dehydroquinase (DHQ1) enzyme active site are reported. The crystal structure of DHQ1 from Salmonella typhi in complex with (2R)-2-methyl-3-dehydroquinic acid, a ...

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Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of {Less than}i{Greater than}Legionella pneumophila{Less than}/i{Greater than}

24-06-2014 | Riedmaier P; Sansom F; Sofian T; Beddoe T; Schuelein R; Newton H; Hartland E, Biochemical Journal, 2014

Legionella pneumophila is an opportunistic pathogen that replicates within alveolar macrophages resulting in the onset of severe atypical pneumonia. Previously we identified Lpg1905, a eukaryotic-type ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) from L. pneumophila that was required ...

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Structural and functional characterization of ochratoxinase, a novel mycotoxin degrading enzyme

20-06-2014 | Dobritzsch D; Wang H; Schneider G; Yu S, Biochemical Journal, 2014

Ochratoxin, with ochratoxin A as the dominant form, is one of the five major mycotoxins most harmful to humans and animals. It is produced by Aspergillus and Penicillium species and occurs in a wide range of agricultural products. Detoxification of contaminated food is a challenging health issue. ...

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