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1,958 Newest Publications of Portland Press

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

01-May-2015 | Bulatov E; Ciulli A, Biochemical Journal, 2015

In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. CRLs [Cullin-RING (really interesting new gene) ...

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Suppression of Interferon {beta} gene transcription by inhibitors of Bromodomain and Extra-Terminal (BET) family members

20-Apr-2015 | Malik N; Vollmer S; Nanda S; Lopez-Pelaez M; Prescott A; Gray N; Cohen P, Biochemical Journal, 2015

Polo-Like Kinase (PLK) inhibitors, such as BI-2536, have been reported to suppress interferon β (IFNβ) gene transcription induced by ligands that activate TLR3 and TLR4. Here, we report that BI-2536 is likely to exert this effect by preventing the interaction of the transcription factors IRF3 and ...

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Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

20-Apr-2015 | McGarry D; Chen W; Chakravarty P; Lamont D; Wolf C; Henderson C, Biochemical Journal, 2015

Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and pathways regulated by S-glutathionylation in whole organisms and current approaches lack the sensitivity to examine this modification ...

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Proteomic approaches to identify substrates of the three Deg/HtrA proteases of the cyanobacterium {Less than}i{Greater than}Synechocystis{Less than}/i{Greater than} sp. PCC 6803

16-Apr-2015 | Tam L; Aigner H; Timmerman E; Gevaert K; Funk C, Biochemical Journal, 2015

The family of Deg/HtrA proteases plays an important role in quality control of cellular proteins in a wide range of organisms. In the genome of the cyanobacterium Synechocystis sp. PCC 6803, a model organism for photosynthetic research and renewable energy products, three Deg proteases are ...

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Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

16-Apr-2015 | Wilson M; Kugel S; Huang J; Wilson L; Wloszczynski P; Ye J; Matherly L; Hou Z, Biochemical Journal, 2015

The human proton-coupled folate transporter (hPCFT) is expressed in solid tumors and is active at pHs characterizing the tumor microenvironment. Recent attention focused on exploiting hPCFT for targeting solid tumors with novel cytotoxic antifolates. hPCFT has 12 transmembrane domains (TMDs) and ...

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Biochemical and redox characterization of the Mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein

16-Apr-2015 | Shaikhali J; Davoine C; Br{a}nnstr{o}m K; ROUHIER N; Bygdell J; Bj{o}rklund S; Wingsle G, Biochemical Journal, 2015

The eukaryotic Mediator integrates regulatory signals from promoter-bound transcription factors and transmits them to RNA polymerase II machinery. Although redox signaling is important in adjusting plant metabolism and development, nothing is known about a possible redox regulation of Mediator. ...

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Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...

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Structural characterisation of high order alpha-synuclein oligomers capable of inducing intracellular aggregation

08-Apr-2015 | Illes-toth E; Ramos M; Cappai R; Dalton C; Smith D, Biochemical Journal, 2015

Misfolding and aggregation of alpha-synuclein (α-syn) into Lewy bodies (LB) is associated with a range of neurological disorders, including Parkinson’s disease (PD). The cell to cell transmission of α-syn pathology has been linked to soluble amyloid oligomer populations that preceded LB ...

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Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases

07-Apr-2015 | Cahn J; Brinkmann-Chen S; Spatzal T; Wiig J; Buller A; Einsle O; Hu Y; Ribbe M; Arnold F, Biochemical Journal, 2015

Although most sequenced members of the industrially important ketol-acid reductoisomerase (KARI) family are Class I enzymes, structural studies to date have focused primarily on the Class II KARIs, which arose through domain duplication. Here, we present five new crystal structures of Class I ...

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