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1,260 Newest Publications of Portland Press
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Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence
01-06-2013 | Wolin MS, Biochemical Journal, 2013
Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence ...
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
01-06-2013 | Reeks J; Sokolowski RD; Graham S; Liu H; Naismith JH; White MF, Biochemical Journal, 2013
The competition between viruses and hosts is played out in all branches of life. Many prokaryotes have an adaptive immune system termed 'CRISPR' (clustered regularly interspaced short palindromic repeats) which is based on the capture of short pieces of viral DNA. The captured DNA is ...
Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer's Drugs Targeting Acetyl- and Butyrylcholinesterase
17-05-2013 | Nachon F; Carletti E; Ronco C; Trovaslet M; Nicolet Y; Jean L; Renard P, Biochemical Journal, 2013
The multifunctional nature of Alzheimer's disease calls for multi-target directed ligands (MTDLs) able to act on different components of the pathology, like the cholinergic dysfunction and amyloid aggregation. Such MTDLs are usually based on cholinesterase inhibitors (e.g., tacrine or ...
Convergent Evolution of Chromatin Modification by Structurally Distinct Enzymes: Comparative Enzymology of Histone 3 Lysine 27 Methylation by Human Polycomb Repressive Complex 2 and Viral vSET
17-05-2013 | Swalm B; Hallenbeck K; Majer C; Jin L; Scott M; Moyer M; Copeland R; Wigle T, Biochemical Journal, 2013
Histone H3 lysine 27 (H3K27) methylation is an important epigenetic modification that regulates gene transcription. In humans, EZH1 and EZH2 are the only enzymes capable of catalyzing methylation of H3K27. There is great interest in understanding structure-function relationships for EZH2, as ...
STIM1 negatively regulates Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} release from the sarcoplasmic reticulum in skeletal myotubes
14-05-2013 | Lee K; Woo J; Hwang J; Hyun C; Cho C; Kim D; Lee E, Biochemical Journal, 2013
Stromal interaction molecule 1 (STIM1) mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. However, the direct role(s) of STIM1 in skeletal muscle, such as Ca2+ release from the sarcoplasmic reticulum (SR) for muscle contraction, have not been identified. The times required for the ...
Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HUR and PP2A
14-05-2013 | Hyv{o}nen M; Koponen T; Weisell J; Pietil{a} M; Khomutov A; Veps{a}l{a}inen J; Alhonen L; Kein{a}nen T, Biochemical Journal, 2013
We previously showed that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. Here, we studied the mechanism of spermidine function by using polyamine biosynthesis inhibitor α-difluoromethylornithine in combination with the metabolically stable polyamine ...
skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity
13-05-2013 | Berkholz J; Zakrzewicz A; Munz B, Biochemical Journal, 2013
Skeletal and heart muscle specific variant of nascent polypeptide associated complex (skNAC) is a skeletal and heart muscle-specific protein known to be involved in the regulation of sarcomerogenesis. The respective mechanism, however, is largely unknown. Here, we demonstrate that skNAC ...
Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of {alpha}-Naphthoflavone
08-05-2013 | Davydov D; Davydova N; Sineva E; Kufareva I; Halpert J, Biochemical Journal, 2013
We investigated the relationship between oligomerization of cytochrome P450 3A4 (CYP3A4) and its response to alpha-naphthoflavone (ANF), a prototypical heterotropic activator. Addition of ANF resulted in over a two-fold increase in the rate of CYP3A4-dependent debenzylation of ...
Receptor for activated C-kinase 1 (RACK1) interacts with F-box and WD-repeat domain containing-2 (FBW2) to upregulate glial cell missing-1 (GCM1) stability and placental cell migration and invasion
07-05-2013 | Wang C; Lo H; Lin S; Chen H, Biochemical Journal, 2013
GCM1 is a short-lived transcription factor essential for placental development. The F-box protein, FBW2, which contains five tryptophan-aspartate (WD) repeats, recognizes GCM1 and mediates its ubiquitination via the SCFFBW2 E3 ligase complex. Although the interaction between GCM1 and FBW2 is ...
Minimal Functional Domains of Paralogues hnRNP L and hnRNP LL Exhibit Mechanistic Differences in Exonic Splicing Repression
07-05-2013 | Shankarling G; Lynch K, Biochemical Journal, 2013
Understanding functional distinctions between related splicing regulatory proteins is critical to deciphering tissue-specific control of alternative splicing. The hnRNP L and hnRNP LL proteins are paralogues that have overlapping but distinct expression patterns and functional consequences. ...
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