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1,819 Newest Publications of Portland Press

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Novel reactivity of Fhit proteins: catalysts for fluorolysis of nucleoside 5{'}-phosphoramidates and nucleoside 5{'}-phosphosulfates to generate nucleoside 5{'}-phosphorofluoridates

31-Mar-2015 | Wojdyla-Mamon A; Zimny J; Romanowska J; Kraszewski A; Stawinski J; Bieganowski P; Guranowski A, Biochemical Journal, 2015

Fragile-histidine-triad proteins (Fhits) occur in all eukaryotes but their function is largely unknown. Human Fhit is presumed to function as a tumor suppressor. Previously, we demonstrated that Fhits catalyze hydrolysis of not only dinucleoside triphosphates but also natural adenosine ...

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Loss of Conserved {Less than}i{Greater than}Gsdma3{Less than}/i{Greater than} Self-Regulation Causes Autophagy and Cell Death

31-Mar-2015 | Shi P; Tang A; Xian L; Hou S; Zou D; Lv Y; Huang Z; Wang Q; Song A; Lin Z; Gao X, Biochemical Journal, 2015

Gsdermin A3 (Gsdma3) was originally identified for associating with hair-loss phenotype in mouse mutants. Our previous study found AE mutant mice, with a Y344H substitution at C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation. Interestingly, we found that the ...

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{Less than}i{Greater than}In vitro{Less than}/i{Greater than} reconstitution of cotranslational D1 insertion reveals a role of the cpSec/Alb3 translocase and Vipp1 in photosystem II biogenesis

24-Mar-2015 | Walter B; Hristou A; Nowaczyk M; Sch{u}nemann D, Biochemical Journal, 2015

Photosystem II (PS II) is a multi subunit complex localized in the thylakoid membrane that performs the light dependent photosynthetic charge separation. The PS II reaction center comprises, amongst others, the D1 protein. De novo synthesis and repair of PS II require efficient mechanisms for ...

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Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

20-Mar-2015 | Li J; Xu F; Hu S; Zhou J; Mei S; Zhao X; Cen S; Jin Q; Liang C; Guo F, Biochemical Journal, 2015

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits HIV-1 infection of myeloid cells and resting CD4+ T cells. Two lineages of primate lentiviruses, the sooty mangabey SIV (SIVsm)/macaque SIV (SIVmac)/HIV-2 lineage and the red-capped mangabey SIV (SIVrcm) lineage, carry a SAMHD1 ...

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Processing of Protein ADP-ribosylation by Nudix Hydrolases

19-Mar-2015 | Palazzo L; Thomas B; Jemth A; Colby T; Leidecker O; Feijs K; Zaja R; Loseva O; Puigvert J; Matic I; Helleday T; Ahel I, Biochemical Journal, 2015

ADP-ribosylation is a post-translational modification of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response, and apoptosis. Several cellular enzymes, such as macrodomain ...

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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

17-Mar-2015 | Lorenz S; Deng P; Hantschel O; Superti-Furga G; Kuriyan J, Biochemical Journal, 2015

Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in ...

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RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

16-Mar-2015 | Sami F; Lu X; Parvathaneni S; Roy R; Gary R; Sharma S, Biochemical Journal, 2015

RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in replication restart mechanisms. Cellular phenotypes of RECQ1 deficiency are indicative of aberrant repair of stalled replication forks, but the molecular functions of RECQ1, ...

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Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

15-Mar-2015 | Bett JS; Ritorto MS; Ewan R; Jaffray EG; Virdee S; Chin JW; Knebel A; Kurz T; Trost M; Tatham MH; Hay RT, Biochemical Journal, 2015

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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Platelet Rho GTPases-a focus on novel players, roles and relationships

15-Mar-2015 | Goggs R; Williams CM; Mellor H; Poole AW, Biochemical Journal, 2015

Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on ...

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SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

13-Mar-2015 | B{e}k{e}s M; Rut W; Kasperkiewicz P; Mulder M; Ovaa H; Drag M; Lima C; Huang T, Biochemical Journal, 2015

Ubiquitin (Ub) and the ubiquitin-like modifier interferon stimulated gene 15 (ISG15) participate in the host defense of viral infections. Viruses, including the Severe Acute Respiratory Syndrome human coronavirus (SARS hCoV), have co-opted Ub/ISG15-conjugation pathways for their own advantage or ...

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