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1,665 Newest Publications of Portland Press

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Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection

01-12-2014 | Bilanges B; Vanhaesebroeck B, Biochemical Journal, 2014

Class II/III PI3Ks (phosphoinositide 3-kinases) produce the PtdIns(3)P lipid that is involved in intracellular vesicular trafficking. In contrast with class I PI3Ks, the potential signalling roles of class II/III PI3Ks are poorly understood. In a recent article in the Biochemical Journal, Bago ...

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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

01-12-2014 | Abdul Azeez KR; Knapp S; Fernandes JMP; Klussmann E; Elkins JM, Biochemical Journal, 2014

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. ...

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Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment

21-11-2014 | Varfolomeev E; Izrael-Tomasevic A; Yu K; Bustos D; Goncharov T; Belmont L; Masselot A; Bakalarski C; Kirkpatrick D; ..., Biochemical Journal, 2014

Evasion of cell death is one crucial capability acquired by tumor cells to ward off anti-tumor therapies, and represents a fundamental challenge to sustaining clinical efficacy for currently available agents. Inhibitor of Apoptosis (IAP) proteins use their ubiquitin E3 ligase activity to promote ...

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A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines

19-11-2014 | Fan G; Wrzeszczynski K; Fu C; Su G; Pappin D; Lucito R; Tonks N, Biochemical Journal, 2014

Although DNA encodes the molecular instructions that underlie control of cell function, it is the proteins that are primarily responsible for implementing those instructions. Therefore, quantitative analyses of the proteome would be expected to yield insights into important candidates for the ...

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{Less than}i{Greater than}nhr-176{Less than}/i{Greater than} regulates {Less than}i{Greater than}cyp-35d1{Less than}/i{Greater than} to control hydroxylation-dependent metabolism of thiabendazole in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than}

19-11-2014 | Jones L; Flemming A; Urwin P, Biochemical Journal, 2014

Knowledge of how drugs are metabolised and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole to be commercially available and remains one of the most important anthelmintic drugs for ...

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The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria

15-11-2014 | Marchi S; Pinton P, Biochemical Journal, 2014

In this issue of the Biochemical Journal, Wu et al. describe the characterization of new low-affinity Ca2+ indicators for monitoring Ca2+ levels in both the ER (endoplasmic reticulum) and mitochondria. In contrast with other ER Ca2+ sensors, these indicators emit in the red part of the spectrum, ...

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The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

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Fe65 Ser{Less than}sup{Greater than}228{Less than}/sup{Greater than} is Phosphorylated by ATM/ATR and Inhibits Fe65-APP-Mediated Gene Transcription

14-11-2014 | Jowsey P; Blain P, Biochemical Journal, 2014

Fe65 binds the amyloid precursor protein (APP) and regulates the secretase-mediated processing of APP into several proteolytic fragments, including the amyloid-β (Aβ) peptides and APP intracellular domain (AICD). Aβ accumulation in neural plaques is a pathological feature of Alzheimer’s disease ...

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{Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than} mitochondria import tRNAs along with {Soft hyphen}{Soft hyphen}{Soft hyphen}{Soft hyphen}an active phenylalanyl-tRNA synthetase{Soft hyphen}{Soft hyphen}{Soft hyphen}{Soft hyphen}

13-11-2014 | Sharma A, Biochemical Journal, 2014

Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases (aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyzes transfer of amino acids to cognate transfer RNAs (tRNAs), thus providing charged tRNAs for ribosomal consumption. P. falciparum proteome ...

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Structure-Dynamic Determinants Governing a Mode of Regulatory Response and Propagation of Allosteric Signal in Splice Variants of Na{Less than}sup{Greater than}{+}{Less than}/sup{Greater than}/Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} Exchange (NCX) Proteins

12-11-2014 | Giladi M; Lee S; Hiller R; Chung K; Khananshvili D, Biochemical Journal, 2014

The Ca2+-dependent allosteric regulation of Na+/Ca2+ exchanger (NCX) proteins represents Ca2+ interaction with the cytosolic domains, CBD1 and CBD2, which is associated either with activation, inhibition or no response to regulatory Ca2+ in a given splice variant. CBD1 contains a high affinity ...

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