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1,888 Newest Publications of Portland Press

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Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

22-May-2015 | De Veer S; Swedberg J; Akcan M; Rosengren K; Brattsand M; Craik D; Harris J, Biochemical Journal, 2015

Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesising a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor’s resistance to ...

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FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21{Less than}sup{Greater than}Cip1/Waf1{Less than}/sup{Greater than}

20-May-2015 | Kloet D; Polderman P; Eijkelenboom A; Smits L; Van Triest M; Van Den Berg M; Groot Koerkamp M; Van Leenen D; Lijnzaa ..., Biochemical Journal, 2015

Activity of Forkhead box O (FOXO) transcription factors is inhibited by growth factor-PI3K-protein kinase B (PKB)/AKT signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we identified a set of ...

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Tail wags the dog: Activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner

18-May-2015 | Sridharan S; Kini M, Biochemical Journal, 2015

Natriuretic peptides (NP) are potent vasoactive hormones, which maintain pressure-volume homeostasis. Snake venom NPs exhibit distinct biological activity compared to mammalian NPs due to subtle changes in their sequences. We recently identified a new NP from krait venom (KNP), with an unusual ...

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Slc5a8, a Na {+} -coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions

18-May-2015 | Gurav A; Sivaprakasam S; Bhutia Y; Boettger T; Singh N; Ganapathy V, Biochemical Journal, 2015

Mammalian colon harbors trillions of bacteria under physiologic conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. Here we show that Slc5a8, a Na + -coupled ...

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The purification and characterization of ATP synthase complexes from the mitochondria of four fungal species

15-May-2015 | Liu S; Charlesworth TJ; Bason JV; Montgomery MG; Harbour ME; Fearnley IM; Walker JE, Biochemical Journal, 2015

The ATP synthases have been isolated by affinity chromatography from the mitochondria of the fungal species Yarrowia lipolytica, Pichia pastoris, Pichia angusta and Saccharomyces cerevisiae. The subunit compositions of the purified enzyme complexes depended on the detergent used to solubilize and ...

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Arc is a flexible modular protein capable of reversible self-oligomerization

15-May-2015 | Myrum C; Baumann A; Bustad HJ; Flydal MI; Mariaule V; Alvira S; Cuellar J; Haavik J; Soule J; Valpuesta JM; Marquez ..., Biochemical Journal, 2015

The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties of Arc have not been elucidated. In the present study, we expressed and ...

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An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

15-May-2015 | Irving JA; Miranda E; Haq I; Perez J; Kotov VR; Faull SV; Motamedi-Shad N; Lomas DA, Biochemical Journal, 2015

A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type protein. Using the common pathogenic E342K (Z) ...

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Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer

13-May-2015 | Babu E; Bhutia Y; Ramachandran S; Gnana-Prakasam J; Prasad P; Thangaraju M; Ganapathy V, Biochemical Journal, 2015

SLC6A14 mediates Na + /Cl --coupled concentrative uptake of a broad-spectrum of amino acids. It is expressed at low levels in many tissues but upregulated in certain cancers. Pharmacologic blockade of SLC6A14 causes amino acid starvation in ER+ breast cancer cells and suppresses their ...

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The focal adhesion kinase Pyk2 links Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} signaling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

13-May-2015 | Canobbio I; Cipolla L; Guidetti G; Manganaro D; Visconte C; Kim S; Okigaki M; Falasca M; Kunapuli S; Torti M, Biochemical Journal, 2015

In blood platelets, stimulation of G protein-coupled receptors by thrombin triggers the activation of Src family kinases (SFKs), resulting in the tyrosine-phosphorylation of multiple substrates, but the mechanism underlying this process is still poorly understood. Here we show that the ...

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Nuclear Cyclophilins Impact Spliceosome Assembly and Function {Less than}i{Greater than}In Vitro{Less than}/i{Greater than}

13-May-2015 | Adams B; Coates M; Jackson S; Jurica M; Davis T, Biochemical Journal, 2015

Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyze cis/trans isomerization of proline residues. There are seventeen annotated members of the cyclophilin family in humans, ubiquitously expressed and localized variously to the cytoplasm, nucleus, or ...

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