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1,773 Newest Publications of Portland Press

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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

01-12-2014 | Abdul Azeez KR; Knapp S; Fernandes JMP; Klussmann E; Elkins JM, Biochemical Journal, 2014

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. ...

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The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria

15-11-2014 | Marchi S; Pinton P, Biochemical Journal, 2014

In this issue of the Biochemical Journal, Wu et al. describe the characterization of new low-affinity Ca2+ indicators for monitoring Ca2+ levels in both the ER (endoplasmic reticulum) and mitochondria. In contrast with other ER Ca2+ sensors, these indicators emit in the red part of the spectrum, ...

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The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

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Fe65 Ser{Less than}sup{Greater than}228{Less than}/sup{Greater than} is Phosphorylated by ATM/ATR and Inhibits Fe65-APP-Mediated Gene Transcription

14-11-2014 | Jowsey P; Blain P, Biochemical Journal, 2014

Fe65 binds the amyloid precursor protein (APP) and regulates the secretase-mediated processing of APP into several proteolytic fragments, including the amyloid-β (Aβ) peptides and APP intracellular domain (AICD). Aβ accumulation in neural plaques is a pathological feature of Alzheimer’s disease ...

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{Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than} mitochondria import tRNAs along with {Soft hyphen}{Soft hyphen}{Soft hyphen}{Soft hyphen}an active phenylalanyl-tRNA synthetase{Soft hyphen}{Soft hyphen}{Soft hyphen}{Soft hyphen}

13-11-2014 | Sharma A, Biochemical Journal, 2014

Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases (aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyzes transfer of amino acids to cognate transfer RNAs (tRNAs), thus providing charged tRNAs for ribosomal consumption. P. falciparum proteome ...

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Structure-Dynamic Determinants Governing a Mode of Regulatory Response and Propagation of Allosteric Signal in Splice Variants of Na{Less than}sup{Greater than}{+}{Less than}/sup{Greater than}/Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} Exchange (NCX) Proteins

12-11-2014 | Giladi M; Lee S; Hiller R; Chung K; Khananshvili D, Biochemical Journal, 2014

The Ca2+-dependent allosteric regulation of Na+/Ca2+ exchanger (NCX) proteins represents Ca2+ interaction with the cytosolic domains, CBD1 and CBD2, which is associated either with activation, inhibition or no response to regulatory Ca2+ in a given splice variant. CBD1 contains a high affinity ...

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C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1{alpha} signaling in acute liver failure

11-11-2014 | Rao J; Zhang C; Wang P; Lu L; Qian X; Qin J; Pan X; Li G; Wang X; Zhang F, Biochemical Journal, 2014

C/EBP Homologous Protein (CHOP) has been shown to be a key molecule in endoplasmic reticulum (ER) stress-mediated apoptosis. ERO1α, a target of CHOP, is an important oxidizing enzyme to regulate ROS, which play a prominent role in hepatocellular death during acute liver failure (ALF). However, ...

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Gremlin1 preferentially binds to Bone Morphogenetic Protein-2 (BMP-2) and BMP-4 over BMP-7

07-11-2014 | Church R; Krishnakumar A; Urbanek A; Geschwindner S; Meneely J; Bianchi A; Basta B; Monaghan S; Elliott C; Stromsted ..., Biochemical Journal, 2014

Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis-associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during DN has been ...

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

07-11-2014 | Henderson C; McLaughlin L; Osuna-Cabello M; Taylor M; Gilbert I; McLaren A; Wolf C, Biochemical Journal, 2014

The relative contribution of hepatic versus intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electron ...

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Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium

07-11-2014 | Samak G; Chaudhry K; Gangwar R; Narayanan D; Jaggar J; Rao R, Biochemical Journal, 2014

Disruption of intestinal epithelial tight junctions is an important event in the pathogenesis of ulcerative colitis. Dextran sodium sulfate (DSS) induces colitis in mice with the symptoms similar to ulcerative colitis. However, the mechanism of DSS-induced colitis is unknown. We investigated the ...

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