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1,821 Newest Publications of Portland Press

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Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

01-Mar-2015 | Bauckman K; Haller E; Taran N; Rockfield S; Ruiz-Rivera A; Nanjundan M, Biochemical Journal, 2015

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although ...

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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

25-Feb-2015 | Shamas-Din A; Bindner S; Chi X; Leber B; Andrews D; Fradin C, Biochemical Journal, 2015

After exposure to stressful stimuli, apoptotic signals can be relayed to mitochondria by pro-apoptotic activator proteins, tBid and Bim, which activate Bax and or Bak to induce mitochondrial outer membrane permeabilization (MOMP). These protein-protein and protein-membrane interactions are ...

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Structural Mechanisms Underlying Sequence-Dependent Variations in GAG Affinities of Decorin Binding Protein A, a {Less than}i{Greater than}Borrelia burgdorferi{Less than}/i{Greater than} Adhesin

19-Feb-2015 | Morgan A; Wang X, Biochemical Journal, 2015

Decorin binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease. DBPA facilitates the bacteria’s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. Interestingly, DBPA sequence ...

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PT-1 selectively activates AMPK-{gamma}1 complexes in mouse skeletal muscle, but activates all three {gamma} subunit complexes in cultured human cells by inhibiting the respiratory chain

19-Feb-2015 | Jensen T; Ross F; Kleinert M; Sylow L; Knudsen J; Gowans G; Hardie D; Richter E, Biochemical Journal, 2015

AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α1/α2) is bound to one of two b subunits (β1/β2) and one of three γ subunits (γ1/γ2/γ3). The ability to selectively activate specific isoforms would be a useful research tool, and a promising ...

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The {Less than}i{Greater than}Leishmania donovani {Less than}/i{Greater than}histidine acid ecto-phosphatase{Less than}i{Greater than} Ld{Less than}/i{Greater than}MAcP: insight into its structure and function

19-Feb-2015 | Papadaki A; Politou A; Smirlis D; Kotini M; Kourou K; Papamarcaki T; Boleti H, Biochemical Journal, 2015

Acid ecto-phosphatase activity has been implicated in Leishmania donovani promastigote virulence. Here we report data contributing to the molecular/structural and functional characterization of the Leishmania donovani LdMAcP, member of the histidine acid phosphatase family. LdMAcP, is membrane ...

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Small Molecule Inhibitors of ERK-mediated Immediate Early Gene Expression and Proliferation of Melanoma Cells Expressing Mutated BRaf

19-Feb-2015 | Samadani R; Zhang J; Brophy A; Oashi T; Priyakumar U; Raman E; St. John F; Jung K; Fletcher S; Pozharski E; MacKerel ..., Biochemical Journal, 2015

Constitutive activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for ...

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Regulation of IGFBP-2 expression during fasting

19-Feb-2015 | Kang H; Kim M; Kim S; Lee J; Kim Y; Seo Y; Bae J; Oh G; Song D; Ahn Y; Im S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorder is well known, its regulatory mechanism remains unclear. Here, we ...

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Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae

15-Feb-2015 | Thota SG; Unnikannan CP; Thampatty SR; Manorama R; Bhandari R, Biochemical Journal, 2015

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol that act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

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JAK2 activation by growth hormone and other cytokines

15-Feb-2015 | Waters MJ; Brooks AJ, Biochemical Journal, 2015

Growth hormone (GH) and structurally related cytokines regulate a great number of physiological and pathological processes. They do this by coupling their single transmembrane domain (TMD) receptors to cytoplasmic tyrosine kinases, either as homodimers or heterodimers. Recent studies have ...

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The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells

01-Feb-2015 | Voronina S; Collier D; Chvanov M; Middlehurst B; Beckett AJ; Prior IA; Criddle DN; Begg M; Mikoshiba K; Sutton R; Te ..., Biochemical Journal, 2015

The inducers of acute pancreatitis trigger a prolonged increase in the cytosolic Ca2+ concentration ([Ca2+]c), which is responsible for the damage to and eventual death of pancreatic acinar cells. Vacuolization is an important indicator of pancreatic acinar cell damage. Furthermore, activation of ...

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