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1,634 Newest Publications of Portland Press

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N-terminus oligomerization is conserved in intracellular calcium release channels

15-04-2014 | Zissimopoulos S; Marsh J; Stannard L; Seidel M; Lai FA, Biochemical Journal, 2014

Oligomerization of all three mammalian ryanodine receptor isoforms, a structural requirement for normal intracellular Ca2+ release channel function, is displayed by the discrete N-terminal domain which assembles into homo- and hetero-tetramers. This is demonstrated in yeast, mammalian cells and ...


Bacillus thuringiensis Cry1A toxins are versatile proteins with multiple modes of action: two distinct pre-pores are involved in toxicity

15-04-2014 | Gomez I; Sanchez J; Munoz-Garay C; Matus V; Gill SS; Soberon M; Bravo A, Biochemical Journal, 2014

Cry proteins from Bacillus thuringiensis are insecticidal PFTs (pore-forming toxins). In the present study, we show that two distinct functional pre-pores of Cry1Ab are formed after binding of the protoxin or the protease-activated toxin to the cadherin receptor, but before membrane insertion. ...


Liver X receptor: from metabolism to cancer

15-04-2014 | Venteclef N; Ferre P, Biochemical Journal, 2014

Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors). LXR is an important regulator of cholesterol ...


Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

15-04-2014 | Roberts AJ; Torrie LS; Wyllie S; Fairlamb AH, Biochemical Journal, 2014

Co- and post-translational N-myristoylation is known to play a role in the correct subcellular localization of specific proteins in eukaryotes. The enzyme that catalyses this reaction, NMT (N-myristoyltransferase), has been pharmacologically validated as a drug target in the African trypanosome, ...


The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

15-04-2014 | Butt A; Higman VA; Williams C; Crump MP; Hemsley CM; Harmer N; Titball RW, Biochemical Journal, 2014

TA (toxin-antitoxin) systems are widely distributed amongst bacteria and are associated with the formation of antibiotic tolerant (persister) cells that may have involvement in chronic and recurrent disease. We show that overexpression of the Burkholderia pseudomallei HicA toxin causes growth ...


The glycation site specificity of human serum transferrin is determinant for the protein functional impairment under elevated glycemic conditions.

10-04-2014 | Silva A; Sousa P; Coimbra J; Br{a}s N; Vitorino R; Fernandes P; Ramos M; Rangel M; Domingues P, Biochemical Journal, 2014

The mechanisms involving iron toxicity in diabetes mellitus are not completely understood. However, the spontaneous reaction of reducing sugars with protein amino groups, known as glycation, has been shown to compromise the action of transferrin (Tf), the systemic iron transporter. In order to ...


Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from {Less than}i{Greater than}Mycobacterium tuberculosis{Less than}/i{Greater than}

09-04-2014 | Cookson T; Castell A; Bulloch E; Evans G; Short F; Baker E; Lott J; Parker E, Biochemical Journal, 2014

Anthranilate phosphoribosyltransferase (AnPRT), required for the biosynthesis of tryptophan, is essential for the virulence of Mycobacterium tuberculosis (Mtb). AnPRT catalyses the Mg2+-dependent transfer of a phosphoribosyl group from 5′-phosphoribosyl 1′-pyrophosphate (PRPP) to anthranilate to ...


Retinal metabolism in human retina induces the formation of an unprecedented lipofuscin fluorophore "pdA2E"

09-04-2014 | Wu Y; Jin Q; Yao K; Zhao J; Chen J; Wu X; Gan L; Li J; Song X; Liu X; Cai X, Biochemical Journal, 2014

Toxic lipofuscin in the retinal pigment epithelium (RPE)is implicated in blindness in age-related macular degeneration (AMD) or recessive Stargardt disease patients. In this study, we identified a novel fluorescent lipofuscin component in human and bovine RPEs. Using one- and two-dimensional NMR ...


Histone chaperone Chz1 facilitates the disfavoring property of Spt16 to H2A.Z-containing genes in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than}

08-04-2014 | Liu H; Zhou Z; Luo K; Mu Y; Wan Y, Biochemical Journal, 2014

Htz1 deposition at promoters is involved in the transcriptional activation of quiescent genes. Chz1 is an Htz1-H2B specific chaperone that delivers H2A.Z for H2A substitution. Spt16 functions in transcription elongation and also possess histone chaperone activity. However, the links among Chz1, ...


Cystathionine-{gamma}-lyase/hydrogen sulfide system maintains cellular glutathione status

07-04-2014 | Lee Z; Low Y; Huang S; Wang T; Deng L, Biochemical Journal, 2014

Hydrogen sulfide (H2S) has been implicated to exhibit an antioxidative property in many models. Cystathionine-γ-lyase (CSE) is an important enzyme responsible for endogenous H2S production in mammalian systems, but little is known about the modulation of endogenous H2S production and its ...


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