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1,636 Newest Publications of Portland Press

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Ceramide Synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

17-04-2014 | Ebel P; Imgrund S; vom Dorp K; Hofmann K; Maier H; Drake H; Degen J; D{o}rmann P; Eckhardt M; Franz T; Willecke K, Biochemical Journal, 2014

Five ceramide synthases (CerS2‑6) are expressed in mouse skin. While CerS3 has been shown to fulfill an essential function during skin development, neither CerS6 nor CerS2 deficient mice show an obvious skin phenotype. In order to study the role of CerS4, we generated CerS4 deficient mice ...


Role of {alpha}-Methylacyl-CoA Racemase (Amacr) and peroxisomal Multifunctional Enzyme 1 (Mfe-1) in bile acid synthesis in mice

16-04-2014 | Autio K; Schmitz W; Nair R; Selk{a}l{a} E; Sormunen R; Miinalainen I; Crick P; Wang Y; Griffiths W; Reddy J; Baes M; ..., Biochemical Journal, 2014

Cholesterol is catabolized to bile acids by peroxisomal β-oxidation in which the side-chain of C27-bile acid intermediates is shortened by three carbon atoms to form mature C24-bile acids. Knock-out mouse models deficient in α-methylacyl coenzyme A racemase (Amacr) or multifunctional enzyme type ...


N-terminus oligomerization is conserved in intracellular calcium release channels

15-04-2014 | Zissimopoulos S; Marsh J; Stannard L; Seidel M; Lai FA, Biochemical Journal, 2014

Oligomerization of all three mammalian ryanodine receptor isoforms, a structural requirement for normal intracellular Ca2+ release channel function, is displayed by the discrete N-terminal domain which assembles into homo- and hetero-tetramers. This is demonstrated in yeast, mammalian cells and ...


Bacillus thuringiensis Cry1A toxins are versatile proteins with multiple modes of action: two distinct pre-pores are involved in toxicity

15-04-2014 | Gomez I; Sanchez J; Munoz-Garay C; Matus V; Gill SS; Soberon M; Bravo A, Biochemical Journal, 2014

Cry proteins from Bacillus thuringiensis are insecticidal PFTs (pore-forming toxins). In the present study, we show that two distinct functional pre-pores of Cry1Ab are formed after binding of the protoxin or the protease-activated toxin to the cadherin receptor, but before membrane insertion. ...


Liver X receptor: from metabolism to cancer

15-04-2014 | Venteclef N; Ferre P, Biochemical Journal, 2014

Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors). LXR is an important regulator of cholesterol ...


Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

15-04-2014 | Roberts AJ; Torrie LS; Wyllie S; Fairlamb AH, Biochemical Journal, 2014

Co- and post-translational N-myristoylation is known to play a role in the correct subcellular localization of specific proteins in eukaryotes. The enzyme that catalyses this reaction, NMT (N-myristoyltransferase), has been pharmacologically validated as a drug target in the African trypanosome, ...


The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

15-04-2014 | Butt A; Higman VA; Williams C; Crump MP; Hemsley CM; Harmer N; Titball RW, Biochemical Journal, 2014

TA (toxin-antitoxin) systems are widely distributed amongst bacteria and are associated with the formation of antibiotic tolerant (persister) cells that may have involvement in chronic and recurrent disease. We show that overexpression of the Burkholderia pseudomallei HicA toxin causes growth ...


The glycation site specificity of human serum transferrin is determinant for the protein functional impairment under elevated glycemic conditions.

10-04-2014 | Silva A; Sousa P; Coimbra J; Br{a}s N; Vitorino R; Fernandes P; Ramos M; Rangel M; Domingues P, Biochemical Journal, 2014

The mechanisms involving iron toxicity in diabetes mellitus are not completely understood. However, the spontaneous reaction of reducing sugars with protein amino groups, known as glycation, has been shown to compromise the action of transferrin (Tf), the systemic iron transporter. In order to ...


Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from {Less than}i{Greater than}Mycobacterium tuberculosis{Less than}/i{Greater than}

09-04-2014 | Cookson T; Castell A; Bulloch E; Evans G; Short F; Baker E; Lott J; Parker E, Biochemical Journal, 2014

Anthranilate phosphoribosyltransferase (AnPRT), required for the biosynthesis of tryptophan, is essential for the virulence of Mycobacterium tuberculosis (Mtb). AnPRT catalyses the Mg2+-dependent transfer of a phosphoribosyl group from 5′-phosphoribosyl 1′-pyrophosphate (PRPP) to anthranilate to ...


Retinal metabolism in human retina induces the formation of an unprecedented lipofuscin fluorophore "pdA2E"

09-04-2014 | Wu Y; Jin Q; Yao K; Zhao J; Chen J; Wu X; Gan L; Li J; Song X; Liu X; Cai X, Biochemical Journal, 2014

Toxic lipofuscin in the retinal pigment epithelium (RPE)is implicated in blindness in age-related macular degeneration (AMD) or recessive Stargardt disease patients. In this study, we identified a novel fluorescent lipofuscin component in human and bovine RPEs. Using one- and two-dimensional NMR ...


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