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1,799 Newest Publications of Portland Press

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...

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Novel reactivity of Fhit proteins: catalysts for fluorolysis of nucleoside 5{'}-phosphoramidates and nucleoside 5{'}-phosphosulfates to generate nucleoside 5{'}-phosphorofluoridates

31-Mar-2015 | Wojdyla-Mamon A; Zimny J; Romanowska J; Kraszewski A; Stawinski J; Bieganowski P; Guranowski A, Biochemical Journal, 2015

Fragile-histidine-triad proteins (Fhits) occur in all eukaryotes but their function is largely unknown. Human Fhit is presumed to function as a tumor suppressor. Previously, we demonstrated that Fhits catalyze hydrolysis of not only dinucleoside triphosphates but also natural adenosine ...

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Loss of Conserved {Less than}i{Greater than}Gsdma3{Less than}/i{Greater than} Self-Regulation Causes Autophagy and Cell Death

31-Mar-2015 | Shi P; Tang A; Xian L; Hou S; Zou D; Lv Y; Huang Z; Wang Q; Song A; Lin Z; Gao X, Biochemical Journal, 2015

Gsdermin A3 (Gsdma3) was originally identified for associating with hair-loss phenotype in mouse mutants. Our previous study found AE mutant mice, with a Y344H substitution at C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation. Interestingly, we found that the ...

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{Less than}i{Greater than}In vitro{Less than}/i{Greater than} reconstitution of cotranslational D1 insertion reveals a role of the cpSec/Alb3 translocase and Vipp1 in photosystem II biogenesis

24-Mar-2015 | Walter B; Hristou A; Nowaczyk M; Sch{u}nemann D, Biochemical Journal, 2015

Photosystem II (PS II) is a multi subunit complex localized in the thylakoid membrane that performs the light dependent photosynthetic charge separation. The PS II reaction center comprises, amongst others, the D1 protein. De novo synthesis and repair of PS II require efficient mechanisms for ...

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Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

20-Mar-2015 | Li J; Xu F; Hu S; Zhou J; Mei S; Zhao X; Cen S; Jin Q; Liang C; Guo F, Biochemical Journal, 2015

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits HIV-1 infection of myeloid cells and resting CD4+ T cells. Two lineages of primate lentiviruses, the sooty mangabey SIV (SIVsm)/macaque SIV (SIVmac)/HIV-2 lineage and the red-capped mangabey SIV (SIVrcm) lineage, carry a SAMHD1 ...

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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

17-Mar-2015 | Lorenz S; Deng P; Hantschel O; Superti-Furga G; Kuriyan J, Biochemical Journal, 2015

Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in ...

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RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

16-Mar-2015 | Sami F; Lu X; Parvathaneni S; Roy R; Gary R; Sharma S, Biochemical Journal, 2015

RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in replication restart mechanisms. Cellular phenotypes of RECQ1 deficiency are indicative of aberrant repair of stalled replication forks, but the molecular functions of RECQ1, ...

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Determinants of oligosaccharide specificity of the carbohydrate binding modules of AMP-activated protein kinase

16-Mar-2015 | Mobbs J; Koay A; Di Paolo A; Bieri M; Petrie E; Gorman M; Doughty L; Parker M; Stapleton D; Griffin M; Gooley P, Biochemical Journal, 2015

AMPK-activated protein kinase (AMPK) is a αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two isoforms (β1 and β2) and contains a carbohydrate binding module (CBM) that interacts with glycogen. The two CBM isoforms (β1- and β2-CBM) are ...

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Platelet Rho GTPases-a focus on novel players, roles and relationships

15-Mar-2015 | Goggs R; Williams CM; Mellor H; Poole AW, Biochemical Journal, 2015

Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on ...

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