My watch list
my.chemeurope.com  
Login  

1,779 Newest Publications of Portland Press

rss
matching the following criteria

Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

20-Mar-2015 | Li J; Xu F; Hu S; Zhou J; Mei S; Zhao X; Cen S; Jin Q; Liang C; Guo F, Biochemical Journal, 2015

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits HIV-1 infection of myeloid cells and resting CD4+ T cells. Two lineages of primate lentiviruses, the sooty mangabey SIV (SIVsm)/macaque SIV (SIVmac)/HIV-2 lineage and the red-capped mangabey SIV (SIVrcm) lineage, carry a SAMHD1 ...

more

Processing of Protein ADP-ribosylation by Nudix Hydrolases

19-Mar-2015 | Palazzo L; Thomas B; Jemth A; Colby T; Leidecker O; Feijs K; Zaja R; Loseva O; Puigvert J; Matic I; Helleday T; Ahel I, Biochemical Journal, 2015

ADP-ribosylation is a post-translational modification of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response, and apoptosis. Several cellular enzymes, such as macrodomain ...

more

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

17-Mar-2015 | Lorenz S; Deng P; Hantschel O; Superti-Furga G; Kuriyan J, Biochemical Journal, 2015

Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in ...

more

RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

16-Mar-2015 | Sami F; Lu X; Parvathaneni S; Roy R; Gary R; Sharma S, Biochemical Journal, 2015

RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in replication restart mechanisms. Cellular phenotypes of RECQ1 deficiency are indicative of aberrant repair of stalled replication forks, but the molecular functions of RECQ1, ...

more

Determinants of oligosaccharide specificity of the carbohydrate binding modules of AMP-activated protein kinase

16-Mar-2015 | Mobbs J; Koay A; Di Paolo A; Bieri M; Petrie E; Gorman M; Doughty L; Parker M; Stapleton D; Griffin M; Gooley P, Biochemical Journal, 2015

AMPK-activated protein kinase (AMPK) is a αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two isoforms (β1 and β2) and contains a carbohydrate binding module (CBM) that interacts with glycogen. The two CBM isoforms (β1- and β2-CBM) are ...

more

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

15-Mar-2015 | Bett JS; Ritorto MS; Ewan R; Jaffray EG; Virdee S; Chin JW; Knebel A; Kurz T; Trost M; Tatham MH; Hay RT, Biochemical Journal, 2015

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

more

Platelet Rho GTPases-a focus on novel players, roles and relationships

15-Mar-2015 | Goggs R; Williams CM; Mellor H; Poole AW, Biochemical Journal, 2015

Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on ...

more

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

13-Mar-2015 | B{e}k{e}s M; Rut W; Kasperkiewicz P; Mulder M; Ovaa H; Drag M; Lima C; Huang T, Biochemical Journal, 2015

Ubiquitin (Ub) and the ubiquitin-like modifier interferon stimulated gene 15 (ISG15) participate in the host defense of viral infections. Viruses, including the Severe Acute Respiratory Syndrome human coronavirus (SARS hCoV), have co-opted Ub/ISG15-conjugation pathways for their own advantage or ...

more

Mechanisms of Biofilm Inhibition and Degradation by Antimicrobial Peptides

12-Mar-2015 | Segev-Zarko L; Saar-dover R; Brumfeld V; Mangoni M; Shai Y, Biochemical Journal, 2015

Many bacteria live as biofilms to cope with unfavorable surroundings. Biofilms start from (i) a planktonic stage, (ii) initial adhesion to surfaces, and (iii) formation of sessile micro-colonies that secrete extracellular polymeric substance (EPS), leading to bacterial resistance to antibiotics. ...

more

Akt-Mediated regulation of antidepressant-sensitive serotonin transporter function, cell surface expression and phosphorylation

12-Mar-2015 | Rajamanickam J; Annamalai B; Rahbek-Clemmensen T; Sundaramurthy S; Gether U; Jayanthi L; Ramamoorthy S, Biochemical Journal, 2015

The serotonin (5-HT) transporter (SERT) controls serotonergic neurotransmission in the brain by rapid clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary target for antidepressants for therapeutic intervention of mood disorders. Our previous studies have ...

more

Page 1 From 178
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE