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1,817 Newest Publications of Portland Press

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...


Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

20-Apr-2015 | McGarry D; Chen W; Chakravarty P; Lamont D; Wolf C; Henderson C, Biochemical Journal, 2015

Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and pathways regulated by S-glutathionylation in whole organisms and current approaches lack the sensitivity to examine this modification ...


Proteomic approaches to identify substrates of the three Deg/HtrA proteases of the cyanobacterium {Less than}i{Greater than}Synechocystis{Less than}/i{Greater than} sp. PCC 6803

16-Apr-2015 | Tam L; Aigner H; Timmerman E; Gevaert K; Funk C, Biochemical Journal, 2015

The family of Deg/HtrA proteases plays an important role in quality control of cellular proteins in a wide range of organisms. In the genome of the cyanobacterium Synechocystis sp. PCC 6803, a model organism for photosynthetic research and renewable energy products, three Deg proteases are ...


Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

16-Apr-2015 | Wilson M; Kugel S; Huang J; Wilson L; Wloszczynski P; Ye J; Matherly L; Hou Z, Biochemical Journal, 2015

The human proton-coupled folate transporter (hPCFT) is expressed in solid tumors and is active at pHs characterizing the tumor microenvironment. Recent attention focused on exploiting hPCFT for targeting solid tumors with novel cytotoxic antifolates. hPCFT has 12 transmembrane domains (TMDs) and ...


Biochemical and redox characterization of the Mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein

16-Apr-2015 | Shaikhali J; Davoine C; Br{a}nnstr{o}m K; ROUHIER N; Bygdell J; Bj{o}rklund S; Wingsle G, Biochemical Journal, 2015

The eukaryotic Mediator integrates regulatory signals from promoter-bound transcription factors and transmits them to RNA polymerase II machinery. Although redox signaling is important in adjusting plant metabolism and development, nothing is known about a possible redox regulation of Mediator. ...


Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...


Structural characterisation of high order alpha-synuclein oligomers capable of inducing intracellular aggregation

08-Apr-2015 | Illes-toth E; Ramos M; Cappai R; Dalton C; Smith D, Biochemical Journal, 2015

Misfolding and aggregation of alpha-synuclein (α-syn) into Lewy bodies (LB) is associated with a range of neurological disorders, including Parkinson’s disease (PD). The cell to cell transmission of α-syn pathology has been linked to soluble amyloid oligomer populations that preceded LB ...


Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases

07-Apr-2015 | Cahn J; Brinkmann-Chen S; Spatzal T; Wiig J; Buller A; Einsle O; Hu Y; Ribbe M; Arnold F, Biochemical Journal, 2015

Although most sequenced members of the industrially important ketol-acid reductoisomerase (KARI) family are Class I enzymes, structural studies to date have focused primarily on the Class II KARIs, which arose through domain duplication. Here, we present five new crystal structures of Class I ...


Activation of Glycoprotein VI (GPVI) and C-type Lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

07-Apr-2015 | Alshehri O; Montague S; Watson S; Carter P; Sarker N; Manne B; Miller J; Herr A; Pollitt A; O'Callaghan C; Kunapuli ..., Biochemical Journal, 2015

Platelets are activated by a range of stimuli that share little or no resemblance in structure to each other or to recognised ligands, including diesel exhaust particles (DEP), small peptides (4N1-1, Champs, LSARLAF), proteins (histones), and large polysaccharides (fucoidan, dextran sulphate). ...


Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

07-Apr-2015 | Haxholm G; Nikolajsen L; Olsen J; Fredsted J; Larsen F; Goffin V; Pedersen S; Brooks A; Waters M; Kragelund B, Biochemical Journal, 2015

Class 1 cytokine receptors regulate essential biological processes through complex intracellular signaling networks. However, the structural platform for understanding their functions is currently incomplete as structure-function studies of the intracellular domains (ICDs) are critically lacking. ...


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