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1,251 Newest Publications of Portland Press
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Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression
01-06-2013 | Lane DJR; Huang ML-H; Richardson DR, Biochemical Journal, 2013
Does the hormone of iron metabolism, hepcidin, exhibit 'self-control'? Hepcidin is a small, disulfide-rich peptide synthesized by the liver, which plays a keystone role in regulating systemic iron metabolism in mammals. Hepcidin acts by binding and triggering the lysosomal degradation of the ...
Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence
01-06-2013 | Wolin MS, Biochemical Journal, 2013
Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence ...
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
01-06-2013 | Reeks J; Sokolowski RD; Graham S; Liu H; Naismith JH; White MF, Biochemical Journal, 2013
The competition between viruses and hosts is played out in all branches of life. Many prokaryotes have an adaptive immune system termed 'CRISPR' (clustered regularly interspaced short palindromic repeats) which is based on the capture of short pieces of viral DNA. The captured DNA is ...
Characterization of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway
15-05-2013 | Dow JM; Gabel F; Sargent F; Palmer T, Biochemical Journal, 2013
The Tat (twin-arginine translocation) system is a protein targeting pathway utilized by prokaryotes and chloroplasts. Tat substrates are produced with distinctive N-terminal signal peptides and are translocated as fully folded proteins. In Escherichia coli, Tat-dependent proteins often ...
STIM1 negatively regulates Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} release from the sarcoplasmic reticulum in skeletal myotubes
14-05-2013 | Lee K; Woo J; Hwang J; Hyun C; Cho C; Kim D; Lee E, Biochemical Journal, 2013
Stromal interaction molecule 1 (STIM1) mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. However, the direct role(s) of STIM1 in skeletal muscle, such as Ca2+ release from the sarcoplasmic reticulum (SR) for muscle contraction, have not been identified. The times required for the ...
ATP-dependent regulation of actin monomer-filament equilibrium by cyclase-associated protein and ADF/cofilin
14-05-2013 | Nomura K; Ono S, Biochemical Journal, 2013
Cyclase-associated protein (CAP) is a conserved regulator of actin filament dynamics. In the nematode Caenorhabditis elegans, CAS-1 is an isoform of CAP that is expressed in striated muscle and regulates sarcomeric actin assembly. Here, we report that CAS-2, a second CAP isoform in C. ...
skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity
13-05-2013 | Berkholz J; Zakrzewicz A; Munz B, Biochemical Journal, 2013
Skeletal and heart muscle specific variant of nascent polypeptide associated complex (skNAC) is a skeletal and heart muscle-specific protein known to be involved in the regulation of sarcomerogenesis. The respective mechanism, however, is largely unknown. Here, we demonstrate that skNAC ...
Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of {alpha}-Naphthoflavone
08-05-2013 | Davydov D; Davydova N; Sineva E; Kufareva I; Halpert J, Biochemical Journal, 2013
We investigated the relationship between oligomerization of cytochrome P450 3A4 (CYP3A4) and its response to alpha-naphthoflavone (ANF), a prototypical heterotropic activator. Addition of ANF resulted in over a two-fold increase in the rate of CYP3A4-dependent debenzylation of ...
Receptor for activated C-kinase 1 (RACK1) interacts with F-box and WD-repeat domain containing-2 (FBW2) to upregulate glial cell missing-1 (GCM1) stability and placental cell migration and invasion
07-05-2013 | Wang C; Lo H; Lin S; Chen H, Biochemical Journal, 2013
GCM1 is a short-lived transcription factor essential for placental development. The F-box protein, FBW2, which contains five tryptophan-aspartate (WD) repeats, recognizes GCM1 and mediates its ubiquitination via the SCFFBW2 E3 ligase complex. Although the interaction between GCM1 and FBW2 is ...
Minimal Functional Domains of Paralogues hnRNP L and hnRNP LL Exhibit Mechanistic Differences in Exonic Splicing Repression
07-05-2013 | Shankarling G; Lynch K, Biochemical Journal, 2013
Understanding functional distinctions between related splicing regulatory proteins is critical to deciphering tissue-specific control of alternative splicing. The hnRNP L and hnRNP LL proteins are paralogues that have overlapping but distinct expression patterns and functional consequences. ...
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