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1,767 Newest Publications of Portland Press

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Conserved Proline-Directed Phosphorylation Regulates SR Protein Conformation and Splicing Function

22-Dec-2014 | Keshwani M; Aubol B; Fattet L; Ma C; Qiu J; Jennings P; Fu X; Adams J, Biochemical Journal, 2014

The alternative splicing of human genes is dependent on SR proteins, a family of essential splicing factors whose name derives from a signature C-terminal domain rich in arginine-serine dipeptide repeats (RS domains). Although the SRPKs (SR-specific protein kinases) phosphorylate these repeats, ...


The insulinotropic effect of insulin-like peptide 5 {Less than}i{Greater than}in vitro{Less than}/i{Greater than} and {Less than}i{Greater than}in vivo{Less than}/i{Greater than}

17-Dec-2014 | Luo X; Li T; Zhu Y; Dai Y; Zhao J; Guo Z; Wang M, Biochemical Journal, 2014

Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein coupled receptor RXFP4, but its precise biological functions are largely unknown. Recent studies suggest that the INSL5/RXFP4 is involved in the control of food intake and glucose homeostasis. ...


The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Activator Inhibitor 1 reveals an unexpected PAN/apple domain-type fold.

16-Dec-2014 | Hong Z; Nowakowski M; Spronk C; Petersen S; Andreasen P; Ko{z}mi{n}ski W; Mulder F; Jensen J, Biochemical Journal, 2014

A decade ago, a Motif at N-terminus with Eight-Cysteines or in short MANEC was defined as a new protein domain family. This domain is found exclusively in the N-terminus of >400 multi-domain type-1 transmembrane proteins from animals. Despite the large number of MANEC-containing proteins, only ...


FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

16-Dec-2014 | Ma W; Fuentes G; Shi X; Verma C; Radda G; Han W, Biochemical Journal, 2014

FoxO1, which is upregulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to SP1-POMC promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription. FoxO1 also binds directly to the POMC promoter and ...


Unraveling the pivotal role of ALIX in MVB sorting and silencing of activated EGFR

16-Dec-2014 | Sun S; Zhou X; Zhang W; Gallick G; Kuang J, Biochemical Journal, 2014

ESCRT-III mediated membrane invagination and scission is a critical step in MVB sorting of ubiquitinated membrane receptors and generally thought to be required for degradation of these receptors in lysosomes. The adaptor protein ALIX is critically involved in multiple ESCRT-III-mediated membrane ...


Differential calcium handling by the {Less than}i{Greater than}cis{Less than}/i{Greater than} and {Less than}i{Greater than}trans{Less than}/i{Greater than} regions of the Golgi apparatus

16-Dec-2014 | Aulestia F; Alonso M; Garcia-Sancho J, Biochemical Journal, 2014

High Ca2+ content in the Golgi apparatus (Go) is essential for protein processing and sorting. Additionally, Go can shape the cytosolic Ca2+ signals by releasing or sequestering Ca2+. We generated two new aequorin-based Ca2+ probes to specifically measure Ca2+ in the cis-/cis to medial Golgi ...


A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation

15-Dec-2014 | Huttner S; Veit C; Vavra U; Schoberer J; Dicker M; Maresch D; Altmann F; Strasser R, Biochemical Journal, 2014

N-glycosylation of proteins plays an important role in the determination of the fate of newly synthesized glycoproteins in the endoplasmic reticulum (ER). Specific oligosaccharide structures recruit molecular chaperones that promote folding or mannose-binding lectins that assist in the clearance ...


Structural and functional consequences of removing the N-terminal domain from the magnesium chelatase ChlH subunit of Thermosynechococcus elongatus

15-Dec-2014 | Adams NBP; Marklew CJ; Qian P; Brindley AA; Davison PA; Bullough PA; Hunter CN, Biochemical Journal, 2014

Magnesium chelatase (MgCH) initiates chlorophyll biosynthesis by catalysing the ATP-dependent insertion of Mg2+ into protoporphyrin. This large enzyme complex comprises ChlH, I and D subunits, with I and D involved in ATP hydrolysis, and H the protein that handles the substrate and product. The ...


The sigma 1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

15-Dec-2014 | Mishra A; Mavlyutov T; Singh D; Biener G; Yang J; Oliver J; Ruoho A; Raicu V, Biochemical Journal, 2014

The sigma-1 receptor (S1R) is a membrane 223-amino acid protein that resides in the endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is regulated by a various synthetic molecules including (+)-pentazocine, cocaine and haloperidol, and endogenous molecules such as ...


TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-Dec-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...


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