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1,853 Newest Publications of Portland Press

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Deletion of phospholipase A{Less than}sub{Greater than}2{Less than}/sub{Greater than} group IV c induces apoptosis in rat mammary tumor cells by the nuclear factor-{kappa}B/lipocalin 2 pathway

27-May-2015 | Nanashima N; Yamada T; Shimizu T; Tsuchida S, Biochemical Journal, 2015

Although some phospholipase A2 forms, the initiator of the arachidonic acid cascade, contribute to carcinogenesis in many organs, the contribution of phospholipase A2 group IVc (Pla2g4c) remains to be clarified and the function of the enzyme in cancer development are unknown. The Hirosaki ...

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Structural analysis of the di-adenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3{'}-dATP

27-May-2015 | M{u}ller M; Deimling T; Hopfner K; Witte G, Biochemical Journal, 2015

The identification of the essential bacterial second messenger cyclic-di-AMP synthesized by the DNA-integrity scanning protein DisA opened up a new and emerging field in bacterial signaling. To further analyze the di-adenylate cyclase reaction catalyzed by the DAC domains of DisA, we crystallized ...

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Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity

26-May-2015 | Abbate V; Reelfs O; Hider R; Pourzand C, Biochemical Journal, 2015

Mitochondrial labile iron (LI) plays a crucial role in oxidative injuries and pathologies. At present, there is no organelle-specific sensitive iron sensor which can reside exclusively in the mitochondria and reliably monitor levels of LI in this organelle. Here we describe the development of ...

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E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signaling and plant development

26-May-2015 | Kim S; Park B; Kim D; Yeu S; Song S; Song J; Seo H, Biochemical Journal, 2015

Gibberellins affect various plant development processes including germination, cell division and elongation, and flowering. A large number of studies have been carried out to address the molecular mechanisms that mediate gibberellin signaling effects on plant growth. However, such studies have ...

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Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

22-May-2015 | De Veer S; Swedberg J; Akcan M; Rosengren K; Brattsand M; Craik D; Harris J, Biochemical Journal, 2015

Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesising a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor’s resistance to ...

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FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21{Less than}sup{Greater than}Cip1/Waf1{Less than}/sup{Greater than}

20-May-2015 | Kloet D; Polderman P; Eijkelenboom A; Smits L; Van Triest M; Van Den Berg M; Groot Koerkamp M; Van Leenen D; Lijnzaa ..., Biochemical Journal, 2015

Activity of Forkhead box O (FOXO) transcription factors is inhibited by growth factor-PI3K-protein kinase B (PKB)/AKT signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we identified a set of ...

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Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme

19-May-2015 | Oka O; Yeoh H; Bulleid N, Biochemical Journal, 2015

The formation of disulfides in proteins entering the secretory pathway is catalysed by the protein disulfide isomerase family of enzymes. These enzymes catalyse the introduction, reduction and isomerisation of disulfides. To function continuously they require an oxidase to reform the disulfide at ...

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Tail wags the dog: Activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner

18-May-2015 | Sridharan S; Kini M, Biochemical Journal, 2015

Natriuretic peptides (NP) are potent vasoactive hormones, which maintain pressure-volume homeostasis. Snake venom NPs exhibit distinct biological activity compared to mammalian NPs due to subtle changes in their sequences. We recently identified a new NP from krait venom (KNP), with an unusual ...

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Slc5a8, a Na {+} -coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions

18-May-2015 | Gurav A; Sivaprakasam S; Bhutia Y; Boettger T; Singh N; Ganapathy V, Biochemical Journal, 2015

Mammalian colon harbors trillions of bacteria under physiologic conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. Here we show that Slc5a8, a Na + -coupled ...

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The purification and characterization of ATP synthase complexes from the mitochondria of four fungal species

15-May-2015 | Liu S; Charlesworth TJ; Bason JV; Montgomery MG; Harbour ME; Fearnley IM; Walker JE, Biochemical Journal, 2015

The ATP synthases have been isolated by affinity chromatography from the mitochondria of the fungal species Yarrowia lipolytica, Pichia pastoris, Pichia angusta and Saccharomyces cerevisiae. The subunit compositions of the purified enzyme complexes depended on the detergent used to solubilize and ...

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