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1,696 Newest Publications of Portland Press

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Metformin and respiratory chain complex I: the last piece of the puzzle?

01-11-2014 | Fontaine E, Biochemical Journal, 2014

Metformin is the most widely prescribed drug used to treat patients affected by Type2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to complex I ...

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NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...

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Biochemical characterization of P-type copper ATPases

15-10-2014 | Inesi G; Pilankatta R; Tadini-Buoninsegni F, Biochemical Journal, 2014

Copper ATPases, in analogy with other members of the P-ATPase superfamily, contain a catalytic headpiece including an aspartate residue reacting with ATP to form a phosphoenzyme intermediate, and transmembrane helices containing cation-binding sites [TMBS (transmembrane metal-binding sites)] for ...

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Fingerprinting of hydroxyl radical-attacked polysaccharides by N-isopropyl-2-aminoacridone labelling

15-10-2014 | Vreeburg RAM; Airianah OB; Fry SC, Biochemical Journal, 2014

Hydroxyl radicals (•OH) cause non-enzymic scission of polysaccharides in diverse biological systems. Such reactions can be detrimental (e.g. causing rheumatic and arthritic diseases in mammals) or beneficial (e.g. promoting the softening of ripening fruit, and biomass saccharification). Here we ...

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Revisiting the Roco G protein cycle

15-10-2014 | Terheyden S; Ho F; Gilsbach B; Wittinghofer A; Kortholt A, Biochemical Journal, 2014

Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson’s disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G domain (Roc) and a C-terminal of Roc domain (COR) tandem. The nucleotide state of small G proteins ...

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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Osteopontin mediates mineralization and not osteogenic cell development {Less than}i{Greater than}in vitro{Less than}/i{Greater than}

13-10-2014 | Holm E; Gleberzon J; Liao Y; S{o}rensen E; Beier F; Hunter G; Goldberg H, Biochemical Journal, 2014

Biomineralization is a complex process in the development of mineralized tissues such as bone, and pathological calcifications such as atherosclerotic plaques, kidney stones, gout, and others. Osteopontin (OPN), an anionic phosphoprotein, is expressed in mineralizing tissues and has previously ...

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The architecture of an Okazaki fragment-processing holoenzyme from the archaeon {Less than}i{Greater than}Sulfolobus solfataricus{Less than}/i{Greater than}

09-10-2014 | Cannone G; Xu Y; Beattie T; Bell S; Spagnolo L, Biochemical Journal, 2014

DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes the enzymatic activities required for this process are supplied by a replicative DNA polymerase, Flap Endonuclease 1 (Fen1) and DNA ligase 1. These factors interact with ...

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Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope-dilution LC-MS/MS: first evidence of DNA methylation in {Less than}i{Greater than}Caenorhabditis elegans{Less than}/i{Greater than}

09-10-2014 | Hu C; Chen J; Hsu Y; Yen C; Chao M, Biochemical Journal, 2014

Since 1986 till now, the popular research model organism Caenorhabditis elegans has been thought to completely lack DNA methylation and seems to lost DNA methylation enzymes from its genomes. Here we report the development of a sensitive and selective assay based on LC-MS/MS to simultaneously ...

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Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...

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