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1,263 Newest Publications of Portland Press
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Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum
15-06-2013 | Engelberg K; Paul AS; Prinz B; Kono M; Ching W; Heincke D; Dobner T; Spielmann T; Duraisingh MT; Gilberger T-W, Biochemical Journal, 2013
Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high affinity receptor-ligand interactions. Signal transduction through the action of specific kinases is a control mechanism for the orchestration of this process. In ...
The CPVT-associated RyR2 Mutation G230C Enhances Store Overload-Induced Ca{Less than}sup{Greater than}2{+} {Less than}/sup{Greater than}Release and Destabilizes the NH{Less than}sub{Greater than}2{Less than}/sub{Greater than}-terminal domains
07-06-2013 | Liu Y; Kimlicka L; Hiess F; Tian X; Wang R; Zhang L; Jones P; van Petegem F; Chen S, Biochemical Journal, 2013
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, life-threatening arrhythmogenic disorder. CPVT is caused by delayed afterdepolarizations (DADs) that are induced by spontaneous Ca2+ release during sarcoplasmic reticulum (SR) Ca2+ overload, a process also known as ...
Hsp104 as a key modulator of prion-mediated oxidative stress in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than}
07-06-2013 | Singh K; Saleh A; Bhadra A; Roy I, Biochemical Journal, 2013
Maintenance of cellular redox homeostasis forms an important part of the cellular defence mechanism and continued cell viability. Despite extensive studies, the role of the chaperone Hsp104 in propagation of misfolded protein aggregates in the cell and generation of oxidative stress remains ...
Spinocerebellar ataxia-13 Kv3.3 potassium channels: Arginine-to-Histidine mutations affect both functional and protein expression on the cell surface
05-06-2013 | Zhao J; Zhu J; Thornhill W, Biochemical Journal, 2013
Voltage-gated potassium channel Kv3.3 is the causative gene of spinocerebellar ataxia type 13 (SCA13), an autosomal dominant neurological disorder. The four dominant mutations identified to date cause Kv3.3 channels to be nonfunctional or have altered gating properties in Xenopus oocytes. In ...
A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation
05-06-2013 | Engel K; Sasaki T; Wang Q; Kuriyan J, Biochemical Journal, 2013
Formation of an asymmetric dimer by the epidermal growth factor receptor (EGFR) kinase domains results in allosteric activation. Since this dimer does not readily form in solution, the EGFR kinase domain phosphorylates most peptide substrates with a relatively low catalytic efficiency. ...
Cell Cycle Regulation of Purine Synthesis by Phosphoribosyl- Pyrophosphate and Inorganic Phosphate
04-06-2013 | Fridman A; Saha A; Chan A; Casteel D; Pilz R; Boss G, Biochemical Journal, 2013
Cells must increase synthesis of purine nucleotides/deoxynucleotides before or during S phase. We found that rates of purine synthesis via the de novo and salvage pathways increased 5.0- and 3.3-fold, respectively, as cells progressed from mid G1 to early S phase. The increased purine ...
Roles of EXTL2, a member of EXT family of tumor suppressors, in liver injury and regeneration processes
04-06-2013 | Nadanaka S; Kagiyama S; Kitagawa H, Biochemical Journal, 2013
The gene products of two members of the EXT gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate. EXTL2, one of the three EXT-like genes in the human genome that are homologous to EXT1 and EXT2, encodes a N-acetylhexosaminyltransferase. ...
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif
03-06-2013 | Wang J; Zhong C; Wang F; Qu F; Ding J, Biochemical Journal, 2013
The activity of the ribosome protein subunit 6 kinase 1 (S6K1) is stimulated by phosphorylation of Thr389 in the hydrophobic motif by mTORC1 and phosphorylation of Thr229 in the activation loop by PDK1; however, the order of the two events is still ambiguous. Here we report six crystal ...
Structural insights into the inhibition of type VI effector Tae3 by its immunity protein Tai3
03-06-2013 | Dong C; Zhang H; Gao Z; Wang W; She Z; Liu G; Shen Y; Su X; Dong Y, Biochemical Journal, 2013
The recently described type VI secretion system (T6SS) acts as a needle that punctures the membrane of the target cells to deliver effector proteins. Type VI amidase effectors can be classified into four divergent families (Tae1-4). These effectors are secreted into the periplasmic space of ...
Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression
01-06-2013 | Lane DJR; Huang ML-H; Richardson DR, Biochemical Journal, 2013
Does the hormone of iron metabolism, hepcidin, exhibit 'self-control'? Hepcidin is a small, disulfide-rich peptide synthesized by the liver, which plays a keystone role in regulating systemic iron metabolism in mammals. Hepcidin acts by binding and triggering the lysosomal degradation of the ...
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