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1,532 Newest Publications of Portland Press

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Deletion of phospholipase A{Less than}sub{Greater than}2{Less than}/sub{Greater than} group IV c induces apoptosis in rat mammary tumor cells by the nuclear factor-{kappa}B/lipocalin 2 pathway

27-May-2015 | Nanashima N; Yamada T; Shimizu T; Tsuchida S, Biochemical Journal, 2015

Although some phospholipase A2 forms, the initiator of the arachidonic acid cascade, contribute to carcinogenesis in many organs, the contribution of phospholipase A2 group IVc (Pla2g4c) remains to be clarified and the function of the enzyme in cancer development are unknown. The Hirosaki ...

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Structural analysis of the di-adenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3{'}-dATP

27-May-2015 | M{u}ller M; Deimling T; Hopfner K; Witte G, Biochemical Journal, 2015

The identification of the essential bacterial second messenger cyclic-di-AMP synthesized by the DNA-integrity scanning protein DisA opened up a new and emerging field in bacterial signaling. To further analyze the di-adenylate cyclase reaction catalyzed by the DAC domains of DisA, we crystallized ...

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Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity

26-May-2015 | Abbate V; Reelfs O; Hider R; Pourzand C, Biochemical Journal, 2015

Mitochondrial labile iron (LI) plays a crucial role in oxidative injuries and pathologies. At present, there is no organelle-specific sensitive iron sensor which can reside exclusively in the mitochondria and reliably monitor levels of LI in this organelle. Here we describe the development of ...

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Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

22-May-2015 | De Veer S; Swedberg J; Akcan M; Rosengren K; Brattsand M; Craik D; Harris J, Biochemical Journal, 2015

Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesising a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor’s resistance to ...

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Tail wags the dog: Activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner

18-May-2015 | Sridharan S; Kini M, Biochemical Journal, 2015

Natriuretic peptides (NP) are potent vasoactive hormones, which maintain pressure-volume homeostasis. Snake venom NPs exhibit distinct biological activity compared to mammalian NPs due to subtle changes in their sequences. We recently identified a new NP from krait venom (KNP), with an unusual ...

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Slc5a8, a Na {+} -coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions

18-May-2015 | Gurav A; Sivaprakasam S; Bhutia Y; Boettger T; Singh N; Ganapathy V, Biochemical Journal, 2015

Mammalian colon harbors trillions of bacteria under physiologic conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. Here we show that Slc5a8, a Na + -coupled ...

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The purification and characterization of ATP synthase complexes from the mitochondria of four fungal species

15-May-2015 | Liu S; Charlesworth TJ; Bason JV; Montgomery MG; Harbour ME; Fearnley IM; Walker JE, Biochemical Journal, 2015

The ATP synthases have been isolated by affinity chromatography from the mitochondria of the fungal species Yarrowia lipolytica, Pichia pastoris, Pichia angusta and Saccharomyces cerevisiae. The subunit compositions of the purified enzyme complexes depended on the detergent used to solubilize and ...

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Arc is a flexible modular protein capable of reversible self-oligomerization

15-May-2015 | Myrum C; Baumann A; Bustad HJ; Flydal MI; Mariaule V; Alvira S; Cuellar J; Haavik J; Soule J; Valpuesta JM; Marquez ..., Biochemical Journal, 2015

The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties of Arc have not been elucidated. In the present study, we expressed and ...

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An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

15-May-2015 | Irving JA; Miranda E; Haq I; Perez J; Kotov VR; Faull SV; Motamedi-Shad N; Lomas DA, Biochemical Journal, 2015

A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type protein. Using the common pathogenic E342K (Z) ...

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Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer

13-May-2015 | Babu E; Bhutia Y; Ramachandran S; Gnana-Prakasam J; Prasad P; Thangaraju M; Ganapathy V, Biochemical Journal, 2015

SLC6A14 mediates Na + /Cl --coupled concentrative uptake of a broad-spectrum of amino acids. It is expressed at low levels in many tissues but upregulated in certain cancers. Pharmacologic blockade of SLC6A14 causes amino acid starvation in ER+ breast cancer cells and suppresses their ...

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