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1,500 Newest Publications of Portland Press

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Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

20-Mar-2015 | Li J; Xu F; Hu S; Zhou J; Mei S; Zhao X; Cen S; Jin Q; Liang C; Guo F, Biochemical Journal, 2015

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits HIV-1 infection of myeloid cells and resting CD4+ T cells. Two lineages of primate lentiviruses, the sooty mangabey SIV (SIVsm)/macaque SIV (SIVmac)/HIV-2 lineage and the red-capped mangabey SIV (SIVrcm) lineage, carry a SAMHD1 ...


Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

17-Mar-2015 | Lorenz S; Deng P; Hantschel O; Superti-Furga G; Kuriyan J, Biochemical Journal, 2015

Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in ...


Determinants of oligosaccharide specificity of the carbohydrate binding modules of AMP-activated protein kinase

16-Mar-2015 | Mobbs J; Koay A; Di Paolo A; Bieri M; Petrie E; Gorman M; Doughty L; Parker M; Stapleton D; Griffin M; Gooley P, Biochemical Journal, 2015

AMPK-activated protein kinase (AMPK) is a αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two isoforms (β1 and β2) and contains a carbohydrate binding module (CBM) that interacts with glycogen. The two CBM isoforms (β1- and β2-CBM) are ...


Mechanisms of Biofilm Inhibition and Degradation by Antimicrobial Peptides

12-Mar-2015 | Segev-Zarko L; Saar-dover R; Brumfeld V; Mangoni M; Shai Y, Biochemical Journal, 2015

Many bacteria live as biofilms to cope with unfavorable surroundings. Biofilms start from (i) a planktonic stage, (ii) initial adhesion to surfaces, and (iii) formation of sessile micro-colonies that secrete extracellular polymeric substance (EPS), leading to bacterial resistance to antibiotics. ...


Akt-Mediated regulation of antidepressant-sensitive serotonin transporter function, cell surface expression and phosphorylation

12-Mar-2015 | Rajamanickam J; Annamalai B; Rahbek-Clemmensen T; Sundaramurthy S; Gether U; Jayanthi L; Ramamoorthy S, Biochemical Journal, 2015

The serotonin (5-HT) transporter (SERT) controls serotonergic neurotransmission in the brain by rapid clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary target for antidepressants for therapeutic intervention of mood disorders. Our previous studies have ...


The purification and characterization of ATP synthase complexes from the mitochondria of four fungal species

11-Mar-2015 | Liu S; Charlesworth T; Bason J; Montgomery M; Harbour M; Fearnley I; Walker J, Biochemical Journal, 2015

The ATP synthases have been isolated by affinity chromatography from the mitochondria of the fungal species, Yarrowia histolytica, Pichia pastoris, Pichia angusta and Saccharomyces cerevisae. The subunit compositions of the purified enzyme complexes depended upon the detergent used to solubilise ...


Arc is a flexible modular protein capable of reversible self-oligomerization

09-Mar-2015 | Myrum C; Baumann A; Bustad H; Flydal M; Mariaule V; Alvira S; Cu{e}llar J; Haavik J; Soul{e} J; Valpuesta J; M{a}rqu ..., Biochemical Journal, 2015

The immediate early gene product, Arc (activity-regulated cytoskeleton associated protein), is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties of Arc have not been elucidated. Here, we expressed and purified ...


Solution Structure of the Reduced Form of Human Peroxiredoxin-6 Elucidated Using Zero-Length Chemical Cross-linking And Homology Modeling

06-Mar-2015 | Rivera-Santiago R; Harper S; Zhou S; Sriswasdi S; Feinstein S; Fisher A; Speicher D, Biochemical Journal, 2015

Peroxiredoxin-6 (PRDX6) is an unusual member of the peroxiredoxin family of antioxidant enzymes that has only one evolutionarily conserved cysteine. It reduces oxidized lipids and ROS by oxidation of the active site cysteine (Cys-47) to a sulfenic acid, but the mechanism for conversion back to a ...


Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

05-Mar-2015 | Ford R; Fullerton M; Pinkosky S; Day E; Scott J; Oakhill J; Bujak A; Smith B; Crane J; Bl{upsilon With Dialytika}mer ..., Biochemical Journal, 2015

Metformin is the mainstay therapy for type 2 diabetes (T2D), and many patients also take salicylate-based drugs (i.e. Aspirin; ASA) for cardioprotection. Metformin and salicylate both increase AMP-activated protein kinase (AMPK) activity but by distinct mechanisms, with metformin altering ...


Bioenergetic Programming Of Macrophages By The Apolipoprotein A-I Mimetic Peptide 4F

05-Mar-2015 | Datta G; Kramer P; Johnson M; Sawada H; Smythies L; Crossman D; Chacko B; Ballinger S; Westbrook D; Mayakonda P; Ana ..., Biochemical Journal, 2015

The apolipoprotein (apo)A-I mimetic peptide 4F favors the differentiation of human monocytes to an alternatively-activated M2 phenotype. The goal of the current study was to test whether the 4F-mediated differentiation of monocyte-derived macrophages (MDMs) requires the induction of an oxidative ...


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