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1,481 Newest Publications of Portland Press

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Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

27-Feb-2015 | Kristariyanto Y; Choi S; Abdul Rehman S; Ritorto M; Campbell D; Morrice N; Toth R; Kulathu Y, Biochemical Journal, 2015

Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin to form topologically different polymers of eight different linkage types. While some linkages have been studied in detail, other linkage types including Lys33-linked ...

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Defining the Cytosolic Pathway of Glutathione Degradation in {Less than}i{Greater than}Arabidopsis thaliana{Less than}/i{Greater than}: Role of the ChaC/GCG Family of {gamma}-glutamyl cyclotransferases as Glutathione Degrading Enzymes and AtLAP1 as the Cys-Gly Peptidase

26-Feb-2015 | Kumar S; Kaur A; Chattopadhyay B; Bachhawat A, Biochemical Journal, 2015

Glutathione homeostasis is critical to plant life and its adaptation to stress. The γ-glutamyl cycle of glutathione biosynthesis and degradation plays a pre-eminent role in glutathione homeostasis. The genes encoding two enzymatic steps of glutathione degradation, the γ-glutamyl cyclotransferase ...

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PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells

23-Feb-2015 | Liu C; Zhang Y; Hou Y; Shen L; Li Y; Guo W; Xu D; Liu G; Zhao Z; Man K; Pan Y; Wang Z; Chen Y, Biochemical Journal, 2015

Histone modification plays important roles in many biological processes such as development and carcinogenesis. Methylation of histone H3 lysine 4 (H3K4) is commonly associated with transcriptional activation of genes. H3K4 methylation in mammalian cells is carried out by COMPASS-like complexes ...

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Structural Mechanisms Underlying Sequence-Dependent Variations in GAG Affinities of Decorin Binding Protein A, a {Less than}i{Greater than}Borrelia burgdorferi{Less than}/i{Greater than} Adhesin

19-Feb-2015 | Morgan A; Wang X, Biochemical Journal, 2015

Decorin binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease. DBPA facilitates the bacteria’s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. Interestingly, DBPA sequence ...

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PT-1 selectively activates AMPK-{gamma}1 complexes in mouse skeletal muscle, but activates all three {gamma} subunit complexes in cultured human cells by inhibiting the respiratory chain

19-Feb-2015 | Jensen T; Ross F; Kleinert M; Sylow L; Knudsen J; Gowans G; Hardie D; Richter E, Biochemical Journal, 2015

AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α1/α2) is bound to one of two b subunits (β1/β2) and one of three γ subunits (γ1/γ2/γ3). The ability to selectively activate specific isoforms would be a useful research tool, and a promising ...

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The {Less than}i{Greater than}Leishmania donovani {Less than}/i{Greater than}histidine acid ecto-phosphatase{Less than}i{Greater than} Ld{Less than}/i{Greater than}MAcP: insight into its structure and function

19-Feb-2015 | Papadaki A; Politou A; Smirlis D; Kotini M; Kourou K; Papamarcaki T; Boleti H, Biochemical Journal, 2015

Acid ecto-phosphatase activity has been implicated in Leishmania donovani promastigote virulence. Here we report data contributing to the molecular/structural and functional characterization of the Leishmania donovani LdMAcP, member of the histidine acid phosphatase family. LdMAcP, is membrane ...

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Regulation of IGFBP-2 expression during fasting

19-Feb-2015 | Kang H; Kim M; Kim S; Lee J; Kim Y; Seo Y; Bae J; Oh G; Song D; Ahn Y; Im S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorder is well known, its regulatory mechanism remains unclear. Here, we ...

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Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae

15-Feb-2015 | Thota SG; Unnikannan CP; Thampatty SR; Manorama R; Bhandari R, Biochemical Journal, 2015

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol that act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

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JAK2 activation by growth hormone and other cytokines

15-Feb-2015 | Waters MJ; Brooks AJ, Biochemical Journal, 2015

Growth hormone (GH) and structurally related cytokines regulate a great number of physiological and pathological processes. They do this by coupling their single transmembrane domain (TMD) receptors to cytoplasmic tyrosine kinases, either as homodimers or heterodimers. Recent studies have ...

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The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells

01-Feb-2015 | Voronina S; Collier D; Chvanov M; Middlehurst B; Beckett AJ; Prior IA; Criddle DN; Begg M; Mikoshiba K; Sutton R; Te ..., Biochemical Journal, 2015

The inducers of acute pancreatitis trigger a prolonged increase in the cytosolic Ca2+ concentration ([Ca2+]c), which is responsible for the damage to and eventual death of pancreatic acinar cells. Vacuolization is an important indicator of pancreatic acinar cell damage. Furthermore, activation of ...

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