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1,470 Newest Publications of Portland Press

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The insulinotropic effect of insulin-like peptide 5 {Less than}i{Greater than}in vitro{Less than}/i{Greater than} and {Less than}i{Greater than}in vivo{Less than}/i{Greater than}

17-Dec-2014 | Luo X; Li T; Zhu Y; Dai Y; Zhao J; Guo Z; Wang M, Biochemical Journal, 2014

Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein coupled receptor RXFP4, but its precise biological functions are largely unknown. Recent studies suggest that the INSL5/RXFP4 is involved in the control of food intake and glucose homeostasis. ...

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Unraveling the pivotal role of ALIX in MVB sorting and silencing of activated EGFR

16-Dec-2014 | Sun S; Zhou X; Zhang W; Gallick G; Kuang J, Biochemical Journal, 2014

ESCRT-III mediated membrane invagination and scission is a critical step in MVB sorting of ubiquitinated membrane receptors and generally thought to be required for degradation of these receptors in lysosomes. The adaptor protein ALIX is critically involved in multiple ESCRT-III-mediated membrane ...

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Differential calcium handling by the {Less than}i{Greater than}cis{Less than}/i{Greater than} and {Less than}i{Greater than}trans{Less than}/i{Greater than} regions of the Golgi apparatus

16-Dec-2014 | Aulestia F; Alonso M; Garcia-Sancho J, Biochemical Journal, 2014

High Ca2+ content in the Golgi apparatus (Go) is essential for protein processing and sorting. Additionally, Go can shape the cytosolic Ca2+ signals by releasing or sequestering Ca2+. We generated two new aequorin-based Ca2+ probes to specifically measure Ca2+ in the cis-/cis to medial Golgi ...

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Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase

15-Dec-2014 | Dodia R; Meunier B; Kay CWM; Rich PR, Biochemical Journal, 2014

Subunit 5 of Saccharomyces cerevisiae cytochrome c oxidase (CcO) is essential for assembly and has two isoforms, 5A and 5B. 5A is expressed under normoxic conditions, whereas 5B is expressed at very low oxygen tensions. As a consequence, COX5A-deleted strains (Δcox5A) have no or only low levels ...

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A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation

15-Dec-2014 | Huttner S; Veit C; Vavra U; Schoberer J; Dicker M; Maresch D; Altmann F; Strasser R, Biochemical Journal, 2014

N-glycosylation of proteins plays an important role in the determination of the fate of newly synthesized glycoproteins in the endoplasmic reticulum (ER). Specific oligosaccharide structures recruit molecular chaperones that promote folding or mannose-binding lectins that assist in the clearance ...

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Structural and functional consequences of removing the N-terminal domain from the magnesium chelatase ChlH subunit of Thermosynechococcus elongatus

15-Dec-2014 | Adams NBP; Marklew CJ; Qian P; Brindley AA; Davison PA; Bullough PA; Hunter CN, Biochemical Journal, 2014

Magnesium chelatase (MgCH) initiates chlorophyll biosynthesis by catalysing the ATP-dependent insertion of Mg2+ into protoporphyrin. This large enzyme complex comprises ChlH, I and D subunits, with I and D involved in ATP hydrolysis, and H the protein that handles the substrate and product. The ...

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TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-Dec-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...

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The function of phosphatidylinositol 5-phosphate 4-kinase {gamma}(PI5P4K{gamma}) explored using a specific inhibitor that targets the PI5P binding site.

11-Dec-2014 | Clarke J; Giudici M; Burke J; Williams R; Maloney D; Marugan J; Irvine R, Biochemical Journal, 2014

NIH-12848 (NCGC00012848-02), a putative phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity, lipid kinase. PI5P 4-kinase assays in vitro showed that NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1μM but ...

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TARP {gamma}-8 glycosylation regulates the surface expression of AMPA receptors

11-Dec-2014 | Zheng C; Chang K; Suh Y; Roche K, Biochemical Journal, 2014

Transmembrane AMPA receptor regulatory protein (TARP) γ-8 is an auxiliary subunit of AMPA receptors that is widely distributed in the hippocampus. It has been shown that TARP γ-8 promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors ...

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The regulatory role of {Less than}i{Greater than}Streptomyces coelicolor{Less than}/i{Greater than} TamR in central metabolism

11-Dec-2014 | Huang H; Sivapragasam S; Grove A, Biochemical Journal, 2014

Trans-aconitate methyltransferase regulator (TamR) is a member of the ligand-responsive multiple antibiotic resistance regulator (MarR) family of transcription factors. In Streptomyces coelicolor, TamR regulates transcription of tamR (encoding TamR), tam (encoding trans-aconitate ...

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