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1,504 Newest Publications of Portland Press

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...

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Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases

07-Apr-2015 | Cahn J; Brinkmann-Chen S; Spatzal T; Wiig J; Buller A; Einsle O; Hu Y; Ribbe M; Arnold F, Biochemical Journal, 2015

Although most sequenced members of the industrially important ketol-acid reductoisomerase (KARI) family are Class I enzymes, structural studies to date have focused primarily on the Class II KARIs, which arose through domain duplication. Here, we present five new crystal structures of Class I ...

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Loss of Conserved {Less than}i{Greater than}Gsdma3{Less than}/i{Greater than} Self-Regulation Causes Autophagy and Cell Death

31-Mar-2015 | Shi P; Tang A; Xian L; Hou S; Zou D; Lv Y; Huang Z; Wang Q; Song A; Lin Z; Gao X, Biochemical Journal, 2015

Gsdermin A3 (Gsdma3) was originally identified for associating with hair-loss phenotype in mouse mutants. Our previous study found AE mutant mice, with a Y344H substitution at C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation. Interestingly, we found that the ...

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Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1

20-Mar-2015 | Li J; Xu F; Hu S; Zhou J; Mei S; Zhao X; Cen S; Jin Q; Liang C; Guo F, Biochemical Journal, 2015

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits HIV-1 infection of myeloid cells and resting CD4+ T cells. Two lineages of primate lentiviruses, the sooty mangabey SIV (SIVsm)/macaque SIV (SIVmac)/HIV-2 lineage and the red-capped mangabey SIV (SIVrcm) lineage, carry a SAMHD1 ...

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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

17-Mar-2015 | Lorenz S; Deng P; Hantschel O; Superti-Furga G; Kuriyan J, Biochemical Journal, 2015

Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in ...

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Determinants of oligosaccharide specificity of the carbohydrate binding modules of AMP-activated protein kinase

16-Mar-2015 | Mobbs J; Koay A; Di Paolo A; Bieri M; Petrie E; Gorman M; Doughty L; Parker M; Stapleton D; Griffin M; Gooley P, Biochemical Journal, 2015

AMPK-activated protein kinase (AMPK) is a αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two isoforms (β1 and β2) and contains a carbohydrate binding module (CBM) that interacts with glycogen. The two CBM isoforms (β1- and β2-CBM) are ...

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Mechanisms of Biofilm Inhibition and Degradation by Antimicrobial Peptides

12-Mar-2015 | Segev-Zarko L; Saar-dover R; Brumfeld V; Mangoni M; Shai Y, Biochemical Journal, 2015

Many bacteria live as biofilms to cope with unfavorable surroundings. Biofilms start from (i) a planktonic stage, (ii) initial adhesion to surfaces, and (iii) formation of sessile micro-colonies that secrete extracellular polymeric substance (EPS), leading to bacterial resistance to antibiotics. ...

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Akt-Mediated regulation of antidepressant-sensitive serotonin transporter function, cell surface expression and phosphorylation

12-Mar-2015 | Rajamanickam J; Annamalai B; Rahbek-Clemmensen T; Sundaramurthy S; Gether U; Jayanthi L; Ramamoorthy S, Biochemical Journal, 2015

The serotonin (5-HT) transporter (SERT) controls serotonergic neurotransmission in the brain by rapid clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary target for antidepressants for therapeutic intervention of mood disorders. Our previous studies have ...

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The purification and characterization of ATP synthase complexes from the mitochondria of four fungal species

11-Mar-2015 | Liu S; Charlesworth T; Bason J; Montgomery M; Harbour M; Fearnley I; Walker J, Biochemical Journal, 2015

The ATP synthases have been isolated by affinity chromatography from the mitochondria of the fungal species, Yarrowia histolytica, Pichia pastoris, Pichia angusta and Saccharomyces cerevisae. The subunit compositions of the purified enzyme complexes depended upon the detergent used to solubilise ...

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