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1,442 Newest Publications of Portland Press

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Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection

01-12-2014 | Bilanges B; Vanhaesebroeck B, Biochemical Journal, 2014

Class II/III PI3Ks (phosphoinositide 3-kinases) produce the PtdIns(3)P lipid that is involved in intracellular vesicular trafficking. In contrast with class I PI3Ks, the potential signalling roles of class II/III PI3Ks are poorly understood. In a recent article in the Biochemical Journal, Bago ...

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{Less than}i{Greater than}nhr-176{Less than}/i{Greater than} regulates {Less than}i{Greater than}cyp-35d1{Less than}/i{Greater than} to control hydroxylation-dependent metabolism of thiabendazole in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than}

19-11-2014 | Jones L; Flemming A; Urwin P, Biochemical Journal, 2014

Knowledge of how drugs are metabolised and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole to be commercially available and remains one of the most important anthelmintic drugs for ...

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The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria

15-11-2014 | Marchi S; Pinton P, Biochemical Journal, 2014

In this issue of the Biochemical Journal, Wu et al. describe the characterization of new low-affinity Ca2+ indicators for monitoring Ca2+ levels in both the ER (endoplasmic reticulum) and mitochondria. In contrast with other ER Ca2+ sensors, these indicators emit in the red part of the spectrum, ...

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Fe65 Ser{Less than}sup{Greater than}228{Less than}/sup{Greater than} is Phosphorylated by ATM/ATR and Inhibits Fe65-APP-Mediated Gene Transcription

14-11-2014 | Jowsey P; Blain P, Biochemical Journal, 2014

Fe65 binds the amyloid precursor protein (APP) and regulates the secretase-mediated processing of APP into several proteolytic fragments, including the amyloid-β (Aβ) peptides and APP intracellular domain (AICD). Aβ accumulation in neural plaques is a pathological feature of Alzheimer’s disease ...

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{Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than} mitochondria import tRNAs along with {Soft hyphen}{Soft hyphen}{Soft hyphen}{Soft hyphen}an active phenylalanyl-tRNA synthetase{Soft hyphen}{Soft hyphen}{Soft hyphen}{Soft hyphen}

13-11-2014 | Sharma A, Biochemical Journal, 2014

Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases (aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyzes transfer of amino acids to cognate transfer RNAs (tRNAs), thus providing charged tRNAs for ribosomal consumption. P. falciparum proteome ...

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C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1{alpha} signaling in acute liver failure

11-11-2014 | Rao J; Zhang C; Wang P; Lu L; Qian X; Qin J; Pan X; Li G; Wang X; Zhang F, Biochemical Journal, 2014

C/EBP Homologous Protein (CHOP) has been shown to be a key molecule in endoplasmic reticulum (ER) stress-mediated apoptosis. ERO1α, a target of CHOP, is an important oxidizing enzyme to regulate ROS, which play a prominent role in hepatocellular death during acute liver failure (ALF). However, ...

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Epithelial MUC1/Muc1 Promotes Cell migration, Reduces Apoptosis and Affects Levels of Mucosal Modulators During Acetylsalicylic Acid (Aspirin) Induced Gastropathy.{Less than}i{Greater than}{Less than}/i{Greater than}

11-11-2014 | Banerjee D; Fernandez H; Patil P; Premaratne P; Quiding-J{a}rbrink M; Lind{e}n S, Biochemical Journal, 2014

MUC1 is a transmembrane mucin highly expressed in the stomach. While extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. Here we showed that acetylsalicylic acid (Aspirin, ASA) upregulated MUC1/Muc1 expression in the ...

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Gremlin1 preferentially binds to Bone Morphogenetic Protein-2 (BMP-2) and BMP-4 over BMP-7

07-11-2014 | Church R; Krishnakumar A; Urbanek A; Geschwindner S; Meneely J; Bianchi A; Basta B; Monaghan S; Elliott C; Stromsted ..., Biochemical Journal, 2014

Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis-associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during DN has been ...

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

07-11-2014 | Henderson C; McLaughlin L; Osuna-Cabello M; Taylor M; Gilbert I; McLaren A; Wolf C, Biochemical Journal, 2014

The relative contribution of hepatic versus intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electron ...

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New aspects of the structure and mode of action of the human cathelicidin LL-37 revealed by the intrinsic probe p-cyanophenylalanine

07-11-2014 | Xhindoli D; Morgera F; Zinth U; Rizzo R; Pacor S; Tossi A, Biochemical Journal, 2014

The human cathelicidin peptide LL-37 is an important effector of our innate immune system and contributes to host defence with direct antimicrobial activity, immunomodulatory properties and by stimulating wound healing. Its sequence has evolved to confer specific structural characteristics that ...

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