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1,867 Newest Publications of Portland Press

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Deletion of phospholipase A{Less than}sub{Greater than}2{Less than}/sub{Greater than} group IV c induces apoptosis in rat mammary tumor cells by the nuclear factor-{kappa}B/lipocalin 2 pathway

27-May-2015 | Nanashima N; Yamada T; Shimizu T; Tsuchida S, Biochemical Journal, 2015

Although some phospholipase A2 forms, the initiator of the arachidonic acid cascade, contribute to carcinogenesis in many organs, the contribution of phospholipase A2 group IVc (Pla2g4c) remains to be clarified and the function of the enzyme in cancer development are unknown. The Hirosaki ...


E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signaling and plant development

26-May-2015 | Kim S; Park B; Kim D; Yeu S; Song S; Song J; Seo H, Biochemical Journal, 2015

Gibberellins affect various plant development processes including germination, cell division and elongation, and flowering. A large number of studies have been carried out to address the molecular mechanisms that mediate gibberellin signaling effects on plant growth. However, such studies have ...


Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

22-May-2015 | De Veer S; Swedberg J; Akcan M; Rosengren K; Brattsand M; Craik D; Harris J, Biochemical Journal, 2015

Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesising a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor’s resistance to ...


FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21{Less than}sup{Greater than}Cip1/Waf1{Less than}/sup{Greater than}

20-May-2015 | Kloet D; Polderman P; Eijkelenboom A; Smits L; Van Triest M; Van Den Berg M; Groot Koerkamp M; Van Leenen D; Lijnzaa ..., Biochemical Journal, 2015

Activity of Forkhead box O (FOXO) transcription factors is inhibited by growth factor-PI3K-protein kinase B (PKB)/AKT signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we identified a set of ...


Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme

19-May-2015 | Oka O; Yeoh H; Bulleid N, Biochemical Journal, 2015

The formation of disulfides in proteins entering the secretory pathway is catalysed by the protein disulfide isomerase family of enzymes. These enzymes catalyse the introduction, reduction and isomerisation of disulfides. To function continuously they require an oxidase to reform the disulfide at ...


Tail wags the dog: Activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner

18-May-2015 | Sridharan S; Kini M, Biochemical Journal, 2015

Natriuretic peptides (NP) are potent vasoactive hormones, which maintain pressure-volume homeostasis. Snake venom NPs exhibit distinct biological activity compared to mammalian NPs due to subtle changes in their sequences. We recently identified a new NP from krait venom (KNP), with an unusual ...


Slc5a8, a Na {+} -coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions

18-May-2015 | Gurav A; Sivaprakasam S; Bhutia Y; Boettger T; Singh N; Ganapathy V, Biochemical Journal, 2015

Mammalian colon harbors trillions of bacteria under physiologic conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. Here we show that Slc5a8, a Na + -coupled ...


Arc is a flexible modular protein capable of reversible self-oligomerization

15-May-2015 | Myrum C; Baumann A; Bustad HJ; Flydal MI; Mariaule V; Alvira S; Cuellar J; Haavik J; Soule J; Valpuesta JM; Marquez ..., Biochemical Journal, 2015

The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties of Arc have not been elucidated. In the present study, we expressed and ...


An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

15-May-2015 | Irving JA; Miranda E; Haq I; Perez J; Kotov VR; Faull SV; Motamedi-Shad N; Lomas DA, Biochemical Journal, 2015

A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type protein. Using the common pathogenic E342K (Z) ...


Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer

13-May-2015 | Babu E; Bhutia Y; Ramachandran S; Gnana-Prakasam J; Prasad P; Thangaraju M; Ganapathy V, Biochemical Journal, 2015

SLC6A14 mediates Na + /Cl --coupled concentrative uptake of a broad-spectrum of amino acids. It is expressed at low levels in many tissues but upregulated in certain cancers. Pharmacologic blockade of SLC6A14 causes amino acid starvation in ER+ breast cancer cells and suppresses their ...


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