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93 Newest Publications of Portland Press
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Specific phosphorylation of the {Less than}i{Greater than}Pf{Less than}/i{Greater than}Rh2b invasion ligand of {Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than}
02-04-2013 | Engelberg K; Paul A; Prinz B; Kono M; Ching W; Heincke D; Dobner T; Spielmann T; Duraisingh M; Gilberger T, Biochemical Journal, 2013
Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high affinity receptor-ligand interactions. Signal transduction through the action of specific kinases is a control mechanism for the orchestration of this process. Here ...
Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes
01-04-2013 | Mikhael MR; Soe-Lin S; Apte S; Ponka P, Biochemical Journal, 2013
AI (anaemia of inflammation) often manifests in patients with chronic immune activation due to cancer, chronic infections, autoimmune disorders, rheumatoid arthritis and other diseases. The pathogenesis of AI is complex and involves cytokine-mediated inhibition of erythropoiesis, ...
GlgS, previously described as a glycogen synthesis control protein, negatively regulates motility and biofilm formation in {Less than}i{Greater than}Escherichia coli{Less than}/i{Greater than}
28-03-2013 | Rahimpour M; Montero M; Almagro G; Viale A; Sevilla A; C{a}novas M; Mu{n}oz F; Baroja-Fern{a}ndez E; Bahaji A; Eydal ..., Biochemical Journal, 2013
Escherichia coli glycogen metabolism involves regulation of the glgBXCAP operon expression and allosteric control of GlgC-mediated catalysis of ATP and glucose-1-phosphate (G1P) to ADP-glucose linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected by glgS. Though the ...
Proteomic analysis of Mesembryanthemum crystallinum leaf microsomal fractions finds an imbalance in V-ATPase stoichiometry during the salt-induced transition from C3 to CAM
01-03-2013 | Cosentino C; Di Silvestre D; Fischer-Schliebs E; Homann U; De Palma A; Comunian C; Mauri PL; Thiel G, Biochemical Journal, 2013
The halophyte Mesembryanthemum crystallinum adapts to salt stress by salt uptake and switching from C3 photosynthesis to CAM (crassulacean acid metabolism). An important role in this process is played by transport proteins in the tonoplast of the central vacuole. In the present study we ...
The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner
01-03-2013 | Kanno T; Tsuchiya A; Tanaka A; Nishizaki T, Biochemical Journal, 2013
In yeast two-hybrid screening, protein 4.1N, a scaffolding protein, was identified as a binding partner of the α7 ACh (acetylcholine) receptor. For rat hippocampal slices, the linoleic acid derivative DCP-LA {8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid} increased the ...
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system.
27-02-2013 | Strickson S; Campbell D; Emmerich C; Knebel A; Plater L; Ritorto M; Shpiro N; Cohen P, Biochemical Journal, 2013
The compound BAY 11-7082 inhibits IκBα phosphorylation in cells and has been used to implicate the canonical IκB kinases (IKKs) and NFκB ...
Prediction of hammerhead ribozyme intracellular activity with the catalytic core fingerprint
19-02-2013 | Gabryelska M; Wyszko E; Szyma{n}ski M; Popenda M; Barciszewski J, Biochemical Journal, 2013
Hammerhead ribozyme is a versatile tool for down-regulation of gene expression in vivo. Due to its small size and high activity, it is used as a model for RNA structure-function relationship studies. Here we describe a new extended hammerhead ribozyme HH-2 with a tertiary stabilizing motif ...
FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress
15-02-2013 | Shimizu M; Li J; Maruyama R; Inoue J; Sato R, Biochemical Journal, 2013
FGF19 (fibroblast growth factor 19), expressed in the small intestine, acts as an enterohepatic hormone by mediating inhibitory effects on the bile acid synthetic pathway and regulating carbohydrate and lipid metabolism. In an attempt to identify novel agents other than bile acids that ...
Structure of a class III engineered cephalosporin acylase. Comparisons to class I acylase and implications for differences in substrate specificity and catalytic activity
04-02-2013 | Golden E; Paterson R; Tie W; Anandan A; Flematti G; Molla G; Rosini E; Pollegioni L; Vrielink A, Biochemical Journal, 2013
The crystal structure of wild-type form of glutaryl-7-ACA acylase from Pseudomonas N176 and a double mutant of the protein (His57βSer/His70βSer) that displays enhanced catalytic efficiency on cephalosporin C over glutaryl-7-aminocephalosporanic acid has been determined. The structures show a ...
Aminolevulinic Acid Synthase of {Less than}i{Greater than}Rhodobacter capsulatus{Less than}/i{Greater than} - High Resolution Kinetic Investigation of the Structural Basis for Substrate Binding and Catalysis
31-01-2013 | Kaufholz A; Hunter G; Ferreira G; Lendrihas T; Hering V; Layer G; Jahn M; Jahn D, Biochemical Journal, 2013
The first enzyme of heme biosynthesis, 5-aminolevulinic acid synthase, catalyses the pyridoxal-5’-phosphate-dependent condensation of glycine and succinyl-CoA to 5-aminolevulinic acid, CO2 and CoA. The crystal structure of Rhodobacter capsulatus ALAS provides first snapshots of the structural ...
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