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115 Newest Publications of Portland Press

matching the following criteria

The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...


Epithelial MUC1/Muc1 Promotes Cell migration, Reduces Apoptosis and Affects Levels of Mucosal Modulators During Acetylsalicylic Acid (Aspirin) Induced Gastropathy.{Less than}i{Greater than}{Less than}/i{Greater than}

11-11-2014 | Banerjee D; Fernandez H; Patil P; Premaratne P; Quiding-J{a}rbrink M; Lind{e}n S, Biochemical Journal, 2014

MUC1 is a transmembrane mucin highly expressed in the stomach. While extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. Here we showed that acetylsalicylic acid (Aspirin, ASA) upregulated MUC1/Muc1 expression in the ...


Synthetic DAF-12 modulators with potential use in controlling nematodes life cycle

06-11-2014 | Dansey M; Alvarez L; Samaja G; Escudero D; Veleiro A; Pecci A; Castro O; Burton G, Biochemical Journal, 2014

Dafachronic acids (DAs) are 3-keto colestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or ...


The role of Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} influx in endocytic vacuole formation in pancreatic acinar cells

05-11-2014 | Voronina S; Collier D; Chvanov M; Middlehurst B; Beckett A; Prior I; Criddle D; Begg M; Mikoshiba K; Sutton R; Tepikin A, Biochemical Journal, 2014

The inducers of acute pancreatitis trigger a prolonged increase in the cytosolic Ca2+ concentration, which is responsible for the damage and eventual death of pancreatic acinar cells. Vacuolisation is an important indicator of pancreatic acinar cell damage. Furthermore, activation of trypsinogen ...


Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...


Structure-based Design and Functional studies of Novel Noroviral 3C Protease Chimeras Offers Insights into Substrate Specificity

02-10-2014 | Herod M; Prince C; Skilton R; Ward V; Cooper J; Clarke I, Biochemical Journal, 2014

The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2,200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural proteins. Studies of the human norovirus NS6 protease, in the ...


Aminoacetone oxidase from Streptococcus oligofermentas belongs to a new three-domain family of bacterial flavoproteins

30-09-2014 | Molla G; Nardini M; Motta P; D{'}Arrigo P; Panzeri W; Pollegioni L, Biochemical Journal, 2014

The aaoso gene from Streptococcus oligofermentas encodes for a 43 kDa flavoprotein (SoAAO), which was reported to possess a low catalytic activity versus several different L-amino acids: accordingly, it was classified as an L-amino acid oxidase. Subsequently, SoAAO was demonstrated to oxidize ...


Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

15-08-2014 | Purschke WG; Hoehlig K; Buchner K; Zboralski D; Schwoebel F; Vater A; Klussmann S, Biochemical Journal, 2014

The sphingolipid S1P (sphingosine 1-phosphate) is known to be involved in a number of pathophysiological conditions such as cancer, autoimmune diseases and fibrosis. It acts extracellularly through a set of five G-protein-coupled receptors, but its intracellular actions are also well documented. ...


The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...


EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

01-10-2013 | Sjogren J; Struwe WB; Cosgrave EFJ; Rudd PM; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...


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