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107 Newest Publications of Portland Press

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

01-10-2013 | Sjogren J; Struwe WB; Cosgrave EFJ; Rudd PM; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...

more

Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling

10-09-2013 | D'Cruz A; Kershaw N; Chiang J; Wang M; Nicola N; Babon J; Gack M; Nicholson S, Biochemical Journal, 2013

Tripartite motif (TRIM) proteins primarily function as ubiquitin E3 ligases that regulate the innate immune response to infection. TRIM25 (also known as estrogen-responsive finger protein (Efp)) has been implicated in the regulation of estrogen receptor α signaling, and in the regulation of ...

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Synthetic Retinoid Am80 Upregulates Apelin Expression by Promoting Interaction of RAR{alpha} with KLF5 and Sp1 in Vascular Smooth Muscle Cells

30-08-2013 | Lv X; Zheng B; Li S; Han A; Wang C; Shi J; Zhang X; Liu Y; Li Y; Wen J, Biochemical Journal, 2013

Previous studies have demonstrated that both retinoids and apelin possess potent cardiovascular properties and that retinoids can mediate the expression of many genes in the cardiovascular system. However, it is not clear whether and how retinoids regulate apelin expression in rat vascular smooth ...

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Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop

02-08-2013 | Harijan R; Kiema T; Karjalainen M; Janardan N; Murthy M; Weiss M; Michels P; Wierenga R, Biochemical Journal, 2013

Thiolases are essential CoA dependent enzymes in lipid metabolism. Here we report on crystal structures of trypanosomal and leishmanial SCP2-thiolases. Trypanosomatidae cause various widespread, devastating (sub)-tropical diseases, for which adequate treatment is lacking. The structures reveal ...

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EndoS{Less than}sub{Greater than}2{Less than}/sub{Greater than} is a unique and conserved enzyme of serotype M49 group A {Less than}i{Greater than}Streptococcus{Less than}/i{Greater than} that hydrolyzes N-linked glycans on IgG and {alpha}{Less than}sub{Greater than}1{Less than}/sub{Greater than}-acid glycoprotein

19-07-2013 | Sj{o}gren J; Struwe W; Cosgrave E; Rudd P; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes (group A Streptococcus [GAS]) secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...

more

The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

11-07-2013 | Chandor-Proust A; Bibby J; R{e}gent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz M; Paine M; Dauphin-Vi ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

more

Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

03-07-2013 | Zou J; Yue F; Jiang X; Li W; Yi J; Liu L, Biochemical Journal, 2013

The mitochondrion-associated protein LRPPRC interacts with one of microtubule-associated protein family MAP1S (originally named as C19ORF5) to form a complex. MAP1S interacts with LC3, the mammalian homologue of yeast autophagy marker ATG8 and one of the most important autophagy markers in ...

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The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP

01-07-2013 | Churamani D; Hooper R; Rahman T; Brailoiu E; Patel S, Biochemical Journal, 2013

TPCs (two-pore channels) are NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of the N-terminal region redirects TPC1 to the ER (endoplasmic reticulum). The introduction of ...

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