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112 Newest Publications of Portland Press

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The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

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Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...

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Structure-based Design and Functional studies of Novel Noroviral 3C Protease Chimeras Offers Insights into Substrate Specificity

02-10-2014 | Herod M; Prince C; Skilton R; Ward V; Cooper J; Clarke I, Biochemical Journal, 2014

The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2,200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural proteins. Studies of the human norovirus NS6 protease, in the ...

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Aminoacetone oxidase from Streptococcus oligofermentas belongs to a new three-domain family of bacterial flavoproteins

30-09-2014 | Molla G; Nardini M; Motta P; D{'}Arrigo P; Panzeri W; Pollegioni L, Biochemical Journal, 2014

The aaoso gene from Streptococcus oligofermentas encodes for a 43 kDa flavoprotein (SoAAO), which was reported to possess a low catalytic activity versus several different L-amino acids: accordingly, it was classified as an L-amino acid oxidase. Subsequently, SoAAO was demonstrated to oxidize ...

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Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

15-08-2014 | Purschke WG; Hoehlig K; Buchner K; Zboralski D; Schwoebel F; Vater A; Klussmann S, Biochemical Journal, 2014

The sphingolipid S1P (sphingosine 1-phosphate) is known to be involved in a number of pathophysiological conditions such as cancer, autoimmune diseases and fibrosis. It acts extracellularly through a set of five G-protein-coupled receptors, but its intracellular actions are also well documented. ...

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

01-10-2013 | Sjogren J; Struwe WB; Cosgrave EFJ; Rudd PM; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...

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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling

10-09-2013 | D'Cruz A; Kershaw N; Chiang J; Wang M; Nicola N; Babon J; Gack M; Nicholson S, Biochemical Journal, 2013

Tripartite motif (TRIM) proteins primarily function as ubiquitin E3 ligases that regulate the innate immune response to infection. TRIM25 (also known as estrogen-responsive finger protein (Efp)) has been implicated in the regulation of estrogen receptor α signaling, and in the regulation of ...

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Synthetic Retinoid Am80 Upregulates Apelin Expression by Promoting Interaction of RAR{alpha} with KLF5 and Sp1 in Vascular Smooth Muscle Cells

30-08-2013 | Lv X; Zheng B; Li S; Han A; Wang C; Shi J; Zhang X; Liu Y; Li Y; Wen J, Biochemical Journal, 2013

Previous studies have demonstrated that both retinoids and apelin possess potent cardiovascular properties and that retinoids can mediate the expression of many genes in the cardiovascular system. However, it is not clear whether and how retinoids regulate apelin expression in rat vascular smooth ...

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