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119 Newest Publications of Portland Press

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The function of phosphatidylinositol 5-phosphate 4-kinase {gamma}(PI5P4K{gamma}) explored using a specific inhibitor that targets the PI5P binding site.

11-12-2014 | Clarke J; Giudici M; Burke J; Williams R; Maloney D; Marugan J; Irvine R, Biochemical Journal, 2014

NIH-12848 (NCGC00012848-02), a putative phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity, lipid kinase. PI5P 4-kinase assays in vitro showed that NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1μM but ...

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Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

08-12-2014 | Chen X; Huang X; Geng L; Xue L; Hou S; Zheng X; Brimijoin S; Zheng F; Zhan C, Biochemical Journal, 2014

Mouse butyrylcholinesterase (mBChE) and an mBChE-based cocaine hydrolase (mCocH, i.e. the A199S/S227A/S287G/A328W/Y332G mutant) have been characterized for their catalytic activities against cocaine, i.e. naturally occurring (-)-cocaine, in comparison with the corresponding human BChE (hBChE) and ...

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Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2

01-12-2014 | Lee S; Swanson M; Sattlegger E, Biochemical Journal, 2014

In eukaryotes, amino acid deprivation leads to the accumulation of uncharged tRNAs that are detected by Gcn2, which in turn phosphorylates eIF2α, an essential process for overcoming starvation. In Saccharomyces cerevisiae, sensing amino acid shortages requires that Gcn2 binds directly to its ...

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The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans

24-11-2014 | Schiefner A; Rodewald F; Neumaier I; Skerra A, Biochemical Journal, 2014

Human glycodelin is an abundant glycoprotein from the lipocalin family and involved in crucial biological processes such as reproduction and immune reaction. In females and males, glycodelin is found in four distinct glycoforms – A, C, F and S – that arise from different N-linked oligosaccharide ...

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The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

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Epithelial MUC1/Muc1 Promotes Cell migration, Reduces Apoptosis and Affects Levels of Mucosal Modulators During Acetylsalicylic Acid (Aspirin) Induced Gastropathy.{Less than}i{Greater than}{Less than}/i{Greater than}

11-11-2014 | Banerjee D; Fernandez H; Patil P; Premaratne P; Quiding-J{a}rbrink M; Lind{e}n S, Biochemical Journal, 2014

MUC1 is a transmembrane mucin highly expressed in the stomach. While extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. Here we showed that acetylsalicylic acid (Aspirin, ASA) upregulated MUC1/Muc1 expression in the ...

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Synthetic DAF-12 modulators with potential use in controlling nematodes life cycle

06-11-2014 | Dansey M; Alvarez L; Samaja G; Escudero D; Veleiro A; Pecci A; Castro O; Burton G, Biochemical Journal, 2014

Dafachronic acids (DAs) are 3-keto colestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or ...

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The role of Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} influx in endocytic vacuole formation in pancreatic acinar cells

05-11-2014 | Voronina S; Collier D; Chvanov M; Middlehurst B; Beckett A; Prior I; Criddle D; Begg M; Mikoshiba K; Sutton R; Tepikin A, Biochemical Journal, 2014

The inducers of acute pancreatitis trigger a prolonged increase in the cytosolic Ca2+ concentration, which is responsible for the damage and eventual death of pancreatic acinar cells. Vacuolisation is an important indicator of pancreatic acinar cell damage. Furthermore, activation of trypsinogen ...

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Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...

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Structure-based Design and Functional studies of Novel Noroviral 3C Protease Chimeras Offers Insights into Substrate Specificity

02-10-2014 | Herod M; Prince C; Skilton R; Ward V; Cooper J; Clarke I, Biochemical Journal, 2014

The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2,200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural proteins. Studies of the human norovirus NS6 protease, in the ...

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