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123 Newest Publications of Portland Press

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Solution Structure of the Reduced Form of Human Peroxiredoxin-6 Elucidated Using Zero-Length Chemical Cross-linking And Homology Modeling

06-Mar-2015 | Rivera-Santiago R; Harper S; Zhou S; Sriswasdi S; Feinstein S; Fisher A; Speicher D, Biochemical Journal, 2015

Peroxiredoxin-6 (PRDX6) is an unusual member of the peroxiredoxin family of antioxidant enzymes that has only one evolutionarily conserved cysteine. It reduces oxidized lipids and ROS by oxidation of the active site cysteine (Cys-47) to a sulfenic acid, but the mechanism for conversion back to a ...

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Bioenergetic Programming Of Macrophages By The Apolipoprotein A-I Mimetic Peptide 4F

05-Mar-2015 | Datta G; Kramer P; Johnson M; Sawada H; Smythies L; Crossman D; Chacko B; Ballinger S; Westbrook D; Mayakonda P; Ana ..., Biochemical Journal, 2015

The apolipoprotein (apo)A-I mimetic peptide 4F favors the differentiation of human monocytes to an alternatively-activated M2 phenotype. The goal of the current study was to test whether the 4F-mediated differentiation of monocyte-derived macrophages (MDMs) requires the induction of an oxidative ...

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The {Less than}i{Greater than}Leishmania donovani {Less than}/i{Greater than}histidine acid ecto-phosphatase{Less than}i{Greater than} Ld{Less than}/i{Greater than}MAcP: insight into its structure and function

19-Feb-2015 | Papadaki A; Politou A; Smirlis D; Kotini M; Kourou K; Papamarcaki T; Boleti H, Biochemical Journal, 2015

Acid ecto-phosphatase activity has been implicated in Leishmania donovani promastigote virulence. Here we report data contributing to the molecular/structural and functional characterization of the Leishmania donovani LdMAcP, member of the histidine acid phosphatase family. LdMAcP, is membrane ...

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The sigma 1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

15-Dec-2014 | Mishra A; Mavlyutov T; Singh D; Biener G; Yang J; Oliver J; Ruoho A; Raicu V, Biochemical Journal, 2014

The sigma-1 receptor (S1R) is a membrane 223-amino acid protein that resides in the endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is regulated by a various synthetic molecules including (+)-pentazocine, cocaine and haloperidol, and endogenous molecules such as ...

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The function of phosphatidylinositol 5-phosphate 4-kinase {gamma}(PI5P4K{gamma}) explored using a specific inhibitor that targets the PI5P binding site.

11-Dec-2014 | Clarke J; Giudici M; Burke J; Williams R; Maloney D; Marugan J; Irvine R, Biochemical Journal, 2014

NIH-12848 (NCGC00012848-02), a putative phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity, lipid kinase. PI5P 4-kinase assays in vitro showed that NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1μM but ...

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Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

08-Dec-2014 | Chen X; Huang X; Geng L; Xue L; Hou S; Zheng X; Brimijoin S; Zheng F; Zhan C, Biochemical Journal, 2014

Mouse butyrylcholinesterase (mBChE) and an mBChE-based cocaine hydrolase (mCocH, i.e. the A199S/S227A/S287G/A328W/Y332G mutant) have been characterized for their catalytic activities against cocaine, i.e. naturally occurring (-)-cocaine, in comparison with the corresponding human BChE (hBChE) and ...

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Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2

01-Dec-2014 | Lee S; Swanson M; Sattlegger E, Biochemical Journal, 2014

In eukaryotes, amino acid deprivation leads to the accumulation of uncharged tRNAs that are detected by Gcn2, which in turn phosphorylates eIF2α, an essential process for overcoming starvation. In Saccharomyces cerevisiae, sensing amino acid shortages requires that Gcn2 binds directly to its ...

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The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans

24-Nov-2014 | Schiefner A; Rodewald F; Neumaier I; Skerra A, Biochemical Journal, 2014

Human glycodelin is an abundant glycoprotein from the lipocalin family and involved in crucial biological processes such as reproduction and immune reaction. In females and males, glycodelin is found in four distinct glycoforms – A, C, F and S – that arise from different N-linked oligosaccharide ...

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The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-Nov-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

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Epithelial MUC1/Muc1 Promotes Cell migration, Reduces Apoptosis and Affects Levels of Mucosal Modulators During Acetylsalicylic Acid (Aspirin) Induced Gastropathy.{Less than}i{Greater than}{Less than}/i{Greater than}

11-Nov-2014 | Banerjee D; Fernandez H; Patil P; Premaratne P; Quiding-J{a}rbrink M; Lind{e}n S, Biochemical Journal, 2014

MUC1 is a transmembrane mucin highly expressed in the stomach. While extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. Here we showed that acetylsalicylic acid (Aspirin, ASA) upregulated MUC1/Muc1 expression in the ...

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