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174 Newest Publications of Portland Press

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Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

15-08-2014 | Lane DJR; Richardson DR, Biochemical Journal, 2014

How is cellular iron (Fe) uptake and efflux regulated in mammalian cells? In this issue of the Biochemical Journal, Yanatori et al. report for the first time that a member of the emerging PCBP [poly(rC)-binding protein] Fe-chaperone family, PCBP2, physically interacts with the major Fe importer ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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HEXIM1 downregulates Hypoxia Inducible Factor-1 alpha protein stability

10-09-2013 | Yeh I; Ogba N; Bensigner H; Welford S; Montano M, Biochemical Journal, 2013

We have previously reported on the inhibition of Hypoxia Inducible Factor alpha (HIF-1α) regulated pathways by Hexamethylene-bis-acetamide-inducible (HMBA) protein 1 (HEXIM1). Disruption of HEXIM1 activity in a knock-in mouse model expressing a mutant HEXIM1 protein resulted in increased ...

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Regulation of the transcriptional activation of the androgen receptor by the UXT binding protein VHL

21-08-2013 | Chen S; Chen K; Zhang Q; Cheng H; Zhou R, Biochemical Journal, 2013

Loss and/or inactivation of VHL (the von Hippel Lindau tumour suppressor) cause various tumours. Using a yeast two-hybrid system, we have identified an AR co-activator, UXT, as a VHL-interacting protein. GST pull-down and co-immunoprecipitation assays show that UXT interacts with VHL. In ...

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Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

16-08-2013 | Madabushi A; Hwang B; Jin J; Lu A, Biochemical Journal, 2013

Thymine DNA glycosylase (TDG) is an essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation, and transcription regulation. TDG is the predominant enzyme to remove thymine from T/G mispair, which arises due to deamination of 5-methyl-cytosine at the CpG ...

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Nogo-A couples with Apg-1 through interaction and coordinate expression under hypoxic and oxidative stress

02-08-2013 | Kern F; Stanika R; Sarg B; Offterdinger M; Hess D; Obermair G; Lindner H; Bandtlow C; Hengst L; Schweigreiter R, Biochemical Journal, 2013

Nogo-A is the largest isoform of the Nogo/RTN4 proteins and has been characterized as a major myelin associated inhibitor of regenerative nerve growth in the adult central nervous system (CNS). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The ...

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Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization

01-08-2013 | Rokach O; Ullrich N; Rausch M; Mouly V; Zhou H; Muntoni F; Zorzato F; Treves S, Biochemical Journal, 2013

Excitation contraction coupling is the physiological mechanism occurring in muscle cells whereby an electrical signal sensed by the dihydropyridine receptor located on the transverse tubules is transformed into a chemical gradient (Ca2+ increase) by activation of the ryanodine receptor located on ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

18-07-2013 | Aregger M; Cowling V, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with addition of 7-methylguanosine to the initiating nucleotide of RNA pol II transcripts, which occurs predominantly during ...

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Role of hypoxia and P1 receptor activation on the high affinity concentrative adenosine transporter CNT2 in PC12 cells

03-07-2013 | Medina-Pulido L; Molina-Arcas M; Justicia C; Soriano E; Burgaya F; Planas A; Pastor-Anglada M, Biochemical Journal, 2013

Under several adverse conditions, such as hypoxia or ischemia, extracellular levels of adenosine (Ado) upraise due to increased energy demands and ATP metabolism. Because extracellular Ado affects metabolism through G protein-coupled receptors, its regulation is of high adaptive importance. ...

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Picking sides: Distinct roles for CYP76M6 and -8 in rice oryzalexin biosynthesis

25-06-2013 | Wu Y; Wang Q; Hillwig M; Peters R, Biochemical Journal, 2013

Natural products biosynthesis often requires the action of multiple cytochromes P450 (CYPs), whose ability to introduce oxygen, increasing solubility, is critical for imparting biological activity. In previous investigations of rice diterpenoid biosynthesis, we have characterized CYPs that ...

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