To use all functions of this page, please activate cookies in your browser.
My watch list
my.chemeurope.com
my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
161 Newest Publications of Portland Press
rss
matching the following criteria
Cross functionalities of {Less than}i{Greater than}Bacillus {Less than}/i{Greater than}deacetylases involved in bacillithiol biosynthesis and bacillithiol-{Less than}i{Greater than}S{Less than}/i{Greater than}-conjugate detoxification pathways.
11-06-2013 | Fang Z; Roberts A; Weidman K; Sharma S; Claiborne A; Hamilton C; Dos Santos P, Biochemical Journal, 2013
BshB, a key enzyme in bacillithiol biosynthesis, hydrolyses the acetyl group from N-acetyl-glucosamine-malate to generate glucosamine-malate. In Bacillus anthracis, BA1557 has been identified as the N-acetyl-glucosamine-malate deacetylase (BshB), however high content of bacillithiol (~70%) ...
The CPVT-associated RyR2 Mutation G230C Enhances Store Overload-Induced Ca{Less than}sup{Greater than}2{+} {Less than}/sup{Greater than}Release and Destabilizes the NH{Less than}sub{Greater than}2{Less than}/sub{Greater than}-terminal domains
07-06-2013 | Liu Y; Kimlicka L; Hiess F; Tian X; Wang R; Zhang L; Jones P; van Petegem F; Chen S, Biochemical Journal, 2013
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, life-threatening arrhythmogenic disorder. CPVT is caused by delayed afterdepolarizations (DADs) that are induced by spontaneous Ca2+ release during sarcoplasmic reticulum (SR) Ca2+ overload, a process also known as ...
Spinocerebellar ataxia-13 Kv3.3 potassium channels: Arginine-to-Histidine mutations affect both functional and protein expression on the cell surface
05-06-2013 | Zhao J; Zhu J; Thornhill W, Biochemical Journal, 2013
Voltage-gated potassium channel Kv3.3 is the causative gene of spinocerebellar ataxia type 13 (SCA13), an autosomal dominant neurological disorder. The four dominant mutations identified to date cause Kv3.3 channels to be nonfunctional or have altered gating properties in Xenopus oocytes. In ...
Roles of EXTL2, a member of EXT family of tumor suppressors, in liver injury and regeneration processes
04-06-2013 | Nadanaka S; Kagiyama S; Kitagawa H, Biochemical Journal, 2013
The gene products of two members of the EXT gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate. EXTL2, one of the three EXT-like genes in the human genome that are homologous to EXT1 and EXT2, encodes a N-acetylhexosaminyltransferase. ...
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
01-06-2013 | Reeks J; Sokolowski RD; Graham S; Liu H; Naismith JH; White MF, Biochemical Journal, 2013
The competition between viruses and hosts is played out in all branches of life. Many prokaryotes have an adaptive immune system termed 'CRISPR' (clustered regularly interspaced short palindromic repeats) which is based on the capture of short pieces of viral DNA. The captured DNA is ...
The folding capacity of the mature domain of the dual-targeted plant tRNA nucleotidyltransferase influences organelle selection
28-05-2013 | Leibovitch M; Bublak D; Hanic-Joyce P; Tillmann B; Flinner N; Amsel D; Scharf K; Mirus O; Joyce P; Schleiff E, Biochemical Journal, 2013
tRNA nucleotidyltransferases are required for the maturation or repair of tRNAs by ensuring that they have an intact cytidine-cytidine-adenosine sequence at their 3’-termini. Therefore, this enzymatic activity is found in all cellular compartments, namely the nucleus, cytoplasm, plastids and ...
Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer's Drugs Targeting Acetyl- and Butyrylcholinesterase
17-05-2013 | Nachon F; Carletti E; Ronco C; Trovaslet M; Nicolet Y; Jean L; Renard P, Biochemical Journal, 2013
The multifunctional nature of Alzheimer's disease calls for multi-target directed ligands (MTDLs) able to act on different components of the pathology, like the cholinergic dysfunction and amyloid aggregation. Such MTDLs are usually based on cholinesterase inhibitors (e.g., tacrine or ...
Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of {alpha}-Naphthoflavone
08-05-2013 | Davydov D; Davydova N; Sineva E; Kufareva I; Halpert J, Biochemical Journal, 2013
We investigated the relationship between oligomerization of cytochrome P450 3A4 (CYP3A4) and its response to alpha-naphthoflavone (ANF), a prototypical heterotropic activator. Addition of ANF resulted in over a two-fold increase in the rate of CYP3A4-dependent debenzylation of ...
Minimal Functional Domains of Paralogues hnRNP L and hnRNP LL Exhibit Mechanistic Differences in Exonic Splicing Repression
07-05-2013 | Shankarling G; Lynch K, Biochemical Journal, 2013
Understanding functional distinctions between related splicing regulatory proteins is critical to deciphering tissue-specific control of alternative splicing. The hnRNP L and hnRNP LL proteins are paralogues that have overlapping but distinct expression patterns and functional consequences. ...
MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein
01-05-2013 | Han K; Ayer D, Biochemical Journal, 2013
The MondoA:Mlx transcription complex plays a pivotal role in glucose homeostasis by activating target gene expression in response to glucose-6-phosphate (G6P), the first reaction intermediate in glycolysis. Thioredoxin-interacting protein (TXNIP) is a direct and glucose-responsive target of ...
Netmeeting
