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177 Newest Publications of Portland Press

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

07-11-2014 | Henderson C; McLaughlin L; Osuna-Cabello M; Taylor M; Gilbert I; McLaren A; Wolf C, Biochemical Journal, 2014

The relative contribution of hepatic versus intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electron ...

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A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-10-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...

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Disruption of integrin{Minus Sign}fibronectin complexes by allosteric but not ligand-mimetic inhibitors

21-10-2014 | Mould A; Craig S; Byron S; Humphries M; Jowitt T, Biochemical Journal, 2014

Failure of Arg-Gly-Asp (RGD)-based inhibitors to reverse integrin−ligand binding has been reported, but the prevalence of this phenomenon among integrin heterodimers is currently unknown. Here we have studied the interaction of four different RGD-binding integrins (α5β1, αVβ1, αVβ3 and αVβ6) with ...

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Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

15-08-2014 | Lane DJR; Richardson DR, Biochemical Journal, 2014

How is cellular iron (Fe) uptake and efflux regulated in mammalian cells? In this issue of the Biochemical Journal, Yanatori et al. report for the first time that a member of the emerging PCBP [poly(rC)-binding protein] Fe-chaperone family, PCBP2, physically interacts with the major Fe importer ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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HEXIM1 downregulates Hypoxia Inducible Factor-1 alpha protein stability

10-09-2013 | Yeh I; Ogba N; Bensigner H; Welford S; Montano M, Biochemical Journal, 2013

We have previously reported on the inhibition of Hypoxia Inducible Factor alpha (HIF-1α) regulated pathways by Hexamethylene-bis-acetamide-inducible (HMBA) protein 1 (HEXIM1). Disruption of HEXIM1 activity in a knock-in mouse model expressing a mutant HEXIM1 protein resulted in increased ...

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Regulation of the transcriptional activation of the androgen receptor by the UXT binding protein VHL

21-08-2013 | Chen S; Chen K; Zhang Q; Cheng H; Zhou R, Biochemical Journal, 2013

Loss and/or inactivation of VHL (the von Hippel Lindau tumour suppressor) cause various tumours. Using a yeast two-hybrid system, we have identified an AR co-activator, UXT, as a VHL-interacting protein. GST pull-down and co-immunoprecipitation assays show that UXT interacts with VHL. In ...

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Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

16-08-2013 | Madabushi A; Hwang B; Jin J; Lu A, Biochemical Journal, 2013

Thymine DNA glycosylase (TDG) is an essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation, and transcription regulation. TDG is the predominant enzyme to remove thymine from T/G mispair, which arises due to deamination of 5-methyl-cytosine at the CpG ...

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Nogo-A couples with Apg-1 through interaction and coordinate expression under hypoxic and oxidative stress

02-08-2013 | Kern F; Stanika R; Sarg B; Offterdinger M; Hess D; Obermair G; Lindner H; Bandtlow C; Hengst L; Schweigreiter R, Biochemical Journal, 2013

Nogo-A is the largest isoform of the Nogo/RTN4 proteins and has been characterized as a major myelin associated inhibitor of regenerative nerve growth in the adult central nervous system (CNS). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The ...

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Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization

01-08-2013 | Rokach O; Ullrich N; Rausch M; Mouly V; Zhou H; Muntoni F; Zorzato F; Treves S, Biochemical Journal, 2013

Excitation contraction coupling is the physiological mechanism occurring in muscle cells whereby an electrical signal sensed by the dihydropyridine receptor located on the transverse tubules is transformed into a chemical gradient (Ca2+ increase) by activation of the ryanodine receptor located on ...

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