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192 Newest Publications of Portland Press

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matching the following criteria

E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signaling and plant development

26-May-2015 | Kim S; Park B; Kim D; Yeu S; Song S; Song J; Seo H, Biochemical Journal, 2015

Gibberellins affect various plant development processes including germination, cell division and elongation, and flowering. A large number of studies have been carried out to address the molecular mechanisms that mediate gibberellin signaling effects on plant growth. However, such studies have ...

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The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module

06-May-2015 | Maryati M; Airhihen B; Winkler G, Biochemical Journal, 2015

In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4-Not deadenylase complex, which can be recruited to its target mRNA by RNA-binding proteins or ...

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Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells {Less than}i{Greater than}ex vivo{Less than}/i{Greater than} through inhibition of {Less than}i{Greater than}de novo{Less than}/i{Greater than} lipogenesis

05-May-2015 | O'Brien A; Villani L; Broadfield L; Houde V; Galic S; Blandino G; Kemp B; Tsakaridis T; Muti P; Steinberg G, Biochemical Journal, 2015

Aspirin, the pro-drug of salicylate, is associated with reduced incidence of death from cancers of the colon, lung and prostate and is commonly prescribed in combination with metformin in individuals with type 2 diabetes. Salicylate activates the AMP-activated protein kinase (AMPK) by binding at ...

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Solution structure of the RNA-binding cold shock domain of the {Less than}i{Greater than}Chlamydomonas reinhardtii {Less than}/i{Greater than}NAB1 protein and insights into RNA recognition

28-Apr-2015 | Sawyer A; Landsberg M; Ross I; Kruse O; Mobli M; Hankamer B, Biochemical Journal, 2015

Light harvesting complex (LHC) proteins are among the most abundant proteins on Earth and play critical roles in photosynthesis, both in light capture and photoprotective mechanisms. The Chlamydomonas reinhardtii nucleic acid-binding protein 1 (NAB1) is a negative regulator of LHC protein ...

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Activation of Glycoprotein VI (GPVI) and C-type Lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands

07-Apr-2015 | Alshehri O; Montague S; Watson S; Carter P; Sarker N; Manne B; Miller J; Herr A; Pollitt A; O'Callaghan C; Kunapuli ..., Biochemical Journal, 2015

Platelets are activated by a range of stimuli that share little or no resemblance in structure to each other or to recognised ligands, including diesel exhaust particles (DEP), small peptides (4N1-1, Champs, LSARLAF), proteins (histones), and large polysaccharides (fucoidan, dextran sulphate). ...

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{Less than}i{Greater than}In vitro{Less than}/i{Greater than} reconstitution of cotranslational D1 insertion reveals a role of the cpSec/Alb3 translocase and Vipp1 in photosystem II biogenesis

24-Mar-2015 | Walter B; Hristou A; Nowaczyk M; Sch{u}nemann D, Biochemical Journal, 2015

Photosystem II (PS II) is a multi subunit complex localized in the thylakoid membrane that performs the light dependent photosynthetic charge separation. The PS II reaction center comprises, amongst others, the D1 protein. De novo synthesis and repair of PS II require efficient mechanisms for ...

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Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

15-Mar-2015 | Bett JS; Ritorto MS; Ewan R; Jaffray EG; Virdee S; Chin JW; Knebel A; Kurz T; Trost M; Tatham MH; Hay RT, Biochemical Journal, 2015

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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Solution Structure of the Reduced Form of Human Peroxiredoxin-6 Elucidated Using Zero-Length Chemical Cross-linking And Homology Modeling

06-Mar-2015 | Rivera-Santiago R; Harper S; Zhou S; Sriswasdi S; Feinstein S; Fisher A; Speicher D, Biochemical Journal, 2015

Peroxiredoxin-6 (PRDX6) is an unusual member of the peroxiredoxin family of antioxidant enzymes that has only one evolutionarily conserved cysteine. It reduces oxidized lipids and ROS by oxidation of the active site cysteine (Cys-47) to a sulfenic acid, but the mechanism for conversion back to a ...

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Bioenergetic Programming Of Macrophages By The Apolipoprotein A-I Mimetic Peptide 4F

05-Mar-2015 | Datta G; Kramer P; Johnson M; Sawada H; Smythies L; Crossman D; Chacko B; Ballinger S; Westbrook D; Mayakonda P; Ana ..., Biochemical Journal, 2015

The apolipoprotein (apo)A-I mimetic peptide 4F favors the differentiation of human monocytes to an alternatively-activated M2 phenotype. The goal of the current study was to test whether the 4F-mediated differentiation of monocyte-derived macrophages (MDMs) requires the induction of an oxidative ...

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