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180 Newest Publications of Portland Press

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matching the following criteria

Structural and functional consequences of removing the N-terminal domain from the magnesium chelatase ChlH subunit of Thermosynechococcus elongatus

15-12-2014 | Adams NBP; Marklew CJ; Qian P; Brindley AA; Davison PA; Bullough PA; Hunter CN, Biochemical Journal, 2014

Magnesium chelatase (MgCH) initiates chlorophyll biosynthesis by catalysing the ATP-dependent insertion of Mg2+ into protoporphyrin. This large enzyme complex comprises ChlH, I and D subunits, with I and D involved in ATP hydrolysis, and H the protein that handles the substrate and product. The ...

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Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

09-12-2014 | Bett J; Ritorto M; Ewan R; Jaffray E; Virdee S; Chin J; Knebel A; Kurz T; Trost M; Tatham M; Hay R, Biochemical Journal, 2014

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex

28-11-2014 | Lopez R; Mosca B; Treves S; Maj M; Bergamelli L; Calderon J; Bentzinger C; Romanino K; Hall M; R{u}egg M; Delbono O; ..., Biochemical Journal, 2014

The protein mammalian target of rapamycin (mTOR) is a serine/threonine kinase regulating a number of biochemical pathways controlling cell growth. mTOR exists in two complexes termed mTORC1 and mTORC2. Raptor is associated with mTORC1 and is essential for its function. Ablation of Raptor in ...

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

07-11-2014 | Henderson C; McLaughlin L; Osuna-Cabello M; Taylor M; Gilbert I; McLaren A; Wolf C, Biochemical Journal, 2014

The relative contribution of hepatic versus intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electron ...

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A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-10-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...

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Disruption of integrin{Minus Sign}fibronectin complexes by allosteric but not ligand-mimetic inhibitors

21-10-2014 | Mould A; Craig S; Byron S; Humphries M; Jowitt T, Biochemical Journal, 2014

Failure of Arg-Gly-Asp (RGD)-based inhibitors to reverse integrin−ligand binding has been reported, but the prevalence of this phenomenon among integrin heterodimers is currently unknown. Here we have studied the interaction of four different RGD-binding integrins (α5β1, αVβ1, αVβ3 and αVβ6) with ...

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Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline

15-08-2014 | Lane DJR; Richardson DR, Biochemical Journal, 2014

How is cellular iron (Fe) uptake and efflux regulated in mammalian cells? In this issue of the Biochemical Journal, Yanatori et al. report for the first time that a member of the emerging PCBP [poly(rC)-binding protein] Fe-chaperone family, PCBP2, physically interacts with the major Fe importer ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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HEXIM1 downregulates Hypoxia Inducible Factor-1 alpha protein stability

10-09-2013 | Yeh I; Ogba N; Bensigner H; Welford S; Montano M, Biochemical Journal, 2013

We have previously reported on the inhibition of Hypoxia Inducible Factor alpha (HIF-1α) regulated pathways by Hexamethylene-bis-acetamide-inducible (HMBA) protein 1 (HEXIM1). Disruption of HEXIM1 activity in a knock-in mouse model expressing a mutant HEXIM1 protein resulted in increased ...

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Regulation of the transcriptional activation of the androgen receptor by the UXT binding protein VHL

21-08-2013 | Chen S; Chen K; Zhang Q; Cheng H; Zhou R, Biochemical Journal, 2013

Loss and/or inactivation of VHL (the von Hippel Lindau tumour suppressor) cause various tumours. Using a yeast two-hybrid system, we have identified an AR co-activator, UXT, as a VHL-interacting protein. GST pull-down and co-immunoprecipitation assays show that UXT interacts with VHL. In ...

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