My watch list
my.chemeurope.com  
Login  

430 Newest Publications of Portland Press

rss
matching the following criteria

Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

01-Mar-2015 | Bauckman K; Haller E; Taran N; Rockfield S; Ruiz-Rivera A; Nanjundan M, Biochemical Journal, 2015

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although ...

more

Small Molecule Inhibitors of ERK-mediated Immediate Early Gene Expression and Proliferation of Melanoma Cells Expressing Mutated BRaf

19-Feb-2015 | Samadani R; Zhang J; Brophy A; Oashi T; Priyakumar U; Raman E; St. John F; Jung K; Fletcher S; Pozharski E; MacKerel ..., Biochemical Journal, 2015

Constitutive activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for ...

more

Regulation of IGFBP-2 expression during fasting

19-Feb-2015 | Kang H; Kim M; Kim S; Lee J; Kim Y; Seo Y; Bae J; Oh G; Song D; Ahn Y; Im S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorder is well known, its regulatory mechanism remains unclear. Here, we ...

more

Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae

15-Feb-2015 | Thota SG; Unnikannan CP; Thampatty SR; Manorama R; Bhandari R, Biochemical Journal, 2015

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol that act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

more

FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

16-Dec-2014 | Ma W; Fuentes G; Shi X; Verma C; Radda G; Han W, Biochemical Journal, 2014

FoxO1, which is upregulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to SP1-POMC promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription. FoxO1 also binds directly to the POMC promoter and ...

more

Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase

15-Dec-2014 | Dodia R; Meunier B; Kay CWM; Rich PR, Biochemical Journal, 2014

Subunit 5 of Saccharomyces cerevisiae cytochrome c oxidase (CcO) is essential for assembly and has two isoforms, 5A and 5B. 5A is expressed under normoxic conditions, whereas 5B is expressed at very low oxygen tensions. As a consequence, COX5A-deleted strains (Δcox5A) have no or only low levels ...

more

A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation

15-Dec-2014 | Huttner S; Veit C; Vavra U; Schoberer J; Dicker M; Maresch D; Altmann F; Strasser R, Biochemical Journal, 2014

N-glycosylation of proteins plays an important role in the determination of the fate of newly synthesized glycoproteins in the endoplasmic reticulum (ER). Specific oligosaccharide structures recruit molecular chaperones that promote folding or mannose-binding lectins that assist in the clearance ...

more

TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-Dec-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...

more

TARP {gamma}-8 glycosylation regulates the surface expression of AMPA receptors

11-Dec-2014 | Zheng C; Chang K; Suh Y; Roche K, Biochemical Journal, 2014

Transmembrane AMPA receptor regulatory protein (TARP) γ-8 is an auxiliary subunit of AMPA receptors that is widely distributed in the hippocampus. It has been shown that TARP γ-8 promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors ...

more

Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that cooperate in a shared-recruitment mechanism.

08-Dec-2014 | Rossiter A; Godfrey R; Connolly J; Busby S; Henderson I; Browning D, Biochemical Journal, 2014

Pet is a cytotoxic autotransporter protein secreted by the pathogenic Enteroaggregative Escherichia coli strain 042. Expression of Pet is co-dependent on two global transcription regulators: CRP (cyclic AMP receptor protein) and Fis (factor for inversion stimulation). At the pet promoter CRP ...

more

Page 1 From 43
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE