My watch list
my.chemeurope.com  
Login  

438 Newest Publications of Portland Press

rss
matching the following criteria

Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

more

Loss of Conserved {Less than}i{Greater than}Gsdma3{Less than}/i{Greater than} Self-Regulation Causes Autophagy and Cell Death

31-Mar-2015 | Shi P; Tang A; Xian L; Hou S; Zou D; Lv Y; Huang Z; Wang Q; Song A; Lin Z; Gao X, Biochemical Journal, 2015

Gsdermin A3 (Gsdma3) was originally identified for associating with hair-loss phenotype in mouse mutants. Our previous study found AE mutant mice, with a Y344H substitution at C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation. Interestingly, we found that the ...

more

Akt-Mediated regulation of antidepressant-sensitive serotonin transporter function, cell surface expression and phosphorylation

12-Mar-2015 | Rajamanickam J; Annamalai B; Rahbek-Clemmensen T; Sundaramurthy S; Gether U; Jayanthi L; Ramamoorthy S, Biochemical Journal, 2015

The serotonin (5-HT) transporter (SERT) controls serotonergic neurotransmission in the brain by rapid clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary target for antidepressants for therapeutic intervention of mood disorders. Our previous studies have ...

more

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

05-Mar-2015 | Richards M; O'Regan L; Roth D; Montgomery J; Straube A; Fry A; Bayliss R, Biochemical Journal, 2015

Proteins of the echinoderm microtubule associated protein-like (EML) family contribute to formation of the mitotic spindle and interphase microtubule (MT) network. EML1-4 consist of WD40 repeats and an N-terminal region containing a putative coiled-coil. Recurrent gene rearrangements in non-small ...

more

Bioenergetic Programming Of Macrophages By The Apolipoprotein A-I Mimetic Peptide 4F

05-Mar-2015 | Datta G; Kramer P; Johnson M; Sawada H; Smythies L; Crossman D; Chacko B; Ballinger S; Westbrook D; Mayakonda P; Ana ..., Biochemical Journal, 2015

The apolipoprotein (apo)A-I mimetic peptide 4F favors the differentiation of human monocytes to an alternatively-activated M2 phenotype. The goal of the current study was to test whether the 4F-mediated differentiation of monocyte-derived macrophages (MDMs) requires the induction of an oxidative ...

more

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

03-Mar-2015 | Stamenkovic J; Andersson L; Adriaenssens A; Bagge A; Sharoyko V; Gribble F; Reimann F; Wollheim C; Mulder H; Sp{e}gel P, Biochemical Journal, 2015

Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 Diabetes, but the mechanisms controlling glucagon secretion from α-cells largely remain unresolved. Therefore, we studied the regulation of glucagon secretion from αTC1-6 cells and compared it to ...

more

Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in {Less than}i{Greater than}Saccharomyces cerevisiae.{Less than}/i{Greater than}

02-Mar-2015 | Ferrer-dalmau J; Randez-Gil F; Marquina M; Prieto J; Casamayor A, Biochemical Journal, 2015

Glc7 is the only catalytic subunit of the protein phosphatase type 1 in the yeast S. cerevisiae and, together with its regulatory subunits, is involved in many and essential processes. Analysis of the non-essential mutants in the regulatory subunits of Glc7 revealed that the lack of Reg1, and no ...

more

Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

01-Mar-2015 | Bauckman K; Haller E; Taran N; Rockfield S; Ruiz-Rivera A; Nanjundan M, Biochemical Journal, 2015

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although ...

more

PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells

23-Feb-2015 | Liu C; Zhang Y; Hou Y; Shen L; Li Y; Guo W; Xu D; Liu G; Zhao Z; Man K; Pan Y; Wang Z; Chen Y, Biochemical Journal, 2015

Histone modification plays important roles in many biological processes such as development and carcinogenesis. Methylation of histone H3 lysine 4 (H3K4) is commonly associated with transcriptional activation of genes. H3K4 methylation in mammalian cells is carried out by COMPASS-like complexes ...

more

Small Molecule Inhibitors of ERK-mediated Immediate Early Gene Expression and Proliferation of Melanoma Cells Expressing Mutated BRaf

19-Feb-2015 | Samadani R; Zhang J; Brophy A; Oashi T; Priyakumar U; Raman E; St. John F; Jung K; Fletcher S; Pozharski E; MacKerel ..., Biochemical Journal, 2015

Constitutive activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for ...

more

Page 1 From 44
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE