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408 Newest Publications of Portland Press

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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Osteopontin mediates mineralization and not osteogenic cell development {Less than}i{Greater than}in vitro{Less than}/i{Greater than}

13-10-2014 | Holm E; Gleberzon J; Liao Y; S{o}rensen E; Beier F; Hunter G; Goldberg H, Biochemical Journal, 2014

Biomineralization is a complex process in the development of mineralized tissues such as bone, and pathological calcifications such as atherosclerotic plaques, kidney stones, gout, and others. Osteopontin (OPN), an anionic phosphoprotein, is expressed in mineralizing tissues and has previously ...

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Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...

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The SARS-Coronavirus Membrane protein induces apoptosis via interfering PDK1-PKB/Akt signaling

01-10-2014 | Tsoi H; Li L; Chen Z; Lau K; Tsui S; Chan H, Biochemical Journal, 2014

A number of viral gene products are capable of inducing apoptosis through interfering with various cellular signaling cascades. We previously reported the pro-apoptotic property of the SARS-CoV Membrane (M) protein and a down-regulation of the phosphorylation level of the cell survival protein ...

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Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20

01-10-2014 | Segawa T; Hazeki K; Nigorikawa K; Morioka S; Guo Y; Takasuga S; Asanuma K; Hazeki O, Biochemical Journal, 2014

Phosphoinositide 5-phosphatases have been implicated in the regulation of phagocytosis. However, their precise roles in the phagocytic process are poorly understood. We prepared RAW264.7 macrophages deficient in Inpp5e (shInpp5e) to clarify the role of this lipid phosphatase. In shInpp5e cells, ...

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DNA polymerase eta is regulated by poly(rC)-binding protein 1 via mRNA stability

30-09-2014 | Ren C; Cho S; Jung Y; Chen X, Biochemical Journal, 2014

DNA polymerase eta (POLH), a target of p53 tumor suppressor, plays a key role in translesion DNA synthesis (TLS). Loss of POLH is responsible for human cancer prone syndrome, Xeroderma Pigmentosum Variant (XPV). Due to its critical role in DNA repair and genome stability, POLH expression and ...

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

01-10-2013 | Sjogren J; Struwe WB; Cosgrave EFJ; Rudd PM; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...

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FGT-1 is the major glucose transporter in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than} and is central to aging pathways

11-09-2013 | Feng Y; Williams B; Koumanov F; Wolstenholme A; Holman G, Biochemical Journal, 2013

Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 receptor for insulin-like peptides and AGE-1 (PI 3-kinase) but the identity of the glucose transporters that may link these processes is ...

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