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402 Newest Publications of Portland Press

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

01-10-2013 | Sjogren J; Struwe WB; Cosgrave EFJ; Rudd PM; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...

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FGT-1 is the major glucose transporter in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than} and is central to aging pathways

11-09-2013 | Feng Y; Williams B; Koumanov F; Wolstenholme A; Holman G, Biochemical Journal, 2013

Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 receptor for insulin-like peptides and AGE-1 (PI 3-kinase) but the identity of the glucose transporters that may link these processes is ...

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HEXIM1 downregulates Hypoxia Inducible Factor-1 alpha protein stability

10-09-2013 | Yeh I; Ogba N; Bensigner H; Welford S; Montano M, Biochemical Journal, 2013

We have previously reported on the inhibition of Hypoxia Inducible Factor alpha (HIF-1α) regulated pathways by Hexamethylene-bis-acetamide-inducible (HMBA) protein 1 (HEXIM1). Disruption of HEXIM1 activity in a knock-in mouse model expressing a mutant HEXIM1 protein resulted in increased ...

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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells

01-09-2013 | Wiejak J; Dunlop J; Mackay SP; Yarwood SJ, Biochemical Journal, 2013

The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) signalling pathway, which is normally down-regulated by the STAT3-dependent ...

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Synthetic Retinoid Am80 Upregulates Apelin Expression by Promoting Interaction of RAR{alpha} with KLF5 and Sp1 in Vascular Smooth Muscle Cells

30-08-2013 | Lv X; Zheng B; Li S; Han A; Wang C; Shi J; Zhang X; Liu Y; Li Y; Wen J, Biochemical Journal, 2013

Previous studies have demonstrated that both retinoids and apelin possess potent cardiovascular properties and that retinoids can mediate the expression of many genes in the cardiovascular system. However, it is not clear whether and how retinoids regulate apelin expression in rat vascular smooth ...

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PKC{delta} as a regulator for TGF-{beta} stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells

29-08-2013 | Lee S; Kang J; Choi S; Kwon O, Biochemical Journal, 2013

Connective tissue growth factor (CTGF) is widely regarded as an important amplifier of the profibrogenic action of transforming growth factor β (TGF-β) in a variety of tissues, although the precise mechanism of how the TGF-β signaling pathways modulates CTGF expression remains unclear. In this ...

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Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

16-08-2013 | Madabushi A; Hwang B; Jin J; Lu A, Biochemical Journal, 2013

Thymine DNA glycosylase (TDG) is an essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation, and transcription regulation. TDG is the predominant enzyme to remove thymine from T/G mispair, which arises due to deamination of 5-methyl-cytosine at the CpG ...

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Mammalian ribosomal and chaperone protein RPS3A counteracts alpha-Synuclein aggregation and toxicity in a yeast model system

07-08-2013 | De Graeve S; Marinelli S; Stolz F; Hendrickx J; Vandamme J; Engelborghs Y; Van Dijck P; Thevelein J, Biochemical Journal, 2013

Accumulation of aggregated forms of alpha-synuclein (αSyn) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson’s disease. When expressed in the yeast Saccharomyces cerevisiae, αSyn interacts with the plasma membrane, forms inclusions and causes a ...

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