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448 Newest Publications of Portland Press

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FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21{Less than}sup{Greater than}Cip1/Waf1{Less than}/sup{Greater than}

20-May-2015 | Kloet D; Polderman P; Eijkelenboom A; Smits L; Van Triest M; Van Den Berg M; Groot Koerkamp M; Van Leenen D; Lijnzaa ..., Biochemical Journal, 2015

Activity of Forkhead box O (FOXO) transcription factors is inhibited by growth factor-PI3K-protein kinase B (PKB)/AKT signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we identified a set of ...

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Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer

13-May-2015 | Babu E; Bhutia Y; Ramachandran S; Gnana-Prakasam J; Prasad P; Thangaraju M; Ganapathy V, Biochemical Journal, 2015

SLC6A14 mediates Na + /Cl --coupled concentrative uptake of a broad-spectrum of amino acids. It is expressed at low levels in many tissues but upregulated in certain cancers. Pharmacologic blockade of SLC6A14 causes amino acid starvation in ER+ breast cancer cells and suppresses their ...

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LRRK2 Dephosphorylation increases its ubiquitination.

05-May-2015 | Zhao J; Molitor T; Langston J; Nichols R, Biochemical Journal, 2015

Activating mutations in the LRRK2 gene are the most common cause of inherited Parkinson’s disease (PD). LRRK2 is phosphorylated on a cluster of phosphosites including Ser910, 935, 955 and 973, which are dephosphorylated in several PD-related LRRK2 mutants [N1347H, R1441C/G, Y1699C and I2020T] ...

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Solution structure of the RNA-binding cold shock domain of the {Less than}i{Greater than}Chlamydomonas reinhardtii {Less than}/i{Greater than}NAB1 protein and insights into RNA recognition

28-Apr-2015 | Sawyer A; Landsberg M; Ross I; Kruse O; Mobli M; Hankamer B, Biochemical Journal, 2015

Light harvesting complex (LHC) proteins are among the most abundant proteins on Earth and play critical roles in photosynthesis, both in light capture and photoprotective mechanisms. The Chlamydomonas reinhardtii nucleic acid-binding protein 1 (NAB1) is a negative regulator of LHC protein ...

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Functional characterization of a mycothiol peroxidase in {Less than}i{Greater than}Corynebacterium glutamicum{Less than}/i{Greater than} that uses both mycoredoxin and thioredoxin reducing systems as proton donor for oxidative stress response

20-Apr-2015 | Si M; Xu Y; Wang T; Long M; Ding W; Chen C; Guan X; Liu Y; Wang Y; Shen X; Liu S, Biochemical Journal, 2015

Previous studies have identified a putative mycothiol peroxidase (MPx) in Corynebacterium glutamicum that shared high sequence similarity to sulfur-containing glutathione peroxidase (CysGPx). In this study we investigated the MPx function by examining its potential peroxidase activity using ...

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Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6

16-Apr-2015 | Wilson M; Kugel S; Huang J; Wilson L; Wloszczynski P; Ye J; Matherly L; Hou Z, Biochemical Journal, 2015

The human proton-coupled folate transporter (hPCFT) is expressed in solid tumors and is active at pHs characterizing the tumor microenvironment. Recent attention focused on exploiting hPCFT for targeting solid tumors with novel cytotoxic antifolates. hPCFT has 12 transmembrane domains (TMDs) and ...

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Erythropoietin mediated expression of Placenta Growth Factor is regulated via activation of hypoxia inducible factor -1{alpha} and post-transcriptionally by mir214 in Sickle Cell Disease

16-Apr-2015 | Gonsalves C; Li C; Mwa Mpollo M; Pullarkat V; Malik P; Tahara S; Kalra V, Biochemical Journal, 2015

Placental growth factor (PlGF) plays an important role in various pathological conditions and diseases such as inflammation, cancer, atherosclerosis and sickle cell disease (SCD). Abnormally high PlGF levels in SCD patients are associated with increased inflammation and pulmonary hypertension and ...

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Lopimune -Induced Mitochondrial Toxicity is attenuated by increased uncoupling protein - 2 level in treated mouse hepatocyes

13-Apr-2015 | El Hoss S; Bahr G; Echtay K, Biochemical Journal, 2015

Though protease inhibitor lopimune has proven to be effective, no studies have examined the side effects of lopimune on mitochondrial bioenergetics in hepatocytes. The objective of this study is to evaluate mitochondrial respiration, production of reactive oxygen species (ROS) and expression of ...

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Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of Interleukin-6 receptor release by A disintegrin and Metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3

07-Apr-2015 | Oldefest M; D{u}sterh{o}ft S; Desel C; Thysen S; Fink C; Rabe B; Lories R; Gr{o}tzinger J; Lorenzen I, Biochemical Journal, 2015

To avoid malformation and disease, tissue development and homeostasis are coordinated precisely in time and space. Secreted Frizzled-related protein 3 (sFRP3), encoded by the Frizzled-related protein gene (FRZB), acts as an antagonist of Wnt signalling in bone development by delaying the ...

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