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72 Newest Publications of Portland Press

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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions

15-08-2013 | Sugden PH; McGuffin LJ; Clerk A, Biochemical Journal, 2013

The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of ...

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Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumor regression

01-07-2013 | Lee H; Kim D; Oh Y; Kwon N; Lee J; Park S; Song J; Lee S; Han J; Park B; Kim S, Biochemical Journal, 2013

Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a potent tumor suppressor, that induces apoptosis in response to various oncogenic signals. AIMP2-DX2, an exon2-deleted splicing variant of AIMP2, is up-regulated in lung cancer and competitively suppresses the ...

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Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I

01-07-2013 | Song L-N; Bowen C; Gelmann EP, Biochemical Journal, 2013

NKX3.1 (NK3 homeobox 1) is a prostate tumour suppressor protein with a number of activities that are critical for its role in tumour suppression. NKX3.1 mediates the cellular response to DNA damage by interacting with ATM (ataxia telangiectasia mutated) and by activation of topoisomerase I. In ...

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ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

18-06-2013 | Halasi M; Wang M; Chavan T; Gaponenko V; Hay N; Gartel A, Biochemical Journal, 2013

N-acetyl-L-cysteine (NAC) is commonly used to identify and test ROS inducers, and to inhibit ROS. In this study, we identified inhibition of proteasome inhibitors as a novel activity of NAC. Both NAC and catalase, another known scavenger of ROS, similarly inhibited ROS levels and apoptosis ...

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Structural and Functional Interactions of the Prostate Cancer Suppressor NKX3.1 with Topoisomerase I

05-04-2013 | Song L; Bowen C; Gelmann E, Biochemical Journal, 2013

NKX3.1 is a prostate tumor suppressor protein that binds to topoisomerase I and enhances its DNA cleavage activity. We show that the NKX3.1 homeodomain binds to a region of topoisomerase I spanning the junction between core and linker domains. NKX3.1 activated N-terminal truncated topoisomerase I ...

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HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage

01-04-2013 | Ju J-h; Yang W; Oh S; Nam K; Lee K-m; Noh D-y; Shin I, Biochemical Journal, 2013

In breast cancer, the HER2 (human epidermal growth factor receptor 2) receptor tyrosine kinase is associated with extremely poor prognosis and survival. Notch signalling has a key role in cell-fate decisions, especially in cancer-initiating cells. The Notch intracellular domain produced by Notch ...

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A requirement for WT Ras Isoforms in mutant KRas-driven signaling and transformation

18-03-2013 | Bentley C; Jurinka S; Kljavin N; Vartanian S; Ramani S; Gonzalez L; Yu K; Modrusan Z; Du P; Bourgon R; Neve R; Stokoe D, Biochemical Journal, 2013

The mutant forms of K, N and HRas are known to drive the initiation and progression of a number of human cancers, but less is known about the role of wild-type (WT) Ras alleles and isoforms in this process. We used zinc finger nucleases targeting HRas and NRas to modify both alleles of these ...

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MicroRNA-138 plays a role in hypoxic pulmonary vascular remodeling by targeting Mst1

13-03-2013 | Li S; Ran Y; Zhang D; Chen J; Zhu D, Biochemical Journal, 2013

Unbalanced apoptosis is a major cause of structural remodeling of vasculatures associated with pulmonary arterial hypertension (PAH), while the underlying mechanisms are still elusive. MicroRNAs (miRNAs) regulate the expression of several proteins that are important for the cell fate including ...

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Sp sites contribute to basal and inducible expression of the human TNF{alpha}-Inducible Protein 3-Interacting Protein 1 (TNIP1) promoter

07-03-2013 | Encarnacao P; Ramirez V; Zhang C; Aneskievich B, Biochemical Journal, 2013

TNFα-induced protein 3-interacting protein 1 (TNIP1) is a corepressor of RAR and PPAR. Additionally, it can reduce signaling stemming from cell membrane receptors such as those for TNFα and EGF. Consequently, it influences a variety of receptor-mediated events as diverse as transcription, ...

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