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75 Newest Publications of Portland Press

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen

03-10-2014 | Radde B; Ivanova M; Mai H; Salabei J; Hill B; Klinge C, Biochemical Journal, 2014

Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated ...

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The SARS-Coronavirus Membrane protein induces apoptosis via interfering PDK1-PKB/Akt signaling

01-10-2014 | Tsoi H; Li L; Chen Z; Lau K; Tsui S; Chan H, Biochemical Journal, 2014

A number of viral gene products are capable of inducing apoptosis through interfering with various cellular signaling cascades. We previously reported the pro-apoptotic property of the SARS-CoV Membrane (M) protein and a down-regulation of the phosphorylation level of the cell survival protein ...

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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions

15-08-2013 | Sugden PH; McGuffin LJ; Clerk A, Biochemical Journal, 2013

The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of ...

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Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I

01-07-2013 | Song L-N; Bowen C; Gelmann EP, Biochemical Journal, 2013

NKX3.1 (NK3 homeobox 1) is a prostate tumour suppressor protein with a number of activities that are critical for its role in tumour suppression. NKX3.1 mediates the cellular response to DNA damage by interacting with ATM (ataxia telangiectasia mutated) and by activation of topoisomerase I. In ...

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Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumor regression

01-07-2013 | Lee H; Kim D; Oh Y; Kwon N; Lee J; Park S; Song J; Lee S; Han J; Park B; Kim S, Biochemical Journal, 2013

Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a potent tumor suppressor, that induces apoptosis in response to various oncogenic signals. AIMP2-DX2, an exon2-deleted splicing variant of AIMP2, is up-regulated in lung cancer and competitively suppresses the ...

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ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

18-06-2013 | Halasi M; Wang M; Chavan T; Gaponenko V; Hay N; Gartel A, Biochemical Journal, 2013

N-acetyl-L-cysteine (NAC) is commonly used to identify and test ROS inducers, and to inhibit ROS. In this study, we identified inhibition of proteasome inhibitors as a novel activity of NAC. Both NAC and catalase, another known scavenger of ROS, similarly inhibited ROS levels and apoptosis ...

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Structural and Functional Interactions of the Prostate Cancer Suppressor NKX3.1 with Topoisomerase I

05-04-2013 | Song L; Bowen C; Gelmann E, Biochemical Journal, 2013

NKX3.1 is a prostate tumor suppressor protein that binds to topoisomerase I and enhances its DNA cleavage activity. We show that the NKX3.1 homeodomain binds to a region of topoisomerase I spanning the junction between core and linker domains. NKX3.1 activated N-terminal truncated topoisomerase I ...

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HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage

01-04-2013 | Ju J-h; Yang W; Oh S; Nam K; Lee K-m; Noh D-y; Shin I, Biochemical Journal, 2013

In breast cancer, the HER2 (human epidermal growth factor receptor 2) receptor tyrosine kinase is associated with extremely poor prognosis and survival. Notch signalling has a key role in cell-fate decisions, especially in cancer-initiating cells. The Notch intracellular domain produced by Notch ...

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