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80 Newest Publications of Portland Press

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Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment

21-11-2014 | Varfolomeev E; Izrael-Tomasevic A; Yu K; Bustos D; Goncharov T; Belmont L; Masselot A; Bakalarski C; Kirkpatrick D; ..., Biochemical Journal, 2014

Evasion of cell death is one crucial capability acquired by tumor cells to ward off anti-tumor therapies, and represents a fundamental challenge to sustaining clinical efficacy for currently available agents. Inhibitor of Apoptosis (IAP) proteins use their ubiquitin E3 ligase activity to promote ...

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C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1{alpha} signaling in acute liver failure

11-11-2014 | Rao J; Zhang C; Wang P; Lu L; Qian X; Qin J; Pan X; Li G; Wang X; Zhang F, Biochemical Journal, 2014

C/EBP Homologous Protein (CHOP) has been shown to be a key molecule in endoplasmic reticulum (ER) stress-mediated apoptosis. ERO1α, a target of CHOP, is an important oxidizing enzyme to regulate ROS, which play a prominent role in hepatocellular death during acute liver failure (ALF). However, ...

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Epithelial MUC1/Muc1 Promotes Cell migration, Reduces Apoptosis and Affects Levels of Mucosal Modulators During Acetylsalicylic Acid (Aspirin) Induced Gastropathy.{Less than}i{Greater than}{Less than}/i{Greater than}

11-11-2014 | Banerjee D; Fernandez H; Patil P; Premaratne P; Quiding-J{a}rbrink M; Lind{e}n S, Biochemical Journal, 2014

MUC1 is a transmembrane mucin highly expressed in the stomach. While extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. Here we showed that acetylsalicylic acid (Aspirin, ASA) upregulated MUC1/Muc1 expression in the ...

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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

29-10-2014 | Knight J; Bastide A; Roobol A; Roobol J; Jackson T; Utami W; Barrett D; Smales C; Willis A, Biochemical Journal, 2014

Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the ...

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Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities

21-10-2014 | Nahomi R; DiMauro M; Wang B; Nagaraj R, Biochemical Journal, 2014

Previous studies have identified peptides in the ‘crystallin-domain’ of the small heat shock protein α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in Hsp20 (71GHFSVLLDVKHFSPEEIAVK91) and Hsp27 (93DRWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin ...

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen

03-10-2014 | Radde B; Ivanova M; Mai H; Salabei J; Hill B; Klinge C, Biochemical Journal, 2014

Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated ...

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The SARS-Coronavirus Membrane protein induces apoptosis via interfering PDK1-PKB/Akt signaling

01-10-2014 | Tsoi H; Li L; Chen Z; Lau K; Tsui S; Chan H, Biochemical Journal, 2014

A number of viral gene products are capable of inducing apoptosis through interfering with various cellular signaling cascades. We previously reported the pro-apoptotic property of the SARS-CoV Membrane (M) protein and a down-regulation of the phosphorylation level of the cell survival protein ...

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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions

15-08-2013 | Sugden PH; McGuffin LJ; Clerk A, Biochemical Journal, 2013

The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of ...

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