15-04-2013 | Bett JS; Ibrahim AFM; Garg AK; Kelly V; Pedrioli P; Rocha S; Hay RT, Biochemical Journal, 2013

HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA. In the present study, we ...

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02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013

PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...

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01-04-2013 | Dingsdale H; Okeke E; Awais M; Haynes L; Criddle DN; Sutton R; Tepikin AV, Biochemical Journal, 2013

We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of ...

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01-04-2013 | Ju J-h; Yang W; Oh S; Nam K; Lee K-m; Noh D-y; Shin I, Biochemical Journal, 2013

In breast cancer, the HER2 (human epidermal growth factor receptor 2) receptor tyrosine kinase is associated with extremely poor prognosis and survival. Notch signalling has a key role in cell-fate decisions, especially in cancer-initiating cells. The Notch intracellular domain produced by ...

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01-04-2013 | Mikhael MR; Soe-Lin S; Apte S; Ponka P, Biochemical Journal, 2013

AI (anaemia of inflammation) often manifests in patients with chronic immune activation due to cancer, chronic infections, autoimmune disorders, rheumatoid arthritis and other diseases. The pathogenesis of AI is complex and involves cytokine-mediated inhibition of erythropoiesis, ...

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22-03-2013 | Andrews P; He Z; Tzenov Y; Popadiuk C; Kao K, Biochemical Journal, 2013

Increased protein synthesis during cell proliferation is accompanied by a compensatory increase in efficient ribosome production, but the mechanisms by which cells adapt to this requirement are not fully understood. Here, we present evidence that Pygopus, a protein originally identified as a ...

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20-03-2013 | Nguyen C; Lang B; Chai R; Vieusseux J; Kouspou M; Price J, Biochemical Journal, 2013

HSF1 is the master regulator of the heat shock response; however, it is also activated by cancer-associated stresses and supports cellular transformation and cancer progression. We examined the role of HSF1 in relation to cancer cell clonogenicity, an important attribute of cancer cells. ...

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12-03-2013 | Beverly L; Howell L; Hernandez-Corbacho M; Casson L; Chipuk J; Siskind L, Biochemical Journal, 2013

Determining mechanistic details about how drugs kill cancer cells is critical for predicting which cancers will respond to given therapeutic regimens and for identifying effective combinations of drugs that more potently kill cancer cells while sparing normal cells. The BCL2-family of ...

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05-03-2013 | Fr{o}hlich C; Klitgaard M; Noer J; Kotzsch A; Nehammer C; Kronqvist P; Berthelsen J; Blobel C; Kveiborg M; Albrechts ..., Biochemical Journal, 2013

ADAM12 is a metalloprotease implicated in cancer progression. ADAM12 can activate membrane-anchored proteins, such as sonic hedgehog, Delta-like 1, and certain epidermal growth factor receptor ligands, through a process called ectodomain shedding. We screened several membrane-anchored ...

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01-03-2013 | Li B; Pi Z; liu L; Zhang B; Huang X; Hu P; Chevet E; Yi P; Liu J, Biochemical Journal, 2013

Induction of Endoplasmic Reticulum (ER) stress-mediated apoptosis in cancer cells represents an alternative approach for cancer therapy. Whether fibroblast growth factor 2 (FGF-2)-induced survival signals may interact with ER stress signalling in cancer cells remains elusive. In this work, we ...

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