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110 Newest Publications of Portland Press

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Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen

03-10-2014 | Radde B; Ivanova M; Mai H; Salabei J; Hill B; Klinge C, Biochemical Journal, 2014

Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated ...

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DNA polymerase eta is regulated by poly(rC)-binding protein 1 via mRNA stability

30-09-2014 | Ren C; Cho S; Jung Y; Chen X, Biochemical Journal, 2014

DNA polymerase eta (POLH), a target of p53 tumor suppressor, plays a key role in translesion DNA synthesis (TLS). Loss of POLH is responsible for human cancer prone syndrome, Xeroderma Pigmentosum Variant (XPV). Due to its critical role in DNA repair and genome stability, POLH expression and ...

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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

15-09-2014 | Bridges HR; Jones AJY; Pollak MN; Hirst J, Biochemical Journal, 2014

The biguanide metformin is widely prescribed for TypeII diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage-specific actions and therapeutic effects, the ...

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Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

15-08-2014 | Purschke WG; Hoehlig K; Buchner K; Zboralski D; Schwoebel F; Vater A; Klussmann S, Biochemical Journal, 2014

The sphingolipid S1P (sphingosine 1-phosphate) is known to be involved in a number of pathophysiological conditions such as cancer, autoimmune diseases and fibrosis. It acts extracellularly through a set of five G-protein-coupled receptors, but its intracellular actions are also well documented. ...

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A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer Triggered by Zinc Channel ZIP6 and Signal Transducer and Activator of Transcription 3 (STAT3)

07-08-2013 | Hogstrand C; Kille P; Ackland M; Hiscox S; Taylor K, Biochemical Journal, 2013

Genes involved in normal developmental processes attract attention as mediators of tumour progression as they facilitate migration of tumour cells. Epithelial-mesenchymal transition (EMT), an essential part of embryonic development, tissue remodelling and wound repair, is crucial for tumour ...

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Evidence of a novel role for Pygopus in rRNA transcription

01-07-2013 | Andrews PGP; He Z; Tzenov YR; Popadiuk C; Kao KR, Biochemical Journal, 2013

Increased protein synthesis during cell proliferation is accompanied by a compensatory increase in efficient ribosome production, but the mechanisms by which cells adapt to this requirement are not fully understood. In the present study, we demonstrate evidence that Pygo (Pygopus), a protein ...

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The Type III TGF-{beta} receptor regulates filopodia formation via a Cdc42-mediated IRSP53: NWASP interaction in epithelial cells

10-06-2013 | Oh S; Knelson E; Blobe G; Mythreye K, Biochemical Journal, 2013

Cell adhesion and migration are tightly controlled by regulated changes in the actin cytoskeleton. Previously we reported that the TGF-β superfamily coreceptor, the type III TGF-β receptor (TβRIII/betaglycan), regulates cell adhesion, migration and invasion and suppresses cancer progression in ...

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The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

15-04-2013 | Bett JS; Ibrahim AFM; Garg AK; Kelly V; Pedrioli P; Rocha S; Hay RT, Biochemical Journal, 2013

HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA. In the present study, we have ...

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PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013

PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...

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Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes

01-04-2013 | Mikhael MR; Soe-Lin S; Apte S; Ponka P, Biochemical Journal, 2013

AI (anaemia of inflammation) often manifests in patients with chronic immune activation due to cancer, chronic infections, autoimmune disorders, rheumatoid arthritis and other diseases. The pathogenesis of AI is complex and involves cytokine-mediated inhibition of erythropoiesis, insufficient ...

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