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106 Newest Publications of Portland Press

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A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer Triggered by Zinc Channel ZIP6 and Signal Transducer and Activator of Transcription 3 (STAT3)

07-08-2013 | Hogstrand C; Kille P; Ackland M; Hiscox S; Taylor K, Biochemical Journal, 2013

Genes involved in normal developmental processes attract attention as mediators of tumour progression as they facilitate migration of tumour cells. Epithelial-mesenchymal transition (EMT), an essential part of embryonic development, tissue remodelling and wound repair, is crucial for tumour ...

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Evidence of a novel role for Pygopus in rRNA transcription

01-07-2013 | Andrews PGP; He Z; Tzenov YR; Popadiuk C; Kao KR, Biochemical Journal, 2013

Increased protein synthesis during cell proliferation is accompanied by a compensatory increase in efficient ribosome production, but the mechanisms by which cells adapt to this requirement are not fully understood. In the present study, we demonstrate evidence that Pygo (Pygopus), a protein ...

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The Type III TGF-{beta} receptor regulates filopodia formation via a Cdc42-mediated IRSP53: NWASP interaction in epithelial cells

10-06-2013 | Oh S; Knelson E; Blobe G; Mythreye K, Biochemical Journal, 2013

Cell adhesion and migration are tightly controlled by regulated changes in the actin cytoskeleton. Previously we reported that the TGF-β superfamily coreceptor, the type III TGF-β receptor (TβRIII/betaglycan), regulates cell adhesion, migration and invasion and suppresses cancer progression in ...

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The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

15-04-2013 | Bett JS; Ibrahim AFM; Garg AK; Kelly V; Pedrioli P; Rocha S; Hay RT, Biochemical Journal, 2013

HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA. In the present study, we have ...

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PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013

PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...

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Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes

01-04-2013 | Mikhael MR; Soe-Lin S; Apte S; Ponka P, Biochemical Journal, 2013

AI (anaemia of inflammation) often manifests in patients with chronic immune activation due to cancer, chronic infections, autoimmune disorders, rheumatoid arthritis and other diseases. The pathogenesis of AI is complex and involves cytokine-mediated inhibition of erythropoiesis, insufficient ...

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HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage

01-04-2013 | Ju J-h; Yang W; Oh S; Nam K; Lee K-m; Noh D-y; Shin I, Biochemical Journal, 2013

In breast cancer, the HER2 (human epidermal growth factor receptor 2) receptor tyrosine kinase is associated with extremely poor prognosis and survival. Notch signalling has a key role in cell-fate decisions, especially in cancer-initiating cells. The Notch intracellular domain produced by Notch ...

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Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells

01-04-2013 | Dingsdale H; Okeke E; Awais M; Haynes L; Criddle DN; Sutton R; Tepikin AV, Biochemical Journal, 2013

We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating ...

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Evidence of a novel role for Pygopus in ribosomal RNA transcription

22-03-2013 | Andrews P; He Z; Tzenov Y; Popadiuk C; Kao K, Biochemical Journal, 2013

Increased protein synthesis during cell proliferation is accompanied by a compensatory increase in efficient ribosome production, but the mechanisms by which cells adapt to this requirement are not fully understood. Here, we present evidence that Pygopus, a protein originally identified as a core ...

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Heat Shock Factor 1 Impacts Both Positively and Negatively Upon Cellular Clonogenic Growth Depending Upon p53 Status

20-03-2013 | Nguyen C; Lang B; Chai R; Vieusseux J; Kouspou M; Price J, Biochemical Journal, 2013

HSF1 is the master regulator of the heat shock response; however, it is also activated by cancer-associated stresses and supports cellular transformation and cancer progression. We examined the role of HSF1 in relation to cancer cell clonogenicity, an important attribute of cancer cells. Ectopic ...

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