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128 Newest Publications of Portland Press

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Acyl-CoA Binding Domain Containing 3 Modulates NAD{+} Metabolism through Activating Poly(ADP-ribose) Polymerase 1

05-May-2015 | Chen Y; Bang S; Park S; Shi H; Kim S, Biochemical Journal, 2015

Nicotinadmide adenine dinucleotide (NAD+) plays essential roles in cellular energy homeostasis and redox state functioning as a cofactor along the glycolysis and citric acid cycle pathways. Recent discoveries indicated that, through the NAD+-consuming enzymes, this molecule may be also involved ...

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Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells {Less than}i{Greater than}ex vivo{Less than}/i{Greater than} through inhibition of {Less than}i{Greater than}de novo{Less than}/i{Greater than} lipogenesis

05-May-2015 | O'Brien A; Villani L; Broadfield L; Houde V; Galic S; Blandino G; Kemp B; Tsakaridis T; Muti P; Steinberg G, Biochemical Journal, 2015

Aspirin, the pro-drug of salicylate, is associated with reduced incidence of death from cancers of the colon, lung and prostate and is commonly prescribed in combination with metformin in individuals with type 2 diabetes. Salicylate activates the AMP-activated protein kinase (AMPK) by binding at ...

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Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

01-May-2015 | Bulatov E; Ciulli A, Biochemical Journal, 2015

In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. CRLs [Cullin-RING (really interesting new gene) ...

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Erythropoietin mediated expression of Placenta Growth Factor is regulated via activation of hypoxia inducible factor -1{alpha} and post-transcriptionally by mir214 in Sickle Cell Disease

16-Apr-2015 | Gonsalves C; Li C; Mwa Mpollo M; Pullarkat V; Malik P; Tahara S; Kalra V, Biochemical Journal, 2015

Placental growth factor (PlGF) plays an important role in various pathological conditions and diseases such as inflammation, cancer, atherosclerosis and sickle cell disease (SCD). Abnormally high PlGF levels in SCD patients are associated with increased inflammation and pulmonary hypertension and ...

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The Tumor Suppressor CHD5 Forms a NuRD-type Chromatin Remodeling Complex

31-Mar-2015 | Kolla V; Naraparaju K; Zhuang T; Higashi M; Kolla S; Blobel G; Brodeur G, Biochemical Journal, 2015

Eukaryotic gene expression is developmentally regulated, in part by chromatin remodeling, and its dysregulation has been linked to cancer. CHD5 is a tumour suppressor gene that maps to a region of consistent deletion on 1p36.31 in neuroblastomas (NBs) and other tumour types. CHD5 encodes a ...

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Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

15-Mar-2015 | Bett JS; Ritorto MS; Ewan R; Jaffray EG; Virdee S; Chin JW; Knebel A; Kurz T; Trost M; Tatham MH; Hay RT, Biochemical Journal, 2015

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

01-Mar-2015 | Bauckman K; Haller E; Taran N; Rockfield S; Ruiz-Rivera A; Nanjundan M, Biochemical Journal, 2015

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although ...

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PT-1 selectively activates AMPK-{gamma}1 complexes in mouse skeletal muscle, but activates all three {gamma} subunit complexes in cultured human cells by inhibiting the respiratory chain

19-Feb-2015 | Jensen T; Ross F; Kleinert M; Sylow L; Knudsen J; Gowans G; Hardie D; Richter E, Biochemical Journal, 2015

AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α1/α2) is bound to one of two b subunits (β1/β2) and one of three γ subunits (γ1/γ2/γ3). The ability to selectively activate specific isoforms would be a useful research tool, and a promising ...

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Small Molecule Inhibitors of ERK-mediated Immediate Early Gene Expression and Proliferation of Melanoma Cells Expressing Mutated BRaf

19-Feb-2015 | Samadani R; Zhang J; Brophy A; Oashi T; Priyakumar U; Raman E; St. John F; Jung K; Fletcher S; Pozharski E; MacKerel ..., Biochemical Journal, 2015

Constitutive activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for ...

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The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

15-Jan-2015 | Ozanne J; Prescott AR; Clark K, Biochemical Journal, 2015

Macrophages switch to an anti-inflammatory, 'regulatory'-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential therapeutic strategy for the treatment of chronic ...

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