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123 Newest Publications of Portland Press
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Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
01-06-2013 | Reeks J; Sokolowski RD; Graham S; Liu H; Naismith JH; White MF, Biochemical Journal, 2013
The competition between viruses and hosts is played out in all branches of life. Many prokaryotes have an adaptive immune system termed 'CRISPR' (clustered regularly interspaced short palindromic repeats) which is based on the capture of short pieces of viral DNA. The captured DNA is ...
Convergent Evolution of Chromatin Modification by Structurally Distinct Enzymes: Comparative Enzymology of Histone 3 Lysine 27 Methylation by Human Polycomb Repressive Complex 2 and Viral vSET
17-05-2013 | Swalm B; Hallenbeck K; Majer C; Jin L; Scott M; Moyer M; Copeland R; Wigle T, Biochemical Journal, 2013
Histone H3 lysine 27 (H3K27) methylation is an important epigenetic modification that regulates gene transcription. In humans, EZH1 and EZH2 are the only enzymes capable of catalyzing methylation of H3K27. There is great interest in understanding structure-function relationships for EZH2, as ...
MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein
01-05-2013 | Han K; Ayer D, Biochemical Journal, 2013
The MondoA:Mlx transcription complex plays a pivotal role in glucose homeostasis by activating target gene expression in response to glucose-6-phosphate (G6P), the first reaction intermediate in glycolysis. Thioredoxin-interacting protein (TXNIP) is a direct and glucose-responsive target of ...
Ube2W conjugates ubiquitin to {alpha}-amino groups of protein N-termini
08-04-2013 | Tatham M; Plechanovov{a} A; Jaffray E; Salmen H; Hay R, Biochemical Journal, 2013
The covalent attachment of the protein ubiquitin to intracellular proteins by a process known as ubiquitylation regulates almost all major cellular systems, predominantly by regulating protein turnover. Ubiquitylation requires the coordinated action of three enzymes termed E1, E2 and E3, and ...
Inhibition of{Less than}i{Greater than} Plasmodium falciparum{Less than}/i{Greater than} CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development
03-04-2013 | Azevedo M; Sanders P; Krejany E; Nie C; Fu P; Bach L; Wunderlich G; Crabb B; Gilson P, Biochemical Journal, 2013
Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) is highly expressed in parasite asexual blood and mosquito stages. Its role is still poorly understood, but unsuccessful gene knockout attempts suggest it is essential for schizont development and/or RBC invasion. Here, by ...
The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells
01-04-2013 | Probst OC; Karayel E; Schida N; Nimmerfall E; Hehenberger E; Puxbaum V; Mach L, Biochemical Journal, 2013
The M6P (mannose 6-phosphate)/IGF2R (insulin-like growth factor II receptor) interacts with a variety of factors that impinge on tumour invasion and metastasis. It has been shown that expression of wild-type M6P/IGF2R reduces the tumorigenic and invasive properties of receptor-deficient ...
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
25-03-2013 | Reeks J; Sokolowski R; Graham S; Liu H; Naismith J; White M, Biochemical Journal, 2013
The competition between viruses and hosts is played out in all branches of life. Many prokaryotes have an adaptive immune system termed “CRISPR” which is based on the capture of short pieces of viral DNA. The captured DNA is integrated into the genomic DNA of the organism flanked by direct ...
FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells
12-03-2013 | Su J; Guise C; Wilson W, Biochemical Journal, 2013
One-electron reductases that reduce nitro compounds in hypoxic human tumour cells are poorly characterised, but are important for targeting hypoxia with nitroaromatic prodrugs. Fluorogenic probes with defined reductase profiles are needed to interrogate the activity of these enzymes in intact ...
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
01-03-2013 | Broder C; Becker-Pauly C, Biochemical Journal, 2013
The metalloproteases meprin α and meprin β exhibit structural and functional features that are unique among all extracellular proteases. Although meprins were discovered more than 30years ago, their precise substrates and physiological roles have been elusive. Both enzymes were originally ...
Identification of an 8-vinyl reductase involved in bacteriochlorophyll biosynthesis in Rhodobacter sphaeroides and evidence for the existence of a third distinct class of the enzyme
01-03-2013 | Canniffe DP; Jackson PJ; Hollingshead S; Dickman MJ; Hunter CN, Biochemical Journal, 2013
The purple phototrophic bacterium Rhodobacter sphaeroides utilises bacteriochlorophyll a for light harvesting and photochemistry. The synthesis of this photopigment includes the reduction of a vinyl group at the C8 position to an ethyl group, catalysed by a C8-vinyl reductase. An active form ...
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