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89 Newest Publications of Portland Press

matching the following criteria

Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...


Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

03-Mar-2015 | Stamenkovic J; Andersson L; Adriaenssens A; Bagge A; Sharoyko V; Gribble F; Reimann F; Wollheim C; Mulder H; Sp{e}gel P, Biochemical Journal, 2015

Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 Diabetes, but the mechanisms controlling glucagon secretion from α-cells largely remain unresolved. Therefore, we studied the regulation of glucagon secretion from αTC1-6 cells and compared it to ...


Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in {Less than}i{Greater than}Saccharomyces cerevisiae.{Less than}/i{Greater than}

02-Mar-2015 | Ferrer-dalmau J; Randez-Gil F; Marquina M; Prieto J; Casamayor A, Biochemical Journal, 2015

Glc7 is the only catalytic subunit of the protein phosphatase type 1 in the yeast S. cerevisiae and, together with its regulatory subunits, is involved in many and essential processes. Analysis of the non-essential mutants in the regulatory subunits of Glc7 revealed that the lack of Reg1, and no ...


PT-1 selectively activates AMPK-{gamma}1 complexes in mouse skeletal muscle, but activates all three {gamma} subunit complexes in cultured human cells by inhibiting the respiratory chain

19-Feb-2015 | Jensen T; Ross F; Kleinert M; Sylow L; Knudsen J; Gowans G; Hardie D; Richter E, Biochemical Journal, 2015

AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α1/α2) is bound to one of two b subunits (β1/β2) and one of three γ subunits (γ1/γ2/γ3). The ability to selectively activate specific isoforms would be a useful research tool, and a promising ...


The insulinotropic effect of insulin-like peptide 5 {Less than}i{Greater than}in vitro{Less than}/i{Greater than} and {Less than}i{Greater than}in vivo{Less than}/i{Greater than}

17-Dec-2014 | Luo X; Li T; Zhu Y; Dai Y; Zhao J; Guo Z; Wang M, Biochemical Journal, 2014

Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein coupled receptor RXFP4, but its precise biological functions are largely unknown. Recent studies suggest that the INSL5/RXFP4 is involved in the control of food intake and glucose homeostasis. ...


TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-Dec-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...


{Less than}i{Greater than}nhr-176{Less than}/i{Greater than} regulates {Less than}i{Greater than}cyp-35d1{Less than}/i{Greater than} to control hydroxylation-dependent metabolism of thiabendazole in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than}

19-Nov-2014 | Jones L; Flemming A; Urwin P, Biochemical Journal, 2014

Knowledge of how drugs are metabolised and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole to be commercially available and remains one of the most important anthelmintic drugs for ...


The ubiquitin proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta cells

12-Sep-2013 | Hofmeister-Brix A; Lenzen S; Baltrusch S, Biochemical Journal, 2013

The ubiquitin proteasome system is important to maintain pancreatic beta cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulus-secretion cascade seem to be affected by protein misfolding, if the proteasome is ...


FGT-1 is the major glucose transporter in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than} and is central to aging pathways

11-Sep-2013 | Feng Y; Williams B; Koumanov F; Wolstenholme A; Holman G, Biochemical Journal, 2013

Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 receptor for insulin-like peptides and AGE-1 (PI 3-kinase) but the identity of the glucose transporters that may link these processes is ...


Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

27-Aug-2013 | Bartolom{e} A; L{o}pez-Herrad{o}n A; Portal-N{u}{n}ez S; Garc{i}a-Aguilar A; Esbrit P; Benito M; Guill{e}n C, Biochemical Journal, 2013

Autophagy is a highly regulated homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered as an important pro-survival mechanism under diverse stress conditions. A diabetic milieu is known to hamper osteoblast viability and ...


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