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89 Newest Publications of Portland Press

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Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...

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Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

03-Mar-2015 | Stamenkovic J; Andersson L; Adriaenssens A; Bagge A; Sharoyko V; Gribble F; Reimann F; Wollheim C; Mulder H; Sp{e}gel P, Biochemical Journal, 2015

Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 Diabetes, but the mechanisms controlling glucagon secretion from α-cells largely remain unresolved. Therefore, we studied the regulation of glucagon secretion from αTC1-6 cells and compared it to ...

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Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in {Less than}i{Greater than}Saccharomyces cerevisiae.{Less than}/i{Greater than}

02-Mar-2015 | Ferrer-dalmau J; Randez-Gil F; Marquina M; Prieto J; Casamayor A, Biochemical Journal, 2015

Glc7 is the only catalytic subunit of the protein phosphatase type 1 in the yeast S. cerevisiae and, together with its regulatory subunits, is involved in many and essential processes. Analysis of the non-essential mutants in the regulatory subunits of Glc7 revealed that the lack of Reg1, and no ...

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PT-1 selectively activates AMPK-{gamma}1 complexes in mouse skeletal muscle, but activates all three {gamma} subunit complexes in cultured human cells by inhibiting the respiratory chain

19-Feb-2015 | Jensen T; Ross F; Kleinert M; Sylow L; Knudsen J; Gowans G; Hardie D; Richter E, Biochemical Journal, 2015

AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α1/α2) is bound to one of two b subunits (β1/β2) and one of three γ subunits (γ1/γ2/γ3). The ability to selectively activate specific isoforms would be a useful research tool, and a promising ...

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The insulinotropic effect of insulin-like peptide 5 {Less than}i{Greater than}in vitro{Less than}/i{Greater than} and {Less than}i{Greater than}in vivo{Less than}/i{Greater than}

17-Dec-2014 | Luo X; Li T; Zhu Y; Dai Y; Zhao J; Guo Z; Wang M, Biochemical Journal, 2014

Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein coupled receptor RXFP4, but its precise biological functions are largely unknown. Recent studies suggest that the INSL5/RXFP4 is involved in the control of food intake and glucose homeostasis. ...

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TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-Dec-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...

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{Less than}i{Greater than}nhr-176{Less than}/i{Greater than} regulates {Less than}i{Greater than}cyp-35d1{Less than}/i{Greater than} to control hydroxylation-dependent metabolism of thiabendazole in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than}

19-Nov-2014 | Jones L; Flemming A; Urwin P, Biochemical Journal, 2014

Knowledge of how drugs are metabolised and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole to be commercially available and remains one of the most important anthelmintic drugs for ...

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The ubiquitin proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta cells

12-Sep-2013 | Hofmeister-Brix A; Lenzen S; Baltrusch S, Biochemical Journal, 2013

The ubiquitin proteasome system is important to maintain pancreatic beta cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulus-secretion cascade seem to be affected by protein misfolding, if the proteasome is ...

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FGT-1 is the major glucose transporter in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than} and is central to aging pathways

11-Sep-2013 | Feng Y; Williams B; Koumanov F; Wolstenholme A; Holman G, Biochemical Journal, 2013

Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 receptor for insulin-like peptides and AGE-1 (PI 3-kinase) but the identity of the glucose transporters that may link these processes is ...

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Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

27-Aug-2013 | Bartolom{e} A; L{o}pez-Herrad{o}n A; Portal-N{u}{n}ez S; Garc{i}a-Aguilar A; Esbrit P; Benito M; Guill{e}n C, Biochemical Journal, 2013

Autophagy is a highly regulated homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered as an important pro-survival mechanism under diverse stress conditions. A diabetic milieu is known to hamper osteoblast viability and ...

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