01-05-2013 | Han K; Ayer D, Biochemical Journal, 2013

The MondoA:Mlx transcription complex plays a pivotal role in glucose homeostasis by activating target gene expression in response to glucose-6-phosphate (G6P), the first reaction intermediate in glycolysis. Thioredoxin-interacting protein (TXNIP) is a direct and glucose-responsive target of ...

more

28-03-2013 | Rahimpour M; Montero M; Almagro G; Viale A; Sevilla A; C{a}novas M; Mu{n}oz F; Baroja-Fern{a}ndez E; Bahaji A; Eydal ..., Biochemical Journal, 2013

Escherichia coli glycogen metabolism involves regulation of the glgBXCAP operon expression and allosteric control of GlgC-mediated catalysis of ATP and glucose-1-phosphate (G1P) to ADP-glucose linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected by glgS. Though the ...

more

28-03-2013 | Suzuki K; Sumitani J; Nam Y; Nishimaki T; Tani S; Wakagi T; Kawaguchi T; Fushinobu S, Biochemical Journal, 2013

Glycoside hydrolase family 3 (GH3) beta-glucosidases (BGLs) from filamentous fungi have been widely and commercially used for supplementation of cellulases. BGL from the fungus Aspergillus aculeatus (AaBGL1) belongs to GH3 and shows high activity toward cellooligosaccharides up to high degree ...

more

15-03-2013 | Bermejo C; Haerizadeh F; Sadoine M; Chermak D; Frommer W, Biochemical Journal, 2013

Successful colonization and survival in variable environments require a competitive advantage during the initial growth phase after experiencing nutrient changes. Starved yeast cells anticipate exposure to glucose by activating the Hxt5p glucose transporter, which provides an advantage during ...

more

01-03-2013 | Kitaguchi T; Oya M; Wada Y; Tsuboi T; Miyawaki A, Biochemical Journal, 2013

Intracellular cAMP and Ca2+ are important second messengers that regulate insulin secretion in pancreatic β-cells; however, the molecular mechanism underlying their mutual interaction for exocytosis is not fully understood. In the present study, we investigated the interplay between ...

more

15-02-2013 | Garcia-Sanz P; Fernandez-Perez A; Vallejo M, Biochemical Journal, 2013

During embryonic development, the aristaless-type homeodomain protein Alx3 is expressed in the forehead mesenchyme and contributes to the regulation of craniofacial development. In the adult, Alx3 is expressed in pancreatic islets where it participates in the control of glucose homoeostasis. ...

more

15-02-2013 | Kopycki J; Wieduwild E; Kohlschmidt J; Brandt W; Stepanova AN; Alonso JM; Pedras MSC; Abel S; Grubb CD, Biochemical Journal, 2013

Plant genomes encode numerous small molecule glycosyltransferases which modulate the solubility, activity, immunogenicity and/or reactivity of hormones, xenobiotics and natural products. The products of these enzymes can accumulate to very high concentrations, yet somehow avoid inhibiting ...

more

07-02-2013 | Kim S; Ao Z; Warnock G; McIntosh C, Biochemical Journal, 2013

The incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gastrointestinal hormones conferring a number of beneficial effects on β-cell secretion, survival and proliferation. In an earlier study, it was demonstrated that delayed rectifier ...

more

01-02-2013 | Cognard E; Dargaville CG; Hay DL; Shepherd PR, Biochemical Journal, 2013

Pancreatic β-cells are highly responsive to changes in glucose, but the mechanisms involved are only partially understood. There is increasing evidence that the β-catenin signalling pathway plays an important role in regulating β-cell function, but the mechanisms regulating β-catenin ...

more

03-01-2013 | Kitaguchi T; Oya M; Wada Y; Tsuboi T; Miyawaki A, Biochemical Journal, 2013

Intracellular cAMP and Ca2+ are important second messengers that regulate insulin secretion in pancreatic β cells. However, the molecular mechanism underlying their mutual interaction for exocytosis is not fully understood. In this study, we investigated the interplay between intracellular ...

more