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82 Newest Publications of Portland Press

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The ubiquitin proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta cells

12-09-2013 | Hofmeister-Brix A; Lenzen S; Baltrusch S, Biochemical Journal, 2013

The ubiquitin proteasome system is important to maintain pancreatic beta cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulus-secretion cascade seem to be affected by protein misfolding, if the proteasome is ...

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FGT-1 is the major glucose transporter in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than} and is central to aging pathways

11-09-2013 | Feng Y; Williams B; Koumanov F; Wolstenholme A; Holman G, Biochemical Journal, 2013

Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2 receptor for insulin-like peptides and AGE-1 (PI 3-kinase) but the identity of the glucose transporters that may link these processes is ...

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Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

27-08-2013 | Bartolom{e} A; L{o}pez-Herrad{o}n A; Portal-N{u}{n}ez S; Garc{i}a-Aguilar A; Esbrit P; Benito M; Guill{e}n C, Biochemical Journal, 2013

Autophagy is a highly regulated homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered as an important pro-survival mechanism under diverse stress conditions. A diabetic milieu is known to hamper osteoblast viability and ...

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TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

05-08-2013 | Cheng K; Lam K; Wang Y; Wu D; Zhang M; Wang B; Li X; Hoo R; Huang Z; Sweeney G; Xu A, Biochemical Journal, 2013

Insulin inhibits hepatic glucose production through activation of the protein kinase Akt, and any defect in this pathway causes fasting hyperglycemia in type 2 diabetes. The adaptor protein APPL1 sensitizes hepatic insulin action on suppression of gluconeogenesis by binding to Akt. However, the ...

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Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

01-08-2013 | Liu Y; Lai Y; Hill E; Tyteca D; Carpentier S; Ingvaldsen A; Vertommen D; Lantier L; Foretz M; Dequiedt F; Courtoy P; ..., Biochemical Journal, 2013

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), the lipid kinase that phosphorylates PtdIns3P to PtdIns(3,5)P2, has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMP-activated protein kinase (AMPK)-stimulated ...

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SatP (YaaH), a succinate-acetate transporter protein in {Less than}i{Greater than}Escherichia coli{Less than}/i{Greater than}

11-07-2013 | S{a}-Pessoa J; Paiva S; Ribas D; Silva I; Viegas S; Arraiano C; Casal M, Biochemical Journal, 2013

In this work we describe a new carboxylic acid transporter in Escherichia coli encoded by the gene yaaH. In contrast to what had been described for other YaaH family members, the E. coli transporter is highly specific for acetic acid (a monocarboxylate) and for succinic acid (a dicarboxylate), ...

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Diacylglycerol Kinase-{theta} Couples FXR-Dependent Bile Acid Signaling to Akt Activation and Glucose Homeostasis in Hepatocytes

17-06-2013 | Cai K; Sewer M, Biochemical Journal, 2013

Diacylglycerol kinases (DGKs) catalyze the conversion of diacylglycerol into phosphatidic acid (PA), a positive modulator of mammalian target of rapamycin (mTOR). We have found that chenodeoxycholic acid and the synthetic farnesoid X receptor (FXR) ligand GW4064 induce the mRNA and protein ...

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Metabolic phenotypes of {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} mutants with altered trehalose-6-phosphate dynamics

14-06-2013 | Walther T; Mtimet N; Alkim C; Vax A; Loret M; Ullah A; Gancedo C; Smits G; Fran{c with cedilla}ois J, Biochemical Journal, 2013

In Saccharomyces cerevisiae, synthesis of trehalose-6-phosphate (T6P) is essential for growth on most fermentable carbon sources. The metabolic response to glucose was analysed in mutants with different capacity to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, ...

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MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein

01-05-2013 | Han K; Ayer D, Biochemical Journal, 2013

The MondoA:Mlx transcription complex plays a pivotal role in glucose homeostasis by activating target gene expression in response to glucose-6-phosphate (G6P), the first reaction intermediate in glycolysis. Thioredoxin-interacting protein (TXNIP) is a direct and glucose-responsive target of ...

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Crystal Structures of Glycoside Hydrolase Family 3 beta-Glucosidase 1 from {Less than}i{Greater than}Aspergillus aculeatus{Less than}/i{Greater than}

28-03-2013 | Suzuki K; Sumitani J; Nam Y; Nishimaki T; Tani S; Wakagi T; Kawaguchi T; Fushinobu S, Biochemical Journal, 2013

Glycoside hydrolase family 3 (GH3) beta-glucosidases (BGLs) from filamentous fungi have been widely and commercially used for supplementation of cellulases. BGL from the fungus Aspergillus aculeatus (AaBGL1) belongs to GH3 and shows high activity toward cellooligosaccharides up to high degree of ...

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