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160 Newest Publications of Portland Press

matching the following criteria

Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...


PKC{delta} as a regulator for TGF-{beta} stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells

29-08-2013 | Lee S; Kang J; Choi S; Kwon O, Biochemical Journal, 2013

Connective tissue growth factor (CTGF) is widely regarded as an important amplifier of the profibrogenic action of transforming growth factor β (TGF-β) in a variety of tissues, although the precise mechanism of how the TGF-β signaling pathways modulates CTGF expression remains unclear. In this ...


Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a {beta}-thujaplicinol analog

09-08-2013 | Herman B; Sluis-Cremer N, Biochemical Journal, 2013

Efavirenz (EFV) and β-thujaplicinol have contrasting effects on the ribonuclease H (RNase H) activity of HIV-1 reverse transcriptase (RT). EFV binds in the nonnucleoside inhibitor binding pocket and accelerates this activity, whereas β-thujaplicinol binds in the RNase H active site and inhibits ...


Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

01-08-2013 | Liu Y; Lai Y; Hill E; Tyteca D; Carpentier S; Ingvaldsen A; Vertommen D; Lantier L; Foretz M; Dequiedt F; Courtoy P; ..., Biochemical Journal, 2013

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), the lipid kinase that phosphorylates PtdIns3P to PtdIns(3,5)P2, has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMP-activated protein kinase (AMPK)-stimulated ...


Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca2+-dependent activation of platelet Rap1b GTPase

01-07-2013 | Guidetti GF; Manganaro D; Consonni A; Canobbio I; Balduini C; Torti M, Biochemical Journal, 2013

In blood platelets the small GTPase Rap1b is activated by cytosolic Ca2+ and promotes integrin αIIbβ3 inside-out activation and platelet aggregation. cAMP is the major inhibitor of platelet function and antagonizes Rap1b stimulation through a mechanism that remains unclear. In the present study ...


Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to the aerotoxic syndrome: Kinetic and molecular dynamics studies

20-06-2013 | Masson P; Lushchekina S; Schopfer L; Lockridge O, Biochemical Journal, 2013

Cresyl saligenin phosphate (CSP) is an irreversible inhibitor of human butyrylcholinesterase (BChE) that has been involved in the aerotoxic syndrome. Inhibition under pseudo-first order conditions is biphasic reflecting a slow equilibrium between two enzyme states E and E’. The elementary ...


ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

18-06-2013 | Halasi M; Wang M; Chavan T; Gaponenko V; Hay N; Gartel A, Biochemical Journal, 2013

N-acetyl-L-cysteine (NAC) is commonly used to identify and test ROS inducers, and to inhibit ROS. In this study, we identified inhibition of proteasome inhibitors as a novel activity of NAC. Both NAC and catalase, another known scavenger of ROS, similarly inhibited ROS levels and apoptosis ...


Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

15-06-2013 | Sommer EM; Dry H; Cross D; Guichard S; Davies BR; Alessi DR, Biochemical Journal, 2013

The majority of human cancers harbour mutations promoting activation of the Akt protein kinase, and Akt inhibitors are being evaluated in clinical trials. An important question concerns the understanding of the innate mechanisms that confer resistance of tumour cells to Akt inhibitors. SGK ...


Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance

12-06-2013 | Stogios P; Spanogiannopoulos P; Evdokimova E; Egorova O; Shakya T; Todorovic N; Capretta A; Wright G; Savchenko A, Biochemical Journal, 2013

Activity of the aminoglycoside phosphotransferase APH(3’)-Ia leads to resistance to aminoglycoside antibiotics in pathogenic Gram-negative bacteria, and contributes to the clinical obsolescence of this class of antibiotics. One strategy to rescuing compromised antibiotics such as aminoglycosides ...


Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif

03-06-2013 | Wang J; Zhong C; Wang F; Qu F; Ding J, Biochemical Journal, 2013

The activity of the ribosome protein subunit 6 kinase 1 (S6K1) is stimulated by phosphorylation of Thr389 in the hydrophobic motif by mTORC1 and phosphorylation of Thr229 in the activation loop by PDK1; however, the order of the two events is still ambiguous. Here we report six crystal structures ...


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