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166 Newest Publications of Portland Press

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Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression

23-10-2014 | Almahariq M; Mei F; Wang H; Cao A; Yao S; Soong L; Sun J; Cong Y; Chen J; Cheng X, Biochemical Journal, 2014

The cyclic adenosine monophosphate (cAMP) signaling pathway plays an essential role in immune functions. In this study we examined the role of the cAMP/EPAC1 (exchange protein directly activated by cAMP) axis in regulatory T-cell (Treg)-mediated immune suppression using genetic and pharmacologic ...

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p58(IPK) is an Inhibitor of the eIF2{alpha} Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity

20-10-2014 | Roobol A; Roobol J; Bastide A; Knight J; Willis A; Smales C, Biochemical Journal, 2014

One of the key cellular responses to stress is the attenuation of mRNA translation and protein synthesis via the phosphorylation of eIF2α. This is mediated by four eIF2α kinases and it has been suggested that each kinase is specific to the cellular stress imposed. Herein we show that both PERK ...

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Osteopontin mediates mineralization and not osteogenic cell development {Less than}i{Greater than}in vitro{Less than}/i{Greater than}

13-10-2014 | Holm E; Gleberzon J; Liao Y; S{o}rensen E; Beier F; Hunter G; Goldberg H, Biochemical Journal, 2014

Biomineralization is a complex process in the development of mineralized tissues such as bone, and pathological calcifications such as atherosclerotic plaques, kidney stones, gout, and others. Osteopontin (OPN), an anionic phosphoprotein, is expressed in mineralizing tissues and has previously ...

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Missing-in-Metastasis regulates cell motility and invasion via PTP{delta}-mediated changes in SRC activity

07-10-2014 | Chaudhary F; Lucito R; Tonks N, Biochemical Journal, 2014

Missing in Metastasis (MIM), also known as MTSS1, is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared to non-metastatic counterparts. MIM regulates cytoskeletal dynamics and actin polymerization, and has been implicated in the control of cell motility ...

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Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

03-10-2014 | Sharma V; Panwar P; O'Donoghue A; Cui H; Guido R; Craik C; Bromme D, Biochemical Journal, 2014

Human cathepsin K (CatK) is a major drug target for the treatment of osteoporosis. While its collagenase activity is unique, CatK also exerts a potent elastolytic activity that is shared with human cathepsins V and S. Other members of the cysteine cathepsin family, which are structurally similar, ...

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Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels

15-08-2014 | Reyhani V; Seddigh P; Guss B; Gustafsson R; Rask L; Rubin K, Biochemical Journal, 2014

The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen typeI) and used the Col I fibre network as a ...

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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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PKC{delta} as a regulator for TGF-{beta} stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells

29-08-2013 | Lee S; Kang J; Choi S; Kwon O, Biochemical Journal, 2013

Connective tissue growth factor (CTGF) is widely regarded as an important amplifier of the profibrogenic action of transforming growth factor β (TGF-β) in a variety of tissues, although the precise mechanism of how the TGF-β signaling pathways modulates CTGF expression remains unclear. In this ...

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Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a {beta}-thujaplicinol analog

09-08-2013 | Herman B; Sluis-Cremer N, Biochemical Journal, 2013

Efavirenz (EFV) and β-thujaplicinol have contrasting effects on the ribonuclease H (RNase H) activity of HIV-1 reverse transcriptase (RT). EFV binds in the nonnucleoside inhibitor binding pocket and accelerates this activity, whereas β-thujaplicinol binds in the RNase H active site and inhibits ...

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Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

01-08-2013 | Liu Y; Lai Y; Hill E; Tyteca D; Carpentier S; Ingvaldsen A; Vertommen D; Lantier L; Foretz M; Dequiedt F; Courtoy P; ..., Biochemical Journal, 2013

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), the lipid kinase that phosphorylates PtdIns3P to PtdIns(3,5)P2, has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMP-activated protein kinase (AMPK)-stimulated ...

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