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114 Newest Publications of Portland Press

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{Less than}i{Greater than}nhr-176{Less than}/i{Greater than} regulates {Less than}i{Greater than}cyp-35d1{Less than}/i{Greater than} to control hydroxylation-dependent metabolism of thiabendazole in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than}

19-11-2014 | Jones L; Flemming A; Urwin P, Biochemical Journal, 2014

Knowledge of how drugs are metabolised and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole to be commercially available and remains one of the most important anthelmintic drugs for ...

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

07-11-2014 | Henderson C; McLaughlin L; Osuna-Cabello M; Taylor M; Gilbert I; McLaren A; Wolf C, Biochemical Journal, 2014

The relative contribution of hepatic versus intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electron ...

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Running on time: the role of circadian clocks in the musculoskeletal system

01-10-2014 | Dudek M; Meng Q-J, Biochemical Journal, 2014

The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues. A central clock in the brain co-ordinates the ...

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Completing the folate biosynthesis pathway in {Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than}: {Less than}i{Greater than}p{Less than}/i{Greater than}-aminobenzoate is produced by a highly divergent, promiscuous aminodeoxychorismate lyase

19-08-2013 | Magnani G; Lomazzi M; Peracchi A, Biochemical Journal, 2013

Enzymes that produce or recycle folates are the targets of widely used antimalarial drugs. Despite the interest in the folate metabolism in Plasmodium falciparum, the molecular identification of aminodeoxychorismate lyase (ADCL), which synthesizes the p-aminobenzoate moiety of folate, remained ...

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Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop

02-08-2013 | Harijan R; Kiema T; Karjalainen M; Janardan N; Murthy M; Weiss M; Michels P; Wierenga R, Biochemical Journal, 2013

Thiolases are essential CoA dependent enzymes in lipid metabolism. Here we report on crystal structures of trypanosomal and leishmanial SCP2-thiolases. Trypanosomatidae cause various widespread, devastating (sub)-tropical diseases, for which adequate treatment is lacking. The structures reveal ...

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A cross-kingdom Nudix enzyme that pre-empts damage in thiamin metabolism

09-07-2013 | Goyer A; Hasnain G; Frelin O; Ralat M; Gregory J; Hanson A, Biochemical Journal, 2013

Genes specifying the thiamin monophosphate phosphatase and adenylated thiazole diphosphatase steps in fungal and plant thiamin biosynthesis remain unknown, as do genes for thiamin diphosphate (ThDP) hydrolysis in thiamin metabolism. A distinctive Nudix domain fused to thiamin diphosphokinase ...

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Role of hypoxia and P1 receptor activation on the high affinity concentrative adenosine transporter CNT2 in PC12 cells

03-07-2013 | Medina-Pulido L; Molina-Arcas M; Justicia C; Soriano E; Burgaya F; Planas A; Pastor-Anglada M, Biochemical Journal, 2013

Under several adverse conditions, such as hypoxia or ischemia, extracellular levels of adenosine (Ado) upraise due to increased energy demands and ATP metabolism. Because extracellular Ado affects metabolism through G protein-coupled receptors, its regulation is of high adaptive importance. ...

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New insights into the catalytic mechanism of histidine phosphatases revealed by a functionally essential arginine residue within the active site of the Sts phosphatases

01-07-2013 | San Luis B; Nassar N; Carpino N, Biochemical Journal, 2013

Sts (suppressor of T-cell receptor signalling)-1 and Sts-2 are HPs (histidine phosphatases) that negatively regulate TCR (T-cell receptor) signalling pathways, including those involved in cytokine production. HPs play key roles in such varied biological processes as metabolism, development and ...

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The transport of carboxylic acids and important role of Jen1p transporter during the development of yeast colonies

21-06-2013 | Paiva S; Strachotov{a} D; Ku{c with caron}erov{a} H; Hlav{a}{c with caron}ek O; Mota S; Casal M; Palkov{a} Z; V{a}ch ..., Biochemical Journal, 2013

On solid substrates, yeast colonies pass through distinct developmental phases characterized by changes in pH of their surroundings from acidic to nearly alkaline and vice versa. At the beginning of the alkali phase colonies start to produce ammonia, which functions as a quorum sensing molecule ...

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Metabolic phenotypes of {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} mutants with altered trehalose-6-phosphate dynamics

14-06-2013 | Walther T; Mtimet N; Alkim C; Vax A; Loret M; Ullah A; Gancedo C; Smits G; Fran{c with cedilla}ois J, Biochemical Journal, 2013

In Saccharomyces cerevisiae, synthesis of trehalose-6-phosphate (T6P) is essential for growth on most fermentable carbon sources. The metabolic response to glucose was analysed in mutants with different capacity to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, ...

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