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118 Newest Publications of Portland Press

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TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-12-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...

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The regulatory role of {Less than}i{Greater than}Streptomyces coelicolor{Less than}/i{Greater than} TamR in central metabolism

11-12-2014 | Huang H; Sivapragasam S; Grove A, Biochemical Journal, 2014

Trans-aconitate methyltransferase regulator (TamR) is a member of the ligand-responsive multiple antibiotic resistance regulator (MarR) family of transcription factors. In Streptomyces coelicolor, TamR regulates transcription of tamR (encoding TamR), tam (encoding trans-aconitate ...

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A directed-overflow and damage-control {Less than}i{Greater than}N-{Less than}/i{Greater than}glycosidase in riboflavin biosynthesis

28-11-2014 | Frelin O; Huang L; Hasnain G; Jeffryes J; Ziemak M; Rocca J; Wang B; Rice J; Roje S; Yurgel S; Gregory J; Edison A; ..., Biochemical Journal, 2014

Plants and bacteria synthesize the essential human micronutrient riboflavin (vitamin B2) via the same multistep pathway. The early intermediates of this pathway are notoriously reactive, and may be over­produced in vivo because riboflavin biosynthesis enzymes lack feedback controls. Here we ...

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Steatosis inhibits liver cell store-operated Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} entry and reduces ER Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} through a protein kinase C dependent mechanism

24-11-2014 | Wilson C; Ali E; Scrimgeour N; Martin A; Hua J; Tallis G; Rychkov G; Barritt G, Biochemical Journal, 2014

Lipid accumulation in hepatocytes can lead to non-alcoholic fatty liver disease, which can progress to non-alcoholic steatohepatitis and type 2 diabetes. Hormone-initiated release of Ca2+ from the endoplasmic reticulum stores and subsequent replenishment of these stores by Ca2+ entry through ...

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{Less than}i{Greater than}nhr-176{Less than}/i{Greater than} regulates {Less than}i{Greater than}cyp-35d1{Less than}/i{Greater than} to control hydroxylation-dependent metabolism of thiabendazole in {Less than}i{Greater than}C. elegans{Less than}/i{Greater than}

19-11-2014 | Jones L; Flemming A; Urwin P, Biochemical Journal, 2014

Knowledge of how drugs are metabolised and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole to be commercially available and remains one of the most important anthelmintic drugs for ...

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

07-11-2014 | Henderson C; McLaughlin L; Osuna-Cabello M; Taylor M; Gilbert I; McLaren A; Wolf C, Biochemical Journal, 2014

The relative contribution of hepatic versus intestinal oxidative metabolism is a crucial factor in drug oral bioavailability and therapeutic efficacy. Oxidative metabolism is mediated by the cytochrome P450 mono-oxygenase system to which cytochrome P450 reductase (POR) is the essential electron ...

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Running on time: the role of circadian clocks in the musculoskeletal system

01-10-2014 | Dudek M; Meng Q-J, Biochemical Journal, 2014

The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues. A central clock in the brain co-ordinates the ...

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Completing the folate biosynthesis pathway in {Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than}: {Less than}i{Greater than}p{Less than}/i{Greater than}-aminobenzoate is produced by a highly divergent, promiscuous aminodeoxychorismate lyase

19-08-2013 | Magnani G; Lomazzi M; Peracchi A, Biochemical Journal, 2013

Enzymes that produce or recycle folates are the targets of widely used antimalarial drugs. Despite the interest in the folate metabolism in Plasmodium falciparum, the molecular identification of aminodeoxychorismate lyase (ADCL), which synthesizes the p-aminobenzoate moiety of folate, remained ...

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Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop

02-08-2013 | Harijan R; Kiema T; Karjalainen M; Janardan N; Murthy M; Weiss M; Michels P; Wierenga R, Biochemical Journal, 2013

Thiolases are essential CoA dependent enzymes in lipid metabolism. Here we report on crystal structures of trypanosomal and leishmanial SCP2-thiolases. Trypanosomatidae cause various widespread, devastating (sub)-tropical diseases, for which adequate treatment is lacking. The structures reveal ...

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A cross-kingdom Nudix enzyme that pre-empts damage in thiamin metabolism

09-07-2013 | Goyer A; Hasnain G; Frelin O; Ralat M; Gregory J; Hanson A, Biochemical Journal, 2013

Genes specifying the thiamin monophosphate phosphatase and adenylated thiazole diphosphatase steps in fungal and plant thiamin biosynthesis remain unknown, as do genes for thiamin diphosphate (ThDP) hydrolysis in thiamin metabolism. A distinctive Nudix domain fused to thiamin diphosphokinase ...

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