01-05-2013 | Han K; Ayer D, Biochemical Journal, 2013

The MondoA:Mlx transcription complex plays a pivotal role in glucose homeostasis by activating target gene expression in response to glucose-6-phosphate (G6P), the first reaction intermediate in glycolysis. Thioredoxin-interacting protein (TXNIP) is a direct and glucose-responsive target of ...

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01-05-2013 | Chini CCS; Escande C; Nin V; Chini EN, Biochemical Journal, 2013

The nuclear receptor Rev-erbα has been implicated as a major regulator of the circadian clock and integrates circadian rhythm and metabolism. Rev-erbα controls circadian oscillations of several clock genes and Rev-erbα protein degradation is important for maintenance of the circadian ...

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09-04-2013 | San Luis B; Nassar N; Carpino N, Biochemical Journal, 2013

Sts-1 and Sts-2 are histidine phosphatases that negatively regulate TCR signaling pathways, including those involved in cytokine production. Histidine phosphatases (HPs) play key roles in such varied biological processes as metabolism, development, and intracellular signaling. They differ ...

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05-04-2013 | Kim W; Hsiao J; Bhatia S; Glaros E; Don A; Tsuruoka S; Shannon Weickert C; Halliday G, Biochemical Journal, 2013

Members of ATP-binding cassette subfamily A (ABCA) are characterized by their ability to transport lipids across cellular membranes and regulate lipid homeostasis in the brain and peripheral tissues. ABCA8 is a little-known member of this subfamily, originally cloned from human brain ...

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02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013

PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...

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28-03-2013 | Rahimpour M; Montero M; Almagro G; Viale A; Sevilla A; C{a}novas M; Mu{n}oz F; Baroja-Fern{a}ndez E; Bahaji A; Eydal ..., Biochemical Journal, 2013

Escherichia coli glycogen metabolism involves regulation of the glgBXCAP operon expression and allosteric control of GlgC-mediated catalysis of ATP and glucose-1-phosphate (G1P) to ADP-glucose linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected by glgS. Though the ...

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12-03-2013 | Su J; Guise C; Wilson W, Biochemical Journal, 2013

One-electron reductases that reduce nitro compounds in hypoxic human tumour cells are poorly characterised, but are important for targeting hypoxia with nitroaromatic prodrugs. Fluorogenic probes with defined reductase profiles are needed to interrogate the activity of these enzymes in intact ...

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15-02-2013 | Shimizu M; Li J; Maruyama R; Inoue J; Sato R, Biochemical Journal, 2013

FGF19 (fibroblast growth factor 19), expressed in the small intestine, acts as an enterohepatic hormone by mediating inhibitory effects on the bile acid synthetic pathway and regulating carbohydrate and lipid metabolism. In an attempt to identify novel agents other than bile acids that ...

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12-02-2013 | Chini C; Escande C; Nin V; Chini E, Biochemical Journal, 2013

The nuclear receptor Rev-erbα has been implicated as a major regulator of the circadian clock and integrates circadian rhythm and metabolism. Rev-erbα controls circadian oscillations of several clock genes and Rev-erbα protein degradation is important for maintenance of the circadian ...

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01-02-2013 | Kukic I; Lee J; Coblentz J; Kelleher S; Kiselyov K, Biochemical Journal, 2013

Zn is critical for a multitude of cellular processes, including gene expression, secretion and enzymatic activities. Cellular Zn is controlled by Zn-chelating proteins and by Zn transporters. The recent identification of Zn permeability of the lysosomal ion channel TRPML1, and the evidence of ...

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