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126 Newest Publications of Portland Press

matching the following criteria

Acyl-CoA Binding Domain Containing 3 Modulates NAD{+} Metabolism through Activating Poly(ADP-ribose) Polymerase 1

05-May-2015 | Chen Y; Bang S; Park S; Shi H; Kim S, Biochemical Journal, 2015

Nicotinadmide adenine dinucleotide (NAD+) plays essential roles in cellular energy homeostasis and redox state functioning as a cofactor along the glycolysis and citric acid cycle pathways. Recent discoveries indicated that, through the NAD+-consuming enzymes, this molecule may be also involved ...


Metabolomic profiling in liver of adiponectin knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action

27-Apr-2015 | Liu Y; Sen S; Wannaiampikul S; Palanivel R; Hoo R; Isserlin R; Bader G; Tungtrongchitr R; Deshaies Y; Xu A; Sweeney G, Biochemical Journal, 2015

Adiponectin mediates antidiabetic effects via increasing hepatic insulin sensitivity and direct metabolic effects. In this study we conducted a comprehensive and unbiased metabolomic profiling of liver tissue from adiponectin knockout (AdKO) mice, with and without adiponectin supplementation, fed ...


Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

20-Apr-2015 | McGarry D; Chen W; Chakravarty P; Lamont D; Wolf C; Henderson C, Biochemical Journal, 2015

Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and pathways regulated by S-glutathionylation in whole organisms and current approaches lack the sensitivity to examine this modification ...


Biochemical and redox characterization of the Mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein

16-Apr-2015 | Shaikhali J; Davoine C; Br{a}nnstr{o}m K; ROUHIER N; Bygdell J; Bj{o}rklund S; Wingsle G, Biochemical Journal, 2015

The eukaryotic Mediator integrates regulatory signals from promoter-bound transcription factors and transmits them to RNA polymerase II machinery. Although redox signaling is important in adjusting plant metabolism and development, nothing is known about a possible redox regulation of Mediator. ...


Determinants of oligosaccharide specificity of the carbohydrate binding modules of AMP-activated protein kinase

16-Mar-2015 | Mobbs J; Koay A; Di Paolo A; Bieri M; Petrie E; Gorman M; Doughty L; Parker M; Stapleton D; Griffin M; Gooley P, Biochemical Journal, 2015

AMPK-activated protein kinase (AMPK) is a αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two isoforms (β1 and β2) and contains a carbohydrate binding module (CBM) that interacts with glycogen. The two CBM isoforms (β1- and β2-CBM) are ...


Bioenergetic Programming Of Macrophages By The Apolipoprotein A-I Mimetic Peptide 4F

05-Mar-2015 | Datta G; Kramer P; Johnson M; Sawada H; Smythies L; Crossman D; Chacko B; Ballinger S; Westbrook D; Mayakonda P; Ana ..., Biochemical Journal, 2015

The apolipoprotein (apo)A-I mimetic peptide 4F favors the differentiation of human monocytes to an alternatively-activated M2 phenotype. The goal of the current study was to test whether the 4F-mediated differentiation of monocyte-derived macrophages (MDMs) requires the induction of an oxidative ...


Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

03-Mar-2015 | Stamenkovic J; Andersson L; Adriaenssens A; Bagge A; Sharoyko V; Gribble F; Reimann F; Wollheim C; Mulder H; Sp{e}gel P, Biochemical Journal, 2015

Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 Diabetes, but the mechanisms controlling glucagon secretion from α-cells largely remain unresolved. Therefore, we studied the regulation of glucagon secretion from αTC1-6 cells and compared it to ...


JAK2 activation by growth hormone and other cytokines

15-Feb-2015 | Waters MJ; Brooks AJ, Biochemical Journal, 2015

Growth hormone (GH) and structurally related cytokines regulate a great number of physiological and pathological processes. They do this by coupling their single transmembrane domain (TMD) receptors to cytoplasmic tyrosine kinases, either as homodimers or heterodimers. Recent studies have ...


TREHALOSE-6-PHOSPHATE SYNTHASE 1 is not the only active TPS in {Less than}i{Greater than}Arabidopsis thaliana.{Less than}/i{Greater than}

12-Dec-2014 | Delorge I; Figueroa C; Feil R; Lunn J; Van Dijck P, Biochemical Journal, 2014

Trehalose metabolism is essential for normal growth and development in higher plants. It is synthesized in a two-step pathway catalyzed by trehalose-6-phosphate (Tre6P) synthase (TPS) and trehalose phosphatase. Arabidopsis thaliana has 11 TPS or TPS-like proteins, which belong to two distinct ...


The regulatory role of {Less than}i{Greater than}Streptomyces coelicolor{Less than}/i{Greater than} TamR in central metabolism

11-Dec-2014 | Huang H; Sivapragasam S; Grove A, Biochemical Journal, 2014

Trans-aconitate methyltransferase regulator (TamR) is a member of the ligand-responsive multiple antibiotic resistance regulator (MarR) family of transcription factors. In Streptomyces coelicolor, TamR regulates transcription of tamR (encoding TamR), tam (encoding trans-aconitate ...


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