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114 Newest Publications of Portland Press
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Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E
01-07-2013 | Mahrhold S; Strotmeier J; Garcia-Rodriguez C; Lou J; Marks JD; Rummel A; Binz T, Biochemical Journal, 2013
The highly specific binding and uptake of BoNTs (botulinum neurotoxins; A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle ...
Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
01-07-2013 | Davies P; Hinkle KM; Sukar NN; Sepulveda B; Mesias R; Serrano G; Alessi DR; Beach TG; Benson DL; White CL; Cowell RM ..., Biochemical Journal, 2013
Missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a major cause of PD (Parkinson's disease). Several antibodies against LRRK2 have been developed, but results using these polyclonal antibodies have varied widely leading to conflicting conclusions. To address this challenge, the ...
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
15-06-2013 | Sommer EM; Dry H; Cross D; Guichard S; Davies BR; Alessi DR, Biochemical Journal, 2013
The majority of human cancers harbour mutations promoting activation of the Akt protein kinase, and Akt inhibitors are being evaluated in clinical trials. An important question concerns the understanding of the innate mechanisms that confer resistance of tumour cells to Akt inhibitors. SGK ...
The CPVT-associated RyR2 Mutation G230C Enhances Store Overload-Induced Ca{Less than}sup{Greater than}2{+} {Less than}/sup{Greater than}Release and Destabilizes the NH{Less than}sub{Greater than}2{Less than}/sub{Greater than}-terminal domains
07-06-2013 | Liu Y; Kimlicka L; Hiess F; Tian X; Wang R; Zhang L; Jones P; van Petegem F; Chen S, Biochemical Journal, 2013
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, life-threatening arrhythmogenic disorder. CPVT is caused by delayed afterdepolarizations (DADs) that are induced by spontaneous Ca2+ release during sarcoplasmic reticulum (SR) Ca2+ overload, a process also known as ...
Spinocerebellar ataxia-13 Kv3.3 potassium channels: Arginine-to-Histidine mutations affect both functional and protein expression on the cell surface
05-06-2013 | Zhao J; Zhu J; Thornhill W, Biochemical Journal, 2013
Voltage-gated potassium channel Kv3.3 is the causative gene of spinocerebellar ataxia type 13 (SCA13), an autosomal dominant neurological disorder. The four dominant mutations identified to date cause Kv3.3 channels to be nonfunctional or have altered gating properties in Xenopus oocytes. In ...
Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions
31-05-2013 | Ke Y; Ng C; Hunter M; Mann S; Heide J; Hill A; Vandenberg J, Biochemical Journal, 2013
Loss of Kv11.1 potassium channel function is the underlying cause of pathology in long QT syndrome type 2, one of the commonest causes of sudden cardiac death in the young. Previous studies have identified the cytosolic Per-Arnt-Sim (PAS) domain as a hotspot for mutations that cause Kv11.1 ...
Molecular Determinants of Co- and Post-translational N-glycosylation of Type I Transmembrane Peptides
29-05-2013 | Malaby H; Kobertz W, Biochemical Journal, 2013
Type I transmembrane peptides acquire N-linked glycans during and after protein synthesis to facilitate anterograde trafficking through the secretory pathway. Mutations in N-glycosylation consensus sites (NXT and NXS, where X ≠ P) that alter the kinetics of the initial N-glycan attachment ...
Multilevel functional and structural defects induced by two pathogenic mitochondrial tRNA mutations
01-05-2013 | Wang M; Zhou X; Liu R; Fang Z; Zhou M; Eriani G; Wang E, Biochemical Journal, 2013
Point mutations in human mitochondrial tRNAs (hmtRNAs) can cause various disorders such as chronic progressive external ophthalmoplegia (CPEO) and mitochondrial myopathy (MM). Mitochondrial tRNALeu , especially UUR isoacceptor is recognised as a hot spot for pathogenic mitochondrial DNA point ...
Identification of the SV2-Protein Receptor Binding Site of Botulinum Neurotoxin Type E
29-04-2013 | Mahrhold S; Strotmeier J; Garcia-Rodriguez C; Lou J; Marks J; Rummel A; Binz T, Biochemical Journal, 2013
The highly specific binding and uptake of botulinum neurotoxins (BoNT/A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle membrane ...
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
15-04-2013 | Sommer E; Dry H; Cross D; Guichard S; Davies B; Alessi D, Biochemical Journal, 2013
The majority of human cancers harbour mutations promoting activation of the Akt protein kinase and Akt inhibitors are being evaluated in clinical trials. An important question concerns understanding the innate mechanisms that confer resistance of tumour cells to Akt inhibitors. The Serum ...
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