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137 Newest Publications of Portland Press

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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

17-Mar-2015 | Lorenz S; Deng P; Hantschel O; Superti-Furga G; Kuriyan J, Biochemical Journal, 2015

Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in ...

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Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule

03-Mar-2015 | Ren J; Feng L; Bai Y; Pei H; Yuan Z; Feng W, Biochemical Journal, 2015

Tandem-arranged PDZ domains often form structural and functional supramodules with distinct target-binding properties. Here, we found that the two PDZ domains within the PDZ34 tandem of Scribble, a cell polarity regulator, tightly pack in a “front-to-back” mode to form a compact supramodule. ...

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Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase

15-Dec-2014 | Dodia R; Meunier B; Kay CWM; Rich PR, Biochemical Journal, 2014

Subunit 5 of Saccharomyces cerevisiae cytochrome c oxidase (CcO) is essential for assembly and has two isoforms, 5A and 5B. 5A is expressed under normoxic conditions, whereas 5B is expressed at very low oxygen tensions. As a consequence, COX5A-deleted strains (Δcox5A) have no or only low levels ...

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The regulatory role of {Less than}i{Greater than}Streptomyces coelicolor{Less than}/i{Greater than} TamR in central metabolism

11-Dec-2014 | Huang H; Sivapragasam S; Grove A, Biochemical Journal, 2014

Trans-aconitate methyltransferase regulator (TamR) is a member of the ligand-responsive multiple antibiotic resistance regulator (MarR) family of transcription factors. In Streptomyces coelicolor, TamR regulates transcription of tamR (encoding TamR), tam (encoding trans-aconitate ...

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The eukaryotic elongation factor eEF1A1 interacts with SAMHD1

24-Nov-2014 | Morrissey C; Schwefel D; Ennis-Adeniran V; Taylor I; Crow Y; Webb M, Biochemical Journal, 2014

Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), a Mendelian inflammatory disease which displays remarkable clinical and biochemical overlap with congenital viral infection. SAMHD1 has also been defined as an HIV-1 restriction-factor that, through a novel triphosphohydrolase activity, ...

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Characterization of excitation-contraction coupling components in human extraocular muscles

11-Nov-2014 | Sekulic-Jablanovic M; Palmowski-Wolfe A; Zorzato F; Treves S, Biochemical Journal, 2014

Excitation-contraction coupling is the physiological mechanism whereby an electrical signal detected by the dihydropyridine receptor, is converted into an increase in [Ca2+], via activation of ryanodine receptors. Mutations in RYR1, the gene encoding ryanodine receptor 1, are the underlying cause ...

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Identification of {Less than}i{Greater than}Leishmania donovani{Less than}/i{Greater than} Peroxin 14 Residues Required for Binding the Peroxin 5 Receptor Proteins

05-Nov-2014 | Hojjat H; Jardim A, Biochemical Journal, 2014

Trafficking of PTS-1 proteins to the Leishmania glycosome is dependent on the docking of the LdPEX5 receptor to LdPEX14 on the glycosomal membrane. A combination of deletion and random mutagenesis was used to identify residues in the LdPEX14 N-terminal region that are critical for mediating the ...

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Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

03-Nov-2014 | Tomlinson C; Moye A; Holien J; Parker M; Cohen S; Bryan T, Biochemical Journal, 2014

The ribonucleoprotein enzyme telomerase maintains telomeres and is essential for cellular immortality in most cancers. Insight into the telomerase mechanism can be gained from syndromes such as dyskeratosis congenita, in which mutation of telomerase components manifests in telomere dysfunction.We ...

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A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-Oct-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...

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Revisiting the Roco G protein cycle

15-Oct-2014 | Terheyden S; Ho F; Gilsbach B; Wittinghofer A; Kortholt A, Biochemical Journal, 2014

Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson’s disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G domain (Roc) and a C-terminal of Roc domain (COR) tandem. The nucleotide state of small G proteins ...

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