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128 Newest Publications of Portland Press

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Revisiting the Roco G protein cycle

15-10-2014 | Terheyden S; Ho F; Gilsbach B; Wittinghofer A; Kortholt A, Biochemical Journal, 2014

Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson’s disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G domain (Roc) and a C-terminal of Roc domain (COR) tandem. The nucleotide state of small G proteins ...

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Running on time: the role of circadian clocks in the musculoskeletal system

01-10-2014 | Dudek M; Meng Q-J, Biochemical Journal, 2014

The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues. A central clock in the brain co-ordinates the ...

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Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

15-09-2013 | Iwai LK; Payne LS; Luczynski MT; Chang F; Xu H; Clinton RW; Paul A; Esposito EA; Gridley S; Leitinger B; Naegle KM; ..., Biochemical Journal, 2013

Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility. The signalling networks driving these processes are propagated by collagen receptors such as the β1 integrins and the DDRs (discoidin ...

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Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...

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Calmodulin Modulates the Termination Threshold for Cardiac Ryanodine Receptor Mediated Ca{Less than}sup{Greater than}2{+} {Less than}/sup{Greater than}Release

30-08-2013 | Tian X; Tang Y; Liu Y; Wang R; Chen S, Biochemical Journal, 2013

Cardiac ryanodine receptor (RyR2)-mediated Ca2+ release in cardiomyocytes terminates when the sarcoplasmic reticulum Ca2+ content depletes to a threshold level, known as the termination threshold. Despite its importance, little is known about the mechanism that regulates the termination ...

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Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

27-08-2013 | Birrell J; Morina K; Bridges H; Friedrich T; Hirst J, Biochemical Journal, 2013

NADH:quinone oxidoreductase (complex I) couples NADH oxidation and quinone reduction to proton translocation across an energy-transducing membrane. All complexes I contain a flavin to oxidise NADH, seven iron-sulfur clusters to transfer electrons from the flavin to quinone, and an eighth cluster ...

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Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

16-08-2013 | Madabushi A; Hwang B; Jin J; Lu A, Biochemical Journal, 2013

Thymine DNA glycosylase (TDG) is an essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation, and transcription regulation. TDG is the predominant enzyme to remove thymine from T/G mispair, which arises due to deamination of 5-methyl-cytosine at the CpG ...

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Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization

01-08-2013 | Rokach O; Ullrich N; Rausch M; Mouly V; Zhou H; Muntoni F; Zorzato F; Treves S, Biochemical Journal, 2013

Excitation contraction coupling is the physiological mechanism occurring in muscle cells whereby an electrical signal sensed by the dihydropyridine receptor located on the transverse tubules is transformed into a chemical gradient (Ca2+ increase) by activation of the ryanodine receptor located on ...

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Phosphoproteomics of Collagen Receptor Networks Reveals SHP-2 Phosphorylation Downstream of Wildtype DDR2 and its Lung Cancer Mutants

04-07-2013 | Iwai L; Payne L; Luczynski M; Chang F; Xu H; Clinton R; Paul A; Esposito E; Gridley S; Leitinger B; Naegle K; Huang P, Biochemical Journal, 2013

Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility. The signalling networks driving these processes are propagated by collagen receptors such as the β1 integrins and the Discoidin Domain ...

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Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

01-07-2013 | Davies P; Hinkle KM; Sukar NN; Sepulveda B; Mesias R; Serrano G; Alessi DR; Beach TG; Benson DL; White CL; Cowell RM ..., Biochemical Journal, 2013

Missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a major cause of PD (Parkinson's disease). Several antibodies against LRRK2 have been developed, but results using these polyclonal antibodies have varied widely leading to conflicting conclusions. To address this challenge, the ...

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