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132 Newest Publications of Portland Press

matching the following criteria

Characterization of excitation-contraction coupling components in human extraocular muscles

11-11-2014 | Sekulic-Jablanovic M; Palmowski-Wolfe A; Zorzato F; Treves S, Biochemical Journal, 2014

Excitation-contraction coupling is the physiological mechanism whereby an electrical signal detected by the dihydropyridine receptor, is converted into an increase in [Ca2+], via activation of ryanodine receptors. Mutations in RYR1, the gene encoding ryanodine receptor 1, are the underlying cause ...


Identification of {Less than}i{Greater than}Leishmania donovani{Less than}/i{Greater than} Peroxin 14 Residues Required for Binding the Peroxin 5 Receptor Proteins

05-11-2014 | Hojjat H; Jardim A, Biochemical Journal, 2014

Trafficking of PTS-1 proteins to the Leishmania glycosome is dependent on the docking of the LdPEX5 receptor to LdPEX14 on the glycosomal membrane. A combination of deletion and random mutagenesis was used to identify residues in the LdPEX14 N-terminal region that are critical for mediating the ...


Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

03-11-2014 | Tomlinson C; Moye A; Holien J; Parker M; Cohen S; Bryan T, Biochemical Journal, 2014

The ribonucleoprotein enzyme telomerase maintains telomeres and is essential for cellular immortality in most cancers. Insight into the telomerase mechanism can be gained from syndromes such as dyskeratosis congenita, in which mutation of telomerase components manifests in telomere dysfunction.We ...


A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-10-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...


Revisiting the Roco G protein cycle

15-10-2014 | Terheyden S; Ho F; Gilsbach B; Wittinghofer A; Kortholt A, Biochemical Journal, 2014

Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson’s disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G domain (Roc) and a C-terminal of Roc domain (COR) tandem. The nucleotide state of small G proteins ...


Running on time: the role of circadian clocks in the musculoskeletal system

01-10-2014 | Dudek M; Meng Q-J, Biochemical Journal, 2014

The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues. A central clock in the brain co-ordinates the ...


Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants

15-09-2013 | Iwai LK; Payne LS; Luczynski MT; Chang F; Xu H; Clinton RW; Paul A; Esposito EA; Gridley S; Leitinger B; Naegle KM; ..., Biochemical Journal, 2013

Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility. The signalling networks driving these processes are propagated by collagen receptors such as the β1 integrins and the DDRs (discoidin ...


Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid-{beta} and the asparagine 23 Iowa mutation

13-09-2013 | Fossati S; Todd K; Sotolongo K; Ghiso J; Rostagno A, Biochemical Journal, 2013

Mutations within amyloid-β (Aβ), especially those clustered at residues 21-23, are linked to early onset Alzheimer’s disease (AD) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of aspartic acid for asparagine at position 23 (D23N), associates with ...


Calmodulin Modulates the Termination Threshold for Cardiac Ryanodine Receptor Mediated Ca{Less than}sup{Greater than}2{+} {Less than}/sup{Greater than}Release

30-08-2013 | Tian X; Tang Y; Liu Y; Wang R; Chen S, Biochemical Journal, 2013

Cardiac ryanodine receptor (RyR2)-mediated Ca2+ release in cardiomyocytes terminates when the sarcoplasmic reticulum Ca2+ content depletes to a threshold level, known as the termination threshold. Despite its importance, little is known about the mechanism that regulates the termination ...


Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

27-08-2013 | Birrell J; Morina K; Bridges H; Friedrich T; Hirst J, Biochemical Journal, 2013

NADH:quinone oxidoreductase (complex I) couples NADH oxidation and quinone reduction to proton translocation across an energy-transducing membrane. All complexes I contain a flavin to oxidise NADH, seven iron-sulfur clusters to transfer electrons from the flavin to quinone, and an eighth cluster ...


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