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114 Newest Publications of Portland Press

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The function of phosphatidylinositol 5-phosphate 4-kinase {gamma}(PI5P4K{gamma}) explored using a specific inhibitor that targets the PI5P binding site.

11-12-2014 | Clarke J; Giudici M; Burke J; Williams R; Maloney D; Marugan J; Irvine R, Biochemical Journal, 2014

NIH-12848 (NCGC00012848-02), a putative phosphatidylinositol-5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity, lipid kinase. PI5P 4-kinase assays in vitro showed that NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1μM but ...

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{Less than}i{Greater than}Bombyx mori{Less than}/i{Greater than} prothoracicostatic peptide receptor is allosterically activated via a G{alpha}{Less than}sub{Greater than}i/o{Less than}/sub{Greater than} protein-biased signaling cascade by {Less than}i{Greater than}Drosophila{Less than}/i{Greater than} sex peptide

25-11-2014 | He X; Zang J; Yang H; Huang H; Shi Y; Zhu C; Zhou N, Biochemical Journal, 2014

In insects, molting and metamorphosis are strictly regulated by ecdysteroids. Ecdysteroid synthesis is positively or negatively controlled by several neuropeptides. The prothoracicostatic peptide BmPTSP, isolated from the larval brain of Bombyx mori, has been demonstrated to inhibit ecdysteroid ...

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Effects of N-glycosylation on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

25-11-2014 | Li M; Tonggu L; Tang L; Wang L, Biochemical Journal, 2014

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are activated by membrane hyperpolarization and conduct an inward cation current, which contributes to rhythmic electrical activity of neural and cardiac pacemaker cells. HCN channels have been shown to undergo N-linked ...

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NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...

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Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin

22-10-2014 | Verma S; Leikina E; Melikov K; Chernomordik L, Biochemical Journal, 2014

Macrophage fusion that leads to osteoclast formation is one of the most important examples of cell-to-cell fusion in development, tissue homeostasis and immune response. Protein machinery that fuses macrophages remains to be identified. Here we explored fusion stage of osteoclast formation for ...

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A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-10-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...

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Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...

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Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification

06-10-2014 | Kitamura T; Takagi S; Naganuma T; Kihara A, Biochemical Journal, 2014

Aldehyde dehydrogenases (ALDHs) catalyze the conversion of toxic aldehydes to non-toxic carboxylic acids. Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes. However, ALDH3B2 and ...

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Mammalian ribosomal and chaperone protein RPS3A counteracts alpha-Synuclein aggregation and toxicity in a yeast model system

07-08-2013 | De Graeve S; Marinelli S; Stolz F; Hendrickx J; Vandamme J; Engelborghs Y; Van Dijck P; Thevelein J, Biochemical Journal, 2013

Accumulation of aggregated forms of alpha-synuclein (αSyn) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson’s disease. When expressed in the yeast Saccharomyces cerevisiae, αSyn interacts with the plasma membrane, forms inclusions and causes a ...

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Subcellular potassium and sodium distribution in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} wild type and vacuolar mutants

05-07-2013 | Herrera R; {A}lvarez M; Gelis S; Ramos J, Biochemical Journal, 2013

Living cells accumulate potassium to fulfill multiple functions. It is well documented that the model yeast Saccharomyces cerevisiae grows at very different concentrations of external alkali cations and keeps high and low intracellular concentrations of potassium and sodium respectively. However ...

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