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111 Newest Publications of Portland Press

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NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...

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Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin

22-10-2014 | Verma S; Leikina E; Melikov K; Chernomordik L, Biochemical Journal, 2014

Macrophage fusion that leads to osteoclast formation is one of the most important examples of cell-to-cell fusion in development, tissue homeostasis and immune response. Protein machinery that fuses macrophages remains to be identified. Here we explored fusion stage of osteoclast formation for ...

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A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA of influenza virus

21-10-2014 | De Vries M; Herrmann A; Veit M, Biochemical Journal, 2014

The HA (haemagglutinin) of influenza viruses must be recruited to membrane rafts to perform its function in membrane fusion and virus budding. We previ-ously showed with Förster Resonance Energy Transfer (FRET) that deletion of the two rafttargeting features of HA, S-acylation at the cytoplasmic ...

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Neutral Sphingomyelinase-2 is a Redox Sensitive Enzyme:Role of Catalytic Cysteine Residues in Regulation of Enzymatic Activity through Changes in Oligomeric State

07-10-2014 | Dotson II P; Karakashian A; Nikolova-Karakashian M, Biochemical Journal, 2014

Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing twenty-two cysteine residues. In this study, we expressed recombinant mouse nSMase-2 ...

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Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification

06-10-2014 | Kitamura T; Takagi S; Naganuma T; Kihara A, Biochemical Journal, 2014

Aldehyde dehydrogenases (ALDHs) catalyze the conversion of toxic aldehydes to non-toxic carboxylic acids. Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes. However, ALDH3B2 and ...

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Mammalian ribosomal and chaperone protein RPS3A counteracts alpha-Synuclein aggregation and toxicity in a yeast model system

07-08-2013 | De Graeve S; Marinelli S; Stolz F; Hendrickx J; Vandamme J; Engelborghs Y; Van Dijck P; Thevelein J, Biochemical Journal, 2013

Accumulation of aggregated forms of alpha-synuclein (αSyn) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson’s disease. When expressed in the yeast Saccharomyces cerevisiae, αSyn interacts with the plasma membrane, forms inclusions and causes a ...

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Subcellular potassium and sodium distribution in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} wild type and vacuolar mutants

05-07-2013 | Herrera R; {A}lvarez M; Gelis S; Ramos J, Biochemical Journal, 2013

Living cells accumulate potassium to fulfill multiple functions. It is well documented that the model yeast Saccharomyces cerevisiae grows at very different concentrations of external alkali cations and keeps high and low intracellular concentrations of potassium and sodium respectively. However ...

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Mercury increases water permeability of a plant aquaporin through a non-cysteine related mechanism

03-07-2013 | Frick A; J{a}rv{a} M; Ekvall M; Uzdavinys P; Nyblom M; T{o}rnroth-Horsefield S, Biochemical Journal, 2013

Water transport across cellular membranes is mediated by a family of membrane proteins known as aquaporins (AQP). AQPs were first discovered based on their ability to be inhibited by mercurial compounds, an experiment which has followed the aquaporin field ever since. While mercury inhibition is ...

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Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E

01-07-2013 | Mahrhold S; Strotmeier J; Garcia-Rodriguez C; Lou J; Marks JD; Rummel A; Binz T, Biochemical Journal, 2013

The highly specific binding and uptake of BoNTs (botulinum neurotoxins; A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle membrane ...

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Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity

01-07-2013 | Dudek KM; Suter L; Darras VM; Marczylo EL; Gant TW, Biochemical Journal, 2013

Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining polysome profiling with genomic methodologies, we ...

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