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106 Newest Publications of Portland Press

matching the following criteria

Mammalian ribosomal and chaperone protein RPS3A counteracts alpha-Synuclein aggregation and toxicity in a yeast model system

07-08-2013 | De Graeve S; Marinelli S; Stolz F; Hendrickx J; Vandamme J; Engelborghs Y; Van Dijck P; Thevelein J, Biochemical Journal, 2013

Accumulation of aggregated forms of alpha-synuclein (αSyn) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson’s disease. When expressed in the yeast Saccharomyces cerevisiae, αSyn interacts with the plasma membrane, forms inclusions and causes a ...


Subcellular potassium and sodium distribution in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} wild type and vacuolar mutants

05-07-2013 | Herrera R; {A}lvarez M; Gelis S; Ramos J, Biochemical Journal, 2013

Living cells accumulate potassium to fulfill multiple functions. It is well documented that the model yeast Saccharomyces cerevisiae grows at very different concentrations of external alkali cations and keeps high and low intracellular concentrations of potassium and sodium respectively. However ...


Mercury increases water permeability of a plant aquaporin through a non-cysteine related mechanism

03-07-2013 | Frick A; J{a}rv{a} M; Ekvall M; Uzdavinys P; Nyblom M; T{o}rnroth-Horsefield S, Biochemical Journal, 2013

Water transport across cellular membranes is mediated by a family of membrane proteins known as aquaporins (AQP). AQPs were first discovered based on their ability to be inhibited by mercurial compounds, an experiment which has followed the aquaporin field ever since. While mercury inhibition is ...


Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E

01-07-2013 | Mahrhold S; Strotmeier J; Garcia-Rodriguez C; Lou J; Marks JD; Rummel A; Binz T, Biochemical Journal, 2013

The highly specific binding and uptake of BoNTs (botulinum neurotoxins; A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle membrane ...


Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity

01-07-2013 | Dudek KM; Suter L; Darras VM; Marczylo EL; Gant TW, Biochemical Journal, 2013

Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining polysome profiling with genomic methodologies, we ...


FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration

01-07-2013 | Nakamura F, Biochemical Journal, 2013

Cell migration, phagocytosis and cytokinesis are mechanically intensive cellular processes that are mediated by the dynamic assembly and contractility of the actin cytoskeleton. GAPs (GTPase-activating proteins) control activities of the Rho family proteins including Cdc42, Rac1 and RhoA, which ...


An aromatic amino acid in the CC1 domain plays a crucial role in the auto-inhibitory mechanism of STIM1

25-06-2013 | Yu J; Zhang H; ZHANG M; Deng Y; Wang H; Lu J; Xu T; Xu P, Biochemical Journal, 2013

STIM1 is one of the key elements that mediate store-operated Ca2+ entry via CRAC (Ca2+ release-activated Ca2+) channels in immune and non-excitable cells. Under physiological conditions, the intramolecular auto-inhibitions in STIM1-C and STIM1-N termini play essential roles in keeping STIM1 in an ...


The transport of carboxylic acids and important role of Jen1p transporter during the development of yeast colonies

21-06-2013 | Paiva S; Strachotov{a} D; Ku{c with caron}erov{a} H; Hlav{a}{c with caron}ek O; Mota S; Casal M; Palkov{a} Z; V{a}ch ..., Biochemical Journal, 2013

On solid substrates, yeast colonies pass through distinct developmental phases characterized by changes in pH of their surroundings from acidic to nearly alkaline and vice versa. At the beginning of the alkali phase colonies start to produce ammonia, which functions as a quorum sensing molecule ...


Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum

15-06-2013 | Engelberg K; Paul AS; Prinz B; Kono M; Ching W; Heincke D; Dobner T; Spielmann T; Duraisingh MT; Gilberger T-W, Biochemical Journal, 2013

Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high affinity receptor-ligand interactions. Signal transduction through the action of specific kinases is a control mechanism for the orchestration of this process. In the ...


Metabolic phenotypes of {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} mutants with altered trehalose-6-phosphate dynamics

14-06-2013 | Walther T; Mtimet N; Alkim C; Vax A; Loret M; Ullah A; Gancedo C; Smits G; Fran{c with cedilla}ois J, Biochemical Journal, 2013

In Saccharomyces cerevisiae, synthesis of trehalose-6-phosphate (T6P) is essential for growth on most fermentable carbon sources. The metabolic response to glucose was analysed in mutants with different capacity to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, ...


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