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94 Newest Publications of Portland Press
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Hepcidin, show some self-control! How the hormone of iron metabolism regulates its own expression
01-06-2013 | Lane DJR; Huang ML-H; Richardson DR, Biochemical Journal, 2013
Does the hormone of iron metabolism, hepcidin, exhibit 'self-control'? Hepcidin is a small, disulfide-rich peptide synthesized by the liver, which plays a keystone role in regulating systemic iron metabolism in mammals. Hepcidin acts by binding and triggering the lysosomal degradation of the ...
Identification of the SV2-Protein Receptor Binding Site of Botulinum Neurotoxin Type E
29-04-2013 | Mahrhold S; Strotmeier J; Garcia-Rodriguez C; Lou J; Marks J; Rummel A; Binz T, Biochemical Journal, 2013
The highly specific binding and uptake of botulinum neurotoxins (BoNT/A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on the plasma membrane and binding to a synaptic vesicle membrane ...
Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity.
16-04-2013 | Dudek K; Suter L; Darras V; Marczylo E; Gant T, Biochemical Journal, 2013
Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. Here we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining polysome profiling with genomic methodologies we were able to ...
Inhibition of{Less than}i{Greater than} Plasmodium falciparum{Less than}/i{Greater than} CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development
03-04-2013 | Azevedo M; Sanders P; Krejany E; Nie C; Fu P; Bach L; Wunderlich G; Crabb B; Gilson P, Biochemical Journal, 2013
Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) is highly expressed in parasite asexual blood and mosquito stages. Its role is still poorly understood, but unsuccessful gene knockout attempts suggest it is essential for schizont development and/or RBC invasion. Here, by ...
Specific phosphorylation of the {Less than}i{Greater than}Pf{Less than}/i{Greater than}Rh2b invasion ligand of {Less than}i{Greater than}Plasmodium falciparum{Less than}/i{Greater than}
02-04-2013 | Engelberg K; Paul A; Prinz B; Kono M; Ching W; Heincke D; Dobner T; Spielmann T; Duraisingh M; Gilberger T, Biochemical Journal, 2013
Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high affinity receptor-ligand interactions. Signal transduction through the action of specific kinases is a control mechanism for the orchestration of this process. Here ...
Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells
01-04-2013 | Dingsdale H; Okeke E; Awais M; Haynes L; Criddle DN; Sutton R; Tepikin AV, Biochemical Journal, 2013
We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of ...
The Arf GAP AGAP2 Interacts with {beta}Arrestin2 and Regulates {beta}{Less than}sub{Greater than}2{Less than}/sub{Greater than}-Adrenergic Receptor Recycling and Erk Activation
26-03-2013 | Wu Y; Zhao Y; Ma X; Zhu Y; Patel J; Nie Z, Biochemical Journal, 2013
AGAP2 is a multidomain Arf GAP (ADP ribosylation factor-directed GTPase-activating protein) that was shown to promote the fast-recycling of transferrin receptors. Here, we tested the hypothesis that AGAP2 regulates trafficking of β2-adrenergic receptors. We found that AGAP2 formed a complex ...
The Muscarinic M{Less than}sub{Greater than}3 {Less than}/sub{Greater than}Acetylcholine receptor exists as two differently sized complexes at the plasma membrane
25-03-2013 | Patowary S; Alvarez-Curto E; Xu T; Holz J; Oliver J; Milligan G; Raicu V, Biochemical Journal, 2013
The literature on G protein-coupled receptor (GPCR) homo-oligomerization encompasses conflicting views that range from interpretations that GPCRs must be monomeric, through comparatively newer proposals that they exist as dimers or higher-order oligomers, to suggestions that such quaternary ...
The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner
01-03-2013 | Kanno T; Tsuchiya A; Tanaka A; Nishizaki T, Biochemical Journal, 2013
In yeast two-hybrid screening, protein 4.1N, a scaffolding protein, was identified as a binding partner of the α7 ACh (acetylcholine) receptor. For rat hippocampal slices, the linoleic acid derivative DCP-LA {8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid} increased the ...
The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function
15-02-2013 | Coothankandaswamy V; Elangovan S; Singh N; Prasad PD; Thangaraju M; Ganapathy V, Biochemical Journal, 2013
SLC5A8 (solute carrier gene family 5A, member 8) is a sodium-coupled transporter for monocarboxylates. Among its substrates are the HDAC (histone deacetylase) inhibitors butyrate, propionate and pyruvate. Expression of SLC5A8 is silenced in cancers via DNA methylation, and ectopic expression ...
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