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408 Newest Publications of Portland Press

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Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

15-09-2013 | Zou J; Yue F; Jiang X; Li W; Yi J; Liu L, Biochemical Journal, 2013

The mitochondrion-associated protein LRPPRC (leucine-rich pentatricopeptide repeat-containing) interacts with one of the microtubule-associated protein family members MAP1S (microtubule-associated protein 1 small form), originally named C19ORF5 (chromosome 19 open reading frame 5), to form a ...

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Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling

10-09-2013 | D'Cruz A; Kershaw N; Chiang J; Wang M; Nicola N; Babon J; Gack M; Nicholson S, Biochemical Journal, 2013

Tripartite motif (TRIM) proteins primarily function as ubiquitin E3 ligases that regulate the innate immune response to infection. TRIM25 (also known as estrogen-responsive finger protein (Efp)) has been implicated in the regulation of estrogen receptor α signaling, and in the regulation of ...

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{Soft hyphen}{Soft hyphen}Reorientation of the first signal-anchor sequence during potassium channel biogene{Soft hyphen}{Soft hyphen}sis at the Sec61 complex

10-09-2013 | Watson H; Wunderley L; Andreou T; Warwicker J; High S, Biochemical Journal, 2013

The majority of the polytopic proteins that are synthesised at the endoplasmic reticulum are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic transmembrane regions (TMs) to the phospholipid bilayer. A prolonged association between TMs of ...

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Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wildtype and NQO1-deficient mice

09-09-2013 | Ingram B; Turbyfill J; Bledsoe P; Jaiswal A; Stafford D, Biochemical Journal, 2013

NQO1 (DT-diaphorase) is a cytosolic enzyme that catalyzes the two-electron reduction of various quinones including vitamin K. The enzyme may play a role in vitamin K metabolism by reducing vitamin K to vitamin K hydroquinone for utilization in the post-translational γ-glutamyl carboxylation ...

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Proteolytic processing of QSOX1A ensures efficient secretion of a potent disulfide catalyst

01-09-2013 | Rudolf J; Pringle MA; Bulleid NJ, Biochemical Journal, 2013

QSOX1 (quiescin sulfhydryl oxidase 1) efficiently catalyses the insertion of disulfide bonds into a wide range of proteins. The enzyme is mechanistically well characterized, but its subcellular location and the identity of its protein substrates remain ill-defined. The function of QSOX1 is likely ...

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Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

27-08-2013 | Bartolom{e} A; L{o}pez-Herrad{o}n A; Portal-N{u}{n}ez S; Garc{i}a-Aguilar A; Esbrit P; Benito M; Guill{e}n C, Biochemical Journal, 2013

Autophagy is a highly regulated homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered as an important pro-survival mechanism under diverse stress conditions. A diabetic milieu is known to hamper osteoblast viability and ...

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Ribonucleases as a host-defense family: Evidence of evolutionary conserved antimicrobial activity at the N-terminus.

20-08-2013 | Torrent M; Pulido D; Valle J; Nogu{e}s M; Andreu D; Boix E, Biochemical Journal, 2013

Vertebrate secreted ribonucleases (RNases) are small proteins that play important roles in RNA metabolism, angiogenesis or host defense. In the present study we describe the antimicrobial properties of the N-terminal domain of the human canonical RNases (hcRNases) and show that its antimicrobial ...

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions

15-08-2013 | Sugden PH; McGuffin LJ; Clerk A, Biochemical Journal, 2013

The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of ...

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Mammalian ribosomal and chaperone protein RPS3A counteracts alpha-Synuclein aggregation and toxicity in a yeast model system

07-08-2013 | De Graeve S; Marinelli S; Stolz F; Hendrickx J; Vandamme J; Engelborghs Y; Van Dijck P; Thevelein J, Biochemical Journal, 2013

Accumulation of aggregated forms of alpha-synuclein (αSyn) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson’s disease. When expressed in the yeast Saccharomyces cerevisiae, αSyn interacts with the plasma membrane, forms inclusions and causes a ...

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A novel fluorescent assay and catalytic properties of Crh1 and Crh2 yeast cell wall transglycosylases

06-08-2013 | Maz{a}{n} M; Blanco N; Kov{a}{c with caron}ov{a} K; Zemkov{a} Z; {R}ehulka P; Farka{s with caron} V; Arroyo J, Biochemical Journal, 2013

Mechanical properties of fungal cell walls are largely determined by composition and mutual cross-linking of their macromolecular components. Previous work showed that the Crh proteins are required for the formation of cross-links between chitin and glucan at the Saccharomyces cerevisiae cell ...

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