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422 Newest Publications of Portland Press

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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

01-12-2014 | Abdul Azeez KR; Knapp S; Fernandes JMP; Klussmann E; Elkins JM, Biochemical Journal, 2014

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. ...

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The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-11-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

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Structure-Dynamic Determinants Governing a Mode of Regulatory Response and Propagation of Allosteric Signal in Splice Variants of Na{Less than}sup{Greater than}{+}{Less than}/sup{Greater than}/Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} Exchange (NCX) Proteins

12-11-2014 | Giladi M; Lee S; Hiller R; Chung K; Khananshvili D, Biochemical Journal, 2014

The Ca2+-dependent allosteric regulation of Na+/Ca2+ exchanger (NCX) proteins represents Ca2+ interaction with the cytosolic domains, CBD1 and CBD2, which is associated either with activation, inhibition or no response to regulatory Ca2+ in a given splice variant. CBD1 contains a high affinity ...

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Characterization of excitation-contraction coupling components in human extraocular muscles

11-11-2014 | Sekulic-Jablanovic M; Palmowski-Wolfe A; Zorzato F; Treves S, Biochemical Journal, 2014

Excitation-contraction coupling is the physiological mechanism whereby an electrical signal detected by the dihydropyridine receptor, is converted into an increase in [Ca2+], via activation of ryanodine receptors. Mutations in RYR1, the gene encoding ryanodine receptor 1, are the underlying cause ...

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Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium

07-11-2014 | Samak G; Chaudhry K; Gangwar R; Narayanan D; Jaggar J; Rao R, Biochemical Journal, 2014

Disruption of intestinal epithelial tight junctions is an important event in the pathogenesis of ulcerative colitis. Dextran sodium sulfate (DSS) induces colitis in mice with the symptoms similar to ulcerative colitis. However, the mechanism of DSS-induced colitis is unknown. We investigated the ...

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Identification of {Less than}i{Greater than}Leishmania donovani{Less than}/i{Greater than} Peroxin 14 Residues Required for Binding the Peroxin 5 Receptor Proteins

05-11-2014 | Hojjat H; Jardim A, Biochemical Journal, 2014

Trafficking of PTS-1 proteins to the Leishmania glycosome is dependent on the docking of the LdPEX5 receptor to LdPEX14 on the glycosomal membrane. A combination of deletion and random mutagenesis was used to identify residues in the LdPEX14 N-terminal region that are critical for mediating the ...

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The structural basis of DNA binding by the single stranded DNA binding protein from {Less than}i{Greater than}Sulfolobus solfataricus{Less than}/i{Greater than}

04-11-2014 | Gamsjaeger R; Kariawasam R; Gimenez A; Touma C; McIlwain E; Bernardo R; Shepherd N; Ataide S; Dong Q; Richard D; Whi ..., Biochemical Journal, 2014

Canonical single-stranded DNA binding proteins (SSBs) from the Oligosaccharide/Oligonucleotide Binding (OB) domain family are present in all known organisms and are critical for DNA replication, recombination and repair. The SSB from the hyperthermophilic crenarchaeote Sulfolobus solfataricus ...

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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

29-10-2014 | Knight J; Bastide A; Roobol A; Roobol J; Jackson T; Utami W; Barrett D; Smales C; Willis A, Biochemical Journal, 2014

Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the ...

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Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities

21-10-2014 | Nahomi R; DiMauro M; Wang B; Nagaraj R, Biochemical Journal, 2014

Previous studies have identified peptides in the ‘crystallin-domain’ of the small heat shock protein α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in Hsp20 (71GHFSVLLDVKHFSPEEIAVK91) and Hsp27 (93DRWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin ...

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Revisiting the Roco G protein cycle

15-10-2014 | Terheyden S; Ho F; Gilsbach B; Wittinghofer A; Kortholt A, Biochemical Journal, 2014

Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson’s disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G domain (Roc) and a C-terminal of Roc domain (COR) tandem. The nucleotide state of small G proteins ...

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