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459 Newest Publications of Portland Press

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E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signaling and plant development

26-May-2015 | Kim S; Park B; Kim D; Yeu S; Song S; Song J; Seo H, Biochemical Journal, 2015

Gibberellins affect various plant development processes including germination, cell division and elongation, and flowering. A large number of studies have been carried out to address the molecular mechanisms that mediate gibberellin signaling effects on plant growth. However, such studies have ...


FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21{Less than}sup{Greater than}Cip1/Waf1{Less than}/sup{Greater than}

20-May-2015 | Kloet D; Polderman P; Eijkelenboom A; Smits L; Van Triest M; Van Den Berg M; Groot Koerkamp M; Van Leenen D; Lijnzaa ..., Biochemical Journal, 2015

Activity of Forkhead box O (FOXO) transcription factors is inhibited by growth factor-PI3K-protein kinase B (PKB)/AKT signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we identified a set of ...


Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme

19-May-2015 | Oka O; Yeoh H; Bulleid N, Biochemical Journal, 2015

The formation of disulfides in proteins entering the secretory pathway is catalysed by the protein disulfide isomerase family of enzymes. These enzymes catalyse the introduction, reduction and isomerisation of disulfides. To function continuously they require an oxidase to reform the disulfide at ...


Nuclear Cyclophilins Impact Spliceosome Assembly and Function {Less than}i{Greater than}In Vitro{Less than}/i{Greater than}

13-May-2015 | Adams B; Coates M; Jackson S; Jurica M; Davis T, Biochemical Journal, 2015

Cyclophilins are ubiquitously expressed proteins that bind to prolines and can catalyze cis/trans isomerization of proline residues. There are seventeen annotated members of the cyclophilin family in humans, ubiquitously expressed and localized variously to the cytoplasm, nucleus, or ...


Deciphering the unconventional peptide binding to the PDZ domain of MAST2

05-May-2015 | Delhommel F; Chaffotte A; Terrien E; Raynal B; Buc H; Delepierre M; Cordier F; Wolff N, Biochemical Journal, 2015

PTEN and MAST2 are key negative regulators of survival pathways in neuronal cells. The two proteins interact via the PDZ domain of MAST2 (MAST2-PDZ). During infection by rabies virus, the viral glycoprotein competes with PTEN for interaction with MAST2-PDZ and promotes neuronal survival. The ...


Structural and biochemical characterization of novel bacterial {alpha}-galactosidases belonging to glycoside hydrolase family 31

05-May-2015 | Miyazaki T; Ishizaki Y; Ichikawa M; Nishikawa A; Tonozuka T, Biochemical Journal, 2015

Glycoside hydrolase family 31 (GH31) proteins have been reportedly identified as exo-α-glycosidases with activity for α-glucosides and α-xylosides. We focused on a GH31 subfamily, which contains proteins with low sequence identity (8-barrel fold that resembles the structures of other GH31 ...


The motor function of {Less than}i{Greater than}Drosophila melanogaster{Less than}/i{Greater than} myosin-5 is activated by calcium and cargo-binding protein dRab11

05-May-2015 | Ji H; Zhang H; Shen M; Yao L; Li X, Biochemical Journal, 2015

In the Drosophila melanogaster compound eye, myosin-5 (DmM5) plays two distinct roles in response to light stimulation: transport of pigment granules to the rhabdomere base to decrease light exposure and transport of rhodopsin-bearing vesicles to the rhabdomere base to compensate for the ...


Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

01-May-2015 | Bulatov E; Ciulli A, Biochemical Journal, 2015

In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. CRLs [Cullin-RING (really interesting new gene) ...


The Two Component Signaling Networks of {Less than}i{Greater than}Mycobacterium tuberculosis{Less than}/i{Greater than} Displays Extensive Crosstalk {Less than}i{Greater than}In Vitro{Less than}/i{Greater than}

01-May-2015 | Agrawal R; Pandey A; Rajankar M; Dixit N; Saini D, Biochemical Journal, 2015

Two component systems (TCSs), which contain paired sensor kinase and response regulator proteins, form the primary apparatus for sensing and responding to environmental cues in bacteria. TCSs are thought to be highly specific, displaying minimal cross-talk, primarily due to the co-evolution of ...


Solution structure of the RNA-binding cold shock domain of the {Less than}i{Greater than}Chlamydomonas reinhardtii {Less than}/i{Greater than}NAB1 protein and insights into RNA recognition

28-Apr-2015 | Sawyer A; Landsberg M; Ross I; Kruse O; Mobli M; Hankamer B, Biochemical Journal, 2015

Light harvesting complex (LHC) proteins are among the most abundant proteins on Earth and play critical roles in photosynthesis, both in light capture and photoprotective mechanisms. The Chlamydomonas reinhardtii nucleic acid-binding protein 1 (NAB1) is a negative regulator of LHC protein ...


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