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413 Newest Publications of Portland Press

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Revisiting the Roco G protein cycle

15-10-2014 | Terheyden S; Ho F; Gilsbach B; Wittinghofer A; Kortholt A, Biochemical Journal, 2014

Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson’s disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G domain (Roc) and a C-terminal of Roc domain (COR) tandem. The nucleotide state of small G proteins ...

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The architecture of an Okazaki fragment-processing holoenzyme from the archaeon {Less than}i{Greater than}Sulfolobus solfataricus{Less than}/i{Greater than}

09-10-2014 | Cannone G; Xu Y; Beattie T; Bell S; Spagnolo L, Biochemical Journal, 2014

DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes the enzymatic activities required for this process are supplied by a replicative DNA polymerase, Flap Endonuclease 1 (Fen1) and DNA ligase 1. These factors interact with ...

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Solution structures and dynamics of ADF/cofilins UNC-60A and UNC-60B from {Less than}i{Greater than}Caenorhabditis elegans{Less than}/i{Greater than}

03-10-2014 | Shukla V; Kabra A; Maheshwari D; Yadav R; Jain A; Tripathi S; Ono S; Kumar D; Arora A, Biochemical Journal, 2014

The nematode Caenorhabditis elegans has two ADF/cofilin isoforms, UNC-60A and UNC-60B, which are expressed from the unc60 gene by alternative splicing.UNC-60A has higher activity to cause net depolymerization, and to inhibit polymerization, than UNC-60B. UNC-60B, on the other hand, shows much ...

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Structure-based Design and Functional studies of Novel Noroviral 3C Protease Chimeras Offers Insights into Substrate Specificity

02-10-2014 | Herod M; Prince C; Skilton R; Ward V; Cooper J; Clarke I, Biochemical Journal, 2014

The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2,200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural proteins. Studies of the human norovirus NS6 protease, in the ...

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The disease-associated mutation of the mitochondrial sulphydryl oxidase Erv1 impairs cofactor binding during its catalytic reaction

01-10-2014 | Ceh-Pavia E; Ang S; Spiller M; Lu H, Biochemical Journal, 2014

Erv1(essential for respiration and viability 1) is an FAD-dependent sulphydryl oxidase of the Erv/ALR (augmenter of liver regeneration) sub-family. It is an essential component of the mitochondrial import and assembly (MIA) pathway, playing an important role in the oxidative folding of ...

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Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

15-09-2013 | Zou J; Yue F; Jiang X; Li W; Yi J; Liu L, Biochemical Journal, 2013

The mitochondrion-associated protein LRPPRC (leucine-rich pentatricopeptide repeat-containing) interacts with one of the microtubule-associated protein family members MAP1S (microtubule-associated protein 1 small form), originally named C19ORF5 (chromosome 19 open reading frame 5), to form a ...

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Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling

10-09-2013 | D'Cruz A; Kershaw N; Chiang J; Wang M; Nicola N; Babon J; Gack M; Nicholson S, Biochemical Journal, 2013

Tripartite motif (TRIM) proteins primarily function as ubiquitin E3 ligases that regulate the innate immune response to infection. TRIM25 (also known as estrogen-responsive finger protein (Efp)) has been implicated in the regulation of estrogen receptor α signaling, and in the regulation of ...

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{Soft hyphen}{Soft hyphen}Reorientation of the first signal-anchor sequence during potassium channel biogene{Soft hyphen}{Soft hyphen}sis at the Sec61 complex

10-09-2013 | Watson H; Wunderley L; Andreou T; Warwicker J; High S, Biochemical Journal, 2013

The majority of the polytopic proteins that are synthesised at the endoplasmic reticulum are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic transmembrane regions (TMs) to the phospholipid bilayer. A prolonged association between TMs of ...

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Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wildtype and NQO1-deficient mice

09-09-2013 | Ingram B; Turbyfill J; Bledsoe P; Jaiswal A; Stafford D, Biochemical Journal, 2013

NQO1 (DT-diaphorase) is a cytosolic enzyme that catalyzes the two-electron reduction of various quinones including vitamin K. The enzyme may play a role in vitamin K metabolism by reducing vitamin K to vitamin K hydroquinone for utilization in the post-translational γ-glutamyl carboxylation ...

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Proteolytic processing of QSOX1A ensures efficient secretion of a potent disulfide catalyst

01-09-2013 | Rudolf J; Pringle MA; Bulleid NJ, Biochemical Journal, 2013

QSOX1 (quiescin sulfhydryl oxidase 1) efficiently catalyses the insertion of disulfide bonds into a wide range of proteins. The enzyme is mechanistically well characterized, but its subcellular location and the identity of its protein substrates remain ill-defined. The function of QSOX1 is likely ...

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