My watch list
my.chemeurope.com  
Login  

428 Newest Publications of Portland Press

rss
matching the following criteria

Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

09-Dec-2014 | Bett J; Ritorto M; Ewan R; Jaffray E; Virdee S; Chin J; Knebel A; Kurz T; Trost M; Tatham M; Hay R, Biochemical Journal, 2014

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

more

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

01-Dec-2014 | Abdul Azeez KR; Knapp S; Fernandes JMP; Klussmann E; Elkins JM, Biochemical Journal, 2014

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. ...

more

A directed-overflow and damage-control {Less than}i{Greater than}N-{Less than}/i{Greater than}glycosidase in riboflavin biosynthesis

28-Nov-2014 | Frelin O; Huang L; Hasnain G; Jeffryes J; Ziemak M; Rocca J; Wang B; Rice J; Roje S; Yurgel S; Gregory J; Edison A; ..., Biochemical Journal, 2014

Plants and bacteria synthesize the essential human micronutrient riboflavin (vitamin B2) via the same multistep pathway. The early intermediates of this pathway are notoriously reactive, and may be over­produced in vivo because riboflavin biosynthesis enzymes lack feedback controls. Here we ...

more

HBx induces the proliferation of hepatocellular carcinoma cells via AP1 overexpressed by ER stress

27-Nov-2014 | Cho H; Kim S; Kyaw Y; Win A; Koo S; Kim H; Cheong J, Biochemical Journal, 2014

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. ...

more

The eukaryotic elongation factor eEF1A1 interacts with SAMHD1

24-Nov-2014 | Morrissey C; Schwefel D; Ennis-Adeniran V; Taylor I; Crow Y; Webb M, Biochemical Journal, 2014

Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), a Mendelian inflammatory disease which displays remarkable clinical and biochemical overlap with congenital viral infection. SAMHD1 has also been defined as an HIV-1 restriction-factor that, through a novel triphosphohydrolase activity, ...

more

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment

21-Nov-2014 | Varfolomeev E; Izrael-Tomasevic A; Yu K; Bustos D; Goncharov T; Belmont L; Masselot A; Bakalarski C; Kirkpatrick D; ..., Biochemical Journal, 2014

Evasion of cell death is one crucial capability acquired by tumor cells to ward off anti-tumor therapies, and represents a fundamental challenge to sustaining clinical efficacy for currently available agents. Inhibitor of Apoptosis (IAP) proteins use their ubiquitin E3 ligase activity to promote ...

more

A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines

19-Nov-2014 | Fan G; Wrzeszczynski K; Fu C; Su G; Pappin D; Lucito R; Tonks N, Biochemical Journal, 2014

Although DNA encodes the molecular instructions that underlie control of cell function, it is the proteins that are primarily responsible for implementing those instructions. Therefore, quantitative analyses of the proteome would be expected to yield insights into important candidates for the ...

more

The structure of lipoyl synthase, a remarkable enzyme that performs the last step of an extraordinary biosynthetic pathway

15-Nov-2014 | Cronan JE, Biochemical Journal, 2014

Lipoic acid is assembled on its cognate proteins (e.g. the E2 subunit of pyruvate dehydrogenase). An octanoyl moiety is transferred from the octanoyl-ACP of fatty acid synthetase to a specific lysine residue of the cognate protein followed by sulfur insertion at C6 and C8 of the octanoyl chain. ...

more

Structure-Dynamic Determinants Governing a Mode of Regulatory Response and Propagation of Allosteric Signal in Splice Variants of Na{Less than}sup{Greater than}{+}{Less than}/sup{Greater than}/Ca{Less than}sup{Greater than}2{+}{Less than}/sup{Greater than} Exchange (NCX) Proteins

12-Nov-2014 | Giladi M; Lee S; Hiller R; Chung K; Khananshvili D, Biochemical Journal, 2014

The Ca2+-dependent allosteric regulation of Na+/Ca2+ exchanger (NCX) proteins represents Ca2+ interaction with the cytosolic domains, CBD1 and CBD2, which is associated either with activation, inhibition or no response to regulatory Ca2+ in a given splice variant. CBD1 contains a high affinity ...

more

Characterization of excitation-contraction coupling components in human extraocular muscles

11-Nov-2014 | Sekulic-Jablanovic M; Palmowski-Wolfe A; Zorzato F; Treves S, Biochemical Journal, 2014

Excitation-contraction coupling is the physiological mechanism whereby an electrical signal detected by the dihydropyridine receptor, is converted into an increase in [Ca2+], via activation of ryanodine receptors. Mutations in RYR1, the gene encoding ryanodine receptor 1, are the underlying cause ...

more

Page 1 From 43
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE