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434 Newest Publications of Portland Press

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Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

01-Mar-2015 | Bauckman K; Haller E; Taran N; Rockfield S; Ruiz-Rivera A; Nanjundan M, Biochemical Journal, 2015

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although ...

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Small Molecule Inhibitors of ERK-mediated Immediate Early Gene Expression and Proliferation of Melanoma Cells Expressing Mutated BRaf

19-Feb-2015 | Samadani R; Zhang J; Brophy A; Oashi T; Priyakumar U; Raman E; St. John F; Jung K; Fletcher S; Pozharski E; MacKerel ..., Biochemical Journal, 2015

Constitutive activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for ...

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Conserved Proline-Directed Phosphorylation Regulates SR Protein Conformation and Splicing Function

22-Dec-2014 | Keshwani M; Aubol B; Fattet L; Ma C; Qiu J; Jennings P; Fu X; Adams J, Biochemical Journal, 2014

The alternative splicing of human genes is dependent on SR proteins, a family of essential splicing factors whose name derives from a signature C-terminal domain rich in arginine-serine dipeptide repeats (RS domains). Although the SRPKs (SR-specific protein kinases) phosphorylate these repeats, ...

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The solution structure of the MANEC-type domain from Hepatocyte Growth Factor Activator Inhibitor 1 reveals an unexpected PAN/apple domain-type fold.

16-Dec-2014 | Hong Z; Nowakowski M; Spronk C; Petersen S; Andreasen P; Ko{z}mi{n}ski W; Mulder F; Jensen J, Biochemical Journal, 2014

A decade ago, a Motif at N-terminus with Eight-Cysteines or in short MANEC was defined as a new protein domain family. This domain is found exclusively in the N-terminus of >400 multi-domain type-1 transmembrane proteins from animals. Despite the large number of MANEC-containing proteins, only ...

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FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

16-Dec-2014 | Ma W; Fuentes G; Shi X; Verma C; Radda G; Han W, Biochemical Journal, 2014

FoxO1, which is upregulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to SP1-POMC promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription. FoxO1 also binds directly to the POMC promoter and ...

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The sigma 1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

15-Dec-2014 | Mishra A; Mavlyutov T; Singh D; Biener G; Yang J; Oliver J; Ruoho A; Raicu V, Biochemical Journal, 2014

The sigma-1 receptor (S1R) is a membrane 223-amino acid protein that resides in the endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is regulated by a various synthetic molecules including (+)-pentazocine, cocaine and haloperidol, and endogenous molecules such as ...

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Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

09-Dec-2014 | Bett J; Ritorto M; Ewan R; Jaffray E; Virdee S; Chin J; Knebel A; Kurz T; Trost M; Tatham M; Hay R, Biochemical Journal, 2014

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

01-Dec-2014 | Abdul Azeez KR; Knapp S; Fernandes JMP; Klussmann E; Elkins JM, Biochemical Journal, 2014

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. ...

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A directed-overflow and damage-control {Less than}i{Greater than}N-{Less than}/i{Greater than}glycosidase in riboflavin biosynthesis

28-Nov-2014 | Frelin O; Huang L; Hasnain G; Jeffryes J; Ziemak M; Rocca J; Wang B; Rice J; Roje S; Yurgel S; Gregory J; Edison A; ..., Biochemical Journal, 2014

Plants and bacteria synthesize the essential human micronutrient riboflavin (vitamin B2) via the same multistep pathway. The early intermediates of this pathway are notoriously reactive, and may be over­produced in vivo because riboflavin biosynthesis enzymes lack feedback controls. Here we ...

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HBx induces the proliferation of hepatocellular carcinoma cells via AP1 overexpressed by ER stress

27-Nov-2014 | Cho H; Kim S; Kyaw Y; Win A; Koo S; Kim H; Cheong J, Biochemical Journal, 2014

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. ...

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