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446 Newest Publications of Portland Press

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Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

01-May-2015 | Bulatov E; Ciulli A, Biochemical Journal, 2015

In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. CRLs [Cullin-RING (really interesting new gene) ...

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Proteomic approaches to identify substrates of the three Deg/HtrA proteases of the cyanobacterium {Less than}i{Greater than}Synechocystis{Less than}/i{Greater than} sp. PCC 6803

16-Apr-2015 | Tam L; Aigner H; Timmerman E; Gevaert K; Funk C, Biochemical Journal, 2015

The family of Deg/HtrA proteases plays an important role in quality control of cellular proteins in a wide range of organisms. In the genome of the cyanobacterium Synechocystis sp. PCC 6803, a model organism for photosynthetic research and renewable energy products, three Deg proteases are ...

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Novel reactivity of Fhit proteins: catalysts for fluorolysis of nucleoside 5{'}-phosphoramidates and nucleoside 5{'}-phosphosulfates to generate nucleoside 5{'}-phosphorofluoridates

31-Mar-2015 | Wojdyla-Mamon A; Zimny J; Romanowska J; Kraszewski A; Stawinski J; Bieganowski P; Guranowski A, Biochemical Journal, 2015

Fragile-histidine-triad proteins (Fhits) occur in all eukaryotes but their function is largely unknown. Human Fhit is presumed to function as a tumor suppressor. Previously, we demonstrated that Fhits catalyze hydrolysis of not only dinucleoside triphosphates but also natural adenosine ...

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{Less than}i{Greater than}In vitro{Less than}/i{Greater than} reconstitution of cotranslational D1 insertion reveals a role of the cpSec/Alb3 translocase and Vipp1 in photosystem II biogenesis

24-Mar-2015 | Walter B; Hristou A; Nowaczyk M; Sch{u}nemann D, Biochemical Journal, 2015

Photosystem II (PS II) is a multi subunit complex localized in the thylakoid membrane that performs the light dependent photosynthetic charge separation. The PS II reaction center comprises, amongst others, the D1 protein. De novo synthesis and repair of PS II require efficient mechanisms for ...

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Processing of Protein ADP-ribosylation by Nudix Hydrolases

19-Mar-2015 | Palazzo L; Thomas B; Jemth A; Colby T; Leidecker O; Feijs K; Zaja R; Loseva O; Puigvert J; Matic I; Helleday T; Ahel I, Biochemical Journal, 2015

ADP-ribosylation is a post-translational modification of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response, and apoptosis. Several cellular enzymes, such as macrodomain ...

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RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

16-Mar-2015 | Sami F; Lu X; Parvathaneni S; Roy R; Gary R; Sharma S, Biochemical Journal, 2015

RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in replication restart mechanisms. Cellular phenotypes of RECQ1 deficiency are indicative of aberrant repair of stalled replication forks, but the molecular functions of RECQ1, ...

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Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

15-Mar-2015 | Bett JS; Ritorto MS; Ewan R; Jaffray EG; Virdee S; Chin JW; Knebel A; Kurz T; Trost M; Tatham MH; Hay RT, Biochemical Journal, 2015

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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Platelet Rho GTPases-a focus on novel players, roles and relationships

15-Mar-2015 | Goggs R; Williams CM; Mellor H; Poole AW, Biochemical Journal, 2015

Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on ...

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SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

13-Mar-2015 | B{e}k{e}s M; Rut W; Kasperkiewicz P; Mulder M; Ovaa H; Drag M; Lima C; Huang T, Biochemical Journal, 2015

Ubiquitin (Ub) and the ubiquitin-like modifier interferon stimulated gene 15 (ISG15) participate in the host defense of viral infections. Viruses, including the Severe Acute Respiratory Syndrome human coronavirus (SARS hCoV), have co-opted Ub/ISG15-conjugation pathways for their own advantage or ...

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Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

05-Mar-2015 | Richards M; O'Regan L; Roth D; Montgomery J; Straube A; Fry A; Bayliss R, Biochemical Journal, 2015

Proteins of the echinoderm microtubule associated protein-like (EML) family contribute to formation of the mitotic spindle and interphase microtubule (MT) network. EML1-4 consist of WD40 repeats and an N-terminal region containing a putative coiled-coil. Recurrent gene rearrangements in non-small ...

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