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442 Newest Publications of Portland Press

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Processing of Protein ADP-ribosylation by Nudix Hydrolases

19-Mar-2015 | Palazzo L; Thomas B; Jemth A; Colby T; Leidecker O; Feijs K; Zaja R; Loseva O; Puigvert J; Matic I; Helleday T; Ahel I, Biochemical Journal, 2015

ADP-ribosylation is a post-translational modification of proteins found in organisms from all kingdoms of life which regulates many important biological functions including DNA repair, chromatin structure, unfolded protein response, and apoptosis. Several cellular enzymes, such as macrodomain ...

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RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

16-Mar-2015 | Sami F; Lu X; Parvathaneni S; Roy R; Gary R; Sharma S, Biochemical Journal, 2015

RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in replication restart mechanisms. Cellular phenotypes of RECQ1 deficiency are indicative of aberrant repair of stalled replication forks, but the molecular functions of RECQ1, ...

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Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

15-Mar-2015 | Bett JS; Ritorto MS; Ewan R; Jaffray EG; Virdee S; Chin JW; Knebel A; Kurz T; Trost M; Tatham MH; Hay RT, Biochemical Journal, 2015

Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of N-terminal alpha amines to generate peptide-linked linear mono-Ub fusions. Protein ubiquitylation can be reversed by the action of ...

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Platelet Rho GTPases-a focus on novel players, roles and relationships

15-Mar-2015 | Goggs R; Williams CM; Mellor H; Poole AW, Biochemical Journal, 2015

Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on ...

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SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

13-Mar-2015 | B{e}k{e}s M; Rut W; Kasperkiewicz P; Mulder M; Ovaa H; Drag M; Lima C; Huang T, Biochemical Journal, 2015

Ubiquitin (Ub) and the ubiquitin-like modifier interferon stimulated gene 15 (ISG15) participate in the host defense of viral infections. Viruses, including the Severe Acute Respiratory Syndrome human coronavirus (SARS hCoV), have co-opted Ub/ISG15-conjugation pathways for their own advantage or ...

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Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

05-Mar-2015 | Richards M; O'Regan L; Roth D; Montgomery J; Straube A; Fry A; Bayliss R, Biochemical Journal, 2015

Proteins of the echinoderm microtubule associated protein-like (EML) family contribute to formation of the mitotic spindle and interphase microtubule (MT) network. EML1-4 consist of WD40 repeats and an N-terminal region containing a putative coiled-coil. Recurrent gene rearrangements in non-small ...

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Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

01-Mar-2015 | Bauckman K; Haller E; Taran N; Rockfield S; Ruiz-Rivera A; Nanjundan M, Biochemical Journal, 2015

The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although ...

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Yeast Hmt1 catalyzes asymmetric dimethylation of histone H3 arginine 2 {Less than}i{Greater than}in vitro{Less than}/i{Greater than}

26-Feb-2015 | Li H; Gong T; Zhou Z; Liu Y; Cao X; He Y; Chen C; Zhou J, Biochemical Journal, 2015

Protein arginine methyltransferases (PRMTs) are a family of enzymes that can methylate protein arginine residues. PRMTs’ substrates include histones and a variety of non-histone proteins. Previous studies have shown that yeast Hmt1 is a type I PRMT, and methylates histone H4 arginine 3 and ...

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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

25-Feb-2015 | Shamas-Din A; Bindner S; Chi X; Leber B; Andrews D; Fradin C, Biochemical Journal, 2015

After exposure to stressful stimuli, apoptotic signals can be relayed to mitochondria by pro-apoptotic activator proteins, tBid and Bim, which activate Bax and or Bak to induce mitochondrial outer membrane permeabilization (MOMP). These protein-protein and protein-membrane interactions are ...

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Small Molecule Inhibitors of ERK-mediated Immediate Early Gene Expression and Proliferation of Melanoma Cells Expressing Mutated BRaf

19-Feb-2015 | Samadani R; Zhang J; Brophy A; Oashi T; Priyakumar U; Raman E; St. John F; Jung K; Fletcher S; Pozharski E; MacKerel ..., Biochemical Journal, 2015

Constitutive activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central to regulating the proliferation and survival of many cancer cells. The current inhibitors of ERK1/2 target ATP binding or the catalytic site and are therefore limited in their utility for ...

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