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73 Newest Publications of Portland Press
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PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli
02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013
PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...
Evidence of a novel role for Pygopus in ribosomal RNA transcription
22-03-2013 | Andrews P; He Z; Tzenov Y; Popadiuk C; Kao K, Biochemical Journal, 2013
Increased protein synthesis during cell proliferation is accompanied by a compensatory increase in efficient ribosome production, but the mechanisms by which cells adapt to this requirement are not fully understood. Here, we present evidence that Pygopus, a protein originally identified as a ...
FGF-2 Prevents Cancer Cells from ER Stress-Mediated Apoptosis via Enhancing Proteasome-mediated Nck Degradation
01-03-2013 | Li B; Pi Z; liu L; Zhang B; Huang X; Hu P; Chevet E; Yi P; Liu J, Biochemical Journal, 2013
Induction of Endoplasmic Reticulum (ER) stress-mediated apoptosis in cancer cells represents an alternative approach for cancer therapy. Whether fibroblast growth factor 2 (FGF-2)-induced survival signals may interact with ER stress signalling in cancer cells remains elusive. In this work, we ...
Proteomic analysis of Mesembryanthemum crystallinum leaf microsomal fractions finds an imbalance in V-ATPase stoichiometry during the salt-induced transition from C3 to CAM
01-03-2013 | Cosentino C; Di Silvestre D; Fischer-Schliebs E; Homann U; De Palma A; Comunian C; Mauri PL; Thiel G, Biochemical Journal, 2013
The halophyte Mesembryanthemum crystallinum adapts to salt stress by salt uptake and switching from C3 photosynthesis to CAM (crassulacean acid metabolism). An important role in this process is played by transport proteins in the tonoplast of the central vacuole. In the present study we ...
FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress
15-02-2013 | Shimizu M; Li J; Maruyama R; Inoue J; Sato R, Biochemical Journal, 2013
FGF19 (fibroblast growth factor 19), expressed in the small intestine, acts as an enterohepatic hormone by mediating inhibitory effects on the bile acid synthetic pathway and regulating carbohydrate and lipid metabolism. In an attempt to identify novel agents other than bile acids that ...
Role of Helicobacter pylori methionine sulfoxide reductase in urease maturation
15-02-2013 | Kuhns LG; Mahawar M; Sharp JS; Benoit S; Maier RJ, Biochemical Journal, 2013
The persistence of the gastric pathogen Helicobacter pylori is due in part to urease and Msr (methionine sulfoxide reductase). Upon exposure to relatively mild (21% partial pressure of O2) oxidative stress, a Δmsr mutant showed both decreased urease specific activity in cell-free extracts ...
Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans
01-02-2013 | Wang H; Gao J; Wong AH-H; Hu K; Li W; Wang Y; Sang J, Biochemical Journal, 2013
Rfa2 is a ssDNA (single-stranded DNA)-binding protein that plays an important role in DNA replication, recombination and repair. Rfa2 is regulated by phosphorylation, which alters its protein-protein interaction and protein-DNA interaction. In the present study, we found that the Pph3-Psy2 ...
Identification of novel candidate phosphatidic acid binding proteins involved in the salt stress response of {Less than}i{Greater than}Arabidopsis thaliana{Less than}/i{Greater than} roots
17-01-2013 | McLoughlin F; Arisz S; Dekker H; Kramer G; de Koster C; Haring M; Munnik T; Testerink C, Biochemical Journal, 2013
Phosphatidic acid (PA) is a lipid second messenger involved in an array of processes occurring during a plant’s life cycle. These include development, metabolism and both biotic and abiotic stress responses. PA levels increase in response to salt, but little is known about its function in the ...
Proteomic analysis of {Less than}i{Greater than}Mesembryanthemum crystallinum{Less than}/i{Greater than} leaf microsomal fractions reports imbalance in V-ATPase stoichiometry during the salt-induced transition from C3 to CAM
20-12-2012 | Cosentino C; Di Silvestre D; Fischer-Schliebs E; Homann U; De Palma A; Comunian C; Mauri P; Thiel G, Biochemical Journal, 2012
The halophyte Mesembryanthemum crystallinum adapts to salt stress by salt uptake and switching from C3 photosynthesis to Crassulacean Acid Metabolism (CAM). An important role in this process is played by transport proteins in the tonoplast of the central vacuole. Here we examine dynamic ...
{Less than}i{Greater than}FGF19{Less than}/i{Greater than} (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress
03-12-2012 | Shimizu M; Li J; Maruyama R; Inoue J; Sato R, Biochemical Journal, 2012
FGF19 (fibroblast growth factor 19), expressed in the small intestine, acts as an enterohepatic hormone by mediating inhibitory effects on the bile acid synthetic pathway and regulating carbohydrate and lipid metabolism. In an attempt to identify novel agents other than bile acids that induce ...
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