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85 Newest Publications of Portland Press

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Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen

03-10-2014 | Radde B; Ivanova M; Mai H; Salabei J; Hill B; Klinge C, Biochemical Journal, 2014

Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated ...

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Endoplasmic reticulum-associated ubiquitin conjugating enzyme- Ube2j1 is a novel substrate of MAPKAP kinase-2 involved in MK2-mediated TNF{alpha} production

11-09-2013 | Menon M; Tiedje C; Lafera J; Ronkina N; Konen T; Kotlyarov A; Gaestel M, Biochemical Journal, 2013

The p38 MAPK/MK2 signalling pathway is a major regulator of stress- and cytokine-induced gene expression at the transcriptional and post-transcriptional level. By phospho-proteomics we identified the ER-associated ubiquitin-conjugating enzyme Ube2j1 as a potential substrate of MK2. We demonstrate ...

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Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

27-08-2013 | Bartolom{e} A; L{o}pez-Herrad{o}n A; Portal-N{u}{n}ez S; Garc{i}a-Aguilar A; Esbrit P; Benito M; Guill{e}n C, Biochemical Journal, 2013

Autophagy is a highly regulated homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered as an important pro-survival mechanism under diverse stress conditions. A diabetic milieu is known to hamper osteoblast viability and ...

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions

15-08-2013 | Sugden PH; McGuffin LJ; Clerk A, Biochemical Journal, 2013

The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of ...

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Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume {-} overload

08-08-2013 | Fetterman J; Zelickson B; Johnson L; Moellering D; Westbrook D; Pompilius M; Sammy M; Johnson M; Dunham-Snary K; Cao ..., Biochemical Journal, 2013

Dysfunctional bioenergetics has emerged as a key feature in many chronic pathologies such as diabetes and cardiovascular disease. This has led to the mitochondrial paradigm in which it has been proposed that mitochondrial DNA (mtDNA) sequence variation contributes to disease susceptibility. In ...

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In response to oxidative stress and energy restriction AMPK and PKC collaborate to induce the phosphorylation of Serine 413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5){Less than}i{Greater than}P{Less than}/i{Greater than}{Less than}sub{Greater than}2{Less than}/sub{Greater than} synthesis

05-08-2013 | van den Bout I; Jones D; Shah Z; Halstead J; Keune W; Mohammed S; D'Santos C; Divecha N, Biochemical Journal, 2013

The spatial and temporal regulation of the second messenger, phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2 ) has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of phosphatidylinositol 4-phosphate 5-kinase (PIP5K1 A, B and C) ...

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Nogo-A couples with Apg-1 through interaction and coordinate expression under hypoxic and oxidative stress

02-08-2013 | Kern F; Stanika R; Sarg B; Offterdinger M; Hess D; Obermair G; Lindner H; Bandtlow C; Hengst L; Schweigreiter R, Biochemical Journal, 2013

Nogo-A is the largest isoform of the Nogo/RTN4 proteins and has been characterized as a major myelin associated inhibitor of regenerative nerve growth in the adult central nervous system (CNS). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The ...

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Evidence of a novel role for Pygopus in rRNA transcription

01-07-2013 | Andrews PGP; He Z; Tzenov YR; Popadiuk C; Kao KR, Biochemical Journal, 2013

Increased protein synthesis during cell proliferation is accompanied by a compensatory increase in efficient ribosome production, but the mechanisms by which cells adapt to this requirement are not fully understood. In the present study, we demonstrate evidence that Pygo (Pygopus), a protein ...

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Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to the aerotoxic syndrome: Kinetic and molecular dynamics studies

20-06-2013 | Masson P; Lushchekina S; Schopfer L; Lockridge O, Biochemical Journal, 2013

Cresyl saligenin phosphate (CSP) is an irreversible inhibitor of human butyrylcholinesterase (BChE) that has been involved in the aerotoxic syndrome. Inhibition under pseudo-first order conditions is biphasic reflecting a slow equilibrium between two enzyme states E and E’. The elementary ...

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p32 Protein Levels are Integral to Mitochondrial and Endoplasmic Reticulum Morphology, Cell Metabolism and Survival

22-05-2013 | Hu M; Crawford S; Henstridge D; Ng I; Boey E; Xu Y; Febbraio M; Jans D; Bogoyevitch M, Biochemical Journal, 2013

p32 (HAPB1, gC1qR or C1qbp) has been previously shown to have both mitochondrial and non-mitochondrial localization and functions. We show here for the first time that endogenous p32 protein is a mitochondrial protein in HeLa cells under control and stress conditions. In defining the impact of ...

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