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88 Newest Publications of Portland Press

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Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities

21-10-2014 | Nahomi R; DiMauro M; Wang B; Nagaraj R, Biochemical Journal, 2014

Previous studies have identified peptides in the ‘crystallin-domain’ of the small heat shock protein α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in Hsp20 (71GHFSVLLDVKHFSPEEIAVK91) and Hsp27 (93DRWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin ...

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Cytoglobin ligand binding regulated by changing haem-coordination in response to intramolecular disulfide bond formation and lipid interaction

20-10-2014 | Beckerson P; Wilson M; Svistunenko D; Reeder B, Biochemical Journal, 2014

Cytoglobin is a hexacoordinate haem protein from the globin superfamily with a physiological function that is unclear. We have previously reported that the haem coordination is changed in the presence of lipids, potentially transforming the redox properties of the protein and hence the function ...

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p58(IPK) is an Inhibitor of the eIF2{alpha} Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity

20-10-2014 | Roobol A; Roobol J; Bastide A; Knight J; Willis A; Smales C, Biochemical Journal, 2014

One of the key cellular responses to stress is the attenuation of mRNA translation and protein synthesis via the phosphorylation of eIF2α. This is mediated by four eIF2α kinases and it has been suggested that each kinase is specific to the cellular stress imposed. Herein we show that both PERK ...

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Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen

03-10-2014 | Radde B; Ivanova M; Mai H; Salabei J; Hill B; Klinge C, Biochemical Journal, 2014

Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated ...

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Endoplasmic reticulum-associated ubiquitin conjugating enzyme- Ube2j1 is a novel substrate of MAPKAP kinase-2 involved in MK2-mediated TNF{alpha} production

11-09-2013 | Menon M; Tiedje C; Lafera J; Ronkina N; Konen T; Kotlyarov A; Gaestel M, Biochemical Journal, 2013

The p38 MAPK/MK2 signalling pathway is a major regulator of stress- and cytokine-induced gene expression at the transcriptional and post-transcriptional level. By phospho-proteomics we identified the ER-associated ubiquitin-conjugating enzyme Ube2j1 as a potential substrate of MK2. We demonstrate ...

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Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function

27-08-2013 | Bartolom{e} A; L{o}pez-Herrad{o}n A; Portal-N{u}{n}ez S; Garc{i}a-Aguilar A; Esbrit P; Benito M; Guill{e}n C, Biochemical Journal, 2013

Autophagy is a highly regulated homeostatic process involved in the lysosomal degradation of damaged cell organelles and proteins. This process is considered as an important pro-survival mechanism under diverse stress conditions. A diabetic milieu is known to hamper osteoblast viability and ...

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SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions

15-08-2013 | Sugden PH; McGuffin LJ; Clerk A, Biochemical Journal, 2013

The GCKIII (germinal centre kinase III) subfamily of the mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises SOK1 (Ste20-like/oxidant-stress-response kinase 1), MST3 (mammalian Ste20-like kinase 3) and MST4. Initially, GCKIIIs were considered in the contexts of ...

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Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume {-} overload

08-08-2013 | Fetterman J; Zelickson B; Johnson L; Moellering D; Westbrook D; Pompilius M; Sammy M; Johnson M; Dunham-Snary K; Cao ..., Biochemical Journal, 2013

Dysfunctional bioenergetics has emerged as a key feature in many chronic pathologies such as diabetes and cardiovascular disease. This has led to the mitochondrial paradigm in which it has been proposed that mitochondrial DNA (mtDNA) sequence variation contributes to disease susceptibility. In ...

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In response to oxidative stress and energy restriction AMPK and PKC collaborate to induce the phosphorylation of Serine 413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5){Less than}i{Greater than}P{Less than}/i{Greater than}{Less than}sub{Greater than}2{Less than}/sub{Greater than} synthesis

05-08-2013 | van den Bout I; Jones D; Shah Z; Halstead J; Keune W; Mohammed S; D'Santos C; Divecha N, Biochemical Journal, 2013

The spatial and temporal regulation of the second messenger, phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2 ) has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of phosphatidylinositol 4-phosphate 5-kinase (PIP5K1 A, B and C) ...

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Nogo-A couples with Apg-1 through interaction and coordinate expression under hypoxic and oxidative stress

02-08-2013 | Kern F; Stanika R; Sarg B; Offterdinger M; Hess D; Obermair G; Lindner H; Bandtlow C; Hengst L; Schweigreiter R, Biochemical Journal, 2013

Nogo-A is the largest isoform of the Nogo/RTN4 proteins and has been characterized as a major myelin associated inhibitor of regenerative nerve growth in the adult central nervous system (CNS). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The ...

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