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95 Newest Publications of Portland Press

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Functional characterization of a mycothiol peroxidase in {Less than}i{Greater than}Corynebacterium glutamicum{Less than}/i{Greater than} that uses both mycoredoxin and thioredoxin reducing systems as proton donor for oxidative stress response

20-Apr-2015 | Si M; Xu Y; Wang T; Long M; Ding W; Chen C; Guan X; Liu Y; Wang Y; Shen X; Liu S, Biochemical Journal, 2015

Previous studies have identified a putative mycothiol peroxidase (MPx) in Corynebacterium glutamicum that shared high sequence similarity to sulfur-containing glutathione peroxidase (CysGPx). In this study we investigated the MPx function by examining its potential peroxidase activity using ...

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Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in {Less than}i{Greater than}Saccharomyces cerevisiae.{Less than}/i{Greater than}

02-Mar-2015 | Ferrer-dalmau J; Randez-Gil F; Marquina M; Prieto J; Casamayor A, Biochemical Journal, 2015

Glc7 is the only catalytic subunit of the protein phosphatase type 1 in the yeast S. cerevisiae and, together with its regulatory subunits, is involved in many and essential processes. Analysis of the non-essential mutants in the regulatory subunits of Glc7 revealed that the lack of Reg1, and no ...

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Defining the Cytosolic Pathway of Glutathione Degradation in {Less than}i{Greater than}Arabidopsis thaliana{Less than}/i{Greater than}: Role of the ChaC/GCG Family of {gamma}-glutamyl cyclotransferases as Glutathione Degrading Enzymes and AtLAP1 as the Cys-Gly Peptidase

26-Feb-2015 | Kumar S; Kaur A; Chattopadhyay B; Bachhawat A, Biochemical Journal, 2015

Glutathione homeostasis is critical to plant life and its adaptation to stress. The γ-glutamyl cycle of glutathione biosynthesis and degradation plays a pre-eminent role in glutathione homeostasis. The genes encoding two enzymatic steps of glutathione degradation, the γ-glutamyl cyclotransferase ...

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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

25-Feb-2015 | Shamas-Din A; Bindner S; Chi X; Leber B; Andrews D; Fradin C, Biochemical Journal, 2015

After exposure to stressful stimuli, apoptotic signals can be relayed to mitochondria by pro-apoptotic activator proteins, tBid and Bim, which activate Bax and or Bak to induce mitochondrial outer membrane permeabilization (MOMP). These protein-protein and protein-membrane interactions are ...

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HBx induces the proliferation of hepatocellular carcinoma cells via AP1 overexpressed by ER stress

27-Nov-2014 | Cho H; Kim S; Kyaw Y; Win A; Koo S; Kim H; Cheong J, Biochemical Journal, 2014

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. ...

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C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1{alpha} signaling in acute liver failure

11-Nov-2014 | Rao J; Zhang C; Wang P; Lu L; Qian X; Qin J; Pan X; Li G; Wang X; Zhang F, Biochemical Journal, 2014

C/EBP Homologous Protein (CHOP) has been shown to be a key molecule in endoplasmic reticulum (ER) stress-mediated apoptosis. ERO1α, a target of CHOP, is an important oxidizing enzyme to regulate ROS, which play a prominent role in hepatocellular death during acute liver failure (ALF). However, ...

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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

29-Oct-2014 | Knight J; Bastide A; Roobol A; Roobol J; Jackson T; Utami W; Barrett D; Smales C; Willis A, Biochemical Journal, 2014

Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the ...

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Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities

21-Oct-2014 | Nahomi R; DiMauro M; Wang B; Nagaraj R, Biochemical Journal, 2014

Previous studies have identified peptides in the ‘crystallin-domain’ of the small heat shock protein α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in Hsp20 (71GHFSVLLDVKHFSPEEIAVK91) and Hsp27 (93DRWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin ...

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Cytoglobin ligand binding regulated by changing haem-coordination in response to intramolecular disulfide bond formation and lipid interaction

20-Oct-2014 | Beckerson P; Wilson M; Svistunenko D; Reeder B, Biochemical Journal, 2014

Cytoglobin is a hexacoordinate haem protein from the globin superfamily with a physiological function that is unclear. We have previously reported that the haem coordination is changed in the presence of lipids, potentially transforming the redox properties of the protein and hence the function ...

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p58(IPK) is an Inhibitor of the eIF2{alpha} Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity

20-Oct-2014 | Roobol A; Roobol J; Bastide A; Knight J; Willis A; Smales C, Biochemical Journal, 2014

One of the key cellular responses to stress is the attenuation of mRNA translation and protein synthesis via the phosphorylation of eIF2α. This is mediated by four eIF2α kinases and it has been suggested that each kinase is specific to the cellular stress imposed. Herein we show that both PERK ...

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