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101 Newest Publications of Portland Press
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PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli
02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013
PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia
01-04-2013 | Zammit VA, Biochemical Journal, 2013
The liver regulates both glycaemia and triglyceridaemia. Hyperglycaemia and hypertriglyceridaemia are both characteristic of (pre)diabetes. Recent observations on the specialised role of DGAT2 (diacylglycerol acyltransferase 2) in catalysing the de novo synthesis of triacylglycerols from ...
Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes
01-04-2013 | Mikhael MR; Soe-Lin S; Apte S; Ponka P, Biochemical Journal, 2013
AI (anaemia of inflammation) often manifests in patients with chronic immune activation due to cancer, chronic infections, autoimmune disorders, rheumatoid arthritis and other diseases. The pathogenesis of AI is complex and involves cytokine-mediated inhibition of erythropoiesis, ...
GlgS, previously described as a glycogen synthesis control protein, negatively regulates motility and biofilm formation in {Less than}i{Greater than}Escherichia coli{Less than}/i{Greater than}
28-03-2013 | Rahimpour M; Montero M; Almagro G; Viale A; Sevilla A; C{a}novas M; Mu{n}oz F; Baroja-Fern{a}ndez E; Bahaji A; Eydal ..., Biochemical Journal, 2013
Escherichia coli glycogen metabolism involves regulation of the glgBXCAP operon expression and allosteric control of GlgC-mediated catalysis of ATP and glucose-1-phosphate (G1P) to ADP-glucose linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected by glgS. Though the ...
Single-strand promoter traps for bacterial RNA polymerase
22-03-2013 | Pupov D; Esyunina D; Feklistov A; Kulbachinskiy A, Biochemical Journal, 2013
Besides canonical double-strand DNA promoters, multisubunit RNA polymerases (RNAPs) recognize a number of specific single-strand DNA and RNA templates, resulting in synthesis of various types of RNA transcripts. The general recognition principles and the mechanisms of transcription initiation ...
BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
12-03-2013 | Beverly L; Howell L; Hernandez-Corbacho M; Casson L; Chipuk J; Siskind L, Biochemical Journal, 2013
Determining mechanistic details about how drugs kill cancer cells is critical for predicting which cancers will respond to given therapeutic regimens and for identifying effective combinations of drugs that more potently kill cancer cells while sparing normal cells. The BCL2-family of ...
Identification of an 8-vinyl reductase involved in bacteriochlorophyll biosynthesis in Rhodobacter sphaeroides and evidence for the existence of a third distinct class of the enzyme
01-03-2013 | Canniffe DP; Jackson PJ; Hollingshead S; Dickman MJ; Hunter CN, Biochemical Journal, 2013
The purple phototrophic bacterium Rhodobacter sphaeroides utilises bacteriochlorophyll a for light harvesting and photochemistry. The synthesis of this photopigment includes the reduction of a vinyl group at the C8 position to an ethyl group, catalysed by a C8-vinyl reductase. An active form ...
Membrane Topology of Yeast Alkaline Ceramidase {Less than}i{Greater than}YPC1{Less than}/i{Greater than}
27-02-2013 | Ramachandra N; Conzelmann A, Biochemical Journal, 2013
Ypc1p and Ydc1p are alkaline ceramide hydrolases, which reside in the ER. Ypc1p can catalyze the reverse reaction, i.e. the condensation of free fatty acids with phytosphingosine or dihydrosphingosine and overexpression of YPC1 or YDC1 can provide enough ceramide synthesis as to rescue the ...
Metal insertion into the molybdenum cofactor: product-substrate channelling demonstrates the functional origin of domain fusion in gephyrin
15-02-2013 | Belaidi AA; Schwarz G, Biochemical Journal, 2013
The complexity of eukaryotic multicellular organisms relies on evolutionary developments that include compartmentalization, alternative splicing, protein domain fusion and post-translational modification. Mammalian gephyrin uniquely exemplifies these processes by combining two enzymatic ...
Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote
15-02-2013 | Musgrave WB; Yi H; Kline D; Cameron JC; Wignes J; Dey S; Pakrasi HB; Jez JM, Biochemical Journal, 2013
Glutathione biosynthesis catalysed by GCL (glutamate-cysteine ligase) and GS (glutathione synthetase) is essential for maintaining redox homoeostasis and protection against oxidative damage in diverse eukaroytes and bacteria. This biosynthetic pathway probably evolved in cyanobacteria with ...
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