My watch list
my.chemeurope.com  
Login  

110 Newest Publications of Portland Press

rss
matching the following criteria

Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

more

In response to oxidative stress and energy restriction AMPK and PKC collaborate to induce the phosphorylation of Serine 413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5){Less than}i{Greater than}P{Less than}/i{Greater than}{Less than}sub{Greater than}2{Less than}/sub{Greater than} synthesis

05-08-2013 | van den Bout I; Jones D; Shah Z; Halstead J; Keune W; Mohammed S; D'Santos C; Divecha N, Biochemical Journal, 2013

The spatial and temporal regulation of the second messenger, phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2 ) has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of phosphatidylinositol 4-phosphate 5-kinase (PIP5K1 A, B and C) ...

more

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

01-08-2013 | Liu Y; Lai Y; Hill E; Tyteca D; Carpentier S; Ingvaldsen A; Vertommen D; Lantier L; Foretz M; Dequiedt F; Courtoy P; ..., Biochemical Journal, 2013

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), the lipid kinase that phosphorylates PtdIns3P to PtdIns(3,5)P2, has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMP-activated protein kinase (AMPK)-stimulated ...

more

Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

18-07-2013 | Aregger M; Cowling V, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with addition of 7-methylguanosine to the initiating nucleotide of RNA pol II transcripts, which occurs predominantly during ...

more

The Mitochondrial Carrier Rim2 Co-Imports Pyrimidine Nucleotides and Iron

26-06-2013 | Froschauer E; Rietzschel N; Hassler M; Binder M; Schweyen R; Lill R; M{u}hlenhoff U; Wiesenberger G, Biochemical Journal, 2013

Mitochondrial iron uptake is of key importance for both organelle function and cellular iron homeostasis. The mitochondrial carrier family members Mrs3 and Mrs4 (homologs of vertebrate mitoferrin) function in organellar iron supply, yet other low efficiency transporters may exist. In S. ...

more

Metabolic phenotypes of {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} mutants with altered trehalose-6-phosphate dynamics

14-06-2013 | Walther T; Mtimet N; Alkim C; Vax A; Loret M; Ullah A; Gancedo C; Smits G; Fran{c with cedilla}ois J, Biochemical Journal, 2013

In Saccharomyces cerevisiae, synthesis of trehalose-6-phosphate (T6P) is essential for growth on most fermentable carbon sources. The metabolic response to glucose was analysed in mutants with different capacity to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, ...

more

Roles of EXTL2, a member of EXT family of tumor suppressors, in liver injury and regeneration processes

04-06-2013 | Nadanaka S; Kagiyama S; Kitagawa H, Biochemical Journal, 2013

The gene products of two members of the EXT gene family, EXT1 and EXT2, function together as a polymerase in the biosynthesis of heparan sulfate. EXTL2, one of the three EXT-like genes in the human genome that are homologous to EXT1 and EXT2, encodes a N-acetylhexosaminyltransferase. Recently, we ...

more

Cell Cycle Regulation of Purine Synthesis by Phosphoribosyl- Pyrophosphate and Inorganic Phosphate

04-06-2013 | Fridman A; Saha A; Chan A; Casteel D; Pilz R; Boss G, Biochemical Journal, 2013

Cells must increase synthesis of purine nucleotides/deoxynucleotides before or during S phase. We found that rates of purine synthesis via the de novo and salvage pathways increased 5.0- and 3.3-fold, respectively, as cells progressed from mid G1 to early S phase. The increased purine synthesis ...

more

The folding capacity of the mature domain of the dual-targeted plant tRNA nucleotidyltransferase influences organelle selection

28-05-2013 | Leibovitch M; Bublak D; Hanic-Joyce P; Tillmann B; Flinner N; Amsel D; Scharf K; Mirus O; Joyce P; Schleiff E, Biochemical Journal, 2013

tRNA nucleotidyltransferases are required for the maturation or repair of tRNAs by ensuring that they have an intact cytidine-cytidine-adenosine sequence at their 3’-termini. Therefore, this enzymatic activity is found in all cellular compartments, namely the nucleus, cytoplasm, plastids and ...

more

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

02-04-2013 | Novellasdemunt L; Bultot L; Manzano A; Ventura F; Rosa J; Vertommen D; Rider M; Navarro-Sabate {A}; Bartrons R, Biochemical Journal, 2013

PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate ...

more

Page 1 From 11
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE