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117 Newest Publications of Portland Press

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Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase

04-12-2014 | Hou X; Wu W; Duan X; Liu N; Li H; Fu J; Dou S; Li M; Xi X, Biochemical Journal, 2014

Recent advances in G-quadruplex (G4) studies have confirmed that G4 structures exist in living cells and may have detrimental effects on various DNA transactions. How helicases resolve G4, however, has just begun to be studied and remains largely unknown. Here we use single-molecule fluorescence ...

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{Less than}i{Greater than}Bombyx mori{Less than}/i{Greater than} prothoracicostatic peptide receptor is allosterically activated via a G{alpha}{Less than}sub{Greater than}i/o{Less than}/sub{Greater than} protein-biased signaling cascade by {Less than}i{Greater than}Drosophila{Less than}/i{Greater than} sex peptide

25-11-2014 | He X; Zang J; Yang H; Huang H; Shi Y; Zhu C; Zhou N, Biochemical Journal, 2014

In insects, molting and metamorphosis are strictly regulated by ecdysteroids. Ecdysteroid synthesis is positively or negatively controlled by several neuropeptides. The prothoracicostatic peptide BmPTSP, isolated from the larval brain of Bombyx mori, has been demonstrated to inhibit ecdysteroid ...

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Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than}

24-11-2014 | Thota S; Unnikannan C; Thampatty S; Manorama R; Bhandari R, Biochemical Journal, 2014

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol which act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

29-10-2014 | Knight J; Bastide A; Roobol A; Roobol J; Jackson T; Utami W; Barrett D; Smales C; Willis A, Biochemical Journal, 2014

Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the ...

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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The architecture of an Okazaki fragment-processing holoenzyme from the archaeon {Less than}i{Greater than}Sulfolobus solfataricus{Less than}/i{Greater than}

09-10-2014 | Cannone G; Xu Y; Beattie T; Bell S; Spagnolo L, Biochemical Journal, 2014

DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes the enzymatic activities required for this process are supplied by a replicative DNA polymerase, Flap Endonuclease 1 (Fen1) and DNA ligase 1. These factors interact with ...

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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

15-09-2014 | Bridges HR; Jones AJY; Pollak MN; Hirst J, Biochemical Journal, 2014

The biguanide metformin is widely prescribed for TypeII diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage-specific actions and therapeutic effects, the ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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In response to oxidative stress and energy restriction AMPK and PKC collaborate to induce the phosphorylation of Serine 413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5){Less than}i{Greater than}P{Less than}/i{Greater than}{Less than}sub{Greater than}2{Less than}/sub{Greater than} synthesis

05-08-2013 | van den Bout I; Jones D; Shah Z; Halstead J; Keune W; Mohammed S; D'Santos C; Divecha N, Biochemical Journal, 2013

The spatial and temporal regulation of the second messenger, phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2 ) has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of phosphatidylinositol 4-phosphate 5-kinase (PIP5K1 A, B and C) ...

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Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

01-08-2013 | Liu Y; Lai Y; Hill E; Tyteca D; Carpentier S; Ingvaldsen A; Vertommen D; Lantier L; Foretz M; Dequiedt F; Courtoy P; ..., Biochemical Journal, 2013

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), the lipid kinase that phosphorylates PtdIns3P to PtdIns(3,5)P2, has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMP-activated protein kinase (AMPK)-stimulated ...

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