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114 Newest Publications of Portland Press

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Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

29-10-2014 | Knight J; Bastide A; Roobol A; Roobol J; Jackson T; Utami W; Barrett D; Smales C; Willis A, Biochemical Journal, 2014

Cells respond to external stress conditions by controlling gene expression, a process which occurs rapidly via post-transcriptional regulation at the level of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the ...

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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The architecture of an Okazaki fragment-processing holoenzyme from the archaeon {Less than}i{Greater than}Sulfolobus solfataricus{Less than}/i{Greater than}

09-10-2014 | Cannone G; Xu Y; Beattie T; Bell S; Spagnolo L, Biochemical Journal, 2014

DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes the enzymatic activities required for this process are supplied by a replicative DNA polymerase, Flap Endonuclease 1 (Fen1) and DNA ligase 1. These factors interact with ...

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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

15-09-2014 | Bridges HR; Jones AJY; Pollak MN; Hirst J, Biochemical Journal, 2014

The biguanide metformin is widely prescribed for TypeII diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage-specific actions and therapeutic effects, the ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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In response to oxidative stress and energy restriction AMPK and PKC collaborate to induce the phosphorylation of Serine 413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5){Less than}i{Greater than}P{Less than}/i{Greater than}{Less than}sub{Greater than}2{Less than}/sub{Greater than} synthesis

05-08-2013 | van den Bout I; Jones D; Shah Z; Halstead J; Keune W; Mohammed S; D'Santos C; Divecha N, Biochemical Journal, 2013

The spatial and temporal regulation of the second messenger, phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2 ) has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of phosphatidylinositol 4-phosphate 5-kinase (PIP5K1 A, B and C) ...

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Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

01-08-2013 | Liu Y; Lai Y; Hill E; Tyteca D; Carpentier S; Ingvaldsen A; Vertommen D; Lantier L; Foretz M; Dequiedt F; Courtoy P; ..., Biochemical Journal, 2013

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), the lipid kinase that phosphorylates PtdIns3P to PtdIns(3,5)P2, has been implicated in insulin-stimulated glucose uptake. We investigated whether PIKfyve could also be involved in contraction/AMP-activated protein kinase (AMPK)-stimulated ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

18-07-2013 | Aregger M; Cowling V, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with addition of 7-methylguanosine to the initiating nucleotide of RNA pol II transcripts, which occurs predominantly during ...

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The Mitochondrial Carrier Rim2 Co-Imports Pyrimidine Nucleotides and Iron

26-06-2013 | Froschauer E; Rietzschel N; Hassler M; Binder M; Schweyen R; Lill R; M{u}hlenhoff U; Wiesenberger G, Biochemical Journal, 2013

Mitochondrial iron uptake is of key importance for both organelle function and cellular iron homeostasis. The mitochondrial carrier family members Mrs3 and Mrs4 (homologs of vertebrate mitoferrin) function in organellar iron supply, yet other low efficiency transporters may exist. In S. ...

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Metabolic phenotypes of {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than} mutants with altered trehalose-6-phosphate dynamics

14-06-2013 | Walther T; Mtimet N; Alkim C; Vax A; Loret M; Ullah A; Gancedo C; Smits G; Fran{c with cedilla}ois J, Biochemical Journal, 2013

In Saccharomyces cerevisiae, synthesis of trehalose-6-phosphate (T6P) is essential for growth on most fermentable carbon sources. The metabolic response to glucose was analysed in mutants with different capacity to accumulate T6P. A mutant carrying a deletion in the T6P synthase encoding gene, ...

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