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194 Newest Publications of Portland Press

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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Regulatory T cells and cAMP suppress effector T cells independently of PKA-CREM/ICER: a potential role for Epac

05-09-2013 | Vang A; Housley W; Dong H; Basole C; Ben-Sasson S; Kream B; Epstein P; Clark R; Brocke S, Biochemical Journal, 2013

cAMP signaling is both a major pathway as well as a key therapeutic target for inducing immune tolerance and is involved in regulatory T cell (Treg cell) function. To achieve potent immunoregulation, cAMP can act through several downstream effectors. One proposed mechanism is that cAMP-mediated ...

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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells

01-09-2013 | Wiejak J; Dunlop J; Mackay SP; Yarwood SJ, Biochemical Journal, 2013

The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) signalling pathway, which is normally down-regulated by the STAT3-dependent ...

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Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

16-08-2013 | Madabushi A; Hwang B; Jin J; Lu A, Biochemical Journal, 2013

Thymine DNA glycosylase (TDG) is an essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation, and transcription regulation. TDG is the predominant enzyme to remove thymine from T/G mispair, which arises due to deamination of 5-methyl-cytosine at the CpG ...

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A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer Triggered by Zinc Channel ZIP6 and Signal Transducer and Activator of Transcription 3 (STAT3)

07-08-2013 | Hogstrand C; Kille P; Ackland M; Hiscox S; Taylor K, Biochemical Journal, 2013

Genes involved in normal developmental processes attract attention as mediators of tumour progression as they facilitate migration of tumour cells. Epithelial-mesenchymal transition (EMT), an essential part of embryonic development, tissue remodelling and wound repair, is crucial for tumour ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

18-07-2013 | Aregger M; Cowling V, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with addition of 7-methylguanosine to the initiating nucleotide of RNA pol II transcripts, which occurs predominantly during ...

more

The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

11-07-2013 | Chandor-Proust A; Bibby J; R{e}gent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz M; Paine M; Dauphin-Vi ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

more

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death

01-07-2013 | Jean Y; Ribe E; Pero M; Moskalenko M; Iqbal Z; Marks L; Greene L; Troy C, Biochemical Journal, 2013

Neuronal apoptotic death generally requires de novo transcription, and activation of the transcription factor c-Jun has been shown to be necessary in multiple neuronal death paradigms. Caspase-2 has been implicated in death of neuronal and non-neuronal cells, but its relationship to ...

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Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity

01-07-2013 | Dudek KM; Suter L; Darras VM; Marczylo EL; Gant TW, Biochemical Journal, 2013

Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining polysome profiling with genomic methodologies, we ...

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