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217 Newest Publications of Portland Press

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Regulation of IGFBP-2 expression during fasting

19-Feb-2015 | Kang H; Kim M; Kim S; Lee J; Kim Y; Seo Y; Bae J; Oh G; Song D; Ahn Y; Im S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorder is well known, its regulatory mechanism remains unclear. Here, we ...

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Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae

15-Feb-2015 | Thota SG; Unnikannan CP; Thampatty SR; Manorama R; Bhandari R, Biochemical Journal, 2015

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol that act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

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The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

15-Jan-2015 | Ozanne J; Prescott AR; Clark K, Biochemical Journal, 2015

Macrophages switch to an anti-inflammatory, 'regulatory'-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of pro-inflammatory cytokines to promote the resolution of inflammation. A potential therapeutic strategy for the treatment of chronic ...

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FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3

16-Dec-2014 | Ma W; Fuentes G; Shi X; Verma C; Radda G; Han W, Biochemical Journal, 2014

FoxO1, which is upregulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to SP1-POMC promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription. FoxO1 also binds directly to the POMC promoter and ...

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The regulatory role of {Less than}i{Greater than}Streptomyces coelicolor{Less than}/i{Greater than} TamR in central metabolism

11-Dec-2014 | Huang H; Sivapragasam S; Grove A, Biochemical Journal, 2014

Trans-aconitate methyltransferase regulator (TamR) is a member of the ligand-responsive multiple antibiotic resistance regulator (MarR) family of transcription factors. In Streptomyces coelicolor, TamR regulates transcription of tamR (encoding TamR), tam (encoding trans-aconitate ...

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Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that cooperate in a shared-recruitment mechanism.

08-Dec-2014 | Rossiter A; Godfrey R; Connolly J; Busby S; Henderson I; Browning D, Biochemical Journal, 2014

Pet is a cytotoxic autotransporter protein secreted by the pathogenic Enteroaggregative Escherichia coli strain 042. Expression of Pet is co-dependent on two global transcription regulators: CRP (cyclic AMP receptor protein) and Fis (factor for inversion stimulation). At the pet promoter CRP ...

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Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5

01-Dec-2014 | Jacob W; Rosenzweig D; V{a}zquez-Martin C; Duce S; Cohen P, Biochemical Journal, 2014

Glucocorticoids play an important role in the treatment of inflammation and immune disorders, despite side effects, which include metabolic derangements such as central adiposity. These studies examine the role of protein phosphatase 5 (Ppp5) in glucocorticoid receptor complexes, which mediate ...

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Transmembrane Oligomeric form of {Less than}i{Greater than}Vibrio cholerae{Less than}/i{Greater than} Cytolysin Triggers TLR2/TLR6-dependent Pro-inflammatory Responses in Monocytes and Macrophages

28-Nov-2014 | Khilwani B; Mukhopadhaya A; Chattopadhyay K, Biochemical Journal, 2014

Vibrio cholerae cytolysin (VCC) kills target eukaryotic cells by forming transmembrane oligomeric β-barrel pores. Once irreversibly converted into the transmembrane oligomeric form, VCC acquires unusual structural stability, and loses cytotoxic property. It is therefore possible that upon ...

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HBx induces the proliferation of hepatocellular carcinoma cells via AP1 overexpressed by ER stress

27-Nov-2014 | Cho H; Kim S; Kyaw Y; Win A; Koo S; Kim H; Cheong J, Biochemical Journal, 2014

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. ...

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MiR-98 delays skeletal muscle differentiation by downregulating E2F5

25-Nov-2014 | Kropp J; Degerny C; Morozova N; Pontis J; Harel-bellan A; Polesskaya A, Biochemical Journal, 2014

A genome-wide screen had previously shown that knocking down miR-98 and let-7g, two miRNAs of the let-7 family, leads to a dramatic increase of terminal myogenic differentiation. Here we report that a transcriptomic analysis of human myoblasts where miR-98 was knocked down revealed that ...

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