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213 Newest Publications of Portland Press

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matching the following criteria

The regulatory role of {Less than}i{Greater than}Streptomyces coelicolor{Less than}/i{Greater than} TamR in central metabolism

11-12-2014 | Huang H; Sivapragasam S; Grove A, Biochemical Journal, 2014

Trans-aconitate methyltransferase regulator (TamR) is a member of the ligand-responsive multiple antibiotic resistance regulator (MarR) family of transcription factors. In Streptomyces coelicolor, TamR regulates transcription of tamR (encoding TamR), tam (encoding trans-aconitate ...

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Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that cooperate in a shared-recruitment mechanism.

08-12-2014 | Rossiter A; Godfrey R; Connolly J; Busby S; Henderson I; Browning D, Biochemical Journal, 2014

Pet is a cytotoxic autotransporter protein secreted by the pathogenic Enteroaggregative Escherichia coli strain 042. Expression of Pet is co-dependent on two global transcription regulators: CRP (cyclic AMP receptor protein) and Fis (factor for inversion stimulation). At the pet promoter CRP ...

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Decreased adipogenesis and adipose tissue in mice with inactivated protein phosphatase 5

01-12-2014 | Jacob W; Rosenzweig D; V{a}zquez-Martin C; Duce S; Cohen P, Biochemical Journal, 2014

Glucocorticoids play an important role in the treatment of inflammation and immune disorders, despite side effects, which include metabolic derangements such as central adiposity. These studies examine the role of protein phosphatase 5 (Ppp5) in glucocorticoid receptor complexes, which mediate ...

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Transmembrane Oligomeric form of {Less than}i{Greater than}Vibrio cholerae{Less than}/i{Greater than} Cytolysin Triggers TLR2/TLR6-dependent Pro-inflammatory Responses in Monocytes and Macrophages

28-11-2014 | Khilwani B; Mukhopadhaya A; Chattopadhyay K, Biochemical Journal, 2014

Vibrio cholerae cytolysin (VCC) kills target eukaryotic cells by forming transmembrane oligomeric β-barrel pores. Once irreversibly converted into the transmembrane oligomeric form, VCC acquires unusual structural stability, and loses cytotoxic property. It is therefore possible that upon ...

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HBx induces the proliferation of hepatocellular carcinoma cells via AP1 overexpressed by ER stress

27-11-2014 | Cho H; Kim S; Kyaw Y; Win A; Koo S; Kim H; Cheong J, Biochemical Journal, 2014

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and chronic hepatitis B virus (HBV) infection is the most common risk factor for HCC. The HBV proteins can induce oncogenic effects or synergy effects with the hyperproliferative response on transformation into HCC. ...

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MiR-98 delays skeletal muscle differentiation by downregulating E2F5

25-11-2014 | Kropp J; Degerny C; Morozova N; Pontis J; Harel-bellan A; Polesskaya A, Biochemical Journal, 2014

A genome-wide screen had previously shown that knocking down miR-98 and let-7g, two miRNAs of the let-7 family, leads to a dramatic increase of terminal myogenic differentiation. Here we report that a transcriptomic analysis of human myoblasts where miR-98 was knocked down revealed that ...

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Andrographolide activates the canonical {Less than}i{Greater than}Wnt {Less than}/i{Greater than}signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3{beta}: Auto regulation of GSK-3{beta} {Less than}i{Greater than}in vivo{Less than}/i{Greater than}

25-11-2014 | Tapia-Rojas C; Sch{u}ller A; Lindsay C; Ureta R; Mej{i}as-Reyes C; Hancke J; Melo F; Inestrosa N, Biochemical Journal, 2014

Wnt/β-catenin signalling is an important pathway that regulates multiple biological processes including cell adhesion and cell fate determination during animal development and in the adult nervous system regulates the structure and function of synapses. Wnt signalling dysfunction is associated ...

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Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in {Less than}i{Greater than}Saccharomyces cerevisiae{Less than}/i{Greater than}

24-11-2014 | Thota S; Unnikannan C; Thampatty S; Manorama R; Bhandari R, Biochemical Journal, 2014

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol which act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

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Fe65 Ser{Less than}sup{Greater than}228{Less than}/sup{Greater than} is Phosphorylated by ATM/ATR and Inhibits Fe65-APP-Mediated Gene Transcription

14-11-2014 | Jowsey P; Blain P, Biochemical Journal, 2014

Fe65 binds the amyloid precursor protein (APP) and regulates the secretase-mediated processing of APP into several proteolytic fragments, including the amyloid-β (Aβ) peptides and APP intracellular domain (AICD). Aβ accumulation in neural plaques is a pathological feature of Alzheimer’s disease ...

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Synthetic DAF-12 modulators with potential use in controlling nematodes life cycle

06-11-2014 | Dansey M; Alvarez L; Samaja G; Escudero D; Veleiro A; Pecci A; Castro O; Burton G, Biochemical Journal, 2014

Dafachronic acids (DAs) are 3-keto colestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or ...

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