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200 Newest Publications of Portland Press

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Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression

23-10-2014 | Almahariq M; Mei F; Wang H; Cao A; Yao S; Soong L; Sun J; Cong Y; Chen J; Cheng X, Biochemical Journal, 2014

The cyclic adenosine monophosphate (cAMP) signaling pathway plays an essential role in immune functions. In this study we examined the role of the cAMP/EPAC1 (exchange protein directly activated by cAMP) axis in regulatory T-cell (Treg)-mediated immune suppression using genetic and pharmacologic ...

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miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation

15-10-2014 | Ouyang M; Su W; Xiao L; Rao J; Jiang L; Li Y; Turner D; Gorospe M; Wang J, Biochemical Journal, 2014

Menin regulates distinct cellular functions by regulating gene transcription through its interaction with partner transcription factors, but the exact mechanisms that control Menin levels remain largely unknown. Here we report that Men1 mRNA, encoding Menin, is a novel target of microRNA-29b ...

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Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen

03-10-2014 | Radde B; Ivanova M; Mai H; Salabei J; Hill B; Klinge C, Biochemical Journal, 2014

Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated ...

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Priming IKKβ kinase for action

01-10-2014 | Ley SC; Beyaert R, Biochemical Journal, 2014

IKKβ (IκB kinase β) is a core component of signalling pathways that control the activation of NF-κB (nuclear factor κB) transcription factors, which regulate many physiological processes, including cell survival, immunity and DNA-damage responses. Like many kinases, activation of IKKβ requires ...

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The SARS-Coronavirus Membrane protein induces apoptosis via interfering PDK1-PKB/Akt signaling

01-10-2014 | Tsoi H; Li L; Chen Z; Lau K; Tsui S; Chan H, Biochemical Journal, 2014

A number of viral gene products are capable of inducing apoptosis through interfering with various cellular signaling cascades. We previously reported the pro-apoptotic property of the SARS-CoV Membrane (M) protein and a down-regulation of the phosphorylation level of the cell survival protein ...

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Chromatin and oxygen sensing in the context of JmjC histone demethylases

15-09-2014 | Shmakova A; Batie M; Druker J; Rocha S, Biochemical Journal, 2014

Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition. Although it is appreciated that gene expression is co-ordinated by changes in ...

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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Regulatory T cells and cAMP suppress effector T cells independently of PKA-CREM/ICER: a potential role for Epac

05-09-2013 | Vang A; Housley W; Dong H; Basole C; Ben-Sasson S; Kream B; Epstein P; Clark R; Brocke S, Biochemical Journal, 2013

cAMP signaling is both a major pathway as well as a key therapeutic target for inducing immune tolerance and is involved in regulatory T cell (Treg cell) function. To achieve potent immunoregulation, cAMP can act through several downstream effectors. One proposed mechanism is that cAMP-mediated ...

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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells

01-09-2013 | Wiejak J; Dunlop J; Mackay SP; Yarwood SJ, Biochemical Journal, 2013

The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) signalling pathway, which is normally down-regulated by the STAT3-dependent ...

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