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225 Newest Publications of Portland Press

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matching the following criteria

FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21{Less than}sup{Greater than}Cip1/Waf1{Less than}/sup{Greater than}

20-May-2015 | Kloet D; Polderman P; Eijkelenboom A; Smits L; Van Triest M; Van Den Berg M; Groot Koerkamp M; Van Leenen D; Lijnzaa ..., Biochemical Journal, 2015

Activity of Forkhead box O (FOXO) transcription factors is inhibited by growth factor-PI3K-protein kinase B (PKB)/AKT signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we identified a set of ...

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Acyl-CoA Binding Domain Containing 3 Modulates NAD{+} Metabolism through Activating Poly(ADP-ribose) Polymerase 1

05-May-2015 | Chen Y; Bang S; Park S; Shi H; Kim S, Biochemical Journal, 2015

Nicotinadmide adenine dinucleotide (NAD+) plays essential roles in cellular energy homeostasis and redox state functioning as a cofactor along the glycolysis and citric acid cycle pathways. Recent discoveries indicated that, through the NAD+-consuming enzymes, this molecule may be also involved ...

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Regulation of IGFBP-2 expression during fasting

01-May-2015 | Kang HS; Kim M-Y; Kim S-J; Lee J-H; Kim Y-D; Seo Y-K; Bae J-H; Oh G-T; Song D-K; Ahn Y-H; Im S-S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In the present ...

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Suppression of Interferon {beta} gene transcription by inhibitors of Bromodomain and Extra-Terminal (BET) family members

20-Apr-2015 | Malik N; Vollmer S; Nanda S; Lopez-Pelaez M; Prescott A; Gray N; Cohen P, Biochemical Journal, 2015

Polo-Like Kinase (PLK) inhibitors, such as BI-2536, have been reported to suppress interferon β (IFNβ) gene transcription induced by ligands that activate TLR3 and TLR4. Here, we report that BI-2536 is likely to exert this effect by preventing the interaction of the transcription factors IRF3 and ...

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Biochemical and redox characterization of the Mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein

16-Apr-2015 | Shaikhali J; Davoine C; Br{a}nnstr{o}m K; ROUHIER N; Bygdell J; Bj{o}rklund S; Wingsle G, Biochemical Journal, 2015

The eukaryotic Mediator integrates regulatory signals from promoter-bound transcription factors and transmits them to RNA polymerase II machinery. Although redox signaling is important in adjusting plant metabolism and development, nothing is known about a possible redox regulation of Mediator. ...

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Erythropoietin mediated expression of Placenta Growth Factor is regulated via activation of hypoxia inducible factor -1{alpha} and post-transcriptionally by mir214 in Sickle Cell Disease

16-Apr-2015 | Gonsalves C; Li C; Mwa Mpollo M; Pullarkat V; Malik P; Tahara S; Kalra V, Biochemical Journal, 2015

Placental growth factor (PlGF) plays an important role in various pathological conditions and diseases such as inflammation, cancer, atherosclerosis and sickle cell disease (SCD). Abnormally high PlGF levels in SCD patients are associated with increased inflammation and pulmonary hypertension and ...

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Development of a new model system to dissect isoform specific Akt signaling in adipocytes

09-Apr-2015 | Kajno E; McGraw T; Gonzalez E, Biochemical Journal, 2015

Akt kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signaling differentially contribute to sustain lipid and glucose homeostasis; howeverAkt isoform-specific effectors remain elusive due to the lack of a suitable model system to ...

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Conversion of Non-adipogenic Fibroblasts into Adipocytes by a Defined Hormone Mixture

02-Mar-2015 | Nie T; Hui X; Gao X; Nie B; Mao L; Tang X; Yuan R; Li K; Li P; Xu A; Liu P; Ding S; Han W; Cooper G; Wu D, Biochemical Journal, 2015

Obesity is accompanied with an increase of the size and the number of adipocytes, the latter of which is thought to differentiate from pre-adipocytes, we postulate that non-adipogenic fibroblasts contribute to adipocyte formation under certain conditions such as obesity. We report here for the ...

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Regulation of IGFBP-2 expression during fasting

19-Feb-2015 | Kang H; Kim M; Kim S; Lee J; Kim Y; Seo Y; Bae J; Oh G; Song D; Ahn Y; Im S, Biochemical Journal, 2015

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorder is well known, its regulatory mechanism remains unclear. Here, we ...

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Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae

15-Feb-2015 | Thota SG; Unnikannan CP; Thampatty SR; Manorama R; Bhandari R, Biochemical Journal, 2015

Ribosome biogenesis is an essential cellular process regulated by the metabolic state of a cell. We examined whether inositol pyrophosphates, energy-rich derivatives of inositol that act as metabolic messengers, play a role in ribosome synthesis in the budding yeast, Saccharomyces cerevisiae. ...

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