16-06-2013 | Carlos M Farinha, Paulo Matos, Margarida D Amaral, FEBS Journal, 2013

Abstract Biogenesis of CFTR starts with its co‐translational insertion in the membrane of the endoplasmic reticulum (ER) and core‐glycosylation. These initial events are followed by a complex succession of steps with the main goal of checking the overall quality of CFTR conformation in ...

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16-06-2013 | Ling Wu, Bufang Xu, Weimin Fan, Xiaobin Zhu, Guangyan Wang, Aijun Zhang, FEBS Journal, 2013

Abstract Adiponectin is an adipocyte hormone, which is predominantly secreted by adipocytes, with important roles in glucose and lipids homeostasis. Recent studies have shown that adiponectin is also involved in the regulation of many endocrine organs, such as the ovary, adrenal gland and ...

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16-06-2013 | Diego A. Fernández, M. Carmen Louzao, Natalia Vilariño, Begoña Espiña, María Fraga, Mercedes R. Vieytes, Albina Romá ..., FEBS Journal, 2013

Abstract Palytoxin is one of the most toxic marine toxins known. Distributed worldwide, it poses a potential human health risk linked to contaminated seafood‐consumption. In spite of its high parenteral toxicity, the lethal oral dose of palytoxin is several times higher than the ...

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16-06-2013 | Friedrich Koch‐Nolte, Mathias Ziegler, FEBS Journal, 2013

ADP‐ribosylation of proteins is emerging as a very versatile post‐translational modification in various signaling pathways. In the cytosol of mammalian cells, this post‐translational modification is mediated by enzymes with a Diphtheria toxin‐homology ADP‐ribosyltransferase domain, the ...

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16-06-2013 | Yanxin Zhao, Fangzhe Chen, Shufen Chen, Xueyuan Liu, Mei Cui, Qiang Dong, Journal of Neurochemistry, 2013

Abstract Our previous study has shown that PTEN‐induced novel kinase 1 (PINK1) knocking down significantly induced mitochondrial fragmentation. Although PINK1 is proved to be associated with autosomal recessive parkinsonism and its function in this chronic pathological process is widely ...

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16-06-2013 | Hanan Awad, Anas El‐Aneed, Mass Spectrometry Reviews, 2013

Abstract With the fast growing market of pure enantiomer drugs and bioactive molecules, new chiral‐selective analytical tools have been instigated including the use of mass spectrometry (MS). Even though MS is one of the best analytical tools that has efficiently been used in several ...

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16-06-2013 | Laura M. López‐Sánchez, Chary López‐Pedrera, Antonio Rodríguez‐Ariza, Mass Spectrometry Reviews, 2013

Abstract Many of nitric oxide (NO) actions are mediated through the coupling of a nitroso moiety to a reactive cysteine leading to the formation of a S‐nitrosothiol (SNO), a process known as S‐nitrosylation or S‐nitrosation. In many cases this reversible post‐translational modification ...

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16-06-2013 | Elien Vandermarliere, Michael Mueller, Lennart Martens, Mass Spectrometry Reviews, 2013

Abstract Nowadays, mass spectrometry‐based proteomics is carried out primarily in a bottom‐up fashion, with peptides obtained after proteolytic digest of a whole proteome lysate as the primary analytes instead of the proteins themselves. This experimental setup crucially relies on a ...

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15-06-2013 | Xuejiao Liu, Wenqi Zhong, Yingjuan Shao, Bing Ren, Baosheng Jin, The Canadian Journal of Chemical Engineering, 2013

Abstract Evaluation on the effect of conical section geometry on the gas–solid flow behaviours in conical–cylindrical spouted beds were carried out by three‐dimensional computational fluid dynamics (CFD) coupling with two‐fluid model (TFM). The simulations were implemented in seven ...

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15-06-2013 | Hau‐Shing Shiu, Kae‐Long Lin, Sao‐Jeng Chao, Chao‐Lung Hwang, Ta‐Wui Cheng, Environmental Progress, 2013

Thin‐film transistor liquid crystal display (TFT–LCD) waste glass comprises mainly SiO2 and Al2O3, which are suitable raw materials for geopolymer. This study investigates the effects of the amount of foam agents on the properties of waste glass‐based cellular geopolymer. In this ...

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