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2,142 Newest Publications about the topic drug delivery


GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release

25-Mar-2015 | Xuan Wu; Yan Li; Chen Lin; Xiao-Yu Hu; Leyong Wang, Chemical Communication, 2015

Novel GSH- and pH-responsive supramolecular vesicles constructed by an amphiphilic inclusion complex formed from water-soluble pillar[5]arene and lysine derivative have been successfully developed, which can efficiently encapsulate anticancer drug MTZ and show rapid MTZ-release in a simulated ...


Preparation and release kinetics of carboxymethyl chitosan/cellulose acetate microspheres as drug delivery system

21-Mar-2015 | Hui Yun Zhou, Pei Pei Cao, Jun Bo Li, Fa Liang Zhang, Pei Pei Ding, Journal of Applied Polymer Science, 2015

ABSTRACT Carboxymethyl chitosan, a water soluble chitosan derivative, was prepared from chitosan using monochloroacetic acid. Carboxymethyl chitosan/cellulose acetate microspheres (CCM) were prepared using the method of W/O/W and emulsification solvent evaporation as drug delivery system. The ...


Iron oxide superparamagnetic nanocarriers bearing amphiphilic N‐heterocyclic choline analogues as potential antimicrobial agents

21-Mar-2015 | Alla Zablotskaya, Izolda Segal, Yuris Popelis, Anatoly Mishnev, Mikhail Maiorov, Dmitry Zablotsky, Elmars Blums, Viz ..., Applied Organometallic Chemistry, 2015

Magnetic nanoparticles represent an advanced tool in biomedicine because they can be simultaneously functionalized and guided using a magnetic field. Iron oxide magnetic nanoparticles precoated with oleic acid and bearing novel antimicrobial N‐heterocyclic choline analogues, namely O‐, N‐ and ...


Exploiting the Lactose–GM3 Interaction for Drug Delivery

20-Mar-2015 | Raghavendra Vasudeva Murthy, Harikrishna Bavireddi, Madhuri Gade, Raghavendra Kikkeri, ChemMedChem, 2015

Abstract Protein–protein and protein–carbohydrate interactions as a means to target the cell surface for therapeutic applications have been extensively investigated. However, carbohydrate–carbohydrate interactions (CCIs) have largely been overlooked. Here, we investigate the concept of ...


Electrostatic swelling of bicontinuous cubic lipid phases

18-Mar-2015 | Arwen I.I. Tyler; Hanna M.G. Barriga; Edward Parsons; Nicola L.C. McCarthy; Oscar Ces; Robert V. Law; John Seddon; N ..., Soft Matter, 2015

Lipid bicontinuous cubic phases have attracted enormous interest as bio-compatible scaffolds for use in a wide range of applications including membrane protein crystallisation, drug delivery and biosensing. One of the major bottlenecks that has hindered exploitation of these structures is an ...


Fabrication and Characterization of Chitosan and Pectin Nanostructured Multilayers

17-Mar-2015 | Laura Pastorino, Svetlana Erokhina, Carmelina Ruggiero, Victor Erokhin, Paola Petrini, Macromolecular Chemistry and Physics, 2015

Chitosan has been used for drug delivery applications for many years, and pectin has been recently used for several biomedical applications too. Both chitosan and pectin have shown to possess mucoadhesive properties. We report the assembly and characterization of biocompatible and biodegradable ...


Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance [Medical Sciences]

17-Mar-2015 | João Conde; Nuria Oliva; Natalie Artzi, Proceedings of the National Academy of Sciences current issue, 2015

Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemotherapeutic drug delivery in vivo with a single local application. Our ...


Current advances in lanthanide ion (Ln3+)-based upconversion nanomaterials for drug delivery

16-Mar-2015 | Dongmei Yang; Ping'an Ma; Zhiyou Hou; Ziyong Cheng; Chunxia Li; Jun Lin, Chemical Society Reviews, 2015

Lanthanide ion (Ln3+)-based upconversion nano/micromaterials that emit higher-energy visible light when excited by low-energy NIR light have aroused considerable attention in the forefront of materials science and biomedical fields, which stems from their unique optical and chemical properties ...


Quantum Dot Surface Chemistry and Functionalization for Cell Targeting and Imaging

13-Mar-2015 | Regina Bilan; Fabrice Fleury; Igor Nabiev; Alyona Sukhanova, Bioconjugate Chemistry, 2015

Quantum dots (QDs) are highly fluorescent nanoscale crystals with size-dependent emission spectra. Due to their excellent photophysical properties, QDs are a promising alternative to organic fluorescent dyes and fluorescent proteins for cell targeting, imaging, and drug delivery. For biomedical ...


Bioactive Polymersomes Self-Assembled from Amphiphilic PPO-GlycoPolypeptides: Synthesis, Characterization, and Dual-Dye Encapsulation

13-Mar-2015 | Soumen Das; Dharmendar Kumar Sharma; Suman Chakrabarty; Arindam Chowdhury; Sayam Sen Gupta, Langmuir, 2015

Glycopolypeptide-based polymersomes have promising applications as vehicles for targeted drug delivery because they are capable of encapsulating different pharmaceuticals of diverse polarity as well as interacting with specific cell surfaces due to their hollow structural morphology and bioactive ...


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