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2,688 Newest Publications about the topic drug delivery


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Mucoadhesion: A promising approach in drug delivery system

07-Feb-2016 | Author(s): Shakir Mansuri, Prashant Kesharwani, Keerti Jain, Rakesh K. Tekade, N.K. Jain, Reactive and Functional Polymers, 2016

Publication date: March 2016 Source:Reactive and Functional Polymers, Volume 100 Author(s): Shakir Mansuri, Prashant Kesharwani, Keerti Jain, Rakesh K. Tekade, N.K. Jain Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other ...


IJMS, Vol. 17, Pages 172: Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

06-Feb-2016 | Ohno, Shin-ichiro ; Drummen, Gregor P. C.; Kuroda, Masahiko, International Journal of Molecular Sciences, 2016

Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a ...


Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image‐Guided Approaches

05-Feb-2016 | Jing Huang, Yuancheng Li, Anamaria Orza, Qiong Lu, Peng Guo, Liya Wang, Lily Yang, Hui Mao, Advanced Functional Materials, 2016

With rapid advances in nanomedicine, magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool in biomedical applications, including diagnostic imaging, drug delivery and novel therapeutics. Significant preclinical and clinical research has explored their functionalization, ...


A Telomerase‐specific Doxorubicin‐releasing Molecular Beacon for Cancer Theranostics

05-Feb-2016 | Yi Ma, Zhaohui Wang, Min Zhang, Zhihao Han, Dan Chen, Qiuyun Zhu, Weidong Gao, Zhiyu Qian, Yueqing Gu, Angewandte Chemie International Edition, 2016

Abstract A molecular beacon‐based drug delivery system was designed for both detection of telomerase activity in living cells and telomerase‐triggered drug release for precise cancer treatment. This system is composed of a gold nanoparticle core densely packed with FITC‐labeled hairpin DNA ...


Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins

05-Feb-2016 | Xi Zhu, Jun Wu, Wei Shan, Wei Tao, Lili Zhao, Jong‐Min Lim, Mathew D'Ortenzio, Rohit Karnik, Yuan Huang, Jinjun Shi, ..., Angewandte Chemie International Edition, 2016

Abstract Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide‐ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and ...


Framework Cationization by Preemptive Coordination of Open Metal Sites for Anion‐Exchange Encapsulation of Nucleotides and Coenzymes

05-Feb-2016 | Xiang Zhao, Chengyu Mao, Karen Tu Luong, Qipu Lin, Quan‐Guo Zhai, Pingyun Feng, Xianhui Bu, Angewandte Chemie International Edition, 2016

Abstract Cationic frameworks can selectively trap anions through ion exchange, and have applications in ion chromatography and drug delivery. However, cationic frameworks are much rarer than anionic or neutral ones. Herein, we propose a concept, preemptive coordination (PC), for targeting ...


Self-Assembled Gold Nanoclusters for Bright Fluorescence Imaging and Enhanced Drug Delivery

05-Feb-2016 | Akram Yahia-Ammar; Daniel Sierra; Fabienne Mérola; Niko Hildebrandt; Xavier Le Guével, ACS Nano, 2016

Nanoparticles combining enhanced cellular drug delivery with efficient fluorescence detection are important tools for the development of theranostic agents. Here, we demonstrate this concept by a simple, fast, and robust protocol of cationic polymer-mediated gold nanocluster (Au NCs) ...


Synthesis of Amino-ADT Provides Access to Hydrolytically Stable Amide-Coupled Hydrogen Sulfide Releasing Drug Targets

04-Feb-2016 | Matthew D. Hammers; Loveprit Singh; Leticia A. Montoya; Alan D. Moghaddam; Michael D. Pluth, Synlett, 2016

SynlettDOI: 10.1055/s-0035-1560603 As additional physiological functions of hydrogen sulfide (H2S) are discovered, developing practical methods for exogenous H2S delivery is important. In particular, nonsteroidal anti-inflammatory drugs (NSAIDs) functionalized with H2S-releasing anethole ...


DNA Origami: Folded DNA‐Nanodevices That Can Direct and Interpret Cell Behavior

03-Feb-2016 | Cathal J. Kearney, Christopher R. Lucas, Fergal J. O'Brien, Carlos E. Castro, Advanced Materials, 2016

DNA origami is a DNA‐based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the ...


Biomaterial‐Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

03-Feb-2016 | Hugh S. O'Neill, Laura B. Gallagher, Janice O'Sullivan, William Whyte, Clive Curley, Eimear Dolan, Aamir Hameed, Joa ..., Advanced Materials, 2016

Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, ...


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