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1,951 Newest Publications about the topic drug delivery

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Cyclic‐Disulfide‐Based Prodrugs for Cytosol‐Specific Drug Delivery

24-10-2014 | Gabor Butora, Ning Qi, Wenlang Fu, Truyen Nguyen, Hsueh‐Cheng Huang, Ian W. Davies, Angewandte Chemie International Edition, 2014

Abstract The cytosolic conversion of therapeutically relevant nucleosides into bioactive triphosphates is often hampered by the inefficiency of the first kinase‐mediated step. Nucleoside monophosphate prodrugs can be used to bypass this limitation. Herein we describe a novel cyclic‐disulfide ...

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Comparing linear and cyclic synthetic homopolypeptides: Synthesis and molecular characterization

24-10-2014 | Nikolaos Politakos, George Liontos, Galder Kortaberria, Jamie M. Messman, Javier Calvo, Sergio E. Moya, Jimmy W. May ..., Journal of Polymer Science Part A: Polymer Chemistry, 2014

ABSTRACT The synthesis and molecular characterization of a linear and a cyclic homopolypeptide of protected l‐tyrosine are reported. In this work, the successful synthesis of polypeptides exhibiting the desired linear and cyclic structures through various characterization methods such as high ...

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ChemInform Abstract: Noncovalent Interaction‐Assisted Polymeric Micelles for Controlled Drug Delivery

23-10-2014 | Jianxun Ding, Linghui Chen, Chunsheng Xiao, Li Chen, Xiuli Zhuang, Xuesi Chen, ChemInform, 2014

Abstract Review: 176 refs.

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Polydopamine and Eumelanin: From Structure–Property Relationships to a Unified Tailoring Strategy

23-10-2014 | Marco d’Ischia; Alessandra Napolitano; Vincent Ball; Chun-Teh Chen; Markus J. Buehler, Accounts of Chemical Research, 2014

ConspectusPolydopamine (PDA), a black insoluble biopolymer produced by autoxidation of the catecholamine neurotransmitter dopamine (DA), and synthetic eumelanin polymers modeled to the black functional pigments of human skin, hair, and eyes have burst into the scene of materials science as ...

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Receptor‐Mediated Uptake of Boron‐Rich Neuropeptide Y Analogues for Boron Neutron Capture Therapy

22-10-2014 | Verena M. Ahrens, René Frank, Solveig Boehnke, Christian L. Schütz, Gabriele Hampel, Dorothée S. Iffland, Nicolas H. ..., ChemMedChem, 2014

Abstract Peptidic ligands selectively targeting distinct G protein‐coupled receptors that are highly expressed in tumor tissue represent a promising approach in drug delivery. Receptor‐preferring analogues of neuropeptide Y (NPY) bind and activate the human Y1 receptor subtype (hY1 receptor), ...

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The development and assessment of high‐throughput mass spectrometry‐based methods for the quantification of a nanoparticle drug delivery agent in cellular lysate

22-10-2014 | Joshua Buse, Randy W. Purves, Ronald E. Verrall, Ildiko Badea, Haixia Zhang, Christopher C. Mulligan, Kerry M. Peru, ..., Journal of Mass Spectrometry, 2014

The safe use of lipid‐based drug delivery agents requires fast and sensitive qualitative and quantitative assessment of their cellular interactions. Many mass spectrometry (MS) based analytical platforms can achieve such task with varying capabilities. Therefore, four novel high‐throughput ...

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Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

22-10-2014 | Wye-Khay Fong; Tracey L. Hanley; Benjamin Thierry; Adam Tilley; Nigel Kirby; Lynne J. Waddington; Ben J. Boyd, Physical Chemistry Chemical Physics, 2014

Lipid-based liquid crystalline systems are showing potential as stimuli-responsive nanomaterials, and NIR-responsive gold nanoparticles have been demonstrated to provide control of transitions in non-lamellar phases. In this study, we focus on a deeper understanding of the photothermal response ...

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Efficient and Stereocontrolled Synthesis of 1,2,4-Trioxolanes Useful for Ferrous Iron-Dependent Drug Delivery

21-10-2014 | Shaun D. Fontaine; Antonio G. DiPasquale; Adam R. Renslo, Organic Letters, 2014

Ferrous iron-promoted reduction of a hindered peroxide bond underlies the antimalarial action of the 1,2,4-trioxane artemisinin and the 1,2,4-trioxolane arterolane. In appropriately designed systems, a 1,2,4-trioxolane ring can serve as a trigger to realize ferrous iron-dependent and ...

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Multi‐functional heparin‐biotin/heparin/calcium carbonate/calcium phosphate nanoparticles for targeting co‐delivery of gene and drug

20-10-2014 | Ping Liang, Chao‐Qun Wang, Hong Chen, Ren‐Xi Zhuo, Si‐Xue Cheng, Polymer International, 2014

Abstract A facile strategy to fabricate multi‐functional polymer/inorganic hybrid nanoparticles for efficient gene and drug co‐delivery was developed. A therapeutic gene (p53 plasmid) and a chemotherapy drug (doxorubicin hydrochloride, DOX) were co‐loaded in hybrid nanoparticles during ...

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Preparation of Polymeric Nanoparticles by Novel Electrospray Nanoprecipitation

20-10-2014 | C. J. Luo, T. Okubo, M. Nangrejo, M. Edirisinghe, Polymer International, 2014

Abstract Polymeric nanoparticles have important applications in drug delivery, biotechnology, diagnostics, and energy harvesting. We report a new technique named electrospray nanoprecipitation, which combines electrospray with agitated solvent displacement. The process enabled one‐step ...

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