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3,080 Newest Publications about the topic drug delivery

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Developing a self-healing supramolecular nucleoside hydrogel

27-Sep-2016 | Kathryn Skilling; Barrie Kellam; Marianne Ashford; Tracey D Bradshaw; Maria Marlow, Soft Matter, 2016

Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2ʹ-deoxycytidine (0.5 ...

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Characterization, in Vivo Evaluation, and Molecular Modeling of Different Propofol–Cyclodextrin Complexes To Assess Their Drug Delivery Potential at the Blood–Brain Barrier Level

23-Sep-2016 | Sergey Shityakov; Ramin Ekhteiari Salmas; Serdar Durdagi; Ellaine Salvador; Katalin Pápai; Maria Josefa Yáñez-Gascón ..., Journal of Chemical Information and Modeling, 2016

In this study, we investigated the ability of the general anesthetic propofol (PR) to form inclusion complexes with modified β-cyclodextrins, including sulfobutylether-β-cyclodextrin (SBEβCD) and hydroxypropyl-β-cyclodextrin (HPβCD). The PR/SBEβCD and PR/HPβCD complexes were prepared and ...

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Novel synthesis of AB-type carbonated hydroxyapatite hierarchical microstructures with sustained drug delivery properties

22-Sep-2016 | Ruixue Sun; Lili Yang; Yuxi Zhang; Fei Chu; Guangyu Wang; Yu-peng Lu; Kezheng Chen, CrystEngComm, 2016

In this study, AB-type carbonated hydroxyapatite (CHAp) nanosheet-assembled hollow microstructures were rapidly synthesized via a hydrothermal process without sintering. Urea was employed both as a pH adjusting agent and CO32- source during hydrothermal reaction. The influence of the hydrothermal ...

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Tumour‐Targeted Drug Delivery with Mannose‐Functionalized Nanoparticles Self‐Assembled from Amphiphilic β‐Cyclodextrins

22-Sep-2016 | Zhou Ye, Quan Zhang, Shengtao Wang, Priya Bharate, Silvia Varela‐Aramburu, Mengji Lu, Peter H. Seeberger, Jian Yin, Chemistry - A European Journal, 2016

Abstract Multivalent mannose‐functionalized nanoparticles self‐assembled from amphiphilic β‐cyclodextrins (β‐CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)‐loaded nanoparticles equipped with multivalent mannose target units were ...

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Direct synthesis of electrically integrated silicon nanowires forming 3D electrodes

22-Sep-2016 | Nicolas Hibst, Steffen Strehle, physica status solidi (a), 2016

Arrays composed of vertically aligned nanoscale electrodes are under discussion for various biological and analytical applications including extra‐ and intracellular measurements, intracellular drug delivery, and cellular interfacing. Based on their nanoscale morphology, conductive nanowires ...

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Dual‐Targeting Heparin‐Based Nanoparticles that Re‐Assemble in Blood for Glioma Therapy through Both Anti‐Proliferation and Anti‐Angiogenesis

22-Sep-2016 | Jihui Wang, Yuantao Yang, Yonghong Zhang, Min Huang, Zhenjun Zhou, Wanxian Luo, Jiao Tang, Jianguo Wang, Qian Xiao, ..., Advanced Functional Materials, 2016

The efficient and specific delivery of nanoparticles (NPs) to brain tumors is crucial for successful glioma treatment. Heparin‐based polymers decorated with two peptides self‐assemble into multi‐functional NPs that specifically target glioma cells. These NPs re‐self‐assemble to a smaller size in ...

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Lipid-based nanovesicles for nanomedicine

22-Sep-2016 | N. Grimaldi; F. Andrade; N. Segovia; L. Ferrer-Tasies; S. Sala; J. Veciana; N. Ventosa, Chemical Society Reviews, 2016

Molecular self-assembly has enabled the fabrication of biologically inspired, advanced nanostructures as lipid-based nanovesicles (L-NVs). The oldest L-NVs, liposomes, have been widely proposed as potential candidates for drug delivery, diagnostic and/or theranostic applications and some ...

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Nanomolar Binding of Steroids to Cucurbit[n]urils: Selectivity and Applications

22-Sep-2016 | Alexandra I. Lazar; Frank Biedermann; Kamila R. Mustafina; Khaleel I. Assaf; Andreas Hennig; Werner M. Nau, Journal of the American Chemical Society, 2016

Cucurbit[n]urils (CBn, n = 7, 8) serve as artificial receptors for steroids (21 tested), including the hormones testosterone and estradiol as well as steroidal drugs. Fluorescence displacement titrations and isothermal titration calorimetry (ITC) provided up to nanomolar binding affinities in ...

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Gold Nanorods as Drug Delivery Vehicles for Rifampicin Greatly Improve the Efficacy of Combating Mycobacterium tuberculosis with Good Biocompatibility with the Host Cells

22-Sep-2016 | Hala R. Ali; Moustafa R. K. Ali; Yue Wu; Salah A. Selim; Hazem F. M. Abdelaal; Essam A. Nasr; Mostafa A. El-Sayed, Bioconjugate Chemistry, 2016

TB remains a challenging disease to control worldwide. Nanoparticles have been used as drug carriers to deliver high concentrations of antibiotics directly to the site of infection, reducing the duration of treatment along with any side effects of off-target toxicities after systemic exposure to ...

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Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

22-Sep-2016 | Marine Protat; Noémie Bodin; Frédéric Gobeaux; Florent Malloggi; Jean Daillant; Nadège Pantoustier; Patrick Guenoun; ..., Langmuir, 2016

Multiple water-in-oil-in-water (W/O/W) emulsions are promising materials in designing carriers of hydrophilic molecules or drug delivery systems, provided stability issues are solved and biocompatible chemicals can be used. In this work, we designed a biocompatible amphiphilic copolymer, ...

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