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1,940 Newest Publications about the topic drug delivery


Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

22-10-2014 | Wye-Khay Fong; Tracey L. Hanley; Benjamin Thierry; Adam Tilley; Nigel Kirby; Lynne J. Waddington; Ben J. Boyd, Physical Chemistry Chemical Physics, 2014

Lipid-based liquid crystalline systems are showing potential as stimuli-responsive nanomaterials, and NIR-responsive gold nanoparticles have been demonstrated to provide control of transitions in non-lamellar phases. In this study, we focus on a deeper understanding of the photothermal response ...


Thiol–norbornene photoclick hydrogels for tissue engineering applications

18-10-2014 | Chien‐Chi Lin, Chang Seok Ki, Han Shih, Journal of Applied Polymer Science, 2014

ABSTRACT Thiol–norbornene (thiol–ene) photoclick hydrogels have emerged as a diverse material system for tissue engineering applications. These hydrogels are crosslinked through light‐mediated orthogonal reactions between multifunctional norbornene‐modified macromers [e.g., poly(ethylene ...


Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

18-10-2014 | Qihang Sun, Xuanrong Sun, Xinpeng Ma, Zhuxian Zhou, Erlei Jin, Bo Zhang, Youqing Shen, Edward A. Van Kirk, William J ..., Advanced Materials, 2014

A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the ...


Codelivery of Chemotherapeutics via Crosslinked Multilamellar Liposomal Vesicles to Overcome Multidrug Resistance in Tumor

17-10-2014 | Yarong Liu et al., PLoS ONE, 2014

by Yarong Liu, Jinxu Fang, Kye-Il Joo, Michael K. Wong, Pin Wang Multidrug resistance (MDR) is a significant challenge to effective cancer chemotherapy treatment. However, the development of a drug delivery system that allows for the sustained release of combined drugs with improved vesicle ...


Stimuli‐Responsive Polymeric Nanoparticles for Nanomedicine

16-10-2014 | Carina I. C. Crucho, ChemMedChem, 2014

Abstract Nature continues to be the ultimate in nanotechnology, where polymeric nanometer‐scale architectures play a central role in biological systems. Inspired by the way nature forms functional supramolecular assemblies, researchers are trying to make nanostructures and to incorporate these ...


Dendritic Ionic Liquids Based on Imidazolium‐Modified Poly(aryl ether) Dendrimers

16-10-2014 | Tianyi Qin, Xuying Li, Jinping Chen, Yi Zeng, Tianjun Yu, Guoqiang Yang, Yi Li, Chemistry - An Asian Journal, 2014

Abstract A series of dendritic ionic liquids (DILs) based on imidazolium‐modified poly(aryl ether) dendrimers IL‐Br‐Gn (n=0–3) were synthesized by a modified convergent approach and “click” chemistry. The resulting DILs exhibited high thermal resistance with decomposition temperatures up to ...


Design of Controlled Drug Delivery System Based on Disulfide Cleavage Trigger

16-10-2014 | Dong Yang; Wulian Chen; Jianhua Hu, Journal of Physical Chemistry B, 2014

The disulfide bond has drawn increasing attention for the application on controlled drug delivery systems (CDDSs) due to its high redox sensibility, which is derived from the fact that the concentration of glutathione (GSH), a disulfide-bond-breaking agent, in the tumor tissue is 1000-fold higher ...


A Pillararene‐Based Ternary Drug‐Delivery System with Photocontrolled Anticancer Drug Release

15-10-2014 | Guocan Yu, Wei Yu, Zhengwei Mao, Changyou Gao, Feihe Huang, Small, 2014

A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py‐Cbl), a water‐soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy‐poly(ethylene glycol)114‐block‐poly(L‐lysine hydrochloride)200. This DDS successfully ...


Cell‐Assembled Graphene Biocomposite for Enhanced Chondrogenic Differentiation

15-10-2014 | Wong Cheng Lee, Candy Haley Lim, Kenry, Chenliang Su, Kian Ping Loh, Chwee Teck Lim, Small, 2014

Graphene‐based nanomaterials are increasingly being explored for use as biomaterials for drug delivery and tissue engineering applications due to their exceptional physicochemical and mechanical properties. However, the two‐dimensional nature of graphene makes it difficult to extend its ...


Effect of Emulsification Process on Multiple Lipid Particles Encapsulating Both Coenzyme Q10 and Tea Polyphenols

15-10-2014 | Guodong Zhao, Caibiao Hu, Rui Sun, Shilei Ni, Qiang Xia, Journal of Food Process Engineering, 2014

Abstract A novel drug delivery system called multiple lipid particles containing both coenzyme Q10 and tea polyphenols were proposed for the stabilization of water‐in‐oil‐in‐water emulsions. The effects of the type and concentration of lipophilic and hydrophilic emulsifier, and drug ...


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