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3,880 Newest Publications about the topic drug delivery

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A Multinuclear NMR Perspective on the Complexation between Bisboronic acids and Bisbenzoxaboroles with cis-Diols

24-Jan-2018 | Adele Larcher; Aurélien Lebrun; Mike Smietana; Danielle Laurencin, New Journal of Chemistry, 2018

The interaction between boronic acids and cis-diols is an intense area of research, with numerous applications in sensing, separation, drug delivery, and materials science. Several analytical tools have been proposed over the past 20 years to probe these interactions, but most of them are limited ...

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Lysine-derived, pH-sensitive and biodegradable poly(beta-aminoester urethane) networks and their local drug delivery behaviour

24-Jan-2018 | Yasemin Tamer; Biqiong Chen, Soft Matter, 2018

In this study, a series of covalently crosslinked, l-lysine based poly(beta-aminoester urethane) (LPBAEU) networks with good biodegradability and pH sensitivity was reported. The effect of hydrophilic/hydrophobic characteristics and diacrylate/amine molar ratio on the structure, swelling and ...

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One-pot Synthesis of Hierarchical-pore Metal−Organic Frameworks for Drug Delivery and Fluorescent Imaging

23-Jan-2018 | Xuechuan Gao; Yuewu Wang; Guanfeng Ji; Ruixue Cui; Zhiliang Liu, CrystEngComm, 2018

Metal−organic frameworks (MOFs) have attracted increased interests in drug delivery. However, MOFs usually have micropores smaller than 2 nm, restraining larger drug molecules from entering into the pores of MOFs, restricting their practical applications as drug carriers. Here we demonstrate a ...

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Property prediction and pharmacokinetic evaluation of mixed stoichiometry cocrystals of zafirlukast, a drug delivery case study

23-Jan-2018 | Philip A. Corner; David J. Berry; James F. McCabe; Rafael Barbas; Rafel Prohens; Hongwen Du; Hongyu Zhou; Antonio Llinas, CrystEngComm, 2018

Cocrystals have been identified as a method for ensuring the delivery of poorly soluble drugs. Development of cocrystal phases presents many challenges, with the in vivo drug delivery benefits difficult to predict robustly. Additional to this, many of the benefits seen in the literature do not ...

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Microfluidic production of nanoscale perfluorocarbon droplets as liquid contrast agents for ultrasound imaging

19-Jan-2018 | Xiaonan Xu; Ruyuan Song; Minghao He; Chuan Peng; Miao Yu; Youmin Hou; Huihe Qiu; Ruhai Zou; Shuhuai Yao, Lab on a Chip, 2018

Liquid perfluorocarbon (PFC) nanodroplets may have a better chance to extravasate through inter-endothelial gaps (400–800 nm) into tumor interstitium for extravascular imaging, which holds promise as an innovative strategy for imaging-guided drug delivery, early diagnosis of cancer and minimally ...

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Combining vitamin B12 and cisplatin-loaded porous silica nanoparticles via coordination: a facile approach to prepare a targeted drug delivery system

19-Jan-2018 | Nattanida Thepphankulngarm; Piyanuch Wonganan; Chaweewan Sapcharoenkun; Thawatchai Tuntulani; Pannee Leeladee, New Journal of Chemistry, 2018

In this work, a novel drug delivery system for targeted therapy is developed based on noncovalent interactions. The strategy is to combine an active targeting unit and a passive targeting moiety via simple dative bonds. The system is composed of carboxyl group-modified porous silica nanoparticles ...

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Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient‐Derived Lung Cancer

19-Jan-2018 | Yuwei Cong, Haihua Xiao, Hejian Xiong, Zigui Wang, Jianxun Ding, Chan Li, Xuesi Chen, Xing‐Jie Liang, Dongfang Zhou, ..., Advanced Materials, 2018

Abstract Most of the current nanoparticle‐based therapeutics worldwide failing in clinical trials face three major challenges: (i) lack of an optimum drug delivery platform with precise composition, (ii) lack of a method of directly monitoring the fate of a specific drug rather than using any ...

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Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

19-Jan-2018 | Shan Peng; Yahua Wang; Na Li; Chong Li, Chemical Communication, 2018

The widely existing transmembrane helices can serve as a novel type of binding site for recognizing corresponding membrane receptors. Through imprinting the transmembrane domain of certain receptors, here we report the construction of polymeric nanoparticles which can achieve enhanced cellular ...

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Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

19-Jan-2018 | Shan Peng; Yahua Wang; Na Li; Chong Li, Chemical Communication, 2018

The widely existing transmembrane helices can serve as a novel type of binding site for recognizing corresponding membrane receptors. Through imprinting the transmembrane domain of certain receptors, here we report the construction of polymeric nanoparticles which can achieve enhanced cellular ...

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Nanoscale Heterogeneities Drive Enhanced Binding and Anomalous Diffusion of Nanoparticles in Model Biomembranes

19-Jan-2018 | Roobala Chelladurai; Koushik Debnath; Nikhil R. Jana; Jaydeep Kumar Basu, Langmuir, 2018

Interaction of functional nanoparticles with cells and model biomembranes has been widely studied to evaluate the effectiveness of the particles as potential drug delivery vehicles and bioimaging labels as well as in understanding nanoparticle cytotoxicity effects. Charged nanoparticles, in ...

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