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2,405 Newest Publications about the topic drug delivery


Hierarchical porous polycaprolactone microspheres generated in a simple pathway combining nanoprecipitation and hydrolysis

26-Aug-2015 | Hailong Fan; Zhaoxia Jin, Chemical Communication, 2015

We demonstrated a one-pot, soap-free fabrication of porous polycaprolactone microspheres by combining nanoprecipitation and hydrolysis. Obtained porous polycaprolactone microspheres show a great advantage in the application of drug delivery.


Ultrasound‐Propelled Nanocups for Drug Delivery

22-Aug-2015 | James J. Kwan, Rachel Myers, Christian M. Coviello, Susan M. Graham, Apurva R. Shah, Eleanor Stride, Robert C. Carli ..., Small, 2015

Ultrasound‐induced bubble activity (cavitation) has been recently shown to actively transport and improve the distribution of therapeutic agents in tumors. However, existing cavitation‐promoting agents are micron‐sized and cannot sustain cavitation activity over prolonged time periods because ...


Contrasting Recognition Behavior of beta‐cyclodextrin and its Sulfobutyl ether Derivative towards 4',6‐diamidino‐2‐phenylindole (DAPI)

20-Aug-2015 | Jyotirmayee Mohanty, Meenakshi Shinde, Achikanath C. Bhasikuttan, ChemPhysChem, 2015

The noncovalent interaction between 4', 6‐diamidino‐2‐phenylindole (DAPI) and sulfobutyl ether β‐cyclodextrin (SBE7β‐CD) has been evaluated by using photochemical measurements and equated with that of native β‐CD. Contrasting recognition and intriguing modulations in the photochemical behaviors ...


Bioinspired Nano‐Prodrug with Enhanced Tumor Targeting and Increased Therapeutic Efficiency

19-Aug-2015 | Wei‐Hai Chen, Qi Lei, Cai‐Xia Yang, Hui‐Zhen Jia, Guo‐Feng Luo, Xiao‐Yong Wang, Gang Liu, Si‐Xue Cheng, Xian‐Zheng Zhang, Small, 2015

Nanotechnology‐based drug delivery has a great potential to revolutionize cancer treatment by enhancing anticancer drug efficacy and reducing drug toxicity. Here, a bioinspired nano‐prodrug (BiNp) assembled by an antineoplastic peptidic derivative (FA‐KLA‐Hy‐DOX), a folate acid (FA)‐incorporated ...


Enzyme-responsive-based polymer-substituted pillar[5]arene amphiphiles: synthesis, self-assembly in water, and application in controlled drug release

19-Aug-2015 | Lingyan Gao; Bo Zheng; Wei Chen; Christoph A. Schalley, Chemical Communication, 2015

An enzyme-responsive drug delivery system was constructed from a pillar[5]arene-based polyethyleneglycol-substituted amphiphile which self-assembles into micelles in water. These micelles exhibit superior drug encapsulation capability, and display drug release behaviour in response to enzyme ...


Magnetic field assisted programming of particle shapes and patterns

19-Aug-2015 | Wenwen Xu; Yuyu Yao; John S. Klassen; Michael J. Serpe, Soft Matter, 2015

Anisotropic particles have generated an enormous amount of research interest due to their applications for drug delivery, electronic displays and as micromotors. However, up till now, there is no single protocol capable of generating particles of “patchy” composition with a variety of ...


Emerging Nanonisation Technologies: Tailoring Crystalline Versus Amorphous Nanomaterials

19-Aug-2015 | R. Serrano, Dolores; H. Gallagher, Kieran; Marie Healy, Anne, Current Topics in Medicinal Chemistry, 2015

Abstract: The overall pharmaceutical market is changing. A more personalised medicine approach is replacing the concept of blockbuster drugs and the “one size fits all” model. The two main forces that fuel the growth of nano-enabled drug technologies are the low aqueous solubility of new ...


Immobilization of Proteins in Ormosil Gels: Functional Properties and Applications

19-Aug-2015 | Ronda, Luca; Bettati, Stefano; Bruno, Stefano, Organic Chemistry, 2015

Abstract: Organically modified silica (Ormosil) gels are three-dimensional matrices obtained by co-polymerizing tetraalkyl orthosilicates and organoalkoxysilanes through the sol-gel technology. Ormosil matrices are highly flexible with respect to macroscopic size and shape, as they can be ...


Peptide Self-Assemblies for Drug Delivery

19-Aug-2015 | M. Leite, Diana; Barbu, Eugen; J. Pilkington, Geoffrey; Lalatsa, Aikaterini, Current Topics in Medicinal Chemistry, 2015

Abstract: Peptide amphiphiles (PAs) are novel engineered biomaterials able to self-assemble into supramolecular systems that have shown significant promise in drug delivery across the cell membane and across challenging biological barriers showing promise in the field of brain diseases, ...


Immobilization of Proteins in Biopolymer-Silica Hybrid Materials: Functional Properties and Applications

19-Aug-2015 | Christoph, Sarah; M. Fernandes, Francisco; Coradin, Thibaud, Organic Chemistry, 2015

Abstract: Biohybrid materials combine the natural diversity of biomolecules with the flexibility of the inorganic sol-gel process. Association of biopolymers with silica is particularly useful for the preparation of threedimensional hosts for protein immobilization with tailored physical ...


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