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2,946 Newest Publications about the topic drug delivery


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Indomethacin-guided cancer selective prodrug system activated by histone deacetylase and tumour-associated protease

22-Jul-2016 | Joo Hee Jang; Hoyeon Lee; Amit Sharma; Sang Min Lee; Tae Hoon Lee; Chulhun Kang; Jong Seung Kim, Chemical Communication, 2016

An indomethacin guided drug delivery system (IGDDS) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consective demasking ventures for drug activation. IGDDS exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting ...


Capillary Origami Inspired Fabrication of Complex 3D Hydrogel Constructs

15-Jul-2016 | Moxiao Li, Qingzhen Yang, Hao Liu, Mushu Qiu, Tian Jian Lu, Feng Xu, Small, 2016

Hydrogels have found broad applications in various engineering and biomedical fields, where the shape and size of hydrogels can profoundly influence their functions. Although numerous methods have been developed to tailor 3D hydrogel structures, it is still challenging to fabricate complex 3D ...


Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery

14-Jul-2016 | Homan Kang, Julien Gravier, Kai Bao, Hideyuki Wada, Jeong Heon Lee, Yoonji Baek, Georges El Fakhri, Sylvain Gioux, B ..., Advanced Materials, 2016

Renally cleared zwitterionic nanocarriers (H‐Dots) are composed of ε‐polylysine backbone for charge variations, near‐infrared fluorophores for bioimaging, and β‐cyclodextrins for potential drug delivery. H‐Dots show ideal systemic circulation and rapid distribution and excrete from normal ...


ChemInform Abstract: Glucose‐Sensitive Polymer Nanoparticles for Self‐Regulated Drug Delivery

14-Jul-2016 | Li Zhao, Chunsheng Xiao, Liyan Wang, Guangqing Gai, Jianxun Ding, ChemInform, 2016

Abstract Review: 128 refs.


IJMS, Vol. 17, Pages 1128: Improved Hepatoprotective Effect of Liposome-Encapsulated Astaxanthin in Lipopolysaccharide-Induced Acute Hepatotoxicity

14-Jul-2016 | Chiu, Chun-Hung ; Chang, Chun-Chao ; Lin, Shiang-Ting ; Chyau, Charng-Cherng ; Peng, Robert Y., International Journal of Molecular Sciences, 2016

Lipopolysaccharide (LPS)-induced acute hepatotoxicity is significantly associated with oxidative stress. Astaxanthin (AST), a xanthophyll carotenoid, is well known for its potent antioxidant capacity. However, its drawbacks of poor aqueous solubility and low bioavailability have limited its ...


Magnetic nanoparticle containing thiol‐ene crosslinked hydrogels for controlled and targeted release of hydrophobic drugs

13-Jul-2016 | Burcu Oktay, Serap Demir, Nilhan Kayaman‐Apohan, Polymer Composites, 2016

This study reports a straightforward but very effective method to produce nanocomposite hydrogels for targeted drug delivery system. An organic network containing both hydrophilic and hydrophobic components was obtained using thiol‐ene cross‐linking. Magnetite nanoparticles (MNPs) were ...


Development of tunable biodegradable polyhydroxyalkanoates microspheres for controlled delivery of tetracycline for treating periodontal disease

13-Jul-2016 | Nootchanartch Panith, Apinya Assavanig, Sittiwat Lertsiri, Magnus Bergkvist, Rudee Surarit, Nuttawee Niamsiri, Journal of Applied Polymer Science, 2016

ABSTRACT This article was aimed at preparation and characterization of drug delivery carriers made from biodegradable polyhydroxyalkanoates (PHAs) for slow release of tetracycline (TC) for periodontal treatment. Four PHA variants; polyhydroxybutyrate (PHB), ...


IJMS, Vol. 17, Pages 1111: Nanodiamonds for Medical Applications: Interaction with Blood in Vitro and in Vivo

12-Jul-2016 | Tsai, Lin-Wei ; Lin, Yu-Chung ; Perevedentseva, Elena ; Lugovtsov, Andrei ; Priezzhev, Alexander ; Cheng, Chia-Liang, International Journal of Molecular Sciences, 2016

Nanodiamonds (ND) have emerged to be a widely-discussed nanomaterial for their applications in biological studies and for medical diagnostics and treatment. The potentials have been successfully demonstrated in cellular and tissue models in vitro. For medical applications, further in vivo studies ...


Local Affinity Release

12-Jul-2016 | Vianney Delplace; Jaclyn Obermeyer; Molly S. Shoichet, ACS Nano, 2016

The use of hydrogels for therapeutic delivery is a burgeoning area of investigation. These water-swollen polymer matrices are ideal platforms for localized drug delivery that can be further combined with specific ligands or nanotechnologies to advance the controlled release of small-molecule ...


Sequence‐Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications

01-Jul-2016 | Rosemary L. Kanasty, Arturo J. Vegas, Luke M. Ceo, Martin Maier, Klaus Charisse, Jayaprakash K. Nair, Robert Langer, ..., Angewandte Chemie International Edition, 2016

Abstract The functionality of natural biopolymers has inspired significant effort to develop sequence‐defined synthetic polymers for applications including molecular recognition, self‐assembly, and catalysis. Conjugation of synthetic materials to biomacromolecules has played an increasingly ...


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