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3,204 Newest Publications about the topic drug delivery


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Simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones

06-Dec-2016 | yajun yin; Can Wu; Junling Wang; Fengjuan Song; Wanqing Yue; Wenying Zhong, Chemical Communication, 2016

An easy self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinones extract. The DDS showed increased loading capacity, sustained drug release and better anticancer capability. Our research proved hydrogel DDS of ...


Structural and dynamic studies of substrate binding in porous metal–organic frameworks

06-Dec-2016 | Timothy L. Easun; Florian Moreau; Yong Yan; Sihai Yang; Martin Schröder, Chemical Society Reviews, 2016

Porous metal–organic frameworks (MOFs) are the subject of considerable research interest because of their high porosity and capability of specific binding to small molecules, thus underpinning a wide range of materials functions such as gas adsorption, separation, drug delivery, catalysis, and ...


Human serum albumin in electrospun PCL fibers: structure, release, and exposure on fiber surface

02-Dec-2016 | Vera S. Chernonosova, Ren I. Kvon, Alena O. Stepanova, Yurii V. Larichev, Andrey A. Karpenko, Boris P. Chelobanov, E ..., Polymers for Advanced Technologies, 2016

Human serum albumin (HSA) introduced to the fibers produced by electrospinning from HSA and polycaprolactone (PCL) solutions in hexafluoroisopropanol has been studied in terms of its structure, release from the fibers, stability of interaction with basic polymer, accessibility for protease ...


Molecules, Vol. 21, Pages 1641: Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation

02-Dec-2016 | Guan, Qingxiang ; Sun, Dandan ; Zhang, Guangyuan ; Sun, Cheng ; Wang, Miao ; Ji, Danyang ; Yang, Wei, Molecules, 2016

Poorly soluble drugs have low bioavailability after oral administration, thereby hindering effective drug delivery. A novel drug-delivery system of docetaxel (DTX)-based stearic acid (SA)-modified Bletilla striata polysaccharides (BSPs) copolymers was successfully developed. Particle size, zeta ...


IJMS, Vol. 17, Pages 2012: Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release

01-Dec-2016 | Wang, Juan ; Yin, Zhuping ; Xue, Xiang ; Kundu, Subhas C.; Mo, Xiumei ; Lu, Shenzhou, International Journal of Molecular Sciences, 2016

Natural silk protein nanoparticles are a promising biomaterial for drug delivery due to their pleiotropic properties, including biocompatibility, high bioavailability, and biodegradability. Chinese oak tasar Antheraea pernyi silk fibroin (ApF) nanoparticles are easily obtained using cations as ...


Cross-Linking Approaches to Tuning the Mechanical Properties of Peptide π-Electron Hydrogels

01-Dec-2016 | Wathsala Liyanage; Herdeline Ann M. Ardoña; Hai-Quan Mao; John D. Tovar, Bioconjugate Chemistry, 2016

Self-assembling peptides are extensively exploited as bioactive materials in applications such as regenerative medicine and drug delivery despite the fact that their relatively weak noncovalent interactions often render them susceptible to mechanical destruction and solvent erosion. Herein, we ...


Understanding Resonant Light-Triggered DNA Release from Plasmonic Nanoparticles

30-Nov-2016 | Amanda M. Goodman; Nathaniel J. Hogan; Samuel Gottheim; Carrie Li; Susan E. Clare; Naomi J. Halas, ACS Nano, 2016

Nanoparticle-based platforms for gene therapy and drug delivery are gaining popularity for cancer treatment. To improve therapeutic selectivity, one important strategy is to remotely trigger the release of a therapeutic cargo from a specially designed gene- or drug-laden near-infrared (NIR) ...


Molecules, Vol. 21, Pages 1643: Drug Release by Direct Jump from Poly(ethylene-glycol-b-ε-caprolactone) Nano-Vector to Cell Membrane

30-Nov-2016 | Till, Ugo ; Gibot, Laure ; Mingotaud, Anne-Françoise ; Ehrhart, Jérôme ; Wasungu, Luc ; Mingotaud, Christophe ; Souc ..., Molecules, 2016

Drug delivery by nanovectors involves numerous processes, one of the most important being its release from the carrier. This point still remains unclear. The current work focuses on this point using poly(ethyleneglycol-b-ε-caprolactone) micelles containing either pheophorbide-a (Pheo-a) as a ...


Programmable Volume Phase Transition of Hydrogels Achieved by Large Thermal Hysteresis for Static-Motion Bilayer Actuators

30-Nov-2016 | Dowan Kim; Haneul Kim; Eunsu Lee; Kyeong Sik Jin; Jinhwan Yoon, Chemistry of Materials, 2016

In order to achieve a hydrogel capable of programmable volume change, poly(N-isopropylacrylamide)-graft-methylcellulose hydrogel (PNIPAm-g-MC) was prepared through the grafting of PNIPAm onto a MC backbone and simultaneous cross-linking of the chains. PNIPAm-g-MC exhibited large thermal ...


The DNA aptamer binds stemness‐enriched cancer cells in pancreatic cancer

28-Nov-2016 | Yoon‐Jin Kim, Hee Seung Lee, Dawoon E. Jung, Jeong Mi Kim, Si Young Song, Journal of Molecular Recognition, 2016

Abstract Pancreatic cancer remains one of the most common and lethal cancers. Most patients (80%) present with inoperable advanced pancreatic cancer at initial diagnosis, and their early diagnosis is a significant unmet challenge. Recent studies indicate that cancer, including pancreatic ...


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