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2,466 Newest Publications about the topic drug delivery


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Self assembled nano fibers of betulinic acid: A selective inducer for ROS/TNF-alpha pathway mediated leukemic cell death

04-Oct-2015 | Author(s): Sandeep Kumar Dash, Sourav Chattopadhyay, Shib Shankar Dash, Satyajit Tripathy, Balaram Das, Sa ..., Bioorganic Chemistry, 2015

Publication date: Available online 30 September 2015 Source:Bioorganic Chemistry Author(s): Sandeep Kumar Dash, Sourav Chattopadhyay, Shib Shankar Dash, Satyajit Tripathy, Balaram Das, Santanu Kar Mahapatra, Braja Gopal Bag, Parimal Karmakar, Somenath Roy The main ...


Fenestrated microneedles for ocular drug delivery

04-Oct-2015 | Author(s): Omid Khandan, Malik Y. Kahook, Masaru P. Rao, Sensors and Actuators B: Chemical, 2015

Publication date: February 2016 Source:Sensors and Actuators B: Chemical, Volume 223 Author(s): Omid Khandan, Malik Y. Kahook, Masaru P. Rao The development of a safe, simple, and efficacious means for ocular drug delivery remains a critical unmet need. Solid microneedles (MNs) show ...


Cancer‐Cell‐Specific Nuclear‐Targeted Drug Delivery by Dual‐Ligand‐Modified Mesoporous Silica Nanoparticles

02-Oct-2015 | Lin Xiong, Xin Du, Freddy Kleitz, Shi Zhang Qiao, Small, 2015

Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer‐cell‐specific nuclear‐targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active ...


Host–Guest Interaction‐Mediated Construction of Hydrogels and Nanovesicles for Drug Delivery

02-Oct-2015 | Xing‐Dong Xu, Xin Li, Hongzhong Chen, Qiuyu Qu, Lingzhi Zhao, Hans Ågren, Yanli Zhao, Small, 2015

Hand‐in‐hand or head‐to‐head: A novel naphthalimide derivative is successfully designed and synthesized, which can self‐assemble to produce hydrogels. When injecting this compound into CB[8] solution, the nanovesicles are obtained with a narrow size distribution. The cytotoxicity assay confirms ...


Acid-Disintegratable Polymersomes of pH-Responsive Amphiphilic Diblock Copolymers for Intracellular Drug Delivery

01-Oct-2015 | Lei Wang; Guhuan Liu; Xiaorui Wang; Jinming Hu; Guoying Zhang; Shiyong Liu, Macromolecules, 2015

Supramolecular vesicles, also referred to as polymersomes, self-assembled from amphiphilic polymers capable of synchronically loading with both hydrophilic and hydrophobic payloads have shown promising potential in drug delivery application. Herein, we report the fabrication of pH-responsive ...


Analytical and Simulation-Based Models for Drug Release and Gel-Degradation in a Tetra-PEG Hydrogel Drug-Delivery System

30-Sep-2015 | Ralph Reid; Miriam Sgobba; Barak Raveh; Giulio Rastelli; Andrej Sali; Daniel V. Santi, Macromolecules, 2015

We have recently reported drug-releasing, degradable Tetra-PEG hydrogels as a new drug delivery system. The gels contain two self-cleaving β-eliminative linkers: one that covalently tethers the drug to the gel and releases it at a predictable rate, and another with slower cleavage that is ...


Glyconanomaterials for Combating Bacterial Infections

29-Sep-2015 | Olof Ramström, Mingdi Yan, Chemistry - A European Journal, 2015

Abstract Bacterial infections constitute an increasing problem to human health in response to build‐up of resistance to present antibiotics and sluggish development of new pharmaceuticals. However, a means to address this problem is to pinpoint the drug delivery to—and into—the bacteria. This ...


DNA Origami and Biotechnology Applications: A Perspective

29-Sep-2015 | Arun Richard Chandrasekaran, Journal of Chemical Technology & Biotechnology, 2015

Abstract The use of DNA as a material has opened up new possibilities in the field of nanobiotechnology. Specifically, DNA origami — a technique in which one long single‐stranded DNA scaffold is folded into nanoscale shapes and structures using hundreds of short 'staple' oligonucleotides — has ...


Stimuli‐responsive molecularly imprinted hybrid polymer gel as a potential system for controlled release

29-Sep-2015 | Orhan Güney, Erdal Serin, Journal of Applied Polymer Science, 2015

ABSTRACT The purpose of this study is to develop a stimuli‐responsive hybrid polymer gel system with an improved mechanical stability as a controlled drug delivery carrier that can undergo phase transition by the stimulation of ethanol–water mixture. For this aim, trimethoxysilane terminated ...


Antimicrobial loading into and release from poly(ethylene glycol)/poly(acrylic acid) semi‐interpenetrating hydrogels

29-Sep-2015 | Yong Wu, Jing Liang, Ferenc Horkay, Matthew Libera, Journal of Polymer Science Part B: Polymer Physics, 2015

ABSTRACT Electrostatic interactions within a semi‐interpenetrating network (semi‐IPN) gel can control the postsynthesis loading, long‐term retention, and subsequent release of small‐molecule cationic antibiotics. Here, electrostatic charge is introduced into an otherwise neutral gel ...


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