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46 Newest Publications about the topic drug tests

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[In Depth] As Ebola wanes, trials jockey for patients

03-Apr-2015 | Kai Kupferschmidt, Science , 2015

The Ebola epidemic in West Africa has caused enormous suffering, but scientists also see it as a chance to test experimental therapies that could save lives in the future. With declining case numbers, however,it is becoming less likely that all the drug tests will reach a conclusion. Now, ...

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Metabolism of norethisterone in the greyhound

09-Sep-2013 | S. T. B. Biddle, A. O'Donnell, E. Houghton, C. S. Creaser, Rapid Communications in Mass Spectrometry, 2013

RATIONALE Norethisterone has been used as a successful oral contraceptive in humans for many years. It was recently permitted for use as an oestrus suppressant in racing greyhounds. To monitor the use of norethisterone as part of a routine drug surveillance programme, knowledge of its ...

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Hydrogen isotope ratio mass spectrometry and high‐resolution/high‐accuracy mass spectrometry in metabolite identification studies: Detecting target compounds for sports drug testing

19-Jul-2013 | Mario Thevis, Thomas Piper, Stevan Horning, Dieter Juchelka, Wilhelm Schänzer, Rapid Communications in Mass Spectrometry, 2013

RATIONALE In sports drug testing, comprehensive studies on the metabolism of therapeutic agents with misuse potential are necessary to identify metabolites that provide utmost retrospectivity and specificity. By commonly employed approaches minor and/or long‐term metabolites in urine might ...

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Methylenedioxypyrovalerone (“Bath Salts”),Related Death: Case Report and Review of the Literature,

04-Jul-2013 | Kilak Kesha, Cassie L. Boggs, Mary G. Ripple, Carol H. Allan, Barry Levine, Rebecca Jufer‐Phipps, Suzanne Doyon, Pao ..., Journal of Forensic Sciences, 2013

Abstract Cathinone derivatives (bath salts) have emerged as the latest drugs of abuse. 3,4‐methylenedioxypyrovalerone (MDPV) is the primary active ingredient in bath salts used in this country. This article presents the second reported cause of death by MDPV intoxication alone. In April 2011, ...

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Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes

19-Jun-2013 | Sebastian Höppner, Wilhelm Schänzer, Mario Thevis, Journal of Mass Spectrometry, 2013

The enzyme SIRT1 is a metabolic key regulator in mitochondrial biogenesis, fat and glucose metabolism. Its activation through pharmaceutical SIRT1 activators such as SRT2104 results in an increased deacetylation of substrates representing important targets for the treatment of metabolic ...

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A microfluidic cell culture array with various oxygen tensions

29-May-2013 | Chien-Chung Peng; Wei-Hao Liao; Ying-Hua Chen; Chueh-Yu Wu; Yi-Chung Tung, Lab on a Chip, 2013

Oxygen tension plays an important role in regulating various cellular functions in both normal physiology and disease states. Therefore, drug testing using conventional in vitro cell models under normoxia often possesses limited prediction capability. A traditional method of setting an oxygen ...

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Expanding sports drug testing assays: Mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP‐105

25-Apr-2013 | Mario Thevis, Thomas Piper, Simon Beuck, Hans Geyer, Wilhelm Schänzer, Rapid Communications in Mass Spectrometry, 2013

RATIONALE Anabolic agents have been top‐ranked for many years among statistics of adverse analytical findings compiled by the World Anti‐Doping Agency (WADA). Besides archetypical anabolic‐androgenic steroids (AAS), alternative substances with similar effects concerning bone and muscle ...

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Modeling Ewing sarcoma tumors in vitro with 3D scaffolds [Engineering]

16-Apr-2013 | Eliza Li Shan Fong; Salah-Eddine Lamhamedi-Cherradi; Emily Burdett; Vandhana Ramamoorthy; Alexander J. Lazar; F. Kur ..., Proceedings of the National Academy of Sciences current issue, 2013

The pronounced biological influence of the tumor microenvironment on cancer progression and metastasis has gained increased recognition over the past decade, yet most preclinical antineoplastic drug testing is still reliant on conventional 2D cell culture systems. Although monolayer cultures ...

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Monitoring phosphodiesterase‐4 inhibitors using liquid chromatography/(tandem) mass spectrometry in sports drug testing

11-Apr-2013 | Mario Thevis, Oliver Krug, Wilhelm Schänzer, Rapid Communications in Mass Spectrometry, 2013

RATIONALE The recent discovery of resveratrol's capability to inhibit cAMP‐specific phosphodiesterases (PDEs) and, as a consequence, to enhance particularly the activity of Sirt1 in animal models has reinforced the interest of preventive doping research organizations, especially in PDE4 ...

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Forensic drug analysis and microfluidics

06-Mar-2013 | Entesar Al‐Hetlani, ELECTROPHORESIS, 2013

The analysis of drugs of abuse in microfluidic devices has the potential to provide solutions to today's on‐site analysis challenges. The use of such devices has not been limited to miniaturising conventional analytical methods used routinely in forensic laboratories; new and interesting ...

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